If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan Liposomal Glutathione 10% Discount tinyurl.com/emypha8y Our All About NMN Playlist Link ruclips.net/video/AijQDJmpCFA/видео.html
Glutathione is another key to healthy aging. There's evidence that merely increasing NAD will also increase glutathione. Therefore, one may be able to argue that NMN or NR are not just NAD precursors but also glutathione elevating precursors, too. This needs more research.
Hi Eric, thanks for sharing. We have discussed this with some of our guests, how everything is connected and improving one aspect of aging (boosting NAD, or reducing senescent cells) also improves other areas. It would indeed be good to see if NMN or NR also improved glutathione, and vice versa.
Super cool! Rooting for your success with this new supplement. What always scares me about this: NAC & Lots of antioxidants have been found harmful in some contexts. In particular, if you have cancer cells somewhere, we worry that antioxidants feed cancer and make them grow faster. There are multiple publications on this. Not sure if it's a practical worry or not, but it stops me from exploring, say, NAC.
Hi Gokhan, thanks for sharing this. this does seem to be the case. The benefits of boosting glutathione do seem to be clear as well. It seems to be like Dr Fahy mentioned, that everything in biology is a trade-off.
Hi like to learn from you please if possible there are so many other questions in my mind.Do you have an insta address? Many thanks.I think you are a Scientists or work in this World.Many Thanks.
@@RealZayComo You should listen to Dr. boyd Haley. He will help you to understand things a bit better there. Once people know what Oxidative Stress it than one has to question what is binding it to stop its force? You are not seeing that here in this.
I would like to see a study comparing Glutathion (preferably liposomal) versus N-acetylcysteine (maybe + Glycine). I would intuitively guess that the body is very good in syntheisizing small peptides like Gluthatione, if you give him the the right elements (NAC!) to do so. IMO the restrictions on NAC show that the big pharma rules Amerika.
It depends on genetics, mainly on GST, Glutathione S Transferase , but the most people have deficiencies in micronutrients to burn calories/energy metabolism, (everything requires energy) and the essential nutrients involved in the reduction of oxidative stress. Melatonin helps, to elevate GSH levels.
Even if you take liposomal glutathione, it will not get absorbed because it only gets produced at the cellular level. If you take it orally, it would be degraded in the stomach and the bile would completely neutralize it, making it completely ineffective and also because it would have to go from the bloodstream, across 2 cell membranes to get inside the cell
Thanks for sharing. Like you I will be starting the Liposomal NMN and Apigenin from Alive by science. It seems by looking on their web site they are migrating a lot of their supplements to liposomal pill form and it has taken them a while to get up to speed in production and shipping. I should have my first Order received here in Florida in two weeks . I look forward to watching you check your NAD levels and keep my fingers crossed you see a bump up.
Hi Tim, thanks for sharing. We are also planning to take Alive By Science apigenin. I am also looking forward to getting the result and hope that it is going up!
I wonder if whey protein, with it's excellent balance of BCAA's, would be sufficient to boost glutathione. The initial study mentioned was just the addition of two of the three constituents and had good effect.
Richard I have ordred a batch of Liposomal Glutathione from ABS and as normal they are backed up with orders but it should SHIP out mid December. Just saw a RUclips video from another life extension youtuber with a warning that liposomal Delivery of Glutathione may raise the level of Glutathione to toxic levels in the brain (He has no studies to show this but thinks that this may be the case since the brain does not show a decrease in Glutathione as we age) Just wanted to see if you have heard anything along these lines? Thanks
Has anyone tried glutathione suppositories? The taste is no longer an issue - um - going that route 😂 and I’ve heard that it performs better than it does after traveling through the digestive system- not as well as IV but more accessible than IV treatment. Curious to learn what others have heard
Hi Richard, I propose that you monitor your sleep. I also used liposomal GSH, when I took it at night it decreased my REM and Deep sleep. So watch out😉. Beside that I had good results e.g more engery. I stopped it because I am afraid of long term use. I am 38, so may I start later again.
Based on the results of the study it's clear that glutathione restoration is not the only mechanism at play. Please read "4.13 Why does GlyNAC work? The "power of 3"" within the study. Note that there are no studies comparing GlyNAC to liposomal glutathione. The results of the GlyNAC study were exceptional, you must not assume glutathione supplementation will achieve the same results- which, based on many variables involved it will not unfortunately. "
NAC and whey protein give me stomach aches. I do take glycine and TMG. Both of which are reported to increase Glutathione. Glycine seems to have a bunch of good attributes: (1) may interfere with methionine metabolism and assist in mimicking a methionine restricted diet (which has been shown to lead to longevity) (2) reported to increase glutathione, (3) may reduce homocysteine, (4) may improve collagen synthesis (5) may extend your life (if you're a mouse); and (6)may inhibit glycation. I have not seen too many negatives of Glycine. It may interfere with autophagy. Is anyone aware of other known potential negative effects of Glycine?
