I was literally crying cause I couldn't find a perfect video that described each step carefully. They never mention what came from where! This video saved me!
literally same. I was panicking but this is incredible. thank you for this video and explaining in such a clear way - the diagrams especially showing the carbon atoms affected really helps immensely to know what on earth is going on!
I searched up millions of videos on glycolysis, but none of them were as clear, and not to mention, as simple as your video. For each step you explain, you give a logical yet simple reason, which is what I liked the most. Thanks to your video I have understood (not memorised) the entire concept. Please do keep making great videos like these, Dr. Mike! It would definitely be a blessing for the people who watch them. P.S. just subscribed and liked.
man you're G.O.A.T in Biochemistry, i mean you gave me what my lecturer tried to give but failed consecutively. i will never fail this module if i got you.
I have searched 100s of RUclips channels to get a better understanding of topics like Glycolysis and to be honest I think you are among the few teachers who explain in an easy way like this. Thanks for your contribution sir. I have subbed you right away. ❤
Dr. Mike, thank you for your videos! Quick point of clarification on this one: It's GLUCOKINASE that's specifically in the LIVER; Hexokinase is in muscle and basically everywhere else. Love that GLUT mnemonic!
Breaking it down here everyone!!! So glycolysis uses glucose to convert into 2 molecules of pyruvate that’s 3Carbon molecule, firstly C6H12O6 is converted into glucose 6-phosphate using glucokinase or you can also hexokinase that’s Irreversible process, and this is rearrange into Fructose 6-phosphate by phosphoisomerase enzyme being a reversible process Now in next step with the help of phosphofructose kinase it is converted into Fructose 1,6-Bisphosphate this molecule is unstable and being unstable it is converted or maybe call it split into Two different molecules called as Dihydroxyacetone phosphate and Glyceraldehyde 3 phosphate using enzyme called aldolase but these two are isomers of each other so ultimately dihydroxyacetone phosphate is converted into glyceraldehyde (G3P) Now keep in mind there are two molecules of G3P, G3P is converted into 1,3 bisphosphate (2x) with (2x) NADH+ by G3P dehydrogenase enzyme, 1,3 bisphosphoglycerate is converted into 3-phosphoglycerate again keep in mind there two molecules of this compound and it is converted into 2 phosphoglycerate and last step till it become pyruvate it is converted into phyosphoenolpyruvate ( 2 molecules) and finally 3 carbon pyruvate is ready. One glucose molecule yields four ATP molecules in total during glycolysis. Since 2 ATP molecules are used up in the first phase of glycolysis, there is a net gain of 2 ATP molecules. In addition, glycolysis results in the production of 2 NADH molecules.
Thank you so much for this. In class within 2 minutes my brain involuntary shuts off and I start day dreaming. You make it so interesting, full of energy and explaining why it does what it does instead of just memorising things without understanding it.
I'm taking a 5 week AP1 class this summer and have never taken biology or Chem. I'm pregame studying and your videos are the bonds between reading and comprehension. Thank you!!!
8:40 I thought the liver used Glucokinase during its first step. Amazing video as always, I love that you explained how NAD+ -> NADH + H+ finally makes sense to me. Thank you!
y'all's videos have helped me so much i can't thank y'all enough. not only do they make everything make sense, but i just love your energy when teaching!!
I almost were about to lose hope and do skip to this whole block of biochemistry but thankfully I’ve found your video dr.Mat thank you so so much. Please never stop what you’re doing
I am so glad i stumbled across your channel! Your videos have helped me better understand my human biology class and makes so so ecstatic to keep learning! Love how you explain everything! Thank you!!
Incredibly helpful! This flowchart just blew the whole concept open for me -- Would love to see a video on Cyclin, Cyclin kinases, tumor supressors and P53 (If you could just squeeze that onto the docket somewhere lol preferably at the top! )
thank u very much sir....I was searching for a video for short tricks to learn this but because of u I actually learned it easily by understanding every single step very nicely. and now I am going to watch your video for Kreb Cycle too.
