What cofactors are needed to synthesize and recycle BH4?
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- Опубликовано: 6 сен 2024
- Question: What cofactors are needed to synthesize and recycle BH4?
Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).
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*Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
*How Much Iron Can We Absorb At Once?
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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
*Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
*How Much Iron Can We Absorb At Once?
*What nutrients are important for long-term PPI use?
*For how long does transferrin saturation respond to recent iron-rich food?
*Muscle spasms: creatine, creatinine, sodium, and potassium.
*Hematologists ignore iron saturation.
*How to detox arsenic?
*Could folic acid supplements impair BH4 recycling?
*How to increase butyrate?
*More on hematologists and transferrin saturation.
Here’s a link to the full AMA: chrismasterjoh...
![ARGENTINA vs. CHILE [3-0] | RESUMEN | ELIMINATORIAS SUDAMERICANAS | FECHA 7](http://i.ytimg.com/vi/De3AWmXzhuA/mqdefault.jpg)
Glad you’ve made a video on this! Something I’ve been researching a lot
Thiamine would also be relevant dude to the PPP
So essentially if i want to increase BH4 and lower excitotoxicity of my Arginine pathway, I should increase dietary Zinc, Magnesium, Potassium, and Niacin?
So going into this a bit more ...if someone has ENOS3 mutations...not me..but someone.... what is the best way to go about supporting the ENOS pathway?
I have A1298c homozygous gene which causes low BH4, and I use Liposomal Vitamin C to increase it.
Can you share the vitamin c supplement you use?
@@jfrm334 Nutrivein is the cheapest Liposomal Vitamin C on amazon and I find that it works fine. I used to buy the very expensive stuff but then I realized how incredibly strong the cheap ones are.
@@jfrm334 I recommend if you take a lot of Liposomal Vitamin C to also use copper glycinate, it will help because most people have low copper anyway. I use "Solgar 2.5mg copper" supplement. Technically it's possible to make copper supplements for free by using copper sulfate.
How does vit c increase bh4?
@@judesterification increasing bh2->bh4 recycling
@jfrm334 liposomal vitamin c
Is niacinimide good for this purpose?
Is it accurate to say that Folic Acid causes competitive inhibition of DHFR?
The key folic acid question 😅 everyone mentions this yet no one provides any proof. Hoping for a definitive answer from Chris.
@@tonipieleanu I don't think we can get any definitive answer from Chris. He is saying absolutely there is no correlation between directly folate and bh4, while in cerebral folate deficiency bh4 is depleted and folinic acid increase the amount of bh4.
It is plausible that you would have extra competition and it probably depends on the tissue. Notably you have competition from dihydrofolate anyway.
Your PhD was well earned. 🙂
SAM e makes me feel terrible, and thoughts?
chrismasterjohnphd.substack.com/p/306-why-would-someone-not-tolerate
Bh4 is required for nitric oxide correct?
@@fitlifeconradcorrect