Bleeding Disorders (ITP vs TTP vs HUS vs DIC) || USMLE

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  • Опубликовано: 10 июл 2024
  • ​​SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
    My goal is to reduce educational disparities by making education FREE.
    These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
    For educational purposes only; NOT medical or other advice.
    Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
    Opinions are entirely my own.

Комментарии • 151

  • @SJ-hd1br
    @SJ-hd1br 3 года назад +108

    It would be amazingly helpful for those of us prepping for step 2 to have this video include treatment. :) From the Third Edition of Step up to Medicine ITP treatment: steroids/IVIG, THEN splenectomy, THEN romiplostim/eltrombopag. For TTP: Plasmapheresis, case by case basis for steroids and splenectomy, but transfusion is contraindicated. For HUS, the only thing I remember from Q banks was an emphasis to NOT give antibiotics in a patient with bloody diarrhea because it could actually trigger HUS. Medscape says that care is supportive.

  • @Queenin06
    @Queenin06 2 года назад +31

    You explained my 6 hour lecture in 7 minutes! THANK YOU!

  • @nightelf4
    @nightelf4 4 года назад +34

    DIC
    D- Decreased fibrinogen with D-Dimer increased
    I- Intravascular hemolysis - MAHA and schistocytes
    C-coagulopathy (or can't stop bleeding) with increased PTT/PT/INR

    • @lotyloty2
      @lotyloty2 Год назад

      What does maha mean?

    • @roshlend1370
      @roshlend1370 Год назад

      Microangiopathic hemolytic anemia

  • @ast1848
    @ast1848 7 лет назад +14

    Glad you guys are back, hope to see a regular flow of vids!

  • @cos244
    @cos244 7 лет назад +44

    You're an absolute life saver man!! :D
    Love the The Terrible Pentad mnemonic - I'm gonna use FAP RN for the pentad memorisation xD

  • @MHSMagicLuver
    @MHSMagicLuver 4 года назад +7

    I just want to say thank you. Im in PA school and I have watched this multiple times. I keep coming back to this video when I need a refresher.

  • @user-sw6hl1dd2x
    @user-sw6hl1dd2x 10 месяцев назад +1

    I can't prescribe the beauty of this lecture..simple, informative and we'll organized.. Thank u so much.

  • @elyandrade5656
    @elyandrade5656 7 лет назад

    this channel is my favorite. glad to see ya'll back :)

  • @cementra2007
    @cementra2007 7 лет назад +7

    I'm so glad I found this channel.

  • @smartaleck05
    @smartaleck05 7 лет назад +19

    God bless you! So glad you posted this sooner- my step exam is in

    • @madamhenry
      @madamhenry 7 лет назад +2

      Did you pass????

    • @smartaleck05
      @smartaleck05 6 лет назад +21

      Sorry, I did! + forgot about this post so I donated lol. Now I'm about to take Step 2 CK :D

    • @judysams3457
      @judysams3457 5 лет назад

      Õ

    • @ANabiha
      @ANabiha 2 года назад +3

      just curious about how you’re doing now :o

    • @attiea85
      @attiea85 Год назад

      @@ANabiha Me too :)

  • @michaelangelo9240
    @michaelangelo9240 7 лет назад +4

    Thank you. Very well explained. Makes perfect sense.

  • @andreafarrar2350
    @andreafarrar2350 3 года назад

    Thank you SO VERY MUCH for clearing this up for me. Just reading a book doesn't help me very much. You rock!

  • @makeitaleapyear6062
    @makeitaleapyear6062 7 лет назад

    good to see you guys back !✌

  • @alejandrabeltran297
    @alejandrabeltran297 3 года назад +4

    You literally saved my life. Thank you so much.

  • @christian9alexander
    @christian9alexander Год назад +3

    Brilliant video - this was a 2 hour lecture for me in school! But I also love how at 2:46 your washing machine ended and you can hear it in the background haha!

  • @Be1smaht
    @Be1smaht 2 года назад +1

    I love that you just got into it. No intro just go

  • @TK24958
    @TK24958 7 лет назад +6

    low key obsessed with your channel. posting this in my academic group

  • @johnklens8812
    @johnklens8812 5 лет назад +1

    Wow this cleared everything up!! Thank you!!

