Correction: 14:43 Primary Membranous Nephropathy is due to anti-Phospholipase-A2-Receptor antibodies. Note that anti-PLA2R is the correct short hand, but the red bolded text should say "anti-Phospholipase-A2-Receptor".
Easy way to remember which glomerular disease is what: Nephritic= "Glomerulonephropathies" (i.e. PSGN RPGN MPGN) + the two "A's" (IgA and Alport) Nephrotic= all the others :P (i.e FSGS MCD Membranous nephropathy Amyloidosis Diabetic nephropathy) Also, Nephrotic is a a problem with the podocytes/basement membrane. MCD and FSGS will both have effacement of foot processes on EM. Membranous is deposition IN the BM so it wil give "Spike and Dome" appearance, as it is still contained within the basement membrane. PSGN and MPGN (of nephritic syndrome) involve the mesangium. PSGN=deposits in the mesangium which grow ALONG the basement membrane which gives it the starry sky "lumpy bumpy" appearance. (starry sky implying widespread deposition of IgG/M and complement(C3). MPGN=deposits in the mesangium which GROW INTO/invade the BM and cause 'splitting', leading to "tram track" appearance. I had alot of trouble with this before, so I hope this helps someone:)
Hey Dirty Med! I'm writing this appreciation post to express my sincere gratitude for your videos, especially this one on nephritic vs nephrotic syndrome. I recently graduated from medical school. Nephritic and nephrotic syndrome was one of the topics on my final state exam. I had watched this video so many times that I knew it by heart. I reformulated what you said in the video and explained it to my nephrology professor. Thanks to you, I aced my final state exam! So, in a way, this video helped me become a doctor. Thank you so much for sharing your knowledge and passion for medicine with us. I'm so grateful for your help!
For Granulomatosis with Polyangiitis (GPA), our professor came up with the mnemonic, "You Cry because your GPA is a C." Cry for the sinusitis and C for C-ANCA
I have a problem with trying to remember that wegners is actually GPA so i grabbed this and changed it to "Wegner cries bcuz his GPA is a C". So helpful. Thank you!
I am just back here to say a special "thank you" to that guy who raised my GPA. I not only dodged a retake in mental health but I also got a 70 for the first time as they set panic attacks, things to do with depression and mania. Many people got retakes in that course unit but thanks to you.
Every video is of high quality and high yield. Thank you so much for all the free education. I mentioned before. I would hope to have a one-time donation option!
HUUGE thanks to you bro! Added your pneumonics & images to my First Aid PDF. This topic should be a lot easier when I go through it now. I'm so grateful to you. 🙌🙏
Just wanted to add that we learned in lecture and First Aid also says that IgA Nephropathy is synpharyngetic, so occurring concurrently with a mucosal infection rather than weeks after an infection. The timing here is different than with post-infectious glomerulonephritis. Great video, thanks!
This is a great video with very easy understanding of all the concepts mentioned , I would just like to make the request that a lot of people face confusion in identifying these diseases on histology slides , so if along with the explanation you can use a pointer to tell us about the salient identification features while you are narrating them verbally . It would be of great help . Overall thankyou so much for an amazing video
Thank you, I needed to revise pathology cause its just makes it easier to study the relevant medicine topics and this was so helpful, i juts reviewed my pathoma notes alongside and it really helped me remember.
Brilliant but at 35:00 IgA nephropathy occurs usually 2-3 days after a respiratory infection, which helps to differentiate from PSGN which occurs after 2-3 weeks of respiratory (or skin) infection.
@@DirtyMedicine I wanted to emphasize on the timeline of symptoms because you mentioned 2-3 weeks for IgA nephropathy. Most of the resources I follow mention a few days, mostly 2-3 days, rarely beyond a week.
