Literally the best explanation on this topic I've ever come across! You are the best. I'm sitting here in awe at how much clarity I've gained from this one video :o Thank you so much DM!
You are a homie and a half, great way of re reviewing all of this. Myself and everyone else who hasnt really should get on donating to you and this channel.
sir I don’t know what this world has done to deserve you , you are amazing teacher. you are doing a great job ,keep going and stay blessed. i almost watched your each and every video and every single video is amazing thank you so much sir !
my personal mnemonic for HMG is " Hey My Glucose!!!!!!" since HMG is only really formed when there is a lack of glucose like in gluconeogenesis by B-oxidation aside from this.
To clarify, the body's primary preference is to eliminate glucose as soon as possible. Before the advent of highly processed foods and the introduction of sugar, mankind relied on burning ketones for energy. It is important to remember that the body will make every effort to get rid of glucose due to its potential harm.
@@whitelion124 I would also think that ETC Complex 2 is an enzyme on TCA Cycle (Succinyl DH). So inhibiting TCA cycle directly inhibits ETC. So they can't use it even though there's a high amount of NADH
I would be very interested in references on this. It seems not quite right in that 1. OAA scan be supplied from Asp via transamination. 2. Acetyl-CoA is an activator of pyruvate carboxylase which will increase OAA when needed for TCA cycle. No? Also, liver is active in gluconeogenesis but liver doesn’t use ketone bodies. Not a challenge but what about these points?
Help me understand the process of alcoholism and TCA cycle shuts down? What happens when that person eats sugar? Where does the sugar go? Stored in the liver and not the cells? Or the sugar doesn’t produce atp energy for the alcoholic? Is seems like the solution would be to take mct oil and exogenous ketones? This is good stuff?? This video has me really curious as to the pathway?
Ketones get converted back to acetyl-coA when they reach their destination. How are ketones then helping to produce energy if the TCA cycle can't continue because of the lack of oxaloacetat? Why form ketones because of oxaloacetate depletion if you need oxaloacetate to gain energy from ketones?
A 4th way you can form ketone bodies is by following the KETO Diet! haha. But I suppose this can go under starvation because the idea is to deprive your body from Carbs so insulin stays low.
Can Someone Please Clear This Doubt For ME.. Why does buildup of acetyl CoA from failure of TCA cycle shunt towards Ketones and not gluconeogenesis? Acetyl CoA stimulates pyruvate carboxylase right
I'm late to the video but just in case you're still active and replying, I have a question. Is acetylacetyl CoA the same as acetoacetyl CoA? That's what I'm seeing in my textbook
Can someone please explain how it is possible to use Ketones as an energy source? If it is actually formed due to oxaloacetate depletion or a NAD/NADH disbalance and if it's degradation would form acetyl CoA as a final product, how would it produce energy without undergoing TCA cycle?
He states when things are depleted and no oxaloacetate, our body will produce ketones as a result of a loss of ATP. The TCA cycle will not commence. Ketones will be the new source of energy.
That TCA cycle takes energy to go thru the whole process? Thus more energy short cut with ketones? Ketones also release less free radicals, so less Glutathione needed?
The high-level overview of the mnemonics doesn’t seem helpful to improving my conceptual understanding of how things actually work. Rather, it seems more like a memorization technique to pass a quiz. I’m just trying to understand how things work. I am not a medical student because I don’t accord with the Sociopolitical ideations of modern college and medical school. Aside: describing things that are important as “high-yield“ is silly and somewhat distracting. I appreciate the effort you put into this. I just don’t completely understand it. The subject matter requires deeper and more involved discussion than a 21 minute video. Do you have more videos to breakdown each of these components in slightly more detail? It would be nice to start with a high-level overview, then go into deeper discussion of bio chemical and physiological pathways, and then draw those pathways back into the high-level topic of discussion. Thank you.
@@sgill4833I don’t think so, cholesterol biosynthesis is a separate pathway from ketone metabolism. It’s just a coincidence that HMG coA is produced in both pathways
![Felix "Unfair" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/Oswujxm2Ag0/mqdefault.jpg)
This one truly left me SHOOK. Big brain moment right here
5:02 Ketones Synthesis Summary
6:04. Starvation
9:44 Diabetic Ketoacidosis (DKA)
13:22 Alcoholism
17:29 Ketone Synthesis Chart (Use & Pathophysiology)
18:09 HMG CoA Synthase mneumonic
19:17 Other high yields
Id recommend this channel to anyone studying medicine
Literally the best explanation on this topic I've ever come across! You are the best. I'm sitting here in awe at how much clarity I've gained from this one video :o Thank you so much DM!
You are a homie and a half, great way of re reviewing all of this. Myself and everyone else who hasnt really should get on donating to you and this channel.
sir I don’t know what this world has done to deserve you , you are amazing teacher.
you are doing a great job ,keep going and stay blessed.
i almost watched your each and every video and every single video is amazing
thank you so much sir !