  • @comedy0stuff
    @comedy0stuff 7 лет назад +3

    Please Please more Cardiology and Respiratory related Dirty USMLE Material
    Thanks so much for all your content

  • @dramina2326
    @dramina2326 4 года назад

    Great as always.Thank so much🙏🙏🙏

  • @info.planet4337
    @info.planet4337 5 лет назад +73

    TTP = PARTNERS
    P: low plt
    A:anemia
    R:renal
    T: temperature rise
    N: neurological defect
    ER: emergency, admission
    S : schistocytes

  • @HafizahHoshni
    @HafizahHoshni 5 лет назад +2

    Simply excellent. Very grateful for clear, concise and well presented video. Thank you for the great channel. 4/9/2018 😊

  • @Kashif259
    @Kashif259 3 года назад

    Thank you so much! This is super helpful!

  • @lisagonzalez2902
    @lisagonzalez2902 7 лет назад +1

    I appreciate this video! Extremely helpful. Thank you so much, once more.

  • @JC-je3jc
    @JC-je3jc Год назад +1

    Increased bleeding time doesn't necessarily mean platelet destruction, but could also be a failure of aggregation or adhesion with normal platelet count

  • @alycks6056
    @alycks6056 6 лет назад +1

    awesome, well explained

  • @VampireDiariesBiebs
    @VampireDiariesBiebs 4 года назад

    You’re the best!!!!!!!! Thank you

  • @Sweetnsilly18
    @Sweetnsilly18 2 года назад

    Thank you so so much this! I hope you get infinite happiness in life 😭🥰

  • @andreayb0523
    @andreayb0523 5 месяцев назад

    Great video! Thank you :)

  • @ericnorthmen4118
    @ericnorthmen4118 5 лет назад +2

    Please make playlist for patho. Your videos are superb

  • @roshanaksharifi1181
    @roshanaksharifi1181 3 года назад

    Thank you so much.

  • @BerniesLife
    @BerniesLife 4 года назад +1

    this was so helpful! thank you

  • @johndube4536
    @johndube4536 5 лет назад +1

    very helpful... thank u so much Sir

  • @Peace597
    @Peace597 5 лет назад

    Thank you!

  • @raedalghamdi1790
    @raedalghamdi1790 7 лет назад

    From Arabia Peninsula 1 million thanks

  • @raroshraj
    @raroshraj 6 лет назад +1

    thank you my guy

  • @salmael-khateeb9989
    @salmael-khateeb9989 4 года назад

    very helpful thanks a million !

  • @LuanO7
    @LuanO7 3 года назад

    Great video!

  • @karimoon270499
    @karimoon270499 5 лет назад +4

    I cracked up at whadufuq and DAMN IM CLOTTING

  • @mariesa7338
    @mariesa7338 5 лет назад +1

    Amaaaazzzinggg

  • @dineomakgobatlou2434
    @dineomakgobatlou2434 6 лет назад

    Really helpful...thanx

  • @colbycarnes5786
    @colbycarnes5786 2 года назад +2

    Note: ITP is IgG antibodies against GpIIb/IIIa

  • @srirambhardwaj2343
    @srirambhardwaj2343 4 года назад

    Thank.you.very.much.

  • @ghassanaswad4034
    @ghassanaswad4034 4 года назад

    well done , thnks alot

  • @sreejithmg9101
    @sreejithmg9101 3 года назад

    thank you...

  • @liebedich2441
    @liebedich2441 7 лет назад

    Thanks but the chart comparing the differences is not so clear in video,where can i get the pics of the chart please?

  • @aayushbhadani8351
    @aayushbhadani8351 3 года назад

    This was so good!

  • @imranafzal3973
    @imranafzal3973 4 года назад

    Thank U sir...Love from Pakistan

  • @ahmadharb13
    @ahmadharb13 4 года назад +2

    May I ask what is the cause of fever in patients with TTP?

  • @tawafraaya3910
    @tawafraaya3910 5 месяцев назад

    best explanation everrr

  • @leeromeo8635
    @leeromeo8635 6 лет назад +1

    Dam man you are a god!

