My silly way to remember the relationships: PTT - play table tennis (you play table tennis inside = intrinsic). Its heparIN PT - play tennis (you play tennis outside = extrinsic) By deduction warfarin is here.
You can remember what drug is for which pathway by thinking of the alphabet. H for heparin is followed by I for intrinsic, W for warfarin is followed by X for eXtrinsic. (Heparin=Intrinsic; Warfarin=eXtrinsic). I just came up with this after watching your video, thanks so much!
I always remember that PTT is affected by Heparin, because PTT has two "ts" next to each other (like tt, or TT) which resemble the capital letter "H" although it depends on your font/handwriting. This might just work for my brain only, but hopefully it helps others! :)
My professor had this mnemonic which actually helped bc I love Brad Pitt haha (brad) PiTT -- intrinsic pathway, PTT (I love) PeTs -- extrinsic pathway, PT Hope that helps!
PT (physical education teacher) is always OUTside. He is FAST and always ready for the WAR! PT → OUT (extrinsic pathway) → FAST (fast reaction) → WAR (warfarin)
Thank God for this video!!! If you go to page 383 of the Hematology and Oncology chapter in the First Aid for USMLE 2016 and look at the coagulation cascade! Thanks to this video it made it way much easier to deal with. Gracias!
I remember heparin=PTT and warfarin-PT by remembering to make 10 letters for both so... it goes like this H E P A R I N ( P T T ) = 10 letters W A R F A R I N ( P T ) = 10 letters
a great way to remember is we measure INR aka PT for warfarin -> warfarin blocks formation of VitK dep factors --> 2 7 9 and 10 --> 7 has the shortest half life and degrades first = easy way to check warfarin levels bc its the first factor to go
I really like this mnemonic, but my OCD struggles with the final picture because the last step of the common pathway is Fibrinogen (I) to Fibrin (Ia). So I add "1" to the bottom of the common pathway and said that it stands for "One common math problem (pathway)".
Heparin is already present in our physiological system in mast cells but inactive anticoagulant ,,,so it's present inside= Intrinsic and oppsite to it warfarin = extrensic
I've a question. As warfarin blocks vit K dependent factors like 2,7,9 and 10, As factor 9 is part of the intrinsic pathway so why does PTT not affected by warfarin?
Is there any chance you can do a video on cytokines? It would be great to get an explanation and some mnemonics for which cytokines are used in which responses. Thanks!
I'm gonna use this. Thanks!! But what about factors I, III, and XIII? I'm gonna have to just memorize those, i guess. This makes it easier though. Also worth mentioning factor IV, which is present all over the place in the whole cascade.
thanks from delhi and keep up the great work....I finally cud cram it up. I remember like this WET your PET for 7SEX ( W=WARFARIN EX =EXTRINSIC 7=FACTOR7 IN EXTRINSIC PATHWAY ) Dr Amit
I hv to tell you that this video confuses most of clinicians who memorized the cascade the way it is. 1st: memorize the cascade as it is with Roman numerals 2nd: remember that 2+7->9->10 that’s Warfarin which is given externally (PO) and thus affect the extrinsic pathway more (PT) 3rd: Heparin is given IV, that’s intrinsic and affects F XII -> F XI -> F IX 4th: heparin works faster (IV), but warfarin works way slower (PO) Pls remember that in clinical practice we rarely use either and now we use other oral inhibitors (NOACS) and SQ inhibitors (LMWH etc), which were not discussed here at all. In summary this video is way confusing and way way way out of date. Pls replace it.
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My silly way to remember the relationships:
PTT - play table tennis (you play table tennis inside = intrinsic). Its heparIN
PT - play tennis (you play tennis outside = extrinsic) By deduction warfarin is here.
Chris Chen
Remember War is Extrinsic .... we don't go to war intrinsically...
or I (Intrinsic) comes after H (Heparin)in the alphabet
Amazing thank you
Thank you!!
