Thank you, a really great video. I like the bar code comparison at the end. I think that one of the cerebral challenges to understanding histone and DNA modifications is to recognize, in the first place, why they are necessary and moreover, how they allow so so many genes to be read, written to, read again, erased, written to again, read again, etc, switching genes on or off, or modulated in some way. The mental barrier is because the focus is too close, to see the big picture. If the big picture is explained FIRST, in broad outline, reasons, and underlying principles, then the mind, when focusing on the fine detail can connect it back to the big picture. So for example, if these medications are explained from the outset as 1) allowing the base 'bar codes' of genes to be read to enable new bar codes top to be created and 2) that new bar codes to be read to do the same, then this creates in the listener's mind and expectation of where the details are heading, or where it connects. I hope that makes sense.
I searched for histone modification alot but didn't find anything interesting except this video. You went into detail and I really liked it. Please make more videos that help medical students.
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
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wow! untill you say that the phosphorylated serine or trionine both have negative charge like DNA backbone does and this results in the repulsion between DNA and histone which makes DNA more accessible to transcription factors, I didn't know how phosphorylation and all of these modification methods work. This video was so clarifying.
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Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Thank you so much. I am doing a research to access the level of Histone acetylation in thyroid cancers using immunohistochemistry and image analysis. This helped me understand the basic 🤗
Hi Arpan. You are one of the best educators in this field. Your thorough presentation has helped me further understand its mechanism in conjunction with my text books. I do have question. For chromo and bromo domains, can you briefly describe their transcription and translation pathways? Thank you.
I am glad to find your channel. Explained quite well. however, I'm still confused about the part pertaining to Bromo and chromodomain protein. Nevermind will do a bit more research. please keep updating more videoes especially on the molecular biology, it is such a complex component of the medicine.
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Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance I'm on Instagram as @animatedbiologywitharpan. Install the app to get notes and flash cards. instagram.com/invites/contact/?i=1p41h314q3fv8&
what kind of effect this combination of multiple bromodomains and histone acetyltransferase in a single complex will have on the spreading of histone marks and what consequences this might have on the structure of chromatin.
We can explain the relaxation of DNA when HAT comes, that could be the fact that the acetylation removes the positive charges of Lysine or Arginine then we have less interaction with the negative charges of the DNA's phosphates.
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According to fundamental textbooks acetylation is possible in both Arg and Lys but frequently lys residues are acetyl ated......I haven't checked the recent literature about this so I would check and answer your question
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Shabnam Khatoon Any molecule, critical for the survival of the organism, is highly conserved.In evolution An organism with aberration in chromatin will not survive or rather not selected. organisms with mutations in histone coding DNA does not survive. In other words, only organisms with perfect histone structure will be selected and get evolutionary advantage
Phenomenal video - thank you so much. I’m researching the potential role of Histone modification to treat substance dependence. Feel free to reach out to me.
@@animatedbiologywitharpan what do u mean by degrade? For u didn't say die. And since the histone is light expressed what happens to that light after death?
@@animatedbiologywitharpan why do you say the histone is protein when it is not part of the protein chain, nor DNA but feeding everything with light energy?
@@animatedbiologywitharpan u do not that degrade is not falling in grade, and it is also not death. U do also know that everything feeding on histone (me) doesn't kill histone (me). Each lifeform in the cell has its own light (expressed the all invisible sound). Hence why we are histone. What sustains and expresses histone is sound invisible.
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance I'm on facebook & Instagram as @animatedbiologywitharpan. Install the app to download notes and flash cards. instagram.com/invites/contact/?i=1p41h314q3fv8& You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me
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I learned more from this video than I did in my entire genetics semester. Thank you
TeamMatt please share my channel link in your college group and help me to reach big audience
Thank you, a really great video. I like the bar code comparison at the end. I think that one of the cerebral challenges to understanding histone and DNA modifications is to recognize, in the first place, why they are necessary and moreover, how they allow so so many genes to be read, written to, read again, erased, written to again, read again, etc, switching genes on or off, or modulated in some way. The mental barrier is because the focus is too close, to see the big picture. If the big picture is explained FIRST, in broad outline, reasons, and underlying principles, then the mind, when focusing on the fine detail can connect it back to the big picture. So for example, if these medications are explained from the outset as 1) allowing the base 'bar codes' of genes to be read to enable new bar codes top to be created and 2) that new bar codes to be read to do the same, then this creates in the listener's mind and expectation of where the details are heading, or where it connects. I hope that makes sense.
I searched for histone modification alot but didn't find anything interesting except this video. You went into detail and I really liked it. Please make more videos that help medical students.
I provide 1 to 1 tutorial session for $10 /h. If interested please email us at arpanparichha1994@gmail.com
Beautifully done Arpan, we need more people like you.
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The most comprehensible video on this topic. Thanks so much!!!
