Coagulation Cascade || USMLE
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- Опубликовано: 22 июл 2016
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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own. 
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You can remember what drug is for which pathway by thinking of the alphabet. H for heparin is followed by I for intrinsic, W for warfarin is followed by X for eXtrinsic. (Heparin=Intrinsic; Warfarin=eXtrinsic). I just came up with this after watching your video, thanks so much!
tnx
good one thank you
thank u
Great thinking. Thx
Thanks
My silly way to remember the relationships:
PTT - play table tennis (you play table tennis inside = intrinsic). Its heparIN
PT - play tennis (you play tennis outside = extrinsic) By deduction warfarin is here.
Chris Chen
Remember War is Extrinsic .... we don't go to war intrinsically...
or I (Intrinsic) comes after H (Heparin)in the alphabet
Amazing thank you
Thank you!!
But warfarIN could work with INtrinsic too... so not ideal to solely rely on this mnemonic
Missing factors
Factor 1 = Fibrinogen
Factor 3 = thromboplastin
Factor 4 = Calcium
Factor 13 = Fibrin stabilizing factor
Thank God for this video!!! If you go to page 383 of the Hematology and Oncology chapter in the First Aid for USMLE 2016 and look at the coagulation cascade! Thanks to this video it made it way much easier to deal with. Gracias!
I always remember that PTT is affected by Heparin, because PTT has two "ts" next to each other (like tt, or TT) which resemble the capital letter "H" although it depends on your font/handwriting. This might just work for my brain only, but hopefully it helps others! :)
Cool!
Nice way of remembering......
another good way to remember it is PT = playing tennis (outdoors -> extrinsic) and PTT = playing table tennis (indoors -> intrinsic)
@@yankzaddict02 this is gold! thank you
a great way to remember is we measure INR aka PT for warfarin -> warfarin blocks formation of VitK dep factors --> 2 7 9 and 10 --> 7 has the shortest half life and degrades first = easy way to check warfarin levels bc its the first factor to go
Thank you so much. Please consider making a video on Anticoagulants as a follow up to this.
I remember warfarin with extrinsic b/c "To WAR with your EX"
WAR= warfarin EX= extrinsic
warfarin will affect both extrinsic pathway and common pathway...remember Vit K dependent factors 2,7,9 and 10
and protein c. you are hypercoagulable on initiating warfarin.
And intrinsic?
thanks from delhi and keep up the great work....I finally cud cram it up.
I remember like this
WET your PET for 7SEX ( W=WARFARIN EX =EXTRINSIC 7=FACTOR7 IN EXTRINSIC PATHWAY )
Dr Amit
you should really teach this stuff part time. your really good at explaining material
Write a capital I ( the one with bars on the either end of the line) and turn it 90 degrees; it becomes H.
I for intrinsic; and H for Heparin.
OMG this video is great, so helpful!!! Keep them coming.
خططططييييررررر ، مبدع والله ✨✨✨
This is abso-freaking-lutely amazing ❤
I remember heparin=PTT and warfarin-PT by remembering to make 10 letters for both so... it goes like this
H E P A R I N ( P T T ) = 10 letters
W A R F A R I N ( P T ) = 10 letters
And he said there's really no good way to remember this. Your memory aid is great! Thank you!!
I really like this mnemonic, but my OCD struggles with the final picture because the last step of the common pathway is Fibrinogen (I) to Fibrin (Ia). So I add "1" to the bottom of the common pathway and said that it stands for "One common math problem (pathway)".
E (for extrinsic) put on it's side makes a W (for warfarin).
You made my day. Thank you!
Please keep making more video.. you are a lifesaver😍
This video is awesome! Thank you!
HINT : HEPARIN INTRINSIC PATHWAY
WEPT: WARFARIN EXTRINSIC PATHWAY
HOPE THIS CAN HELP YOU REMEMBER .
Lol I expected that 'HOPE' was also going to be a mnemonic. 😅😂
Very good video! Thank you.
just awesome
I like to remember that in WAR(farin) you need a PT (physical therapist)
This is genius!! Thank you soo much! :))
Thank you, nicely done.
PT (physical education teacher) is always OUTside. He is FAST and always ready for the WAR!
PT → OUT (extrinsic pathway) → FAST (fast reaction) → WAR (warfarin)
Superb.... I've always struggled with this topic.... Thank u so so much❤
I'm gonna use this. Thanks!! But what about factors I, III, and XIII? I'm gonna have to just memorize those, i guess. This makes it easier though. Also worth mentioning factor IV, which is present all over the place in the whole cascade.
