Methylation | The Top 4 Supplements & How To Use Them.
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- Опубликовано: 3 авг 2024
- This is part 2 of the 2-part series on methylation. In today's episode, I will dive into the top supplements and lifestyle advice for people with methylation issues.
Timestamp
00:00 - Intro
02:06 - B9 (folate, folic acid, 5-MTHF)
06:59 - B12 (methylcobalamin, adenosylcobalamin, cyanocobalamin)
09:26 - SAMe (s-adenosylmethionine)
11:22 - Betaine (trimethylglycine)
14:30 - Lifestyle factors to consider
I was diagnosed with homogeneous MTHFR, thankfully my NP was educated on this subject ( 28 years ago!). This information is so valuable and yes, you can feel better. Take out the darn processed foods. 😊
Thank you for the helpful comment! Yes, we would all be better without our processed food!
Wow, divine timing with your video coming out! Your series on this has been extremely helpful. Thank you!
I’m so glad you found help in it!! 🙂
Thankyou for the clarity . Very well explained.❤
You’re welcome!
you are are a great speaker and very detailed , i learned so much from your videos,,thank you so much for your great work
You’re welcome, thanks for the kind words 🙂
Bless you for sharing this educational information for all of us so that we can improve our lives. Thank you
You’re very welcome!
great video, so much valuable information i learned alot. thank you for explaining it in such a simple way for us people that are just starting to learn about methylation. absolutely the best , to the point video ive seen. also i live in vancouver bc so always nice to subscribe to a fellow neighbour :)
Thank you so much and hey there neighbour 🙂
In life everything is balance, neither too little nor too much.
💯
Thank you! Really informative episode. 🙌🏻
You’re welcome!
What a brilliant presentation, thank you. 🙏🏼
You’re welcome! Thank you for the kind words 🙂
yes.
Excellent video, thanks for explaining it so well. Where can I find a list of your top picks as far as brands for these supps? Thank you!
Great job!!! 👏😊
Thank you!
Good video, Thank you 🙏
You’re welcome!
Thank you! for the vidoe it was good here!
You’re welcome!
WOW!! TMG CHANGED MY LIFE!!! :)
Thanks for Pts 1& 2, I learned a lot! I'm an older man & I take a B vitamin complex, which I imagine is the inactivated forms of B9 & B12. What about nutritional yeast? Does it have B9 & 12? You mentioned Betaine. I take Apple Cider Vinegar before I break my fast & eat at about 11 AM. But sometimes if we are having a "heavy" meal, like steak or pasta I will take Betaine Hydrochloride to increase stomach acid. How is that different from Betaine?
Nutritional yeast is good source of B12. The betaine HCL is the same betaine but you take that more for the HCl and it would be hard to achieve the therapeutic doses getting it through that combination. I would try it on its own so you don’t end up overdoing hydrochloric acid in the meantime. I hope that helps 🙂
New to the channel thank you new subscriber shared and liked❤❤❤❤
Beautiful 🙏
Do you have any supplement recommendations for B9, B12,TMG and Sam-e that are within the recommended ranges you discussed in the video? All I seem to find are mega doses of these supplements.
B12 injectable only works because of missing transcobalamine factor..take with folinic acid..activated..and P5P active B6..because forms of anemia are present so get a bloodvsmear,CBC,b12 may test high,folate may test high,though they are not functioning ..also have thyroid T3 T4 TSH and Liver Enzyme Test for differtial on fatigue...abd a good life style factor like exercise is great and avoiding too much partying with your spouse
In older age, above 60, Pernicious Anemia stems from autoimmune causing lack of protein in the stomach to carry B12 from digested food.
Sublingual B12, under the tongue until fully dissolved and absorbed into the veins under the tongue, is a simpler remedy than iv B12. See Kirkland's 5000mcg sublingual B12...works very well at 10cents.
Add a grounding blanket to this regimen.
Love it
Hello love the video. I have high blood pressure, not taking a supper high dose just 4mg. It still stays around 136/80 I’d like to get the top number down. I have read TMG is good for high blood pressure, would this be good to supplement with and potentially get of my blood pressure med.