But warfarIN could work with INtrinsic too... so not ideal to solely rely on this mnemonic
You can remember what drug is for which pathway by thinking of the alphabet. H for heparin is followed by I for intrinsic, W for warfarin is followed by X for eXtrinsic. (Heparin=Intrinsic; Warfarin=eXtrinsic). I just came up with this after watching your video, thanks so much!
tnx
good one thank you
thank u
Great thinking. Thx
Thanks
Missing factors
Factor 1 = Fibrinogen
Factor 3 = thromboplastin
Factor 4 = Calcium
Factor 13 = Fibrin stabilizing factor
I always remember that PTT is affected by Heparin, because PTT has two "ts" next to each other (like tt, or TT) which resemble the capital letter "H" although it depends on your font/handwriting. This might just work for my brain only, but hopefully it helps others! :)
Cool!
Nice way of remembering......
another good way to remember it is PT = playing tennis (outdoors -> extrinsic) and PTT = playing table tennis (indoors -> intrinsic)
@@yankzaddict02 this is gold! thank you
warfarin will affect both extrinsic pathway and common pathway...remember Vit K dependent factors 2,7,9 and 10
and protein c. you are hypercoagulable on initiating warfarin.
And intrinsic?
@@rickkarsan4491 also protein S :)
Write a capital I ( the one with bars on the either end of the line) and turn it 90 degrees; it becomes H.
I for intrinsic; and H for Heparin.
I remember warfarin with extrinsic b/c "To WAR with your EX"
WAR= warfarin EX= extrinsic
This is dope
HINT : HEPARIN INTRINSIC PATHWAY
WEPT: WARFARIN EXTRINSIC PATHWAY
HOPE THIS CAN HELP YOU REMEMBER .
Lol I expected that 'HOPE' was also going to be a mnemonic. 😅😂
My professor had this mnemonic which actually helped bc I love Brad Pitt haha
(brad) PiTT -- intrinsic pathway, PTT
(I love) PeTs -- extrinsic pathway, PT
Hope that helps!
PT (physical education teacher) is always OUTside. He is FAST and always ready for the WAR!
PT → OUT (extrinsic pathway) → FAST (fast reaction) → WAR (warfarin)
Thank God for this video!!! If you go to page 383 of the Hematology and Oncology chapter in the First Aid for USMLE 2016 and look at the coagulation cascade! Thanks to this video it made it way much easier to deal with. Gracias!
E (for extrinsic) put on it's side makes a W (for warfarin).
I remember heparin=PTT and warfarin-PT by remembering to make 10 letters for both so... it goes like this
H E P A R I N ( P T T ) = 10 letters
W A R F A R I N ( P T ) = 10 letters
And he said there's really no good way to remember this. Your memory aid is great! Thank you!!
WEPT: Warfarin Extrinsic PT
a great way to remember is we measure INR aka PT for warfarin -> warfarin blocks formation of VitK dep factors --> 2 7 9 and 10 --> 7 has the shortest half life and degrades first = easy way to check warfarin levels bc its the first factor to go
When I'm learning coagulation cascade I'm "IN Hell" and I need "EXtra WAter". Heparin for intrinsic and Warfarin for extrinsic
Thank you 🤩
you should really teach this stuff part time. your really good at explaining material
I like to remember that in WAR(farin) you need a PT (physical therapist)
I really like this mnemonic, but my OCD struggles with the final picture because the last step of the common pathway is Fibrinogen (I) to Fibrin (Ia). So I add "1" to the bottom of the common pathway and said that it stands for "One common math problem (pathway)".
Heparin is already present in our physiological system in mast cells but inactive anticoagulant ,,,so it's present inside= Intrinsic and oppsite to it warfarin = extrensic
(warfarin)War outside-extrinsic
(Heparin )Hepatic inside body -intrinsic
two times five that's 10, minus 1 that's 9 quick maffs.
ya dun know.
This was just shared to me:
PeT: PT is for Extrinsic
PiTT: PTT is for intrinsic
This video is a a life saviour & comment section is another saviour 😂
خططططييييررررر ، مبدع والله ✨✨✨
Thank you so much. Please consider making a video on Anticoagulants as a follow up to this.
Heparin = Help comes from inside (Intrinsic)
Warfarin = War comes from outside (Extrinsic)
Dr. Sattar has a great pnemonic. on the floor you refer to Heparin as HEP. 3 letters. like PTT
ive never heard it referred to as Hep, but yeah that definitely works if you can envision/hear it like that in your brain
We've gotta get your channel more subscribers!!