@@obaid.h yes ..for igA nephropathy,time line will be less then 72 hrs, that's why its aka synpharyngitic macroscopic hematurea while as for psgn,if its impetigo,then time line will be 2-6 wks n if its pharyngitis ,time line will be 1-3 wks ..moreover some other points to distinguish will be that psgn can have a mixed picture of nephritic plus nephrotic ,increased kft,increased B.p ,c3 low while as bergers disease has normal bp,normal kft,normal c3..look out for these also in the mcq apart from timeline..
Till my 1st day of med school piling up a lot of frustration for biochem but nowadays your high yield videos just blown me away ,just fall in love wid these study stuffs and also subconsciously dreaming about cracking usmle /complex haha ,thanks for existing just loved it :")
I'm a PGY1 in the UK, an F1 as we call it, who is coming to the end of a nephrology rotation. I NEVER thought id encounter these patients in my career, and yet ... I've seen them all multiple times. This video remains useful and fascinating. If you are here, late at night, cramming this for the boards, keep going - it's useful!
Focal Segmental Glomerulosclerosis F - e-F-facement (of podocytes) Sickle cell sclerosis Hispanic Hyalinosis I like alliteration, works for me.. might help :)
"wire loop" is also used in description of membranous GN, so be careful with that buzz word, but just ensure to know the difference of immune deposits location (membranous would be subEPIthelial vs the lupus example here for proliferative GN, where deposits would be most likely multi-compartmental, but mainly subENDOthelial location)
Came up with a bit of a longer mnemonic for Alport syndrome, but think it could be pretty helpful because it ties in the genetics, as well as what you see on EM: "You can't fly fighter jets if you can't see, can't pee, or can't hear a bee (clinical symptoms), so instead at the X-wing fighter jet (X-linked dominant, Star Wars reference) airport (Alport), you partake in basket-weaving (EM finding) to pass time"
Hi. I just want to correct. IgA nephropathy (Berger D.) occur CONCURRENTLY with respiratory or GI infection (and not 3wks as the video mention), also have EPISODIC hematuria. Source : 1st AID 2022.
Hello, will you ever put out an app, so that we will have access to all your videos on the go as well. I really think that would be helpful and cool. Thanks for the amazing job.
All your vids are amazing, they have saved soo many med students like me, a million times, thank u for all ur hard work & efforts, God continue to bless u.. I wanna make a request, if you could make some immunology vids too, plz & thank you
Love the video - But NBME got me a few days ago with membranous glomerulonephritis instead of listing it as membranous nephropathy and I knew it was nephrotic but the question said which glomerulonephritis does this patient have.
34:31 IgA1 (Serum IgA) is capable of activating complement pathway through binding to " Mannan binding lectin " (MBL) protein. MBL then activates C4 into C4b ; which in turn initiates the formation of " C3 convertase " . C3 convertase activates C3 into C3b ! So , how comes serum C3 levels are normal in case of IgA nephropathy
Correction: 14:43 Primary Membranous Nephropathy is due to anti-Phospholipase-A2-Receptor antibodies. Note that anti-PLA2R is the correct short hand, but the red bolded text should say "anti-Phospholipase-A2-Receptor".
Just review the anti phospholipase A1 you wrote in the slide ! Thank you so much for your great effort , doctor !
A trick : watch movies on flixzone. Me and my gf have been using them for watching all kinds of movies during the lockdown.
@Alonso Jaden yup, have been using flixzone} for years myself :D
Can you please drop a link in the reply of this comment of mine where I can join and give back ?
thank you GOAT
Most anticipated release of the year! So excited. Deep breath
Thanks for being a Dirty Medicine member!
@@DirtyMedicine life saving!
Easy way to remember which glomerular disease is what:
Nephritic= "Glomerulonephropathies" (i.e. PSGN RPGN MPGN) + the two "A's" (IgA and Alport)
Nephrotic= all the others :P (i.e FSGS MCD Membranous nephropathy Amyloidosis Diabetic nephropathy)
Also, Nephrotic is a a problem with the podocytes/basement membrane. MCD and FSGS will both have effacement of foot processes on EM. Membranous is deposition IN the BM so it wil give "Spike and Dome" appearance, as it is still contained within the basement membrane.