  • @nwabuezeozuzu6370
    @nwabuezeozuzu6370 7 месяцев назад

    Thank you for breaking this down 🥲

  • @josebento1772
    @josebento1772 Год назад

    Thanks

  • @zhwart.hassan2199
    @zhwart.hassan2199 5 месяцев назад

    THANKS KEEP GOING

  • @daphrosemukabaranga4946
    @daphrosemukabaranga4946 6 лет назад

    God bless you. Can you talk about TPK?
    Thanks.

  • @tanyaradzwagahadzikwa9545
    @tanyaradzwagahadzikwa9545 3 года назад

    this is a good explanation

  • @imgingi
    @imgingi 7 лет назад +28

    I was WAITING for FAT RNS for TTP!!!!!! ( Fever, Anemia, Thrombocytopenia, Renal, Neurologic)

    • @DirtyMedicine
      @DirtyMedicine  7 лет назад +68

      we don't waste our time with shitty FA mnemonics that make no sense

    • @lisagonzalez2902
      @lisagonzalez2902 7 лет назад +3

      Yeah. There's a lot of mnemonics in FA that is pure nonsense, random letters.

    • @raroshraj
      @raroshraj 6 лет назад

      hahaha i love it

    • @SaiRam-nz9sy
      @SaiRam-nz9sy 3 года назад +2

      @@DirtyMedicine once a rebel, always a rebel.

  • @alijilani1214
    @alijilani1214 5 лет назад +17

    I thought ADAMSTS13 cleaved vWF multimers into monomers and those multimers are the ones that activate the platelets

    • @amandahlaba8875
      @amandahlaba8875 5 лет назад

      me too

    • @salmael-khateeb9989
      @salmael-khateeb9989 4 года назад

      SAME

    • @Dranamolous
      @Dranamolous 3 года назад

      The end result is the same So his description is good for the sake of simplicity. I’ve never seen a question that hinged on that detail

  • @soumitroy4549
    @soumitroy4549 7 лет назад

    thanks

  • @Anonymous20186
    @Anonymous20186 5 лет назад

    Thx alot

  • @alexabentley1617
    @alexabentley1617 4 года назад

    LOVED THIS VIDEO OMG

  • @wakylaugh
    @wakylaugh 2 года назад

    Amazing

  • @eakkaya204
    @eakkaya204 6 лет назад

    just..... I LOVE YOU

  • @gokul8326
    @gokul8326 2 года назад

    Thank u

  • @muhammadjunaidali769
    @muhammadjunaidali769 3 года назад

    awesome

  • @DOC_951
    @DOC_951 7 лет назад +1

    can you make a video for the vision defects? (bitemporal hemianopia, macular sparing, etc)

    • @drsultansaudagar2733
      @drsultansaudagar2733 6 лет назад

      Mr. 2006 for this you can watch video of armando hasudungan.you will understand it.

  • @joshmcgoo
    @joshmcgoo 4 года назад

    From first aid: TTP = FAT RN
    Fever
    Anemia
    Thrombocytopenia
    Renal Sx
    Neuro Sx

  • @leezhengyangbrandon5080
    @leezhengyangbrandon5080 5 лет назад +5

    Bro, it's schistocytes btw, not schistiocytes. I love the video, thank you

  • @loganmarshall7380
    @loganmarshall7380 7 месяцев назад

    Tooooooooo good

  • @mahmoudkazim572
    @mahmoudkazim572 5 лет назад

    Nice

  • @AJohnson0325
    @AJohnson0325 6 лет назад +1

    Aren't you not supposed to give platelets to TTP? I think the treatment is steroids and plasma exchange.

  • @ResistmeJocy
    @ResistmeJocy 7 лет назад +1

    Damnn im clotting lol love your videos

  • @ahmedhussin1834
    @ahmedhussin1834 7 лет назад

    Updates about the book ?

  • @thabephalane8961
    @thabephalane8961 5 лет назад +1

    ITP isn't a immune thrombocyptopnic purpura

  • @bashayeralrefei2963
    @bashayeralrefei2963 5 лет назад +3

    Sir, how can i thank you? You are a life saver. Looooooooove you, your channel and your amaaaaaazing mnemonics

    • @quadtos857
      @quadtos857 5 лет назад +1

      @Bashayer Alrefei, you can thank him by donating on Patreon every month from $1/month to .......