Thank you SOOOO MUCCCCHHHH I M FROM FRANCE AND I WATCH YOUR VIDEOS TO UNDERSTAND BIOCHEM I M IN MY FIRST YEAR OF MED SCHOOL I CANT EXPRESS HOW GREATFUL I M TO FIND YOUR CHANNEL TYSMM FOR ALL THE EFFORT YOU PUT ONN YOUR VIDEOS IT S MORE THAN HELPFUL I SWEAR
Ahhhhhhhhhhh WOW!!! you made it so easy I just want to cry so hard I can’t believe that I finally understand It !!! THANK YOU is just not enoughhhh for your work dr mike ❤️❤️❤️❤️🙉🙉🙉
~ Glycolysis is what cancer uses to reproduce uncontrolled, when cellular respiration is bypassed, whereas oxygen depletion has taken over, as in when smoking or other toxins prevent cells from using oxygen adequately.
Ahhh thank you SO much Dr. Mike!!! This video is 10/10 amazing! You make glycolysis so easy to follow along and understand. Best glycolysis video out there, thank you!
Why did I find this when my exam is this week? 😭 Very very helpful! I actually enjoyed the lecture and it was super beneficial. I’m definitely sharing this video with my colleagues, you can see that we are all struggling with biochemistry. Thank you for your marvellous work, much appreciated.
@@LilyGraceySa Oh, that's so sweet of you. Thanks a zillion times! I'm done with anatomy and physiology, I am only struggling with a few concepts of biochemistry 😓
@Jayant Congratulations on getting done with Anatomy and Physiology! I know, Biochemistry is so challenging and most of the times the lack of tutors you can find make it insufferable. I'd recommend Ninja Nerd, I didn't find others who explained things in detail apart from him. Best of luck, always happy to engage with other students working hard. Keep it up and I hope you get the best grades.🫶🏽
Dr Mike had a slight querry about hexokinase and glucokinase...I thought it's glucokinase found only in the liver while hexokinase is found esle where in the body cells
Thanks a lot for being so clear! As for the playlist, wouldn´t it be a good idea to put the thing in the right order, e.g. glucolysis, then the Krebs cycle, then the electron transport chain? For beginners like myself it would help!
It was really insightful thanks dr mike I really like your lectures because you properly explain your basics, I'm here in Africa Uganda doing pharmacy I would really like to reach out to you for more information like getting your contact
I was literally crying cause I couldn't find a perfect video that described each step carefully. They never mention what came from where! This video saved me!
literally same. I was panicking but this is incredible. thank you for this video and explaining in such a clear way - the diagrams especially showing the carbon atoms affected really helps immensely to know what on earth is going on!
If only professors were like you, seriously we would all be saved. Thank you for what you do, Dr!
I searched up millions of videos on glycolysis, but none of them were as clear, and not to mention, as simple as your video. For each step you explain, you give a logical yet simple reason, which is what I liked the most. Thanks to your video I have understood (not memorised) the entire concept. Please do keep making great videos like these, Dr. Mike! It would definitely be a blessing for the people who watch them. P.S. just subscribed and liked.
I came to say the same thing. The best video explaining Glycolysis I have ever watched.
This is going well already. I came here too after checking out other pages
Very talented guy. In the right field. Passionate and only a passionate scientist can communicate like this. 🙏
How do we remove oxygen from phosphopiruvate to get piruvate
man you're G.O.A.T in Biochemistry, i mean you gave me what my lecturer tried to give but failed consecutively. i will never fail this module if i got you.
I have searched 100s of RUclips channels to get a better understanding of topics like Glycolysis and to be honest I think you are among the few teachers who explain in an easy way like this. Thanks for your contribution sir. I have subbed you right away. ❤
Wow, thank you!
Every video I've watched from your channel has helped me immeasurably. You're an exceptional teacher. Thank you, Dr. Mike!