PSGN and MPGN (of nephritic syndrome) involve the mesangium. PSGN=deposits in the mesangium which grow ALONG the basement membrane which gives it the starry sky "lumpy bumpy" appearance. (starry sky implying widespread deposition of IgG/M and complement(C3).
MPGN=deposits in the mesangium which GROW INTO/invade the BM and cause 'splitting', leading to "tram track" appearance.
I had alot of trouble with this before, so I hope this helps someone:)
this is amazing thank you
Thanks
Thank you
thankkuu
thank you so much T______T
Hey Dirty Med!
I'm writing this appreciation post to express my sincere gratitude for your videos, especially this one on nephritic vs nephrotic syndrome. I recently graduated from medical school.
Nephritic and nephrotic syndrome was one of the topics on my final state exam. I had watched this video so many times that I knew it by heart. I reformulated what you said in the video and explained it to my nephrology professor. Thanks to you, I aced my final state exam!
So, in a way, this video helped me become a doctor.
Thank you so much for sharing your knowledge and passion for medicine with us. I'm so grateful for your help!
For Granulomatosis with Polyangiitis (GPA), our professor came up with the mnemonic, "You Cry because your GPA is a C." Cry for the sinusitis and C for C-ANCA
Thank you!
I'm not crying, you're crying :'(
It’s a good one, thank u
Le me who remembered wegners granulomatosis😂
I have a problem with trying to remember that wegners is actually GPA so i grabbed this and changed it to "Wegner cries bcuz his GPA is a C". So helpful. Thank you!
You are the reason I still have faith in humanity ! Free and the best medical content without the shenanigans ! Binge watching all of them :)
Saving my lifeee! I've probably gotten more nephritic/nephrotic questions right in the last 4 days than in the last 3 weeks. Ty!!!
Thanks for being a Dirty Medicine member!
Thanks!
I am just back here to say a special "thank you" to that guy who raised my GPA. I not only dodged a retake in mental health but I also got a 70 for the first time as they set panic attacks, things to do with depression and mania. Many people got retakes in that course unit but thanks to you.
You're doing God's work Dirty. Love you bro. When I get my benjis straight I"ll join your support team for sure
😅😅😅
Thanks
Every video is of high quality and high yield. Thank you so much for all the free education. I mentioned before. I would hope to have a one-time donation option!
Thanks Kathleen. Unfortunately RUclips doesn't have that option yet, so the work around is to just cancel your membership after the first month.
@@DirtyMedicine Please have a donation page on some website! There are plenty available. Thank you for this amazing content, dirty!
Thank you so much Dirty, this is such a pain in the a$$ topic no matter how many times I review it.
i loved it , you summarize a lot of hours of study in 40 minutes... You are the best
Your videos are easier to remember than BnB and pathoma. Looking forward to more content as I approach my step1 exam!
have you already took an exam?
HUUGE thanks to you bro! Added your pneumonics & images to my First Aid PDF. This topic should be a lot easier when I go through it now. I'm so grateful to you. 🙌🙏
I just love this channel.
I got the notification and felt happier than receiving my stimulus check
In dedicated right now- I’ve definitely been waiting for this video to save me!
Hope you enjoyed it! Thanks for being a Dirty Medicine member!
Commenting to boost your page, thanks for the very helpful free content!
Just wanted to add that we learned in lecture and First Aid also says that IgA Nephropathy is synpharyngetic, so occurring concurrently with a mucosal infection rather than weeks after an infection. The timing here is different than with post-infectious glomerulonephritis.
Great video, thanks!
