EPIGENETICS & CHROMATIN STATES - An introduction to histone modifications & gene transcription roles

This lecture introduces you to histones and histone modifications and how they contribute to transcriptional regulation. It is an ideal starting point for those who are new to the subject or professionals in other fields needing a quick primer.
Contents:
0:35 Defining the epigenetic memory of gene expression
2:37 Chromatin and histones
7:12 Histone modifications
7:59 Histone acetylation and reading by bromodomain proteins
12:02 Histone methylation and reading by chromodomain proteins
19:17 The complex language of histone modifications
21:53 How a core set of marks help define chromatin states
This lecture is brought to you by Dr Adam West in the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. We hope you found this video useful. Please support us by liking the video and consider subscribing for more informative content. Leave us a comment if you thought this video was helpful or if there is further information you would like to share with us and the community. Thank you!
www.gla.ac.uk/people/adamwest
/ genomicsgurus
/ genomicsgurus
Download the Epigenetic Modifications poster from Abcam here: www.abcam.com/pathways/epigen...
Read more about ChromHMM and view the data here: www.encodeproject.org/search/...
Use my UCSC genome browser session to look at chromatin states in your cells of interest:
bit.ly/HOXBUCSCGenomeBrowser
CC licensed content, shared previously:
Chromatin fibre model: Marx V. Epigenetics: Reading the second genomic code. Nature. 2012 491(7422):143-7. doi: 10.1038/491143a.
Homeotic gene diagram: Biology. Provided by: OpenStax CNX. Located at: cnx.org/contents/185cbf87-c72e.... License: CC BY: Attribution. License Terms: Download for free at cnx.org/contents/185cbf87-c72e...
Animated nucleosome structure model: proteopedia.org/wiki/index.ph...
Chromatin condensation and histone folding diagrams: Johnson A.D., Alberts B., Morgan D., Lewis J., Roberts K., Raff M. and Walter P. Molecular Biology of the Cell, Sixth Edition. WW Norton. ISBN: 978-1-317-56374-7

[@cherylmockotr]

Fabulous! I haven't paid attention to epigenetic advancements in a decade or more, and am amazed at how much more has been discovered. The complexity blows me away!!

[@aidaririvera8783]

I must complement you because you were much, much thorough in explaining a wider array of terms and processes than other Epigenetic tutorials do not cover. Congratulations for being so illuminating in such a vast and complicated discipline!

[@GenomicsGurus]

Thanks for your kind feedback Aidari. Best wishes for your ongoing studies!

[@hamidkiangaikani]

Dr Adam West. I'll remember this name. It is an amazing video. I just needed to get a little familiar with modification marks and I learned much more than I needed. Great Job and thanks

[@user-sh2ct4sk2o]

Thanks! Beatifull lecture. Really sad that you stopped making videos

[@pmathew63]

Lucid and beautifully structured. As a neophyte I felt I learned a substantial amount of basic knowledge in a short time.

[@GenomicsGurus]

Thanks for your feedback. Glad it has helped you move forward

[@bighistorysclh8456]

For those of us with only one college course in organic chemistry this is by far the easiest to understand description of the incredibly complex process of histone modification. What I would really like to understand better is how and when are the enzymes which drive the histone modification created during embryo development and later during a typical sleep wake cycle when different proteins are made depending on the time of day.

[@GenomicsGurus]

Thanks David. These are good questions and are an active area of research in the field!

[@faridhakimi1146]

Lovely ❤thanks for the great lecture

[@StevenMGruber]

Great visualizations, thanks!

[@sabirasharif2207]

Thankyou

[@aashishgyawali9239]

very insightful. Thank You :-)

[@CataM1988]

Super useful lecture. Thanks so much for sharing!

[@GenomicsGurus]

You are very welcome Catalina. Glad you found it useful!

[@farzanehrezazadehshojaee7526]

Such a great video. Thank you so much.

[@leonardoblankenburg5425]

A marvellous class! The practice part was absolutely necessary for understanding this complex and dense theme.

[@GenomicsGurus]

Glad you found it helpful Leonardo!

[@aashishgyawali9239]

Very insightful. You are doing great job :--)

[@So1asola]

thank you. great lecture and you made it very easy to understand

[@SvitlanaKamenska]

Thank you! It is very well explained complext topic

[@RockerProf]

This is an amazing video. Thank you for making it.

[@polycarpnalela6951]

It was definitely a very good and enlightening lecture

[@GenomicsGurus]

Glad you found it helpful!

[@crimsonstarr6122]

Amazing video, thanks so much!

[@GenomicsGurus]

Glad you liked it!

[@elisabethdiveraalidacathar9672]

Super. Thank you!

[@GenomicsGurus]

Glad you found it useful Elisabeth

[@anitataksas9536]

This was such a helpful video! Thank you! I would love to see a similar one about the Polycomb group and maybe a review on the techniques for epigenome analysis!

[@GenomicsGurus]

Glad you found it helpful Anita. Good suggestions

[@hengzhao308]

Extremely good presentation!!!

[@GenomicsGurus]

Glad you liked it!

[@Desola1826]

This is so good. Thank you very much.

[@GenomicsGurus]

You're very welcome!

[@vasilisazhukova]

Great video. Thanks a lot!

[@GenomicsGurus]

Glad it helped!

[@thenaturalsourceofourhealth]

Excellent video, thank you

[@GenomicsGurus]

You're welcome John. Best wishes

[@user-sz3cw3jr8v]

Greetings from Bulgaria

[@rafaelsolerortuno6159]

Thanks! Very informative :D I would love an ChIP-Seq/ATAC-Seq vídeo :D

[@GenomicsGurus]

Good idea! Are you more interested in what these techniques are and interpreting figures using them? or do you want advice on carrying them out and doing the bioinformatic analysis?

[@rafaelsolerortuno6159]

@@GenomicsGurus actually both of them are great ideas!! 🥰

[@shiva_1114]

Thank you

[@GenomicsGurus]

Glad it was helpful!

[@edthoreum7625]

5:00 histone

[@lumpyspaceprincess6335]

Is this channel aims scientists