    • @bashayeralrefei2963
      @bashayeralrefei2963 5 лет назад

      @@quadtos857 hahaha ok

  • @waqasashraf6552
    @waqasashraf6552 4 года назад

    How do we differentiate HUS and TTP since both will have everything in common (including creatinine elevation)
    Is it just by the hx of diarrhea or am i missing something ?

    • @andrewholst5067
      @andrewholst5067 4 года назад +1

      Yes, recent illness in the vignette most likely

  • @MSDawar2k17
    @MSDawar2k17 6 месяцев назад

  • @leeromeo8635
    @leeromeo8635 6 лет назад

    Dam you are too great I have to leave another comment OMG

  • @amyjojinkerson6745
    @amyjojinkerson6745 3 года назад

    how do they get these medical terms

  • @vikramadityajha8924
    @vikramadityajha8924 Год назад

    Sir role of Vit b12 and folic acid in thromcytopinia.

  • @batoolqassim9715
    @batoolqassim9715 5 лет назад

    I can’t find your seronegative arithritis video 😭😭😭😭😭😭 did you remove it ?? Please bring it back 😢

  • @kamalghimire4148
    @kamalghimire4148 6 лет назад +1

    hemolysis in hus : toxin mediated hemolysis or due to thrombosis? written sth else n u told sth else.......

  • @michaelmakarchuk8662
    @michaelmakarchuk8662 4 года назад

    TTP - pentad = My Kid Throw Fits
    Microangiopathic haemolytic anaemia (My)
    Acute Kidney injury (Kid)
    Thrombocytopenia (Throws)
    Fever & Fits/seizure (Fits)

  • @mehrdadpilsham4211
    @mehrdadpilsham4211 5 лет назад

    I accually had itp and it’s super serious the doctors thought I was gonna die😭

  • @frostmageshark6277
    @frostmageshark6277 6 лет назад

    I had itp

  • @riccikalaya4614
    @riccikalaya4614 5 лет назад +2

    Damn I’m Clotting

  • @shirinaminoroaya3171
    @shirinaminoroaya3171 2 года назад

    coolllllll

  • @JeanetteAAvila
    @JeanetteAAvila 5 лет назад

    My daughter has TTP she can relapse she feels so dizzy😭😭😭😭

  • @Amritpalsingh-mc4kx
    @Amritpalsingh-mc4kx Год назад

    The natural treatment of ITP is possible without causing any side effects. Planet Ayurveda from India offers ITP Care pack which are very effective and treat the condition of ITP naturally without any side effects

  • @Be1smaht
    @Be1smaht 2 года назад

    Idk about damn I’m clotting… because the DIC leads to decrease in clotting factors….

    • @DirtyMedicine
      @DirtyMedicine  2 года назад +2

      But yet you clot everywhere. Hence the mnemonic

  • @silvermartin4160
    @silvermartin4160 4 года назад

    TTP: F'N RATS
    Fever
    Neuro symptoms
    Renal failure
    Anemia
    Thrombocytopenia
    Schistocytes

  • @Kidszone01238
    @Kidszone01238 6 лет назад +1

    I m itp patient

  • @luna.kashyap1313
    @luna.kashyap1313 5 лет назад

    I love u

  • @optikalillusion777
    @optikalillusion777 4 года назад

    More like stomach bacteria...

    • @DirtyMedicine
      @DirtyMedicine  4 года назад

      the term was used in the common vernacular, calm down

    • @optikalillusion777
      @optikalillusion777 4 года назад +1

      @@DirtyMedicine That bothered you? LOL.

  • @HockeyGuy_in_STL
    @HockeyGuy_in_STL 3 года назад

    spellcheck: Schistocytes, histiocytes

  • @LilFella67
    @LilFella67 Месяц назад

    Sounds like you have a sinus infection but you just press on! Get well.

  • @irisartin385
    @irisartin385 5 лет назад +2

    You're misspelling and mispronouncing "schistocytes".

  • @MILITO110
    @MILITO110 5 лет назад +1

    1746366636366 words in a second am not American and many like me 😔🤬

  • @gdhbgsgsuhfg9048
    @gdhbgsgsuhfg9048 3 года назад

    Yang milih allah like 40000 ya