Thank you so much Dr Mike, you've been a legend . Just started first year med, I'm going to be watching all of your videos x
Dr. Mike, thank you for your videos!
Quick point of clarification on this one: It's GLUCOKINASE that's specifically in the LIVER; Hexokinase is in muscle and basically everywhere else.
Love that GLUT mnemonic!
Breaking it down here everyone!!! So glycolysis uses glucose to convert into 2 molecules of pyruvate that’s 3Carbon molecule, firstly C6H12O6 is converted into glucose 6-phosphate using glucokinase or you can also hexokinase that’s Irreversible process, and this is rearrange into Fructose 6-phosphate by phosphoisomerase enzyme being a reversible process Now in next step with the help of phosphofructose kinase it is converted into Fructose 1,6-Bisphosphate this molecule is unstable and being unstable it is converted or maybe call it split into Two different molecules called as Dihydroxyacetone phosphate and Glyceraldehyde 3 phosphate using enzyme called aldolase but these two are isomers of each other so ultimately dihydroxyacetone phosphate is converted into glyceraldehyde (G3P) Now keep in mind there are two molecules of G3P, G3P is converted into 1,3 bisphosphate (2x) with (2x) NADH+ by G3P dehydrogenase enzyme, 1,3 bisphosphoglycerate is converted into 3-phosphoglycerate again keep in mind there two molecules of this compound and it is converted into 2 phosphoglycerate and last step till it become pyruvate it is converted into phyosphoenolpyruvate ( 2 molecules) and finally 3 carbon pyruvate is ready. One glucose molecule yields four ATP molecules in total during glycolysis. Since 2 ATP molecules are used up in the first phase of glycolysis, there is a net gain of 2 ATP molecules. In addition, glycolysis results in the production of 2 NADH molecules.
Thank you so much for this. In class within 2 minutes my brain involuntary shuts off and I start day dreaming. You make it so interesting, full of energy and explaining why it does what it does instead of just memorising things without understanding it.
The best one who explained glycolysis , good job 👏🏻
I spent almost one hour on such a course, a great one. I learned a lot. Thank you, Dr. Mike.🙂
Amazing. The most clear explanation of glycolysis I have found anywhere. Thank you!
I'm taking a 5 week AP1 class this summer and have never taken biology or Chem. I'm pregame studying and your videos are the bonds between reading and comprehension. Thank you!!!
thank you for genuinely explaining how and why each step happens, this rlly helped me
8:40 I thought the liver used Glucokinase during its first step.
Amazing video as always, I love that you explained how NAD+ -> NADH + H+ finally makes sense to me. Thank you!
You are right!! I mispoke!! 🤦🏻♂️
Sir I am in a tight situation right now, but so far you are saving me, thank you so much.
y'all's videos have helped me so much i can't thank y'all enough. not only do they make everything make sense, but i just love your energy when teaching!!
I was waiting for the ‘easy’ part 😅 - great video as always!
Quite literally the best video on glycolysis in the world!! Thanks, Dr. Mike! You just saved my grades
Literally no words left.
Explaination was osm.
Continue it mr /Dr Mike
THANKS A LOT.😊
I almost were about to lose hope and do skip to this whole block of biochemistry but thankfully I’ve found your video dr.Mat thank you so so much. Please never stop what you’re doing
Best video for explaining glycolysis! Thank you for making it as comprehensive as possible👏
Glad it was helpful! 😊
Sooo helpful, THANK YOU. Seconding what someone said - "logical yet simple reason" for each step
Your way of teaching is just wow🙌
I am learning this right now and my lecture prof cant explain this at ALL. THANK YOU
I am so glad i stumbled across your channel! Your videos have helped me better understand my human biology class and makes so so ecstatic to keep learning! Love how you explain everything! Thank you!!
To be honest Dr Mike you are just exceptional, i really understand 100 percent. We will continue to follow you even we graduate ❤❤❤
Thank you very much, Dr. Mike! You helped me to study for my biochemistry exam and made glycolysis so much easier!
