Glycolysis

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  • Опубликовано: 4 окт 2024
  • ​​SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
    My goal is to reduce educational disparities by making education FREE.
    These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
    For educational purposes only; NOT medical or other advice.
    Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
    Opinions are entirely my own.

Комментарии • 232

  • @patrickwmed
    @patrickwmed 4 месяца назад +101

    Dirty, I recently passed step 1 and I just wanted to come back and tell you how much I appreciate you. There were many questions I got right on my test because of your pearls of wisdom and awesome Dirty Med mnemonics. For those studying for step 1, I cannot recommend this channel highly enough. Please please please watch as many of his videos as you can and memorize the mnemonics. They really do work!!

    • @annsophia9503
      @annsophia9503 3 месяца назад +2

      needed this! mine is in 2.5 weeks. will watch as many as I can

    • @fatimamuhammad3606
      @fatimamuhammad3606 2 месяца назад

      ​@@annsophia9503 How was it?

    • @annsophia9503
      @annsophia9503 2 месяца назад

      @@fatimamuhammad3606 ended up with covid which kinda derailed my studying and then clerskhips started right after so just taking step 2 only (I'm a do student).

    • @fatemaha7453
      @fatemaha7453 Месяц назад

      Just started med school and this guy is awesome!

  • @ogwangfrancis3608
    @ogwangfrancis3608 2 года назад +261

    You are chosen by God to save medical students or biochemistry students. After attending three lectures of glycolysis and gluconeogenesis I didn't understand but your few minutes videos have made me understand. Long live

  • @turrlerabbit4884
    @turrlerabbit4884 4 года назад +449

    Thank you so much for this. i'll definitely donate the second i stop being a broke student

  • @marial1217
    @marial1217 3 года назад +155

    When Dirty said "love you" at the end, I felt that. Love you too SO MUCH lol. Thank you, Dirty. I've gained a new appreciation of Biochemistry (and tbh, medicine in general) thanks to you. You're awesome.

  • @1004hl
    @1004hl 4 года назад +78

    I was so confused about the fructose 2,6 bisphosphate part until I watched this video. It cleared up all my confusions within a couple minutes. Thank you so much for your videos and saving me hours of frustration!!

  • @maxbilo6191
    @maxbilo6191 3 года назад +131

    1:08 Glycolysis Overview
    3:15 Entire Glycolysis Pathway
    4:04 Glucokinase
    4:59 Hexokinase
    6:49 Rate Limiting Enzyme (PFK-1)
    7:44. PFK-1 Regulatory Mechanisms
    10:45 PFK-2 Regulatory Mechanisms
    12:20 Pyruvate Kinase
    12:53 Glycolysis Overview Final Chart

  • @JustinMoreira
    @JustinMoreira 3 года назад +52

    You inspired me to come up with this one.
    Difference in the relationship between hexokinase and glucokinase:
    "Hexokinase asks for Help"

    • @jax40001
      @jax40001 Год назад +5

      and Glucokinase Gives help

  • @sunshine-bj8ih
    @sunshine-bj8ih 4 года назад +59

    You were called to teach. Thank you!

  • @luabastos1493
    @luabastos1493 Год назад +11

    Your videos have proven to be not only simple but also highly comprehensible, allowing me to successfully pass my biochem test. Thank you so much!

  • @daughteroftheking3220
    @daughteroftheking3220 Год назад +6

    I wish we could give you all our tuition. You are literal God-sent to us to save us from misery, mental-breakdowns,and final cramming for a test. Thank you doesn't even do you enough justice!!

  • @NateMcGrath-l6q
    @NateMcGrath-l6q 10 месяцев назад +2

    This playlist is better for biochem than boards and beyond or anything else out there. Absolute legend, thank you.

  • @umairjaved4755
    @umairjaved4755 4 года назад +10

    The min I pass my steps , I'll start donating IA....Thank u so much brother♡

  • @elsielc6826
    @elsielc6826 3 года назад +7

    almost thinking of giving up medicine, not until i discovered your channel. Thanks Dirty!

  • @vincefox8
    @vincefox8 4 года назад +12

    You literally read my mind! Searched for glycolysis on your channel before bed, didn't find it, was sad, and then woke up to a brand new video on exactly what I needed!! Thank you!!

