Metabolism | Fatty Acid Synthesis: Part 2 (Updated)
HTML-код
- Опубликовано: 25 июл 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/fat...
Join us for part 2 of this two part series on fatty acid synthesis. During this lecture we will be concluding our discussion on fatty acid synthesis. We will also be talking about how Malonyl-CoA is converted into 16 carbon fatty acids. We also talk about the main enzyme in this process called fatty acid synthetase and the different domains of the fatty acid synthetase. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
/ @ninjanerdofficial
APPAREL |
We are switching merchandise suppliers.
DONATE
PATREON | / ninjanerdscience
PAYPAL | www.paypal.com/paypalme/ninja...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #FattyAcidSynthesis #Metabolism
this guy is a doctor synthase.
😅😅😅😅😅
This cracked me up ngl
Genius
😂😂
never getting tired of seeing how excited he is about teaching. wish more teachers were like him. he's the best!
thank you
❤
bro i might not even enjoy playing a game that i love as much as he does teaching. Truly a gem
ummmm okay
@@andrewmontoya8511boo!
This man is a hero!! Saving students one video at a time. Thank you for your work that continues to be discovered year after year🙏
I just wanna say that these videos are priceless for me. Instead of reading the textbook and feeling sleepy, now im watching and learning and it's much more effective for me to absorb new knowledge. Thanks so much
So trueeee🥹🥹🥹
i am a year one med student, thanks so much for these videos!! Wouldn't survive biochem without you!
I found your channel when I was desperate to learn something about facial nerve for anatomy lessons and I discovered that you teach biochemistry too! I can't be more grateful for what you do for medicine students all over the world
Bro watch his physiology vedios
It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!
Yess that 2 Cs from Acetyl stay in the ultimate fatty acid chain at the terminal end.
Makes sense if then every time another malonyl is added, it is decarboxylated. Thanks!
When I noticed, i was like, okay let’s read the comments 😄
@@arnabdas5883 you mean the side that isn't -COOH right?
You are correct. The teacher is teaching something that is WRONG. He should replace the tutorial video and reupload it correctly. 🤦♂️
I don't know how I would survive med school without you ,love how you explain in detail and make high yield videos
You deserve the Nobel price for this service. 👏👏👏❤️❤️
Nobel price is at least $100k. I agree.
agreed
honestly bng!
3:58 pyruvate has 3 carbons, not 2... I've been doctor for 23 years and studying again all of these issues. Thanks a lot for your help in this process
If Ninja nerd would not be there I would have pass my 5 year course in 7 years.. thanks a lot Ninja nerd ❤️
You're amazing brother. Really helping us med student here. You're the best Teacher we all dream to get in our Universities
Your videos are very detailed, easy to understand and informative. You make the pathways easier to understand. Thank you your videos are saving my grade in Macronutrients!!
Having teachers like you nowadays is kind of impossible! Thank you for saving our lives and all the efforts that you put on those great videos you are such a HERO even though English isn't my first language and I really struggle with it, but you made everything look easy.
Thank you so much.
Thank you so much for correcting this video! Needed this badly for an upcoming test. Much love ❤️
Dude, you’re a true blessing. You make my life so much easier in Biochemistry
You are just Amazing!
I learn more from you lectures than from my actual modules, Keep it up
Thank you so so much for being our saviour Zach. Very well explained, and you have got that talent. No doubt about it
OMG! that's really cool you are being more and more organized, keep going, love it :)
Love your work... that smile you got while explaining Ochem is genuine!!! Very wholesome 1000
I love how its so clearly taught. 37 mins and I understand everything.
this is amazing, I love learning biochemistry with ninja nerd❤
Thank you so much
You make all topics easier and enjoyable , thank you
This is really amazing. I hate watching videos that are more than 5mins but I really love this explanation and watched both videos. Thanks a lot for these explanations.
You are a life saviour for many of us 💕 lots of love for you professor. Thanks alot for such conceptual videos. May God bless you
I am out of words to appreciate and thank 😊🙏 you Ninja Nerd!
