Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal. The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.
NER Problem : Pyrimidine dimer Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage Helicase unwind DNA XPF and XPG remove DNA DNA polymerase bound and made a new DNA.Ligase connect everything.
MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.
Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.
For me, it's the PACE OF YOUR VOICE that made the explanation more worthwhile.
Thank you 😊
this series on genetics is super helpful!
Thank you 😊
The best to explain genetic Biology. Very detailed and helpful to understand thank you for your videos.❤
You are welcome 🤗
wow, this is exactly what I was looking for. Thank you so much.
You are welcome 😊
Very good explanation.much love from kenya
Thank you 😊
I'm so interested in these subjects and I'm really lucky because I follow your channel... Thank you so much 🌹
You are welcome 😊
Really I love your explanation 🤩really good to understand
Thank you! 😃
I thank God that I found ur channel,Ican understand better❤
That's great. Thank you for your comment. 🤗
Thanks you so much Sehar ..
You are welcome 😊
thank you so much
single handedly helping me not flunk my classes haha
You are welcome 😊
Very informative nicely explained 👌👌
Thank you 😊
It's simply super🤩thank you so much and it helps me a lot to improve my knowledge
You are welcome 😊
Great explanation. Thank you
You are welcome 😊
Thank you!
You are welcome 😊
Great explanation only one question.. doesnt mmr rely on dna pol 3 not 1?
Thank you so much for this amazing explanation .Ma'am, I have a question to ask you. What is the function of DNA helicase II in NER of Prokaryotes?
Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal.
The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.
6:40 that bingo is soothing sehar ❤🥰
Ur a mom now, so sry to say
Ur voice is 🎉🎉🎉🎉🎉
Thank you ☺️
Helped a lot 🥰 Keep up the good work 👍
Thank you 😊
You're following "Biochemistry" by Jeremy M. Berg, John L. Tymoczko, and Lubert Stryer.??
This is more of Lippincott and lehninger's
ok thanks
Very well explained
Thanks
Thank you🌼
You are welcome 😊
That's a perfect video Madam
Thank you 😊
@@EasyPeasyLearning I will watch all your videos
i love you you saved my life
Thank you 😊
great video thanks!
You are welcome 😊
good summary, thanks :)
You are welcome 😊
NER
Problem : Pyrimidine dimer
Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage
Helicase unwind DNA
XPF and XPG remove DNA
DNA polymerase bound and made a new DNA.Ligase connect everything.
Do these occur in prokaryotes? Or in eukaryotes only?
MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.
Every thing all right...but we need written notes for this
Yes 🤧
Hi there, The material was taken from the book of Lippincott's Biochemistry 5th edition.
When dna repair mechanism don’t function properly, is there any chance the damage cell become malignant cell?
Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.
@@EasyPeasyLearning thanks
@@littlefinger8613 you are welcome
Okay,, :D
Oye kirti dhang se padh lena 🐒
Thank you ❤❤❤
You are welcome 😊