  • @dramgcastillo
    @dramgcastillo 8 месяцев назад +1

    I promise that when I get my licence in the US and get a job or match, I will unite to your channel and pay... tanks for these. You and Ninja Nerd are saviors

  • @zukagavasheli9262
    @zukagavasheli9262 3 года назад +6

    you have no idea how thankful i am of yours, on behalf of all medical students thank you for these easy explanatory videos.

  • @somiomer3503
    @somiomer3503 Год назад +3

    Thank you so much dude. When I get to the US I'll definitely donate a lot because you helped me A LOT!
    YOU'RE THE BEST.

  • @srana5049
    @srana5049 8 месяцев назад +2

    Thank you so much dirty medicine. I recently passed my step 1 exam and all your videos were of great help in my step 1 journey. Thanks

    • @muzamara
      @muzamara 8 месяцев назад

      Is the real deal similar to UWorld, Free 120 or NBME?

  • @innominadojustis2224
    @innominadojustis2224 3 года назад +7

    I try Physeo, Prixorize, USmle rx express videos, BnB, but it was YOU : OUR USMLE KING DIRTY MEDICINE who explain it simple and easy, GOD BLESS YOU i want to be like you👏🏻👏🏻👏🏻👏🏻

    • @Mariamhamwi
      @Mariamhamwi 2 года назад

      Did biochem videos feel sufficient to solve biochem well?

  • @uniteUsk
    @uniteUsk 3 года назад +5

    your 15min lesson just saved me in biochemistry. Thanks man your a life saver

  • @mspinkdomi
    @mspinkdomi 4 года назад +25

    Damn I'm in crunch time mode freaking out and this just made me understand this shit in less than 10 min 1.75x speed love you dirty

  • @Mayavee617
    @Mayavee617 Год назад +1

    Thank you , you are a life saver. To the point as always,
    I can’t thank you enough!❤
    Wish for the best in every aspect !

  • @nasrudinabdi1635
    @nasrudinabdi1635 10 месяцев назад

    You have done great service for humanity. God bless you

  • @evelynn3941
    @evelynn3941 6 месяцев назад

    God bless you, you're the only youtuber that makes it easy for me to understand.

  • @Skyguy19
    @Skyguy19 Год назад

    Not all heroes wear capes, you're one. Thank you

  • @nikowlll
    @nikowlll 4 года назад +9

    you really helped me to understand this better than i ever imagined. i’m struggling reading its module bc our prof did not manage to discuss this due to quarantine & thank you omg you’re a life saver!!

  • @waybeyondtheblue434
    @waybeyondtheblue434 2 года назад +5

    your videos are a gift from heaven!! I'm a student from germany, and sadly there are very few good videos in my language on this topic, and yours help me so so much!! Keep up the good work!

  • @yuta2349
    @yuta2349 2 года назад

    This channel is seriously the best for understanding topics of med school

  • @najumudhina.m.k3966
    @najumudhina.m.k3966 3 года назад +2

    PFK 1 & PFK 2 part is best explained. Awesome superb🤗🤗

  • @yana-marisaedwards1765
    @yana-marisaedwards1765 2 года назад +2

    Thank you so much for your videos! I know you've heard this before but you just saved me!!

  • @lovedazzle95
    @lovedazzle95 10 месяцев назад

    Dirty thank you so much. You a literally saving my life right now.

  • @lailaaljazairia7884
    @lailaaljazairia7884 Год назад

    Thank you so much for these videos you have no idea how many students you are saving

  • @BryanBjay
    @BryanBjay 8 месяцев назад

    GOD BLESS YOU!!!! This is all that I need. Just what I need to know!

  • @kshanikdayaram3984
    @kshanikdayaram3984 4 года назад +6

    i think i might name my firstborn after you thank you so much

    • @b.u.8709
      @b.u.8709 3 года назад

      @V LOOOOOOL!!!

  • @lindembergsilveirafilho1842
    @lindembergsilveirafilho1842 2 года назад +1

    Your explanation is simply outstanding. Thank you

  • @diandrad406
    @diandrad406 Год назад

    After 7 years, I finally understand Glycolysis!! Blessss

  • @rajmukhopadhyay4837
    @rajmukhopadhyay4837 4 года назад +8

    This is an excellent video with excellent analogies that makes it super simple to understand. One extra detail to note here is that Pyruvate Kinase can also be activated by F16BP (+ feedback). I believe this was mentioned in Kaplan MCAT Biochemistry.