I’m glad you enjoyed it! It can help some people but not everyone! It’s fairly safe and worth trying.
@dr.robinlewis Hi, I got gene tests done and it confirmed I have MTHFR gene variants. So I took a very small amount of methylfolate about 4 days ago and have been suffering with anxiety and insomnia since. Should I have taken B12 prior then as you suggested? And can you take it after methylfolate or does it have to be prior? FYI I did not continue to take methylfolate after the reaction 4 days ago.
You would take the B12 alone for at least a week and then you can try them together 🙂
@@dr.robinlewis thanks for your reply. I will try this.
I am new to your channel, and wow, you're brilliant! Do you do online consultations? I'm located in FL, US. I am actively searching for a doctor willing to review my elaborate history, which has been challenging for years. Very long story short, I'm curious. on top of a slew of other issues, can this gene mutation cause estrogen metabolism problems? I know that MTHFR is involved in methylation, a key process that facilitates proper estrogen breakdown and excretion from the body and that the 677T mutations reduce MTHFR activity. With less active MTHFR, methylation capacity decreases over time. Can this slow the clearance of used estrogen from cells, allowing levels to build up?
Thank you! I can’t see patients formally outside of Canada which is why I wanted to make the channel! There are some amazing naturopathic doctors in the states though.
The issue with MTHFR variations is poor detox and that includes the excessive estrogen as well!
I believe I have this gene mutation as I have the symptoms of poor methylation, my homocysteine is high and my some of my B status is low based on my metabolic text however when I take SAMe or methylmax, I feel like garbage. I took b12 sub con and got a painful purple bruise that last about a week. Thoughts ?
I would get tested properly to know for sure and then go from there. None of those products are blood thinners so they shouldn’t cause easier bruising but if it keeps happening get it checked out.
What about if homocysteine is low , not high? In this case , is it wise to use methylated forms , Im dealing with Autism case
Would you recommend a methylated B complex or its kinda imbalanced often? Are 2-3 B vitamins safer than 5+ in the same product?
Any suggestions on Methylated B vitamins supplements to take as I have great trouble taking them ? Many thanks 🌻🌻
To be fair many are similar but I like the brands Thorne, AOR, NFH and DFH!
@@dr.robinlewis thank you Robin, I was able to get some from a compounding chemist which make to suit the individual 🌈
Do you have any recommendations, such as a multivitamin or brand to lean towards ?
Not just one but the brands I use are professional grade because they hold themselves to higher standards. Ie AOR, Cytomatrix, designs for health, etc.
@@dr.robinlewis thank you!
So, you can take a SamE, methionine, and the others we lack? Good to know. 😊
This was super useful - thanks!
You’re very welcome!!
I have multiple copies of this gene. My latest blood work, b12 was 4000! I’ve never taken b9 before. I just wonder how to balance that with my high b12 at the moment.
Were you taking a B vitamins or something containing b12 at the time of the test? 9/10 times elevated b12 is simply because you took b12 too close to the time of the blood draw.
Yes I was! I stopped taking it because I was scared of that high number. I need to get my homecystine levels tested. Thanks for the video.
You’re welcome! If that’s the case then you likely don’t actually have elevated B12. I’d suggest retesting when you go in for the homocysteine but make sure to stop the B12 3 days beforehand. That way you will get an accurate reflection of your true B12 stores :)
I had been low on b 12 and then started supplementing. It got corrected... Recently I tested for folate it turned low as defined by range... I had been very anxious and moody though out my life.. Now 35... Now it has been a week taking folate 300 mcg.... And let's what comes the result.. Any further suggestion you would put in plz
I’m glad you’re finally figuring it out! The moodiness could be cause by a lot of things but starting one thing at a time is a good idea. You could always explore hormones and dopamine next if that doesn’t help, but ultimately there are a lot of causes!