WEPT: Warfarin Extrinsic PT
You are awesome, thank you
i learned a lot! thank you
This video is a a life saviour & comment section is another saviour 😂
(warfarin)War outside-extrinsic
(Heparin )Hepatic inside body -intrinsic
holy damn. this is amazing
Dr. Sattar has a great pnemonic. on the floor you refer to Heparin as HEP. 3 letters. like PTT
ive never heard it referred to as Hep, but yeah that definitely works if you can envision/hear it like that in your brain
Heparin is already present in our physiological system in mast cells but inactive anticoagulant ,,,so it's present inside= Intrinsic and oppsite to it warfarin = extrensic
most helpful...
You are the best
thank you
two times five that's 10, minus 1 that's 9 quick maffs.
ya dun know.
You are a genius
I've a question. As warfarin blocks vit K dependent factors like 2,7,9 and 10, As factor 9 is part of the intrinsic pathway so why does PTT not affected by warfarin?
We've gotta get your channel more subscribers!!
I agree!! Please share :) Thanks
brilliant!
You saved my life
amazing
genious
Did you delete some videos ?!
Brilliant
Thank you soo much sir😊
PT is influenced by coagulation system, APTT is not. An exception is vWD.
Why he didn’t mention factor XIII ?
Great
Thank uuuuuuu
nice,! I recomend that after watching the video get a pen, a paper and try to do it on your own
or I (Intrinsic) comes after H (Heparin)in the alphabet
You rock!
How can you remember a nemonic that makes no sense but not the actual coagulation cascade information!
pneumonic or mnemonic?
This was just shared to me:
PeT: PT is for Extrinsic
PiTT: PTT is for intrinsic
Is there any chance you can do a video on cytokines? It would be great to get an explanation and some mnemonics for which cytokines are used in which responses. Thanks!
I have one.. search the channel :)
Thank you so much! Can't believe I didn't see that initially @@DirtyMedicine
cool!
H is HIGH UP there for Heparin.
This is the bestttttttttttt
❤❤
I like the video even before watching it. I trust you lol
Really having trouble memorizing glycogen and lysosomal diseases, Please share mnemonics for those. Thanks
I have a video for Lysosomal Storage Diseases already. Link: ruclips.net/video/7udUG8KkN_E/видео.html
Alright, a few pathway disorder (ie. galatosemia) mnemonics would be nice
smart !
Sometimes, it's just better to rote memorize things. IMO
Heparin = Help comes from inside (Intrinsic)
Warfarin = War comes from outside (Extrinsic)
Play tennis outside for PT for extrinsic and play table tennis inside for PTT for intrinsic ;)
Remember War is Extrinsic .... we don't go to war intrinsically...
But then there is the civil war... lol
😂😂
Nice 👍
Summary from 6:05
Mannn...
I love 10 dollars rules❤
Note : calcium used in most of step except first two step ( calcium = factor 4 IV) thx❤
When I'm learning coagulation cascade I'm "IN Hell" and I need "EXtra WAter". Heparin for intrinsic and Warfarin for extrinsic
omg !
HePARin = PARty INside, WARFARin = warfare outside
Ohmba balaya 😏
Hip Brad Pitt - heparin ptt
Heparin intrinsic because administred IN the body (s/c or i/v), warfarin extrinsic because administred from OUTSIDE the body (oral) ;)
pEt pItt bull
pt - Extrinsic
ptt - Intrinsic
i love you
WEPT at war
W- Warfarin
E- extrinsic
PT affected
I hv to tell you that this video confuses most of clinicians who memorized the cascade the way it is.
1st: memorize the cascade as it is with Roman numerals
2nd: remember that 2+7->9->10 that’s Warfarin which is given externally (PO) and thus affect the extrinsic pathway more (PT)
3rd: Heparin is given IV, that’s intrinsic and affects F XII -> F XI -> F IX
4th: heparin works faster (IV), but warfarin works way slower (PO)
Pls remember that in clinical practice we rarely use either and now we use other oral inhibitors (NOACS) and SQ inhibitors (LMWH etc), which were not discussed here at all.
In summary this video is way confusing and way way way out of date. Pls replace it.
Ahhh the math lost me 😭
soo silly...simple things made complex
thank you