Suggested video ruclips.net/video/An9WkN4_Hbk/видео.html
Bro legit saved my life
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yeah 10 minutes with this helped more than over 25 hours reading textbook
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I learned more from this video than I did in my entire genetics semester. Th!
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Just so cool man! Im a chemist going into this world and for me this is jus freaking spontaniously amazing
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You are really doing great. I am referring your videos to my students. The animation is great to explain genetics. Wish you success. From Kolkata
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wow! untill you say that the phosphorylated serine or trionine both have negative charge like DNA backbone does and this results in the repulsion between DNA and histone which makes DNA more accessible to transcription factors, I didn't know how phosphorylation and all of these modification methods work. This video was so clarifying.
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
Tqsm sir , this concept I couldn't understand in my university class but from your my concept become crystal cleard
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Ma Shaa Allaah....💕💕💕
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Very well explained thanks alot sir 🙏😇 May god bless u with lots of love and blessings
Don’t call me sir..... I am one of you guys... just a student... we are all learners
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Your explanation is the best! Thanks a lot!
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Thank you so much. I am doing a research to access the level of Histone acetylation in thyroid cancers using immunohistochemistry and image analysis. This helped me understand the basic 🤗
Very nice... good to hear that it was useful. Please share my channel link in your friends group such that they get help as well...
Eiii.... people are really learning.
I’m really really thankful for this…it helps a lot in short time..you are a great man..keep it man..love from pakistan ❤️
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Hi Arpan. You are one of the best educators in this field. Your thorough presentation has helped me further understand its mechanism in conjunction with my text books. I do have question. For chromo and bromo domains, can you briefly describe their transcription and translation pathways? Thank you.
I will answer your question in a short video....will upload soon. I am away for a conference
What a superb explanation , hats off !!!
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@@animatedbiologywitharpan surely I'll do my best 🙏🙏
nicely explained and illustrated, thank you
Please share my channel link with your friends and help me to reach big audiance .
8:58 wow ADP ribosylation is what SIRT6 does.
bromodomain recognizes acetylation at one place and methylation at antoher place?
I LOVE IT THANK YOU SO MUCH. YOUR EXPLANATION STYLE IS WONDERFUL.
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Your expiation is good. Thank you
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complete and comprehensible, perfect!
Please share among your friends and help me to reach big audience
Thank you
I was so confused in my class today and this helped a lot
Please share my channel link with your friends and help me to reach big audience...I am unable to reach many people. Anyway lots of love from India
I am glad to find your channel. Explained quite well. however, I'm still confused about the part pertaining to Bromo and chromodomain protein. Nevermind will do a bit more research. please keep updating more videoes especially on the molecular biology, it is such a complex component of the medicine.
Please share among your friends and help me to reach big audience........I will post more on molecular biology
Cutely understandable vid ! धन्यवाद
Thanks for your feedback. Please share among your friends and colleagues
Very well explained, thank you.
checkout the entire molbio playlist. Its high yield and time saving ruclips.net/p/PLKtiwIJ8Q7rppT2_xeMbIbrfTvAttgVcP&si=Sos4WhUnlK7mYCpP
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Simply amazing!
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My suggestion is please keep it up🤟
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Excellent video. Thank you
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what kind of effect this combination of multiple bromodomains and histone acetyltransferase in a single complex will have on the spreading of histone marks and what consequences this might have on the structure of chromatin.
Thanks for this video i got something called post finasteride syndrome and hdaci is pretty much needed for a cure
I am so sorry to hear about your situation. Feel better soon.
Thank you so much, this really helped
Please share
Great explaination. Thank you for the video.
Please share among friends and help me to reach big audience
Thanks for this explaining... keep working 😀
Keep sharing with your friends
very nice work here
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Nice video.
Please make a video upon Mitochondria & Chloroplast. As soon as possible.
As your videos are pretty helpful for understanding. 😊😊
Yes it’s in the list
We can explain the relaxation of DNA when HAT comes, that could be the fact that the acetylation removes the positive charges of Lysine or Arginine then we have less interaction with the negative charges of the DNA's phosphates.
Please share my channel link with your friends and help me to reach big audience
Great video! Thanks
Please share my channel link with your friends and help me to reach big audience
Wow the video is amazing thanks
Go in depth to understand Histone methylation: ruclips.net/video/ka6s1fi6yZQ/видео.htmlsi=0YR6euYEjNJmof7d
go in depth to understand histone acetylation :ruclips.net/video/CR954dU6Yag/видео.htmlsi=sDoVBVhQBj-gJkHA
Learn about histine variants ruclips.net/video/oHxYoyL9HJA/видео.htmlsi=Go3R0lPFz2KV3eyq
Learn how to experimentally investigate histone modification ruclips.net/video/992RkrUwGfo/видео.htmlsi=_N_0jPaxJ5ByoPoQ
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Thanks sir for nice explanation
Easy to understand all the points
👍
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Excellent video!!!