Wowwwwwwwwwwwwww Masha Allah ..........love from Pakistan ..... Mbbs student ......thank you sir ❤❤❤❤❤❤❤ no words for such Clear explanation
Incredibly helpful! This flowchart just blew the whole concept open for me -- Would love to see a video on Cyclin, Cyclin kinases, tumor supressors and P53 (If you could just squeeze that onto the docket somewhere lol preferably at the top! )
this is the best ever explanation I've evr had on this topic, and everthing is explained in easy way to undestand. DR mike you are the G.O.A.T 💪.
To be honest it's my first time ever I hit that like button with satisfaction I really like the way he made things clear and simple 👌
This vidéo have reaally helped me understand glycolysis
This so powerful Dr keep it up. I have basically understood Glycolysis than ever before.
I watched this video over three times right now and I’m trying to build something out of it
Thank you for your great help Dr. Mike ❤❤❤❤❤❤❤❤❤❤❤
I don't know how to thank you.!!!!!!!!! Love and big respect for you, teacher from Ethiopia.🥰🥰😍😘💯💌
thank u very much sir....I was searching for a video for short tricks to learn this but because of u I actually learned it easily by understanding every single step very nicely.
and now I am going to watch your video for Kreb Cycle too.
Physiotherapy student here,! thank you mr.matt and Mr. mike 🎉❤😊..
You are a saint! Really helped me understand the system a lot better thank you for all your videos💪🏽
Thank you SOOOO MUCCCCHHHH I M FROM FRANCE AND I WATCH YOUR VIDEOS TO UNDERSTAND BIOCHEM I M IN MY FIRST YEAR OF MED SCHOOL I CANT EXPRESS HOW GREATFUL I M TO FIND YOUR CHANNEL TYSMM FOR ALL THE EFFORT YOU PUT ONN YOUR VIDEOS IT S MORE THAN HELPFUL I SWEAR
You are the best!!! I’ve mastered Glycolysis now cause of you
This was really helpful! Thank you, Dr. Mike!
Glad it was helpful!
very very much helpful video with each step being crystal clear THANK YOU SO MUCH FOR THIS LECTURE, Dr. Mike
Ahhhhhhhhhhh WOW!!! you made it so easy I just want to cry so hard I can’t believe that I finally understand It !!! THANK YOU is just not enoughhhh for your work dr mike ❤️❤️❤️❤️🙉🙉🙉
Wow.. probably one of the best bio teachers on this app
Uh r the only person I believe in for my pharmacist exam 🙇🙇thnkoo for being here 🙇
I salute uh🙇🙆
Legend! Thank you for imparting these crystal clear connections, amazing!
This is very clear how it go in the glycolysis step and make lots of sences and easy to understand, perfect. Thank you
Glad it was helpful! 😊
You really know your stuff. Thank you so much for sharing your teaching talent with us.
This lecture is clear. Thanks Dr Matt and Dr Mike. Keep it up.
You are the best!!! This is definitely well explained with clarity and detailed!
Thank you.
I don't need to cram the names, this will just make me understand each step making me know the names
Glad I could help! 🙌 😊
Thank you Dr. Mike you just helped me🙇🙇. Biochemistry looks easy today🤭 God bless u Sir.
Im so glad i came across your channel, your a blessing. Thank you sir ❤️❤️
This is AMAZING. Thank you for your video Dr. Mike. I can now ace my exercise physiology course!
Best of luck! 😊
Whoa! This was so helpful🙏💕 thank you so much for this! - sincerely, a struggling pharmacy student (biochem)
the reason I subscribed to this❤. the best teacher in the world
You are a GOD!!!! Thank you, so helpful I could cry from happiness!
Finally it makes sense ! I always wondered about the utility of the phosphorilation .
Great video really helped me understand! You did an amazing job breaking things down amd explaining things that my book and teacher didnt.