I'm a "fan" of glycine too. No side effects at high dosage (except for nausea etc in sensible people). Regarding tmg it seems to me a bit exaggerated if you take standard dosage of nmn, it's a common ingredient. I prefer to eat beats etc. If someone needs tmg maybe nam recycling doesn't work well. Or maybe its just the same old marketing: if you take this, you need also that and so on 😉
Basically my understanding of these two antioxidants is that LG makes NAC work better?!? So they work in conjunction with each other. The literal science behind this explains it better. But, that’s it in a nutshell
H Marc, thanks for sharing. S-Acetyl glutathione does seem interesting as a way to increase GSH levels. We chose the lipo GSH because there was some research and the brand that we are using has it available.
I bought a bottle of NAC a few months ago but stopped due to the smell, I just can't take it. Lipo Glutathione seems a good alternative, very helpful, thank you!
Hi Philip thanks for your great question. From the paper Mitochondrial fuel oxidation MFO was measured by calorimetry (Vmax Encore metabolic cart, CareFusion Inc., San Diego, CA) and reported as respiratory quotient, mitochondrial fatty‐acid, and glucose oxidation. And Mitochondrial fuel oxidation Compared to fasting YAs, fasting OA had a significantly higher respiratory quotient and abnormal mitochondrial fuel oxidation, with a significant 54% lower mitochondrial fatty‐acid oxidation and 51% higher MGO (Table 3) (Figure 2). GlyNAC supplementation corrected defective MFO (in mitochondrial fatty‐acid and glucose oxidation) but did not affect energy expenditure. We did not measure body composition after stopping GlyNAC, but the respiratory quotient showed an increase suggesting recurrence of mitochondrial fuel impairment after discontinuing GlyNAC. So I think that means how well they burned fuel and what type of fuel.
Hi Thanks for sharing and interesting. We had N-Acetyl Cysteine from Life extension and it has a sulphury (rotten eggs) smell to it. Can I ask what brand you are using?
@@ModernHealthspan I've actually used the same brand (life extension) for at least some of the time but as of late have used "Integrative Therapeutics" as well as "Thorne". My naturopath recommended nebulizing NAC for my sinuses and the liquid vials of NAC that are used for that certainly do smell horrid. But with the pills, I chew them and actually like the taste!
Glutathione production can be stimulated through NRF2. Our body knows exactly how much should produce it...but with supplementation you can over/under dose it.
@@eaappell I think P Peja is not arguing against raising glutathione as one ages. Rather P Peja is suggesting to raise it through by NRF2, rather than by supplementing it directly or perhaps by other methodologies. NRF2 can be overexpressed and over expression is correlated with certain cancers and may be correlated with heart damage. So it's not clear to me that our bodies "know" how much to produce.
I think the issue isn't so much that our bodies don't know how much glutathione to make, I think the issues is that as we age, there are more and more things glutathione is needed to fix. Therefore our bodies find it more and more difficult to keep up. Providing raw materials (NAC) helps, but depending on need, more may be needed.
@@secretweapon7764 When we get older, we have much more oxidative stress and depletion of glutathione is more pronounced. Over NRF2 pathway, we could additionally stimulate our body to produce glutathione.
Hi thanks for your comment. A couple of comments on this. We are sharing what we are doing, not trying to persuade people on a particular point of view. The paper referred to from Baylor showed positive results from raising GSH levels in healthy adults. Though they used NAC and Glycine the benefits were attributed to the GSH levels being higher. So my thinking is to use lipo GSH to achieve the same effect, though I am sure that there are other ways of raising GSH levels.
I just saw a video indicating that LG supplimentation can increase reductice stress by throwing iff oxidant / anti oxidant levels within the cell and that the proper way to increase glutathione levels is to supplement glycine and NAC. Anyone have any information about this?
If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan
Liposomal Glutathione 10% Discount tinyurl.com/emypha8y
Our All About NMN Playlist Link ruclips.net/video/AijQDJmpCFA/видео.html
Glutathione is another key to healthy aging. There's evidence that merely increasing NAD will also increase glutathione. Therefore, one may be able to argue that NMN or NR are not just NAD precursors but also glutathione elevating precursors, too. This needs more research.
Hi Eric, thanks for sharing. We have discussed this with some of our guests, how everything is connected and improving one aspect of aging (boosting NAD, or reducing senescent cells) also improves other areas. It would indeed be good to see if NMN or NR also improved glutathione, and vice versa.
Dr. Brad S just put out a video saying how dangerous liposomal Glutathione is. I don't know what to do now!!!!!
Thanks Richard. Looking forward to the progress of this new supplement. anything on Calcium AKG, if you plan to start it again in morning. Thanks.
