i dont wanna get all emotional, but i hope u guys are going to make it big in life, i would have never understood this without ur help, god bless u man!
Just wanted to add a little extra to dirty's amazing video. If they show ringed sideroblast, its only present in the bone marrow whereas on a peripheral smear its called basophilic stippling. How i remember it is stiPPling is in the PeriPhery, SideroBlast are in Bone.
One minor correction: Beta thalassemia unlike alpha is not the result of a a deletion mutation, its a point mutation in the splice site and promoter sequence which results in a reduced synthesis. I've seen this come up as an important distinction between the two types in Q banks. Also, thank you for taking the time to make these videos.
I was chuckling to myself because "piga" in Swahili means to hit/beat, so the CD55 + CD59 slapping the C3 convertase was surprisingly accurate, hopefully that's another memory point! Thanks for summarizing anemias!!
Damn, I can only imagine what an AMAZING preceptor you'd be !! Thank you so much for all your videos and helpful tips to remember everything :) You're phenomenal at explaining things !
I was bored of studying the slides of anemia😢then i found this..very interesting.subscribed right away❤i love the way of talking😂yoo hide all iron😂..thank you for this video❤
Dear Dirty Medicine bro, love your explanations, mneumonic devices, and character. Countless number of people, including me, deeply appreciate you! Wish you the best in life regardless.
Howel jolly bodies appear in hereditary spherocytosis after therapeutic splenectomy is done so splen function is compromised resulting in howel jolly bodies
so minor correction, in thalassemia the problem is not in the heme but in the globin...............huge fan, you have helped me alot................thank you kind sir
At 21:10 you mentioned that C3b causes a MAC to be formed. How does that happen? Is it not C5b and other peptide mediators? That's what it says according to my lectures and Google.
C3b cause it indirectly by initiating the alternating complement pathway and lead eventually to the formation of MAC from c5b and others . That’s what he meant
@@themusicbasement2542 Oh okay, thanks! Could you maybe provide a link of some sorts detailing this pathway? In my lectures, we learnt that C3b is an opsonin, but then again I'm in first year med so I suppose they don't teach you everything :).
Recently, I had anemia, or low red blood cell counts, which is common in CLL, and I have CLL.. Red blood cells are needed to carry oxygen to all the cells in the body. With my anemia I experienced fatigue and weakness, and I had pneumonia. My CLL specialist said 'time to treat' as my bone marrow was affected.
Thank you tremendously for all these VIDEOS... No lie, I often watch these videos before going to bed! Speaking of which, how would you feel about making a video on SHOCK? Could really utilize some tricks for the various forms of shocks... just a thought
Thanks for your video ❤️ Please tell me, is it all anaemia patients that have SS genotype? Since there are different types, can someone with genotype other than SS be anemic?
So I know the Fenton reaction uses iron to make the hydroxyl radical... I've always thought the hydroxyl radical was very dangerous because to my knowledge there aren't specific enzymes that scavenge/neutralize the hydroxyl radical and it causes a lot of oxidative damage... Do you think a deficiency in b6 may exacerbate this hydroxyl radical damage?? Because if you have a lack of b6 then the iron can't be used to make hemoglobin so there would be a lot of iron and a lot of the Fenton reaction and a lot of hydroxyl radical formation and oxidative damage??? Does this make sense is there something about this rationale that isn't not accurate or I maybe missing? I begin med school next year I haven the started yet so I have a lot of holes in my understanding of Biochemistry 😕
If anyone knows or has a deeper insight on these processes I’d really appreciate it.... I know high amounts of iron can apparently accelerate aging? I’m concerned that there’s some hole in my thought processes and there’s something I’m missing or misunderstanding about b6 and iron and Fenton reaction metabolism?
Firstly Fenton Reaction is for free Iron that is circulating in the blood, not the one that is overloaded in mitochondria.After this I think your question becomes self explanatory.
The body is not stupid , but we are because still we do not know the reason yet This video was amazing and you are smart I want you to read more about miracles in this universe created by god like the barrier between the river and the sea in which they never mix once you start read about these miracles You will understand the reason of our existence
B12 vs Folate: B12 has the #12 for 12 Cranial Nerves so it reminds you that it affects the Nervous System.
b12=b braine
B =bra brain
i dont wanna get all emotional, but i hope u guys are going to make it big in life, i would have never understood this without ur help, god bless u man!
Thanks for your nice words!
Likewise!