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Thank you so much for clear explanation
Please share my channel link with your friends and help me to reach big audience
Can you pls explain the importance and role/function of SUMOylation of histones as a histone modification process?
Thanks for the suggestion. I will try to make a video on this
Sir make a video on Prokaryotic post translational modification
what are the resources you used plz ? thanks for the great explaination
The references could be found in Watson molecular biology of the gene
Well explained 😊
Hitaishi Boora please share among your friends and help me reach out big audiance
Nice explanation
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2:35 As far as I can tell, adding an acetyl group is only possible on lys...
According to fundamental textbooks acetylation is possible in both Arg and Lys but frequently lys residues are acetyl ated......I haven't checked the recent literature about this so I would check and answer your question
Congratulations for the explanation! This helped me a lot!
Gustavo Henrique Ferreira Gonçalinho please share among your friends and help me to reach big audience
Sir have u made lectures on operon concept
yes . checkout the entire molbio playlist to find it ruclips.net/p/PLKtiwIJ8Q7rppT2_xeMbIbrfTvAttgVcP&si=59fhtAn6n0dSyDOP
Great video. Could you explain histone lactylation and its effect on transcription?
Soon would upload
Great lecture, thank you very much
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Really good video!
Please share among friends and help me to reach big audience
Lovely
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
I'm on Instagram as @animatedbiologywitharpan. Install the app to follow the notes and flash cards instagram.com/invites/contact/?i=1p41h314q3fv8&
Thank you vey much 😍😍
Please share among your friends
Sir can you please tell from which book you refer these topics ?
You can follow molecular biology of the gene for the basic understanding but eventually i will make detailed video
For example watch this video ruclips.net/video/CR954dU6Yag/видео.html
Thank you very much
The last 5 mins of the video you introduced several names and processes not known by me and I felt they were not fully explained.
Thanks for the feedback....I would try to make a detailed video in that case
good video
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Sir does DNA methylation also cause epigenitic change?
Yes ...there are methyl transferase enzyme who deposits methylation marks on DNA
@@animatedbiologywitharpan ok sir
@@animatedbiologywitharpan is the phenotypic change heritable?rather to say epigenetic change
Thank you so much bro
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Tooop❤❤
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too good explaination
Please subscribe to my other channel ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg
I have a doubt
Why histones are highly conserved ??
Sir plz answer the question
Shabnam Khatoon Any molecule, critical for the survival of the organism, is highly conserved.In evolution An organism with aberration in chromatin will not survive or rather not selected. organisms with mutations in histone coding DNA does not survive. In other words, only organisms with perfect histone structure will be selected and get evolutionary advantage
Shabnam Khatoon this answer is very hand waving and I am not happy with it.
@@animatedbiologywitharpan thank you very much sir
Shabnam Khatoon please share among your friends and help me to reach big audience
Phenomenal video - thank you so much. I’m researching the potential role of Histone modification to treat substance dependence. Feel free to reach out to me.
Thanks for your comment
Ty
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thank youuuu
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@@animatedbiologywitharpan of course!!
Very good explanation, could you sent the ppt file for the lecture please?
Please share among your friends and help me to reach big audience.... send me your email
amjedhu73@gmail.com
Are u from Bnagladesh?
No .. from India
@@animatedbiologywitharpan ❤️ from bd
Dhonnobad vaya.... video ta friends der modhhe share kore dio
By the way ami bangali
@@animatedbiologywitharpan অবশ্যই, আপনার কনটেন্ট কোয়ালিটিফুল। শেয়ার করবো ডিপার্টমেন্টে
What happens to the histone after death?
Universal Eye like all proteins it would degrade
@@animatedbiologywitharpan what do u mean by degrade? For u didn't say die. And since the histone is light expressed what happens to that light after death?
@@animatedbiologywitharpan why do you say the histone is protein when it is not part of the protein chain, nor DNA but feeding everything with light energy?
@@animatedbiologywitharpan u do not that degrade is not falling in grade, and it is also not death. U do also know that everything feeding on histone (me) doesn't kill histone (me). Each lifeform in the cell has its own light (expressed the all invisible sound). Hence why we are histone. What sustains and expresses histone is sound invisible.
Explained it really well..
Please share among your friends and help me to reach big audience
Surely Arpan.. But can you tell some instances where histone modifications have resulted in any disease or phenotypic modification in human?
Sipra S. Panigrahi stay tuned....more video would be uploaded
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Sipra S. Panigrahi oo ities in Macedonia
Brother this channel was name before arpan paricha????
Yes. Name was changed sometime earlier.
Ya it’s the same person
Seek Christ Jesus YHVH.
Thank you
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
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You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me
thank you
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.