Hi Ankur, thanks for your comment. We have just re-started taking CaAKG in the morning. We are taking ProHealth CaAKG.
Super cool! Rooting for your success with this new supplement. What always scares me about this: NAC & Lots of antioxidants have been found harmful in some contexts. In particular, if you have cancer cells somewhere, we worry that antioxidants feed cancer and make them grow faster. There are multiple publications on this. Not sure if it's a practical worry or not, but it stops me from exploring, say, NAC.
Hi Gokhan, thanks for sharing this. this does seem to be the case. The benefits of boosting glutathione do seem to be clear as well. It seems to be like Dr Fahy mentioned, that everything in biology is a trade-off.
@@ModernHealthspan hi does taking glutathione boost cancer cells ? 🙏🙏
Hi like to learn from you please if possible there are so many other questions in my mind.Do you have an insta address? Many thanks.I think you are a Scientists or work in this World.Many Thanks.
@@RealZayComo You should listen to Dr. boyd Haley. He will help you to understand things a bit better there. Once people know what Oxidative Stress it than one has to question what is binding it to stop its force? You are not seeing that here in this.
I would like to see a study comparing Glutathion (preferably liposomal) versus N-acetylcysteine (maybe + Glycine). I would intuitively guess that the body is very good in syntheisizing small peptides like Gluthatione, if you give him the the right elements (NAC!) to do so. IMO the restrictions on NAC show that the big pharma rules Amerika.
It depends on genetics, mainly on GST, Glutathione S Transferase , but the most people have deficiencies in micronutrients to burn calories/energy metabolism, (everything requires energy) and the essential nutrients involved in the reduction of oxidative stress.
Melatonin helps, to elevate GSH levels.
Great video, Richard! The studies are promising and the interview was super interesting!
Thank you Richard- always look forward to your videos.
Even if you take liposomal glutathione, it will not get absorbed because it only gets produced at the cellular level. If you take it orally, it would be degraded in the stomach and the bile would completely neutralize it, making it completely ineffective and also because it would have to go from the bloodstream, across 2 cell membranes to get inside the cell
Thanks for sharing. Like you I will be starting the Liposomal NMN and Apigenin from Alive by science. It seems by looking on their web site they are migrating a lot of their supplements to liposomal pill form and it has taken them a while to get up to speed in production and shipping. I should have my first Order received here in Florida in two weeks . I look forward to watching you check your NAD levels and keep my fingers crossed you see a bump up.
Hi Tim, thanks for sharing. We are also planning to take Alive By Science apigenin. I am also looking forward to getting the result and hope that it is going up!
I wonder if whey protein, with it's excellent balance of BCAA's, would be sufficient to boost glutathione. The initial study mentioned was just the addition of two of the three constituents and had good effect.
Richard I have ordred a batch of Liposomal Glutathione from ABS and as normal they are backed up with orders but it should SHIP out mid December. Just saw a RUclips video from another life extension youtuber with a warning that liposomal Delivery of Glutathione may raise the level of Glutathione to toxic levels in the brain (He has no studies to show this but thinks that this may be the case since the brain does not show a decrease in Glutathione as we age) Just wanted to see if you have heard anything along these lines? Thanks
Has anyone tried glutathione suppositories? The taste is no longer an issue - um - going that route 😂 and I’ve heard that it performs better than it does after traveling through the digestive system- not as well as IV but more accessible than IV treatment. Curious to learn what others have heard
Hi Richard, I propose that you monitor your sleep. I also used liposomal GSH, when I took it at night it decreased my REM and Deep sleep. So watch out😉. Beside that I had good results e.g more engery. I stopped it because I am afraid of long term use. I am 38, so may I start later again.
Thank you sir. 👍🏻
Hi Ron, you're quick, thank you for watching!
Based on the results of the study it's clear that glutathione restoration is not the only mechanism at play. Please read "4.13 Why does GlyNAC work? The "power of 3"" within the study.
Note that there are no studies comparing GlyNAC to liposomal glutathione. The results of the GlyNAC study were exceptional, you must not assume glutathione supplementation will achieve the same results- which, based on many variables involved it will not unfortunately.
"
Please, keep us posted if any noticeable effect.
Hi Cybair, thanks, we will do!
Hello, do you have an update video on this?
are there any major differences with taking liposomal glutathione vs having a glutathione iv treatment?
NAC and whey protein give me stomach aches. I do take glycine and TMG. Both of which are reported to increase Glutathione. Glycine seems to have a bunch of good attributes: (1) may interfere with methionine metabolism and assist in mimicking a methionine restricted diet (which has been shown to lead to longevity) (2) reported to increase glutathione, (3) may reduce homocysteine, (4) may improve collagen synthesis (5) may extend your life (if you're a mouse); and (6)may inhibit glycation. I have not seen too many negatives of Glycine. It may interfere with autophagy. Is anyone aware of other known potential negative effects of Glycine?