Just wanted to add a little extra to dirty's amazing video. If they show ringed sideroblast, its only present in the bone marrow whereas on a peripheral smear its called basophilic stippling. How i remember it is stiPPling is in the PeriPhery, SideroBlast are in Bone.
One minor correction:
Beta thalassemia unlike alpha is not the result of a a deletion mutation, its a point mutation in the splice site and promoter sequence which results in a reduced synthesis. I've seen this come up as an important distinction between the two types in Q banks.
Also, thank you for taking the time to make these videos.
True
Plz confirm it also please mention if there is any other corrections because we are learning from this video.
@dirty medicine, can you make sure you annotate where the incorrect information are? We don't want to be misinformed.
Sickle Cell Anemia could be listed as another microcytotic anemia.
@@Sim.DeGuss normocytic no?
One minor correction:
The PIGA gene does not code for CD 55 and CD 59, It codes for a surface protein on the RBC, which is anchor for these two!
Specifically the GPI anchor protein!
And also, CD 59 inhibits the MAC.
This page is a life saver for medical students before exams
I can’t thank you enough, the way you make this simple to learn makes me believe that I can make it.
At 6Pm, I get my Heinz ketchup and have a Bite. 6P = G6PD, Heinz bodies, Bite cells. Bonus: Heinz ketchup is red (RBCs).
love this one lol
I was chuckling to myself because "piga" in Swahili means to hit/beat, so the CD55 + CD59 slapping the C3 convertase was surprisingly accurate, hopefully that's another memory point! Thanks for summarizing anemias!!
Swahili meds tupo😁
Damn, I can only imagine what an AMAZING preceptor you'd be !! Thank you so much for all your videos and helpful tips to remember everything :) You're phenomenal at explaining things !
Thank you so much for this!! Anemia has been such an uphill battle but this really consolidated things so well!!
I was bored of studying the slides of anemia😢then i found this..very interesting.subscribed right away❤i love the way of talking😂yoo hide all iron😂..thank you for this video❤
Thank you sooo sooo much! God bless you, this is such a HUGEEEE help to the pathology quiz tom!
to be honest it never made sense until I seen the mnemonics thank you so much!!
Dear Dirty Medicine bro, love your explanations, mneumonic devices, and character.
Countless number of people, including me, deeply appreciate you!
Wish you the best in life regardless.
您真的拯救了很多医学生。听君一席话胜读十年书。
I have exam tomorrow but dont have enough time to read book so i m watching this video and its pretty much helping me in revising everything .
Howel jolly bodies appear in hereditary spherocytosis after therapeutic splenectomy is done so splen function is compromised resulting in howel jolly bodies
so minor correction, in thalassemia the problem is not in the heme but in the globin...............huge fan, you have helped me alot................thank you kind sir
Yeah . Genetics of the globulin , a protein
Merci dirty pour vos immense efforts..
Words cannot describe how amazing you are, Dirty! Keep at it, man, you are the real MVP!
There are a million pathoma anemia videos. Do you have a link? Most of the ones I’m finding are difficult to understand the accent of the speaker.
I wasn't ready 😂😂when he said that Red bloods cells get FUCKED UP.🙊🤭
Please make a video on Hodgkin and non Hodgkin lymphoma
Nothing short of amazing! Thank you for your videos!
Chronic diseases I know could be under microcytic type of anemia, because of increase in hepcidin level which affects the iron absorption
Doesn't c5b form MAC and not c3b? 20:07
At 21:10 you mentioned that C3b causes a MAC to be formed. How does that happen? Is it not C5b and other peptide mediators? That's what it says according to my lectures and Google.
C3b cause it indirectly by initiating the alternating complement pathway and lead eventually to the formation of MAC from c5b and others .
That’s what he meant
@@themusicbasement2542 Oh okay, thanks! Could you maybe provide a link of some sorts detailing this pathway? In my lectures, we learnt that C3b is an opsonin, but then again I'm in first year med so I suppose they don't teach you everything :).
Microcytic causes can be remembered by TAILS, Thalassemia, Anaemia of chronic disease, IDA, Lead poisioning and sideroblastic
Imp point in Hereditary Spherocytosis - lacks a central pallor
Recently, I had anemia, or low red blood cell counts, which is common in CLL, and I have CLL.. Red blood cells are needed to carry oxygen to all the cells in the body. With my anemia I experienced fatigue and weakness, and I had pneumonia. My CLL specialist said 'time to treat' as my bone marrow was affected.
