Histone Post Translational Modifications
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- Опубликовано: 15 авг 2020
- This Video Explains In Detail About The Post Transcriptional Modifications On Histone Proteins, Epigenetics, Methylation, Phosphorylation, Acetylation, Ubiquitylation And SUMOylation.
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The simplest and most detailed explanation I have seen so far. Thanks:)
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Much needed video , the simplest and the easiest explanation . Thanks a ton .:)
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The best explanation on the whole internet. Thank you ma'am.
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Very comprehensive. Thanks.
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Nice video. Easy to understand.
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Very nice explanation..
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Very nice video :). Thanks a lot ! A question, how is the conservation of the lysine/methylation positioning for activation/desactivation throughout the eukaryotes? Thanks
Hi Carol This Article will help you more about the conservation of the lysine/methylation www.ncbi.nlm.nih.gov/pmc/articles/PMC4023394/
Thanks
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Thanku
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Hi, Thank you for the video. This is very useful summing up all important information as other videos on your channel. But I am confused that in histone phosphorylation sldie (10:52) you say red kinase enzyme (Dlk/Zip) attaches the phoshorylated histone and then this leads to increased demethylation of another histone mark. But the figure shows red enzyme results in chromosome segragation, and your example for increased demethylation is actually resulted from PRK1 binding to the phosphorylated histone? Am I wrong?
Hi Selcen you are right, but PRK1 enzyme is also Kinase enzyme. The red box I mentioned should be on PRK1 and not on DIK/ZIP
Excellent
Thanks
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Mam Plzzz one video on epigenetic. It's very confusing
Ok the topic is noted and put it in the queue.
Can you guys please put accurate captions for this?
A lot of this is new vocab for me, so I want to know how to spell it correctly in my notes
Sure, will let you know when its done.
I am very confused about SUMOylation. Here you explain that SUMO binds to histone modifier enzymes and makes them non-functional. But in some research papers that I found on internet, it is written that SUMOylation of the specific histone modifier enhances its activity multifold and not inactivate it. I don't understand which one is the correct function of SUMOylation. Pls guide on this.
Hi Rohit, SUMO target proteins are transcriptional co-activators or co-repressors. It also depend on which site they were attach and which specie the experiment was done on.
Reference for the video is www.tandfonline.com/doi/pdf/10.4161/epi.4.7.9807
@@EasyPeasyLearning Thank you very much. I'll refer to this link.
In topic name you write translation
But it should transcrition
Love the videos. I just wish you would say PRO-teins instead of PRI-teins. :D
This problem is already fixed in recent videos. It was hard but I tried my best :)
@@EasyPeasyLearning Haha thank you for your response! I really love you videos - I only know one language unfortunately. :(
Keep up the good work!!! Epigenetics is so interesting right now!
I am happy to have people like you ☺. Your comments always make me happy. Well English is my 4th language and the best part is that you want to speak every language with same accent heheh. That messes up the words sometime.
Everybody is learning dear, including me. Have a great day 😀 😊
Helpful but we want post transcriptional-capping,poly adenylation
There is a separate video for that topic.
4:36 +/-