  • @peskyseagull
    @peskyseagull 4 года назад +37

    Oh yes, Daddy Dirty going high yield

  • @shabbirahmad7015
    @shabbirahmad7015 3 года назад +1

    my dude you are so freaking amazing

  • @sole23md
    @sole23md 4 года назад +2

    thank you for posting this, stuck in the house trying to learn from harpers is much harder than this! great help

  • @michellechavez970
    @michellechavez970 7 месяцев назад

    You’re the best! I wish you were my professor, thank you for your help!

  • @kiruthikabalasubramani8874
    @kiruthikabalasubramani8874 4 года назад +1

    One person who focus on clear understanding and of course on dirty exam questions... 😂...Thank u so much

  • @dvperez14
    @dvperez14 Год назад

    I am not sure what you are doing now in life, but you are such a blessing! God bless you , protect you and keep you safe and nourished in the years ahead in Jesus name. You are such a blessing and I am actually loving this instead of HATING it like i used to!!

  • @sahibklol
    @sahibklol 2 года назад +1

    Great video! Thanks!

  • @VampireDiariesBiebs
    @VampireDiariesBiebs 4 года назад +2

    thann you for the entire biochem playlist!

  • @edgarmartos6016
    @edgarmartos6016 3 года назад +4

    It is also high yield to know that conversion of glyceraldehyde 3 phospate into 1,3 biphosphohlycerate needs NAD+ as cofactor of glyceraldehyde 3 phosphate dehydeogenase. This is something that has been asked in uworld in the context of alcohol ketoacidosis where there is NAD depletion (due to NADH acummulation) or LDH deficiency, where you are NAD depleted, as in normal conditios the conversion of pyruvate into lactate uses NADH and finally converts into NAD to be used in this specific glycolisis step. In this 2 scenarios you would not have NAD, thus glycolisis can not procede anymore as there would not be any cofactor for G3P dehydeogenase, explaining why patients with alcoholic ketoacidosis and LDH Deficiency have hypoglycemia.

  • @SK1MD
    @SK1MD Год назад

    This is so great!! Thank you so much!! God bless!!!😃❤

  • @drjeniferpreethi9305
    @drjeniferpreethi9305 3 года назад +1

    God bless this channel

  • @justinarnold3951
    @justinarnold3951 3 года назад

    How did you manage to make understanding 2,6-BP sooo easy?!?! What a life saver

  • @aletheiathreskeia1844
    @aletheiathreskeia1844 3 года назад

    How I wish these kinds of channels existed 10 yearas ago when I was still a medical student....

  • @bhavanigaddameedhi8870
    @bhavanigaddameedhi8870 3 года назад

    you're just awesome and thanksss for making the most tough parts easy

  • @TheRealBlackPanda
    @TheRealBlackPanda 4 года назад

    This dude is the plug for all things biology

  • @wisercommunication4791
    @wisercommunication4791 2 года назад

    Amazingly explained ! Thank you so much

  • @ramshamahmood6413
    @ramshamahmood6413 4 года назад +1

    Thank you for breaking it down, and making it easier for me to understand. Love your work!

  • @shreyaveldurthy
    @shreyaveldurthy 2 года назад

    You are a life saver! Thank you so much

  • @lidiateshome819
    @lidiateshome819 3 года назад

    Ur awesome! How you easily break down concepts is mesmerizing!!

  • @chloesworld2083
    @chloesworld2083 2 года назад +1

    Thank you so much for creating these videos! It's honestly a great help for Biochemistry students like myself. :)

  • @shriyamahapatra
    @shriyamahapatra 4 года назад +1

    Sir urs explanations are just awesome... Respect for u sir🙏

  • @az71003
    @az71003 2 месяца назад

    thank you dirty , really appreciate your videos

  • @kayallen7603
    @kayallen7603 5 месяцев назад

    Hexokinase is the main enzyme while glucokinase is the back-up enzyme.

  • @zachary.ramsumair
    @zachary.ramsumair 7 месяцев назад

    rate liming and regulatory enzymes . WOW thanks

  • @emmanuelflourish-morris4073
    @emmanuelflourish-morris4073 2 года назад

    Thanks for making this very easy to understand and remember.

  • @zilanayhan7864
    @zilanayhan7864 3 года назад +1

    Thank you for a nice and clear lecture!