19:36
"heres a red blood cell"
*shows a blue circle*
You're a riot, DM
What happens to the MCV if there is both iron deficiency and B12 deficiency?
Can you make one for fanconi and diamond blackfan anemia since they're so annoyingly tested on CK?
When you said "our bodies are pretty stupid when it comes to anemia", my Brain took that seriously. 😂
But thank you. ❤
PNH - The H can also stand for Hypercoagulability which shows up as a weird association.
What about perniciious anemia in relation to Zollinger- Ellison?
Perfect timing with this video! We're literally half-way through our heme and lymph pathology module! 😂
Thank you for videos. . I really like the way you teaching; i think you should share more videos 😊
Thank you for your wonderful explaining
“they’re really quite stupid when it comes to anemia” 😂😂😂
Wowww.....👍👍
Excellent video! It is super helpful! Thank you
Thank you tremendously for all these VIDEOS... No lie, I often watch these videos before going to bed! Speaking of which, how would you feel about making a video on SHOCK? Could really utilize some tricks for the various forms of shocks... just a thought
Thank you sir, explained very well👍🏼
Thank you very very very much..really it’s very beneficial video
I wish I could give another 1000 thumbs up. Thank you!
(Stress) makes me eat (bites) of (favabean) with (Heinz) ketchup
G6pd deficiency
Haemolytic anemias?
Helpful videos thank you soo much sir
excellent
Thanks a lot... Very helpful 👍👍👍
Thank you! Great video really helped clarify the topics for me!
Amazing 🤩
Can you make a video about fanconi anemia plz 😅
One of Our final proff exam question I wish I had watched this video ....
Should have included sickle cell
Dude dis is so dope. Thank you
Great 😌
This was amazing!
Thanks for your video ❤️
Please tell me, is it all anaemia patients that have SS genotype?
Since there are different types, can someone with genotype other than SS be anemic?
Very helpful 👌 thanks so much
Could you please attach the ppt slide?
Good job brother
Best explanation...thanku sir ♥️🥰
Thanks
Thanks for this
Great video thank you
You are truly a Gem! dirty medicine
How about lymphoma pls cover this topic and ANS TOO
Thank you so much
Great video thanks
Awsome, thank you👌🏻👌🏻👌🏻
Excellent!
where's the link??
If we have to check b12 or folate deficiency... We can get folate and b12 tests... What's the need of homocystein and mma
B12 can show up as normal even when the patient is B12 deficient. Mentioned in another video :)
Thanks!
How can I donate to you dirty?
Excellent review!
Including Pernicious Anemia ????
Awesome review!
Great work as always
❤thx
So I know the Fenton reaction uses iron to make the hydroxyl radical...
I've always thought the hydroxyl radical was very dangerous because to my knowledge there aren't specific enzymes that scavenge/neutralize the hydroxyl radical and it causes a lot of oxidative damage...
Do you think a deficiency in b6 may exacerbate this hydroxyl radical damage?? Because if you have a lack of b6 then the iron can't be used to make hemoglobin so there would be a lot of iron and a lot of the Fenton reaction and a lot of hydroxyl radical formation and oxidative damage???
Does this make sense is there something about this rationale that isn't not accurate or I maybe missing? I begin med school next year I haven the started yet so I have a lot of holes in my understanding of Biochemistry 😕
If anyone knows or has a deeper insight on these processes I’d really appreciate it.... I know high amounts of iron can apparently accelerate aging? I’m concerned that there’s some hole in my thought processes and there’s something I’m missing or misunderstanding about b6 and iron and Fenton reaction metabolism?
Firstly Fenton Reaction is for free Iron that is circulating in the blood, not the one that is overloaded in mitochondria.After this I think your question becomes self explanatory.
Why tf were you watching this when you weren't even in med school
@@abdullahahmad4239 😭😭😭
thank you
The body is not stupid , but we are because still we do not know the reason yet
This video was amazing and you are smart I want you to read more about miracles in this universe created by god like the barrier between the river and the sea in which they never mix once you start read about these miracles You will understand the reason of our existence
Do a video on sickle cell disease 😢
Wow i could literally see that fight scene with the cd3😂
CRACKS ME UP WHEN HE SWEARS :)))
Thanks sir!
You are amazing♥️
Thank you so much :)
Thank You!!!
Thanks man
Thank youuu
I'm in love, u deserve the heaven bro
You saved me. lol. But, seriously, thank you!
goated.
💝📚
15:20 go buckeyes