Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal. The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.
MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.
NER Problem : Pyrimidine dimer Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage Helicase unwind DNA XPF and XPG remove DNA DNA polymerase bound and made a new DNA.Ligase connect everything.
Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.
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Thank you so much for this amazing explanation .Ma'am, I have a question to ask you. What is the function of DNA helicase II in NER of Prokaryotes?
Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal.
The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.
It's simply super🤩thank you so much and it helps me a lot to improve my knowledge
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Thanks you so much Sehar ..
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Great explanation only one question.. doesnt mmr rely on dna pol 3 not 1?
Very informative nicely explained 👌👌
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Helped a lot 🥰 Keep up the good work 👍
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You're following "Biochemistry" by Jeremy M. Berg, John L. Tymoczko, and Lubert Stryer.??
This is more of Lippincott and lehninger's
ok thanks
Great explanation. Thank you
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Thank you!
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Do these occur in prokaryotes? Or in eukaryotes only?
MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.
NER
Problem : Pyrimidine dimer
Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage
Helicase unwind DNA
XPF and XPG remove DNA
DNA polymerase bound and made a new DNA.Ligase connect everything.
Thank you ❤❤❤
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That's a perfect video Madam
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@@EasyPeasyLearning I will watch all your videos
Very well explained
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great video thanks!
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good summary, thanks :)
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Every thing all right...but we need written notes for this
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Hi there, The material was taken from the book of Lippincott's Biochemistry 5th edition.
When dna repair mechanism don’t function properly, is there any chance the damage cell become malignant cell?
Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.
@@EasyPeasyLearning thanks
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