I'm a "fan" of glycine too. No side effects at high dosage (except for nausea etc in sensible people). Regarding tmg it seems to me a bit exaggerated if you take standard dosage of nmn, it's a common ingredient. I prefer to eat beats etc. If someone needs tmg maybe nam recycling doesn't work well. Or maybe its just the same old marketing: if you take this, you need also that and so on 😉
Hey Richard, have you been able to find good data on absorption rates of oral Liposomal Glutathione? How does it compare to NAC?
Basically my understanding of these two antioxidants is that LG makes NAC work better?!? So they work in conjunction with each other. The literal science behind this explains it better. But, that’s it in a nutshell
Beautiful home
Why would you not go with S-Acetyl glutathione instead?
H Marc, thanks for sharing. S-Acetyl glutathione does seem interesting as a way to increase GSH levels. We chose the lipo GSH because there was some research and the brand that we are using has it available.
I bought a bottle of NAC a few months ago but stopped due to the smell, I just can't take it. Lipo Glutathione seems a good alternative, very helpful, thank you!
Hi Sharapova, thanks for your comment. I completely understand!
????? My LG is in liquid and I gotta have a stick of gum ready to rescue my gag reflex from the taste( like rotten milk)
How is mitochondria function measured ??
Hi Philip thanks for your great question. From the paper
Mitochondrial fuel oxidation
MFO was measured by calorimetry (Vmax Encore metabolic cart, CareFusion Inc., San Diego, CA) and reported as respiratory quotient, mitochondrial fatty‐acid, and glucose oxidation.
And
Mitochondrial fuel oxidation
Compared to fasting YAs, fasting OA had a significantly higher respiratory quotient and abnormal mitochondrial fuel oxidation, with a significant 54% lower mitochondrial fatty‐acid oxidation and 51% higher MGO (Table 3) (Figure 2). GlyNAC supplementation corrected defective MFO (in mitochondrial fatty‐acid and glucose oxidation) but did not affect energy expenditure. We did not measure body composition after stopping GlyNAC, but the respiratory quotient showed an increase suggesting recurrence of mitochondrial fuel impairment after discontinuing GlyNAC.
So I think that means how well they burned fuel and what type of fuel.
Excess glutathione can cause over reduction.what about NACET?
Interesting, I’ve never noticed NAC pills smelling terrible. And I actually like the taste
Hi Thanks for sharing and interesting. We had N-Acetyl Cysteine from Life extension and it has a sulphury (rotten eggs) smell to it. Can I ask what brand you are using?
@@ModernHealthspan I've actually used the same brand (life extension) for at least some of the time but as of late have used "Integrative Therapeutics" as well as "Thorne". My naturopath recommended nebulizing NAC for my sinuses and the liquid vials of NAC that are used for that certainly do smell horrid. But with the pills, I chew them and actually like the taste!
Glutathione production can be stimulated through NRF2. Our body knows exactly how much should produce it...but with supplementation you can over/under dose it.
As we age, the body stops producing glutathione for whatever reason, so supplementation is required.
@@eaappell I think P Peja is not arguing against raising glutathione as one ages. Rather P Peja is suggesting to raise it through by NRF2, rather than by supplementing it directly or perhaps by other methodologies. NRF2 can be overexpressed and over expression is correlated with certain cancers and may be correlated with heart damage. So it's not clear to me that our bodies "know" how much to produce.
I think the issue isn't so much that our bodies don't know how much glutathione to make, I think the issues is that as we age, there are more and more things glutathione is needed to fix. Therefore our bodies find it more and more difficult to keep up. Providing raw materials (NAC) helps, but depending on need, more may be needed.
@@secretweapon7764 When we get older, we have much more oxidative stress and depletion of glutathione is more pronounced.
Over NRF2 pathway, we could additionally stimulate our body to produce glutathione.
How can an amino acid be a regulated drug? What kind of messed up clown-world are we living in?
Show me the positive research..............I'm not aware of any other than modest help for elderly with type 2 diabetes.
Hi thanks for your comment. A couple of comments on this. We are sharing what we are doing, not trying to persuade people on a particular point of view. The paper referred to from Baylor showed positive results from raising GSH levels in healthy adults. Though they used NAC and Glycine the benefits were attributed to the GSH levels being higher. So my thinking is to use lipo GSH to achieve the same effect, though I am sure that there are other ways of raising GSH levels.
@@ModernHealthspan Understood! Thx
I just saw a video indicating that LG supplimentation can increase reductice stress by throwing iff oxidant / anti oxidant levels within the cell and that the proper way to increase glutathione levels is to supplement glycine and NAC. Anyone have any information about this?
I have infusion with vitamin c.
Hello.
Can you share your method with us please.
Thanks Richard
Hi Thanks!
👍❗