This is a great video with very easy understanding of all the concepts mentioned , I would just like to make the request that a lot of people face confusion in identifying these diseases on histology slides , so if along with the explanation you can use a pointer to tell us about the salient identification features while you are narrating them verbally . It would be of great help . Overall thankyou so much for an amazing video
DPGN isn’t always a RPGN. It can occur without crescents and rapid progression. Excellent video as always
Yes this is true.
I planned on studying this subject deeply next week, I guess I'm doing it today in less than 30 minutes! thanks to you😂😂😂
😂not 30 I guess...
@@muhammadikrama9286 I so wanted to update it exactly the way you put it, but I was like naaaah who cares?! 😂😂😂
Thank you, I needed to revise pathology cause its just makes it easier to study the relevant medicine topics and this was so helpful, i juts reviewed my pathoma notes alongside and it really helped me remember.
Brilliant but at 35:00 IgA nephropathy occurs usually 2-3 days after a respiratory infection, which helps to differentiate from PSGN which occurs after 2-3 weeks of respiratory (or skin) infection.
PSGN typically occurs post GABHS infection which is usually, albeit not always, a throat/skin infection on USMLE/COMLEX.
@@DirtyMedicine I wanted to emphasize on the timeline of symptoms because you mentioned 2-3 weeks for IgA nephropathy. Most of the resources I follow mention a few days, mostly 2-3 days, rarely beyond a week.
@@obaid.h yes ..for igA nephropathy,time line will be less then 72 hrs, that's why its aka synpharyngitic macroscopic hematurea while as for psgn,if its impetigo,then time line will be 2-6 wks n if its pharyngitis ,time line will be 1-3 wks ..moreover some other points to distinguish will be that psgn can have a mixed picture of nephritic plus nephrotic ,increased kft,increased B.p ,c3 low while as bergers disease has normal bp,normal kft,normal c3..look out for these also in the mcq apart from timeline..
@@lazymedic5988 LIKE YOUR POINT TO DIFFERENTIATE BOTH DISEASES APART..
Can’t stop Thanking you enough , every video of urs is just brilliant ❤️
Till my 1st day of med school piling up a lot of frustration for biochem but nowadays your high yield videos just blown me away ,just fall in love wid these study stuffs and also subconsciously dreaming about cracking usmle /complex haha ,thanks for existing just loved it :")
Damn, can't wait for this album to drop!
Awesome video as always, thanks for all the high yield videos!
I'm a PGY1 in the UK, an F1 as we call it, who is coming to the end of a nephrology rotation. I NEVER thought id encounter these patients in my career, and yet ... I've seen them all multiple times. This video remains useful and fascinating. If you are here, late at night, cramming this for the boards, keep going - it's useful!
Thanks Dirty! Always coming in clutch
Bloody love this guy's channel❤
I will support you when I become a doctor! keep up the great work! thank you!
Focal Segmental Glomerulosclerosis
F - e-F-facement (of podocytes)
Sickle cell sclerosis
Hispanic Hyalinosis
I like alliteration, works for me.. might help :)
I have read it a 100 times & I was still excitingly looking forward to your take on this topic
Kudos for always giving Dr. Sattar credit!!
NP student here. Got to memorize all these. Thank you for this video and all the other videos! Helping me ace my exams! 😎
Can't believe I am so hyped for this!
Thank you! Studying renal pathology right now ❤
"wire loop" is also used in description of membranous GN, so be careful with that buzz word, but just ensure to know the difference of immune deposits location (membranous would be subEPIthelial vs the lupus example here for proliferative GN, where deposits would be most likely multi-compartmental, but mainly subENDOthelial location)
Omgn needed this today! renal block tomorrow thank you dirty!😊
This is amazing! Super organized and great pneumonics!