تعبت وانا اقول اسطورة، توفير وقت وجهد، الطب صار سهل
I'm learning so much from you sir.You explain everything really well. 🤗💕
Amazing work NinjaNerd! Appreciate your videos!
You are really a gem 💎 to medical and biomedical students 👍
This dude is actually a blessing, I love this channel!
This man is every medic's joy and salvation.... if I finish med, would love to someday repay all these videos somehow.
I thank you from the bottom of my heart for making this an easy concept !🤩🤧
It was absolutely fun and enjoyable, thanks for being there, you're a miracle that happened in my life ❤❤
Thanks alot!
Pyruvate has 3 carbons tho, not 2 (3:55).
I thought pyruvate was a 1-carbon molecule?????
@@1Dann123 glucose is a six carbon molecule which is split into two pyruvate so each pyruvate is 3 carbons. No CO2 is removed during glycolysis
@@annajoyoregan4744 Anna… I thought the multiple question marks would have tipped you off… maybe ninja has some videos on sarcasm you can watch!
Thanks man.
What I do Without your Lectures !
Stay Blessed.
no words, just emotions. I finally understood this topic, of course with the help of the greatest professor on our Planet- professor Zack Murphy. Infinite Love and Respect from me to Ninja Nerd channel
thank you so much. you are the only thing getting me through my biochemistry exams
It's simply Amazing and mind-boggling of how you simplify the concepts for the learners.....hats off for the Nobel endeavour 👏👏👏👌🙌
Consistent, detailed, and comprehensive...thank you so, so much!
currently learning fatty acid synthesis and this is a life saver
I have been grappling with this all week, just trying to understand FA synthase. This is just gold. Plus it's been recently updated! How perfect!
All the powerpoint slides I have been given at med school was just useless...
Thank you and congratulations on your website launch!
Fantastic, as always! You are a blessing! Thank you very very much!
am a first year med student ,i have been studying this thing on biochem book but i havent be understanding it bt after i have watched this videos .everything looks easier,i thank you prof zach together with your team
I am a university student in Sri Lanka. I couldn't get any idea about FA synthesis before but now I have a perfect understanding about this. Thank you very much
God brought this angel to earth to help students 🥺👌🏻
His passion and enthusiasm is fabulous 😀
When it all clicks ✨
This gotta be the perfect time that you uploaded this just a couple weeks ago thank you proff
THANK YOU SO MUCH!!! THIS IS A VERY VERY BIG HELP! 😭
I could never express how much these videos help me! You are such a joy to watch and I've never had so much fun learning for my exams :)
Love from Germany
Thank you sir I'm gonna graduate. No questions about that. Your drawings tend to have everlasting impact on the way We understand. What a great channel. From Africa.👏👏👏
Thank you so much Sir for making my concepts crystal clear about fatty acid synthesis
You are amazing, me an smy daughter are in love with you enthusiasm to teach others your love for the science. again THANKS so much.
It was just amazing and mind-blowing!!!
Loved it!❤
I just covered a whole lec in just 37 minutes man you are awesome❤❤ and i just wanted to mention it's actually 3-hydroxy ACP dehydratase rather than what you wrote on the board and i think you even corrected it in the end mid-explaining
Everything becomes easier after watching these videos.
God bless you, legend
Professor Zach is truly a diamond in our lifes
Thankyou professor for making our med journey easier
came here from ur website just to comment and say- the way you get excited about biochem (those nadphs) is like a kid in a candy store! thank you and ur team for putting in so much effort for all of us out here!
the strongest channel in medical history bro... much better than osmosis, kaplan and everything else... really GJ
I honestly love you so much. Hats off for you!
Much love and appreciation to your content❤
My God, I actually clapped at the end of this video. Spectacular lecture with an ethusiasm I could only envy if I didn't possess it myself.
You do it happilyyyyy.. this happenss transfers to us💙💙💙 really appreciate it god bless you guys💙💙💎
I have exam this friday and this was updated today hehe.. Thank you so much!
