Ubiquitination of Proteins and Protein Degradation

Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protein is attached to a substrate protein. This process most commonly binds the last amino acid of ubiquitin to a lysine residue on the substrate. The ubiquitination tags the protein for degradation via Proteosome Pathway.

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[@hussainbiology]

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This was fantastic. Thank you so much for the diagrams and step instruction on both processes

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[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins
ruclips.net/video/NW-kADFHKTc/видео.html

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[@caseybertina507]

Hi! This really helped me understand. Thanks!
But what does "SH" in "E1-SH" and "E2-SH" mean?

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I also found this video very helpful for ubiquitination of proteins
ruclips.net/video/NW-kADFHKTc/видео.html

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I also found this video very helpful for ubiquitination of proteins
ruclips.net/video/NW-kADFHKTc/видео.html

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[@siddhantdhingra6422]

Can ubiquitination be done at cysteine residues in a protein backbone?

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I also found this video very helpful for ubiquitination of proteins
ruclips.net/video/NW-kADFHKTc/видео.html

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[@hussainbiology]

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[@abinashbeherabiology9578]

I have a doubt how many types of proteasom are there in human cells?

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[@Teklemarim21]

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Thank you so much...

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Thanks buddy.....Keep supporting

[@anandruban8348]

Why you did not mentioned about the parts of proteosome like Ubiquitin receptors - Rpn-13 and Rpn-10, DUB- De-ubiquitination enzyme, and Rpt-1 to Rpt-6 (ATPase subunit). Examples of Ubiquitin ligase enzyme like SCF- (Skp 1, cullin, and F-box protein) and APC/C - Anaphase Promoting Complex or Cyclosome which degrades cyclins in cell cycle.

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[@hussainbiology]

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[@mehwishnawaz9369]

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[@hussainbiology]

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[@dikshyapanthi7681]

I also found this video very helpful for ubiquitination of proteins
ruclips.net/video/NW-kADFHKTc/видео.html

[@zarlishattique4167]

Hi, Thankyou sir, but can you please tell how upregulation and downregulation of UBC cause tumor or cancer or its progression.

[@fathmanawaz5025]

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[@hussainbiology]

Thanks for appreciation.....Glad to know that it helps...

[@ramchandrasuthar2848]

Very nice analysis bhai ji

[@hussainbiology]

Thanks Bhai..

[@nastarannazari5062]

Thank you, sir. It was so helpful as usual. I have a question. Are all misfolded proteins destined for degradation or are there some helpers that protect misfolded proteins until they are ready to get folded properly?

[@saimaahad7238]

There are first helper proteins called chaperones ( Hsp 70 , Hsp 60 ) which help misfolded proteins to fold correctly , still if misfolded proteins are not capable of folding properly or their functions are lost then they are directed to degradation.

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Can Ubiquitin tag on prions ?

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What is the mechanism of keratin degredation

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Protein degradation control and protein degradation is same? ?

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[@sakshin7324]

how to control its degradation of casien???

[@Tony-xl2ob]

excuse me , i want to ask a question. the numbers of ub need three or four? cuz i remember it need at least four ub.

[@hussainbiology]

Yes for 26 Protesome to work , it needs at least 4 Ubiquitins to degrade the Protein effectively.

[@azzmangal8722]

Soooo nice

[@hussainbiology]

Thanks for appreciation

[@wardtaylore]

Ub4 is the shortest chain that binds to the cap of the proteasome. Not Ub3.

[@hussainbiology]

Yes for 26 Protesome to work , it needs at least 4 Ubiquitins to degrade the Protein effectively.
In diagram i have shown only 3 Ubiquitins which is a mistake.

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[@cheshtaagarwal3945]

sir 26 proteasome consist only one cap of 19s RP with two cap it becomes 30s proteasomes

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Plz watch this video first

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