Mnemonics*
Came up with a bit of a longer mnemonic for Alport syndrome, but think it could be pretty helpful because it ties in the genetics, as well as what you see on EM:
"You can't fly fighter jets if you can't see, can't pee, or can't hear a bee (clinical symptoms),
so instead at the X-wing fighter jet (X-linked dominant, Star Wars reference) airport (Alport),
you partake in basket-weaving (EM finding) to pass time"
Hi. I just want to correct. IgA nephropathy (Berger D.) occur CONCURRENTLY with respiratory or GI infection (and not 3wks as the video mention), also have EPISODIC hematuria. Source : 1st AID 2022.
Awesome content! I took screen shots of your slides to study with!! 🤞Thank you!! 💕
Thank you sir😭Really cool explanation
God bless you
Just superb video......
Understood every topic..
Thanks✌️ thinking about making you my number one resource😆
Hello, will you ever put out an app, so that we will have access to all your videos on the go as well. I really think that would be helpful and cool. Thanks for the amazing job.
You saved my ass on this topic. Thanks a million.
This is from Pathoma: Anything with "Glomerulo" = Granular Depositions.
psGn, dpGn, mpGn = granular depositions.
Our king, thank you! 👑
All your vids are amazing, they have saved soo many med students like me, a million times, thank u for all ur hard work & efforts, God continue to bless u.. I wanna make a request, if you could make some immunology vids too, plz & thank you
For diffuse proliferative i made
Dslr camera pneumonic
D for DPGN
S for SLE
L for wire Loop
thhhanks a lot your allll videos are life savverrr ,
I needed this one week ago!! 😂😂 but fine Ill watch
Must watch for high yield / important differentiating features
Thank You🙏🙏
It's about to be lit boys
Back 3 years later; because STEP 2 is calling; and this video is still gold. Always rewatch it once in a while when I start forgetting stuff.
Love the video - But NBME got me a few days ago with membranous glomerulonephritis instead of listing it as membranous nephropathy and I knew it was nephrotic but the question said which glomerulonephritis does this patient have.
Joined. Thanks for everything
thanks so much for being a member!!
tnks for mentioning dr sattar
You always give A reason to live 👌😍
Excellent as always.
Purpura Schönlein Henoch is associated with IgA-Nephritis
Just a quick correction on Diabetic glomerulonephropathy:
"nonenzymatic glycosylation" should be *glycation* (which is always nonenzymatic)
When im working, im going to be your best donations guy
I know you already have a video on the different types of collagen, but could you make one on the collagen synthesis pathway?
Thanks for being a Dirty Medicine member, David. I will try to make this for you
Amazing work!
Thank you 💕
Great grrrrrreat thank you very much 😍😍😍😍😍😍
Excellent work dirty 👏 keep going
very lovely. thank u
please make video on hernia ....
Thank you so much for this video
thank youuuu this really helped me a lot!
You are awesome thank you!!!
Great help
Outstanding work
Thank you ❤️❤️
Is there a way to get all of your tables all at once or a place to download them without needing to screenshot them from the actual video?
thank you
OMG I always get these uworld questions wrong. Thank you.
Thanks and thanks
THANK YOU !
Can’t thank u enough.. but why there is not a similar video for heart diseases ??
Awesome!!! Thank you
I love this video ❤
You are the best ever
Its phospholipase A2 not A1
Fabulous.
Great explanation !
so helpful! thank you!
Can you upload all these to Spotify or something so I can listen in the car?
Thankkkkkk you!
great video thanka.... i always get confused between 'lumpy bumpy" and "spike and dome'
If you've watched Sketchy, then Strep Pyogenes "Pie in the Sky" to associate PSGN and Starry Sky pathology!
34:31 IgA1 (Serum IgA) is capable of activating complement pathway through binding to " Mannan binding lectin " (MBL) protein.
MBL then activates C4 into C4b ; which in turn initiates the formation of " C3 convertase " .
C3 convertase activates C3 into C3b ! So , how comes serum C3 levels are normal in case of IgA nephropathy
Because the c3 is being deposited into the mesangium.
@@The_Kirk_Lazarus C3 deposition in the mesangium would eventually result in the reduction of SERUM C3 .
Tq
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