Hello
Is taking only one working (like TMG) or should we take MB12 MB9 and Sam-e as well ? Thanks a lot
It totally depends on which methylation genes are affected.
@@dr.robinlewis Thanks. Could you give us a breakdown please ?
Does it work to take it all "just in case" ^^" ?
@@rogerdupont8348read her response above...depends
We are using Thorne's "Methyl-Guard" supplement (my daughter has 2 bad genes, so she's limited in function of her MTHFR gene by 70-80%. She gets migraines as a symptom). The Methyl-Guard supplement says that it contains as written "folate (1.2 mg as L-5-methyltetrahydrafolate from L-5-methyltetrahydrofolic acid, glucosamine salt)" Is this the same as methylfolate? The folic acid part is throwing me off. We are being very intentional with her (and the rest of my family's) diet. We have elimated all folic acid and have upped folate rich foods (broccoli sprouts, beef liver, pasture raised eggs ect). I do not want her taking a supplement with folic acid. Can you help me figure out if this supplement contains folic acid?
These are essentially the same and that is a good supplement!
Thank you so much! Your videos are so helpful and easy to follow! Thank you for the work you put into them ☺ @@dr.robinlewis
@@tinaholbrook9719 You're very welcome! I am so glad you're getting value out of them.
Good afternoon, I read your comment. Most are misunderstanding something. The MTHFR scare is that people are deficient in riboflavin. Also the headache she is getting is because she does not have the energy to use the methylfolate. NAD in the energy cycle is “Riboflavin” AKA vitamin B2. You need riboflavin(Vitamin B2) for the methylation cycle to work correctly. Also folate(methylfolate) needs b12 break down the homocysteine that’s produced in the methylation cycle. All b vitamins are needed for the body to function appropriately but for the methylation cycle mainly Riboflavin(B2), Folate”(B9), and pyridoxine(B6).
Just don’t overdo with b6.
The methylfolate with B12 and added riboflavin will remove the headaches.
I’m an adult so use small doses or see what your child’s body responds to. I had the same issue with the headaches until I realized most b supplements give small doses of Riboflavin, Folate but synthetic(folic acid) and low dose b12. I’ve taken all at high doses with the exception of B6 and most issues have been corrected.
You can see Chris Masterjohn PHD for the info on the Riboflavin deficiency as the culprit regarding the mthfr gene mutation. There isn’t one… people are just deficient in riboflavin(B2). There are 11 B vitamins total.
Inositol, Choline,PABA, folate, thiamin, niacin, riboflavin, pyridoxine, panthothenic acid,biotin and methylcobalamin
Hey beautiful doctor what does it mean when somebody does very bad with vitamins and supplements including vit D?Thanks !
It often means your liver has issues running certain pathways, sometimes genetics can also give a bit of insight into.
I have been overmethykated after taking a methylated b12 3 months ago. I stopped taking the supplements but still having symptoms and they are debilitating. Do you have info on how to help with overmethylation
It could be many things but some literature suggests that niacin may be helpful for over methylation.
Nothing is more attractive than a beautiful woman who is smart.
🙂🙂
Hi Doctor
I read that B12., May read High.. Because it may build up in the Fat Tissues!
Is this true please? ?
I take 10 000 D3.. and my D3 blood level with this is normal.. Been Taking 5mg of K2 M7 .( Natto) could not Tolerate more..
The dizzy sensation. Light headed feeling is debilitating..
Although., it gives one a feeling.. of having more energy.. but Do Struggle to fall asleep with this K2…
Do you know if Vitamin K2 M 4 will have this same problem?Too much Caffeine feeling please? ??
Tnx kindly 🎊
The body doesn’t tend to store excess amounts of B12 and the main stores are in the liver so I don’t believe that’s true.
K2 is not generally considered stimulating but the only way to know would be to try taking it away from bed and see how you get on. I hope that helps.
@@dr.robinlewisThank you. Soo kindly I’ve Stopped taking the Vit K2 m7. Anxiety gone away .. 5mg Due to it Being SOY and With Hashimotis .. Just started a Vitamin K2 M4 5mg with my D3.. . 10 000 daily.