I agree!! Please share :) Thanks
This is abso-freaking-lutely amazing ❤
I've a question. As warfarin blocks vit K dependent factors like 2,7,9 and 10, As factor 9 is part of the intrinsic pathway so why does PTT not affected by warfarin?
PT is influenced by coagulation system, APTT is not. An exception is vWD.
Remember War is Extrinsic .... we don't go to war intrinsically...
But then there is the civil war... lol
😂😂
Nice 👍
Play tennis outside for PT for extrinsic and play table tennis inside for PTT for intrinsic ;)
Note : calcium used in most of step except first two step ( calcium = factor 4 IV) thx❤
Summary from 6:05
or I (Intrinsic) comes after H (Heparin)in the alphabet
How can you remember a nemonic that makes no sense but not the actual coagulation cascade information!
Please keep making more video.. you are a lifesaver😍
Very good video! Thank you.
Is there any chance you can do a video on cytokines? It would be great to get an explanation and some mnemonics for which cytokines are used in which responses. Thanks!
I have one.. search the channel :)
Thank you so much! Can't believe I didn't see that initially @@DirtyMedicine
nice,! I recomend that after watching the video get a pen, a paper and try to do it on your own
Superb.... I've always struggled with this topic.... Thank u so so much❤
OMG this video is great, so helpful!!! Keep them coming.
Bless you man❤
pneumonic or mnemonic?
I'm gonna use this. Thanks!! But what about factors I, III, and XIII? I'm gonna have to just memorize those, i guess. This makes it easier though. Also worth mentioning factor IV, which is present all over the place in the whole cascade.
You made my day. Thank you!
thanks from delhi and keep up the great work....I finally cud cram it up.
I remember like this
WET your PET for 7SEX ( W=WARFARIN EX =EXTRINSIC 7=FACTOR7 IN EXTRINSIC PATHWAY )
Dr Amit
Why he didn’t mention factor XIII ?
Awesome !
You saved my life
HePARin = PARty INside, WARFARin = warfare outside
Really having trouble memorizing glycogen and lysosomal diseases, Please share mnemonics for those. Thanks
I have a video for Lysosomal Storage Diseases already. Link: ruclips.net/video/7udUG8KkN_E/видео.html
Alright, a few pathway disorder (ie. galatosemia) mnemonics would be nice
Did you delete some videos ?!
H is HIGH UP there for Heparin.
This video is awesome! Thank you!
You are a genius
i learned a lot! thank you
You are awesome, thank you
thank you
Heparin intrinsic because administred IN the body (s/c or i/v), warfarin extrinsic because administred from OUTSIDE the body (oral) ;)
Thank you, nicely done.
just awesome
Thank you soo much sir😊
amazing
Sometimes, it's just better to rote memorize things. IMO
You are the best
This is genius!! Thank you soo much! :))
Brilliant
I hv to tell you that this video confuses most of clinicians who memorized the cascade the way it is.
1st: memorize the cascade as it is with Roman numerals
2nd: remember that 2+7->9->10 that’s Warfarin which is given externally (PO) and thus affect the extrinsic pathway more (PT)
3rd: Heparin is given IV, that’s intrinsic and affects F XII -> F XI -> F IX
4th: heparin works faster (IV), but warfarin works way slower (PO)
Pls remember that in clinical practice we rarely use either and now we use other oral inhibitors (NOACS) and SQ inhibitors (LMWH etc), which were not discussed here at all.
In summary this video is way confusing and way way way out of date. Pls replace it.
brilliant!
most helpful...
holy damn. this is amazing
❤❤
This is the bestttttttttttt
Mannn...
I love 10 dollars rules❤
pEt pItt bull
pt - Extrinsic
ptt - Intrinsic
genious
Great
Thank uuuuuuu
I like the video even before watching it. I trust you lol
Love you ❤
WEPT at war
W- Warfarin
E- extrinsic
PT affected
You rock!
cool!
Hip Brad Pitt - heparin ptt
smart !
Ohmba balaya 😏
Tysm🥹🥹🥹🥹🥹
Ahhh the math lost me 😭
omg !
i love u
i love you
War with your EX so you wePT
soo silly...simple things made complex
thank you