  • @Alex-ov4xl
    @Alex-ov4xl 3 года назад

    Awesome video. thanks

  • @Rayray.johnson00
    @Rayray.johnson00 8 месяцев назад

    Very informative, much appreciated

  • @prernasoni5386
    @prernasoni5386 3 года назад +1

    Just wow🔥

  • @ruemubarak1702
    @ruemubarak1702 8 месяцев назад

    Thank you.... thank you... thank you

  • @user-cd8xd1cm6i
    @user-cd8xd1cm6i 4 года назад +1

    Thank you!

  • @Gamerbr..
    @Gamerbr.. 5 месяцев назад

    Thanks!

  • @Gulshangurban
    @Gulshangurban 4 месяца назад

    Great video

  • @VampireDiariesBiebs
    @VampireDiariesBiebs 4 года назад +1

    seriously thank you so much

  • @excuseme1543
    @excuseme1543 4 года назад +6

    DADDY IS BACK

  • @sanverse6807
    @sanverse6807 5 месяцев назад

    Sir you're here saving lives ❤❤

  • @dr.fatemaomran3105
    @dr.fatemaomran3105 Год назад

    Perfect teaching ever

  • @ChrisDebbie-tq2po
    @ChrisDebbie-tq2po 4 месяца назад

    Thank you 👍🙏

  • @fatimahah6707
    @fatimahah6707 6 месяцев назад

    Wow.
    Thank you soooo much.

  • @ClaytonNeuner
    @ClaytonNeuner 2 года назад

    Thank you so much!!!

  • @fatimamemon1996
    @fatimamemon1996 2 года назад

    Thank you so much I love your videos

  • @missbailey7280
    @missbailey7280 Год назад

    I love your videos I have been struggling to get the big picture of everything and have watched a ton of videos I should have found this earlier 😢😢 thank you ❤❤

  • @mernahammouda4175
    @mernahammouda4175 Месяц назад

    i love you too bro, thank you for everything

  • @gentlegenius6778
    @gentlegenius6778 2 года назад

    Really helpful
    Thank you sir
    God bless you

  • @jerenashyrova6490
    @jerenashyrova6490 3 месяца назад

    Thanks ❤

  • @christinac1195
    @christinac1195 2 года назад

    i wish everyone taught like you~ big picture first! thank youuuuuuu

  • @kayallen7603
    @kayallen7603 5 месяцев назад

    The process by which sugar/starch is used to make fuel to power the body and the body's organs.

  • @babyfishyyy97
    @babyfishyyy97 Год назад

    This help A LOT! Thank youu! ❤❤

  • @sadiakanwal1064
    @sadiakanwal1064 Год назад

    Awesome sir,gud job

  • @stevejonan
    @stevejonan 4 года назад

    Great job, very useful lecture

  • @archonsouthpaw8690
    @archonsouthpaw8690 7 месяцев назад

    bless you sir

  • @1412Z
    @1412Z Год назад

    Thank you!!!

  • @rakeshgoud5144
    @rakeshgoud5144 2 года назад

    Thank you ! 💞🥰

  • @wicterwterr4245
    @wicterwterr4245 3 года назад

    Thank you so much - It was a great explaination!

  • @SarahAlhamdan
    @SarahAlhamdan Год назад

    you saved my life, thank you

  • @FYkjDefh
    @FYkjDefh Год назад

    I wish I could see these things maybe it would make sense then!

  • @osamaal-faqeh3462
    @osamaal-faqeh3462 22 дня назад

    thanks

  • @Afife1002
    @Afife1002 7 месяцев назад

    ❤❤❤❤❤ you are the best.

  • @Mariamhamwi
    @Mariamhamwi 2 года назад +1

    Wow no way... I never expected to understand biochem instead of just memorizing. TYSM!! hoping I pass my step 1 this novemeber :)

    • @SteveSaxony
      @SteveSaxony Год назад

      did you pass? was there a lot of biochem? thanks mariam

    • @dr_yoube
      @dr_yoube Год назад

      @@SteveSaxony I didnt do it haha… Im gonna do it next year.

  • @caffeinateddoctor9714
    @caffeinateddoctor9714 4 года назад +2

    Much needed this.. 😭😭thank you Dirty.

  • @idlechicajan
    @idlechicajan 2 года назад

    Excellent video

  • @samsonridge4526
    @samsonridge4526 3 года назад

    i hear every word from you very very well

  • @MohamedOsama-ny7ix
    @MohamedOsama-ny7ix 3 года назад

    you are a legend mate