Taking 1333 Mg methyl Folate in my Mutli B. Take 2 two Glycogenics Metagenics And have added B12 as extra. 3000mg adeno B12 sublingual
Need to have homocysteine and Copper Checked in time.
Take from 30-Mg - 45 Mg Zinc at night get too sleepy In morning from Zinc . Have a C p450 .. And add Boron and SELENIUM Nocte. With 600 Mg Magnesium. Being Citrate and Biglycinate..
added recently a 100 mg Betaine hcl with Breakfast.. ( digestive enzyme) helps my digestion. A lot in a few days .. But it just started to hurts Knees. 🤣🥲
Is this too much Hcl please. It has 10mg Tumeric too. ? Plus I take 3 g Tumeric per Day.. cooked ..
Tnx kindly.. 🎉💐🩷🩵💛
I take my stimulating supplements in the morning. I find B vitamins are stimulating. I take regenerative supplements in the evening D (if I didn't get sun), K2/MK7 and nattokinase. I take a lot more supplements, but that is how I group them. Also B vitamins and vitamin C are water soluble and your body should eliminate excess in your pee.
doc my b12 is 190 may i go for basic b complex or b12 jarrow or thorne?
I can’t give direct medical advice but if b12 is below the reference range I will typically do B12 alone in a supplement or as muscle injections to boost the levels quickly and then maintain with a B complex.
The under the tongue B12 drops worked for me…
I was taking supplements but I wasn’t absorbing it.
The drops saved my life.
is it OK for people that might not have this genetic mutation to take the methylated forms instead of the non methylated forms if already taking folic acid & b12? Im asking for a friend. Because i took the test and actually do have 2 variants. I suspect he may have it too, but I doubt he will be taking test.
Absolutely, I always recommend my b vitamins in their active or methylated forms! Not everyone does the test
@@dr.robinlewisthank you ! Followed
Are the side effects always from not taking enough b12? Because I think I get a lot of b12, and of the right form. I think I just can’t tolerate the methylation? It’s been really rough…Only a few online medical “experts” seem to understand that it can be a lot more complicated, and many C6777T people can’t actually the methylated bs. Might it not work for those of us?
Who knows
Can l give TMG t a 9 year Child? Thank you
With children you have to adjust the dose based on their weight but otherwise it’s generally safe.
i am having frequent renal stones issues . i did 2 lazer surgery and frustrated . any test how to solve this isssue?
Magnesium citrate is used to reduce recurrence of renal stones. I have had stones four times one in bladder (large one- 26 mm) for which I did lazer surgery but three renal stones I passed with Ayurvedic herbs within month. I am from India. After I started Mg Citrate I have not had kidney stone.
Didn't you hear which element / substance these stones contained ? For oxaletes you can change your diet, no more spinach and such. For calcium maybe extra vitamin K2 can help, because it channels the calcium in the blood into where it belongs: the bones. If I remember well, your blood/urine PH also plays a role, you could eat more acidic food or take applecider vinegar pills or so. Check these suggestions online to see if I'm correct :$ I guess drinking more water is also a good idea in general.
@@joelsombroek calcium oxalate.
@@joelsombroek If your reply is directed at me I don't have renal stone issue anymore as I said earlier after supplementing with Mg Citrate.
(I am already on K2 as I take Vitamin D3- combination)
Just for info to viewers : Citrate combines with Calcium reducing formation of Calcium oxalate crystals. Also Magnesium has antagonistic effect on Calcium throughout the body. Hence in cardiology it's called natural Calcium channel blocker. CCB are drugs used for hypertension etc.
I don’t see a ring on that finger 😉 what a lovely woman
in one of your videos you said vancouver was moist,was an understatement, i lived in port alberni up until i was 35 and there is only one worst place, is ocean falls, i wonder why it was called that? i live in ventura ca. high and dry ,love my lemon tree and my tomato plants don't shrink when i transplant them outside
😂 so you can relate! I’m glad you found drier climate!