Studying for the 3-packet cumulative exam right now and I would just like you to know how much you have done for me this year. Your videos are the sole reason I know ATP synthase in detail, voltage-gated ion channels, fatty acid degradation/synthesis and much much more. I say this on behalf of my roommate as well who is in the class with me. There were many days/nights where we would have your videos up on the plasma screen in the common room. I've been promoting your videos, I hope it is helping. Keep this up, because it is doing wonders for students like my roommate and I. Happy Holidays
+Christopher Tavani They Christopher! Thank you for taking the time to write that! I really appreciate you promoting my videos and its great to hear that you and your room mate are benefiting from them! If you still haven't taken your finals, best of luck on them, let me know how you both do!
You are simply the absolute best teacher on RUclips. Thank you for saving us all and simplifying such difficult concepts so incredibly well. Thank you thank you thank you!!!
This is great!!! I wish if you were my professor. You answered all of my questions and you have such a great way to keep people focused with you and follow along. Thank you so much.
true, that's why the lipoic acid becomes a lipoamide, because its carboxyl group reacts with the amine group from the side chain of the lysine. this wouldn't be possible with serine, as serine has a OH group on the side chan, which would form a ester if they were condensated.
First things first-your videos are amazing! All the explanations are clear and easy to understand, THANK YOU!!!!!!!! I am confused on one thing though-isn't the lipoamide attached to a lysine residue of E2? Once again, Thank You!!!
During Step 2: where did the two H+ go? You said two H+ were added on to the acetyl group to form the Hydroxyethyl-TPP complex, but when the acetyl group is removed from this complex and added onto Lipoamide, they completely disappear.
I looked on Google and actually I think he made a mistake. The lone H on the carbon of the hydroxyethyl-thiamine pyrophosphate (or biphosphate) doesn't actually exist. I think it's a reduced carbon (-1).
When hydroxyethyl TPP is reacting with lipomide and it is forming acetyllipomide, one hydrogen from the hydroxyethyl group is attaching with Sulphur..Now my question is where the other hydrogen from the hydroxyethyl group does go?
Studying for the 3-packet cumulative exam right now and I would just like you to know how much you have done for me this year. Your videos are the sole reason I know ATP synthase in detail, voltage-gated ion channels, fatty acid degradation/synthesis and much much more. I say this on behalf of my roommate as well who is in the class with me. There were many days/nights where we would have your videos up on the plasma screen in the common room. I've been promoting your videos, I hope it is helping. Keep this up, because it is doing wonders for students like my roommate and I. Happy Holidays
+Christopher Tavani They Christopher! Thank you for taking the time to write that! I really appreciate you promoting my videos and its great to hear that you and your room mate are benefiting from them! If you still haven't taken your finals, best of luck on them, let me know how you both do!
+AK LECTURES (Andrey K) just got back from the test. It was difficult, but fair. I definitely didn't fail! Thanks again.
Christopher Tavani will it help me in msc biotechnology studies of first year
Same here
You are simply the absolute best teacher on RUclips. Thank you for saving us all and simplifying such difficult concepts so incredibly well. Thank you thank you thank you!!!
I've learned a lot from all your biochemistry videos that I've watched. your videos are the reason why I got to love biochemistry.
thank you for making medical school A LOOTTTT MORE UNDERSTANDABLE. ak lectures, honestly thank you.
Chill it’s not harvard
You're amazing! This helped me a lot for my biochem course and it's now helping me study for the MCAT. Thank you for these.
This is great!!! I wish if you were my professor. You answered all of my questions and you have such a great way to keep people focused with you and follow along. Thank you so much.
how can u be this great!! please don't stop your precious work!! you're a life saver
I love this lectures so much. So clear. just nothing to memorize. Explain like the professor who found this . so damn good
Your videos have saved my Biochemistry grade. You have no idea how much these videos have helped me!
You are simply amazing. Please never stop making these videos!
you sir, rock!! thanks for saving my biochemistry exam:)
I showed some of your videos to my classmates (in the class act) using the big screen. You're kind of our hero now. Thank you so much sir
thank you so much, i swear when i have enough money i will be one of your life-long patrons because you are just a lifesaver. i appreciate you so much
Bullshit
oh he shaved
😂
THANK YOU! The exact level of detail needed!
Thank you for your videos 😭 I thought biochemistry was a class I could never pass but I got a B with a lot of help from your videos !!
THIS IS THE KIND OF DETAIL EXAM CREATORS LOVEEEEE TYSM!!!!
Lipoamide is actually attached to the lysine residue of the E2 enzyme, not the serine. Please make this note on the video.