Thank you sir. Two idea different from my book
1. The four carbons of acyl group , two from aceyl coa and two from malonyl coa, while the carbon removed is the one added by acetyl carboxylase enzyme.
2. The condensing enzyme is called ketoacyl synthetase
Thank you sir
you’re just perfect ❤️❤️ I don’t know how to thank you
Thank you so much for this video i need it for my upcoming test.
the best teacher ever!!!!
YOU ARE SOOO AMAZING JUST KEEP GOING
Thank you so much for all of your help!
Dude youre awsome i didnt think i could undrestand it but u made it look so easy thankuuuu
As a kinetic-visual learner, this form of gradually adding to a picture is ideal for me!
Thank you Ninja Nerd. You're the real OG
I love you. My biochemistry final is in 1 day, and I am cramming my life away. Thank you brotha.
I am preparing for my residency exam which I failed the first time , thnx bro you are saving my ass , and even though my studies were done in French I have no problem understanding given how amazingly you are explaining this even better than my Professor back then , thank you
Your channel gives me hope that lessons can be fun and enjoyable
this is the first time i smile while i study, doesn't mean i don't like the material but i am just focused. but his enthusiasm and smiling laughing. i like how he mention when the NADPH are used in the 5th step of FA synthesis, he's like "they're comin in baby"
This process is hella cool! Had fun learning it!!!
Im so happy to have you guys 💗
We're learning this in BCH! Thank you so much for this! 😊
Thanks for your great work!
Ur amazing,fabulous teacher, mind-blowing,the way u explained it was superb,,,10q very much
the best content on youtube right here - thanks
Awesome video, what a great teacher.
Just saying, your videos are really helping me understand stuff for my metabolism class in university
This guy made biochemistry really interesting and easy to understand and remember.
Thanx very much Doc Zack,welldone
thank you! this is really helpful, i owe you big time :')
You're the best teacher that I've ever had❤❤,
hey Zach, in the reaction catalyzed by Condensing enzyme, the CO2 is released from malonyl bound to ACP domain and not the acetyl group ..it is the same CO2 added to acetyl coA by ACC previously . so there should be 2 red and 2 blue carbons in step 3
YESS exactly i was going to comment this!
I just thought the same thing and came to check the comments to see if there is anyone else who thinks like me :)
Thank you, I was about to comment this too - the extra CO2 (acetyl to malonyl) is there in the first place to make the pathway, specifically the condensation step, thermodynamically viable. The CO2 that "leaves" the cycle each turn during condensation is ALWAYS from an incoming malonyl-CoA because of this specific reason :) The resulting palmitate (the product after its hydrolysis from FAS I) therefore has C15 and C16 from the original ACETYL-CoA, the rest comes from these "temporarily carboxylated" building blocks, malonyl-CoAs :) Hope that made sense!
Anyways, I absolutely love these videos. I'm in the final stages of cramming for my very last exam for my PhD in biochemistry and these videos always give me an immense motivational boost... and I can listen to them anywhere, too! Good thing I have discovered this channel before it's too late. NinjaNerd, prof. Zach, you are a lifesaver :)
amazing. thanks for these videos
thanks for your effort very good explanation
Best video sir u r so hard working u explained even small points too
Thanks for the great video! Small notice: ATP is negatively regulating Isocitrate Dehydrogenase, not the Aconitase. You explained it correctly in part 1. Cheers.
At step 10: IMO the leaving CO2 should be the one from the Malonyl, the Acyl group does not have oxidized carbons to release as CO2.
@@hmone yea I was just about to comment this lol
@@hmone yeah. in the next step too. to retain the OG 4Cs, the CO2 should evolve from the new malonyl group on ACP
The best!! Thank you guys
Saviour…understood n learned every bit ….all credit to my report card goes to you😭thank u sm❤️🥺😭❤️❤️
I truly love your passion. ^ ^
Yeah ninja nerd it makes perfect sense and we enjoyed it❤😊❤