Lysosomal Protein Targeting

In this video we will be discussing about Protein Targeting to Lysosomes that involves the Transport of Proteins from Trans Golgi Network to Lysosomes via Endosomes.
This is the vesicular transport where we see the formation of vesicles in the form of Clathrin coated and Retromer coated vesicles being bud off from the Trans Golgi and Endosome respectively.
The Mannose 6 Phosphate receptor is used during the transport of Lysosomal Hydrolase Precursors.

[@lilydiaz3971]

This was sooo helpful! I was so lost in class when the professor was talking about this but your drawing really helped clarify what was happening.

[@hussainbiology]

thanks for appreciation...Glad to know that it helps

[@asramohammadi9339]

Lol its 4:50 am and I'm having exam today. This was so easy to understand. Thank you so much. 😭

[@hussainbiology]

thanks for appreciation....Glad to know that it helps✌️

[@fatimaqasim7001]

So what is Lol in this

[@kavsydv9591]

Lots of love❤​@@fatimaqasim7001

[@pandora7372]

This is very very helpful, even someone like me without a bio background can actually visualize how it works after this video instead of reading from my sch lecture notes. Thank you so much!

[@hussainbiology]

Thanks Pandora for appreciation.. Glad to know that it helps ✌️

[@kavsydv9591]

After watching this, I got ans. of my ques on this topic. Thank you!!

[@hussainbiology]

most welcome...Glad to know that

[@thestudymuse_myrsini]

This was truly helpful, thank you so much!

[@hussainbiology]

thanks for appreciation..Glad it helps

[@gsr97_]

please add subtitles to your videos. they are extremely helpful but sometimes I find myself lost trying to understand what you are saying. thanks again for uploading

[@hussainbiology]

I will be adding subtitles , to all of my new videos and will try my best to add subtitles to this one also.. Thanks for appreciation

[@elatejada4648]

Same

[@travettedaniel3708]

This is very helpful! Thank you!

[@hussainbiology]

thanks for appreciation...Glad to know that it helps

[@tahirtantary7438]

Hi bro I am highly thankful to u beacuse yesterday I watched this video I done two correct questions in entrance exam today ...thanku soooo much

[@hussainbiology]

Thanks Tahir for appreciation and i am really glad to know that my work pays off. This is my main motto to make study easy and free for everybody.....
BTW what entrance exam it was and where???

[@thechonk3959]

Thank you so much, really helping me out here!

[@hussainbiology]

Happy to help!

[@francescabaysa1773]

👏 this was very helpful

[@ianheart4843]

Sir thank you for this! My lecturer explained it to me but I still cant visualised it, your drawing and explanation make it easier to understand 🙏

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@xiscasansoelle333]

This video is great! but you should consider adding subtitles since some people don't understand English with an accent that well (me, for example... I'm not native and I find it hard) but the explanations are great and have helped me a lot, keep it up!!!!

[@hussainbiology]

Thank you so much for appreciation.. really glad to know that it helps 😊
And surely i will be adding subtitles very soon. ( My accent is lil weird bcz I am not native speaker)

[@debaswapnaray3295]

Wonderful coordination. ..

[@hussainbiology]

thanks for appreciation

[@ethanwhitt2348]

Amazing. Thank you

[@hussainbiology]

thanks for appreciation

[@shosholovely6897]

thank you this is sooo good

[@wendylaurean6874]

Beautiful!

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@jyoti2446]

Very helpful,thank you sir

[@rafiubillah3448]

Amazing video man, ur doing god's work out here :)

[@hussainbiology]

thanks for appreciation...Glad to know that it helps

[@ayadjellab5957]

Thank you so much this was really helpful❤❤

[@hussainbiology]

most welcome

[@rahafalmutairi2714]

Thank you so much 👍🏻👍🏻👍🏻👍🏻

[@priyasingh4859]

I must say ur videos are mind blowing....n really after reading book if anyone will see your videos then each and every image get stick in mind of that person......

[@hussainbiology]

thanks Priya for appreciation.. Really glad to know that it helps....Keep sharing and supporting ✌️✌️

[@priyasingh4859]

@@hussainbiology yes...of course😊

[@azadbharath7444]

Sir u r always outstanding. .....

[@hussainbiology]

Thanks Bharath for appreciation.... Keep Sharing and supporting

[@user-oo2jy1ir1x]

thanks for the video. in this video, lysosomal hydrolase's destination is early endosome. are there some articles about this? i wonder that lysosomal hydrolases trafficked into early or late endosome.

[@gifslang95]

Good job!

[@hussainbiology]

Thanks for appreciation

[@hj9057]

THANK YOU SOSO MUCH

[@nifatjan7458]

Thnx a million sir

[@hussainbiology]

you are welcome

[@poonampatil3040]

Thank you sir.... Its really help me😊

[@hussainbiology]

thanks for appreciation

[@karyobasar6001]

Thankyou ☺️

[@hussainbiology]

You are welcome

[@brindhas540]

THANK YOU SO MUCH. ple tell the textbook for studying this topic

[@celiavz548]

Merci !!

[@hussainbiology]

thanks

[@hui9044]

Thank you very much! I’m curious about how M6P removes phosphoric acid. Hope you explain more thanks.

[@hussainbiology]

thanks for appreciation..Glad it helps

[@SakunoEchizen]

omg thank u so much

[@hussainbiology]

Happy to help

[@noormeshal8003]

You are perfect 👌

[@hussainbiology]

Thanks Noor for appreciation.....Glad to know that it helps

[@xyz..ironlady]

Nice

[@hussainbiology]

thanks for appreciation...Glad to know that it helps ✌️

[@mallakaljarawen888]

very well

[@hussainbiology]

Thanks MA for appreciation

[@yuvraj66]

Sir you can tell about anograde and retrograde pathaway for protein transportation from cis golgi to trans golgi and from trans to cis respectively .
Thank you 😊

[@hussainbiology]

Some part has already been explained here briefly but i will be making a video separately on anterograde and retrograde transport.

[@adamlorincz3025]

How does the M-6-P receptor (or the vesicle) know where the lysosome is? What makes the vesicle go to the lysosome and not somewhere else?

[@hussainbiology]

M-6-p directs the Vesicle towards the Endosome which has m6p receptor and then this Endosome will fuse with the lysosome.

[@adamlorincz3025]

So there is a M-6-P receptor on the vesicle and on the endosome as well?

[@hussainbiology]

M-6-p is lodged into Vesicle like a tag....
And this tag (m-6-p ) is recognized by Endosome m-6-p receptor.

[@adamlorincz3025]

Thanks for your answers and for the video!

[@anavictoriagonzalezcarreon252]

Soy tu fan amiguito si paso mi examen de histología va a ser graxs a ti tqm

[@hussainbiology]

Unable to understand ,?????????

[@anavictoriagonzalezcarreon252]

Dije en pocas palabras que thank you

[@ignacioavendanopena5289]

Estás estudiando del histología de ross? no entendí una mierda en los temas de la manosa 6 fosfato y por eso busco estos videos jajajajaja

[@hussainbiology]

U guys can plz tell me what language is this so that i could Google translate it.......

[@hussainbiology]

Only thank you is understandable.....

[@subhashreesahoo432]

Sir... This topic is also called as sorting of lysosomal enzyme?

[@hussainbiology]

u can use this explanation into creating that topic too

[@jebranrahimi5907]

At last we get mannose hydrolase🙄

[@vairamuthuraj8921]

is this lysosomal degradation of protein??