@ 8:40
true, that's why the lipoic acid becomes a lipoamide, because its carboxyl group reacts with the amine group from the side chain of the lysine. this wouldn't be possible with serine, as serine has a OH group on the side chan, which would form a ester if they were condensated.
I wish I could get a book that has been written the way you were teaching. You are the best
It is a great video indeed. I use it on the 5th year of High school for a lesson on Tiamine ( B1) thank you
THANK GOD I HAVE THIS GUY IN MY LIFE
Man, that was super-clear! Thank you so much!
First things first-your videos are amazing! All the explanations are clear and easy to understand, THANK YOU!!!!!!!!
I am confused on one thing though-isn't the lipoamide attached to a lysine residue of E2?
Once again, Thank You!!!
It is.
Exactly what I was thinking. It is attached to a lysine, not a serine.
I was struggling to understand this, thank you!
Got an A+ in biochem and now I’m rewatching your videos to study for the MCAT. You are truly a fantastic teacher
hes making med school doable!!
@@andresbeltre7378Are you graduated now ? In which specialty?
This was very very helpful thank you so much!
والله انك احسن واحد يشرح فالعالمممممممم وكل اللي معاي شهود
Watching it in 2020
God bless you🙌
u are simply the best
You are just Amazing..... You saved my day. Thank You Sir.
Excellent performance and delivery!
Thanks a lot for such a nice explanation 😊
During Step 2: where did the two H+ go? You said two H+ were added on to the acetyl group to form the Hydroxyethyl-TPP complex, but when the acetyl group is removed from this complex and added onto Lipoamide, they completely disappear.
slideplayer.com/slide/3419339/
@@LoversGrief what is this link excuse me?
Thank you so much. This is so helpful.
Awesome man, you are a good teacher.
The lipoate is in an amide linkage with the Lysine residue of E2 actually.
him: "I didn't have space for the other four steps"
me: *looking at my notes page filled to the brim*
"understandable have a great day"
Great presentation as always 😊😊😊
Amazing content! Thank you.
I like this prof a lot .
Thank you, you're so good
Conceptual.... great work
Sir you only make me to love biochemistry
Excellent, as per usual.
savior of med school stud
Thank you so much
In step 2 I can see one H shown in orange bonds with an S in the lipoamide but where does the other orange H go?
Yeah me too I asked myself why but maybe it releases a H+ ion
I looked on Google and actually I think he made a mistake. The lone H on the carbon of the hydroxyethyl-thiamine pyrophosphate (or biphosphate) doesn't actually exist. I think it's a reduced carbon (-1).
Isnt lipoamide attached to the lysine residue?
Could u do something on the primary uses of lipoic acid, and which vitamins and minerals are required for its synthesis/regeneration?
incredibly helpful 👌
When hydroxyethyl TPP is reacting with lipomide and it is forming acetyllipomide, one hydrogen from the hydroxyethyl group is attaching with Sulphur..Now my question is where the other hydrogen from the hydroxyethyl group does go?
Thank u sir
Hey AK! When you said FAD attached to the enzyme, are you talking about the dihydrolipoyl dehydrogenase?
That was awesome 👌🤯🤯
you are my super hero man ♥
On the Product side of the net equation, where did the Hydrogen ion come from since FAD transferred the 2 electrons onto NAD?
You are super lec THANKYOU
Why are the orange H+ (from step 1) not in the reaction equation? They need to be inserted to
thank you
Isn't lipoamide normally attached to a lysine residue, rather than serine? (8'40")
Sir, you need to be a university professor if you are not already. Thank you.
what is the difference between decarboxalses and dehydrogenases in link reaction?
Gracias
+Reyes Jim?nez Elas Soc 2011 welcome!
NAD+ is a cofactor and why is it not regenerated at the end?
you are a god! i will be eternally grateful
U r owesome🎓🎓
where the merch link at? lol
www.etsy.com/listing/458728846/short-sleeve-t-shirt-blue?ref=shop_home_active_1&crt=1
great .
Thank you!!!!!
Should say "extracts," not abstracts, on the board
Out of The two h+ ions added in step 1,one gets addded to S- in step 2;what happens to the second one?
slideplayer.com/slide/3419339/
Thank you!!!!!!!! 👏🏼
why is a part of the doublebunds from c to o in the co2 group drawn with dots?
Jamal George because it's a double bond, and in reality, the double bond has resonance over both the oxygens connected to the C
Just realized acetyl and acetal are different functional groups. WHY LORD
please turkish subtitles
Here's the background image if anyone wants a copy for their notes: imgur.com/Gb7VIBO
ppl who disliked this video have a special place in..................
He seems to like the word "actually" an awful lot.
i love you
Thank you for these video.
Help me a loooot
Thank you sir
Thank you so much