Cute and a good teacher. thanks so much!
This is just extremely good...if all tutors explained this way
Another outstanding lecture. ❤ loved it and made my life more enjoyable.
Many thanks 😊 🙏
So easy when you know how! Great production, well done sir!
THANK YOU VERY MUCH😭 I HOPE U LIVE A LONG LIFEE❤
~ Glycolysis is what cancer uses to reproduce uncontrolled, when cellular respiration is bypassed, whereas oxygen depletion has taken over, as in when smoking or other toxins prevent cells from using oxygen adequately.
can't be more grateful I think
Ahhh thank you SO much Dr. Mike!!! This video is 10/10 amazing! You make glycolysis so easy to follow along and understand. Best glycolysis video out there, thank you!
Enjoyed your video from Iraq💕
ههههه اني هم استمتعت
Thank you so much for your clarification, Sir.
Though I am a beginner... I got the entire thing... All thanks to your awesome explanation😊
Thank you for making it easy to understand Doc 👏
Thank you Dr.Mike❤
Why did I find this when my exam is this week? 😭
Very very helpful! I actually enjoyed the lecture and it was super beneficial.
I’m definitely sharing this video with my colleagues, you can see that we are all struggling with biochemistry.
Thank you for your marvellous work, much appreciated.
I'm in the same pit dear.😢
@Jayant
Oh, my exam didn't go well, I hope yours does.
@@LilyGraceySa Oh, that's so sweet of you. Thanks a zillion times! I'm done with anatomy and physiology, I am only struggling with a few concepts of biochemistry 😓
@Jayant
Congratulations on getting done with Anatomy and Physiology!
I know, Biochemistry is so challenging and most of the times the lack of tutors you can find make it insufferable.
I'd recommend Ninja Nerd, I didn't find others who explained things in detail apart from him.
Best of luck, always happy to engage with other students working hard.
Keep it up and I hope you get the best grades.🫶🏽
@@LilyGraceySa Thanks my dear friend 💕
Thank you so much! Most helpful video I've found on Glycolysis :))
I'm so glad! 😌
omg this video was great! currently studying for my MCAT rn and this was very very very very very very helpful
you made it so easy to remember thankyou so much
God bless you ❤
This is incredible!
Thank u so much dr.mike u made it easy😃🇾🇪
Thank you very much
I understand glycolisis now
A very very interesting topic for me.And you taught me very simply.
This is indeed easy😮,,, Thanks a looot Doc..🤝👍
This is amazing. Never ever stop
Hi. just one quick correction: glucokinase is used predominantly in the liver while hexokinase is used elsewhere
Honestly wish I had you guys when I was in school 13yrs ago. but it's not too late, I'm returning for post graduate school
So helpful and clear, thank you so much ❤
YOU make me like chemistry. WOW. Thanks.
Dr Mike had a slight querry about hexokinase and glucokinase...I thought it's glucokinase found only in the liver while hexokinase is found esle where in the body cells
Yes you are absolutely right, I guess he misspoke it. Glucokinase is only found in the liver.
Thanks for your insight
I was wondering the same thing! I am sure it’s the other way around of what he said.
This comment should be pinned lmao
This was really helpful and so simple ❤
Very helpful and easily described the glycosis
This is amazing!! Thank you! Just wish that you had the white board available as a printout :)
Fantastic explanation with Amazing knowledge thank you sir
Thanks a lot for being so clear! As for the playlist, wouldn´t it be a good idea to put the thing in the right order, e.g. glucolysis, then the Krebs cycle, then the electron transport chain? For beginners like myself it would help!
Love your videos!! Great explanations on biology
I was absent wn my teacher taught glycolysis but I hv got the whole concept thanks Dr mike
Another banger. Thanks Doc
Any time!
This video is so beautiful 🥺
It was really insightful thanks dr mike I really like your lectures because you properly explain your basics, I'm here in Africa Uganda doing pharmacy I would really like to reach out to you for more information like getting your contact