Wow this video just blew my mind, you absolutely killed it sir, BRAVO to you
Your biochem series is amazing! Great job. 😄
Thank u very much 😍 this literary saves tons of time!!!! It's amazing how you cover THIS huge topic just in 20 mins!!
The BHB tests will measure only the BHB that has NOT been used by the body.
Getting ready for my step 1 with Dirty medicine! AMAZING!!! Thank you so much for your videos, don't stop!!!
Did it help for solving Uworld and passing step 1?
hi did it help in usmle step 1 exam?
You’re amazing. Seriously you’re GOD to me, I was severely depressed about biochem but I see hope for myself now 🙏🏻
yeah, this teacher is amazing
@Oscar Rodriguez Agreed!
my personal mnemonic for HMG is " Hey My Glucose!!!!!!" since HMG is only really formed when there is a lack of glucose like in gluconeogenesis by B-oxidation aside from this.
NAD-y Light. Genius. I wish I could've partied with Dirty back in his undergrad 😂
You have clarified the content and point out some very important parts for me. Big thump up !!,
Looking into metabolism for a year now. These are awesome lectures. Thanks a lot
You're the best teacher ever!!! Just incredible!!!!
I recently discovered your channel, and you are a lifesaver, thank you your videos are amazing.
You are awesomely has the science, the general vision and the detailed one..beside the marvilous mnemonics.
Go on plz
You hammered it down with repetition, WAY TOO MUCH, so that it can be engraved in my brain.😍 I love it because it's just what I need!
it 's really help me for my final examination . GOOD EXPLANATION !!!!
Incredibly helpful. Thank you so much!!!
Maaan you are simply the best!! Thank you!!
Great job .... You have made the topic so simple ...
I will pass Philippine Licensure Examination because of you.
Very good explanation ❤😊 love from India ❤ best ever taught, thank you so much sir
You make biochem so easy. Bravo
God Bless you for the great work....
This content is forever strong. Learning from Dirty in 2024!
Same here just discovered him!
you ATE with this one. Thank you so so much
this video should have 2million views. its that good👌
me - 'fasting'
brain - *gimme them ketones*
To clarify, the body's primary preference is to eliminate glucose as soon as possible. Before the advent of highly processed foods and the introduction of sugar, mankind relied on burning ketones for energy. It is important to remember that the body will make every effort to get rid of glucose due to its potential harm.
This
Ok, but how glucose actually harms?
WOW!! You ate this up! THANK YOU!
Such a godsend, thank you DirtyMedicine
Another informative enlightening video! Could you please make a video on cholesterol synthesis?
If alcoholic have increase NADH why dont they directly go to ETC?????
Probably because we're in the liver, at least that's my best guess.
@@whitelion124 I would also think that ETC Complex 2 is an enzyme on TCA Cycle (Succinyl DH). So inhibiting TCA cycle directly inhibits ETC. So they can't use it even though there's a high amount of NADH
Amazing job, Dirty Medicine. You rock!!
I absolutely loved this. I am a fan now.....
You are simply HIM, dirty medicine, HIM I say!!! GOD BLESS YOU FROM A STRUGGLING M1
Best video ever. Thank you!
homg you are helping a lot ❤, thank you so much!!!
this is brilliant! Thank you, guys!
Amazing explanation
Increased NADH to NAD ration in alcholics and pyruvate - lactate pathway
you are THE SAVIOUR!
Thank you for creating this video. God bless you
I would be very interested in references on this. It seems not quite right in that 1. OAA scan be supplied from Asp via transamination. 2. Acetyl-CoA is an activator of pyruvate carboxylase which will increase OAA when needed for TCA cycle. No? Also, liver is active in gluconeogenesis but liver doesn’t use ketone bodies. Not a challenge but what about these points?
Help me understand the process of alcoholism and TCA cycle shuts down?
What happens when that person eats sugar?
Where does the sugar go? Stored in the liver and not the cells?
Or the sugar doesn’t produce atp energy for the alcoholic?
Is seems like the solution would be to take mct oil and exogenous ketones?
This is good stuff?? This video has me really curious as to the pathway?
Super helpful, thanks so much!
Ketones get converted back to acetyl-coA when they reach their destination. How are ketones then helping to produce energy if the TCA cycle can't continue because of the lack of oxaloacetat? Why form ketones because of oxaloacetate depletion if you need oxaloacetate to gain energy from ketones?
Excellent, as always.....
A 4th way you can form ketone bodies is by following the KETO Diet! haha. But I suppose this can go under starvation because the idea is to deprive your body from Carbs so insulin stays low.
Hands down. u r the best! If I was a millinore, i would sponsor ur channel.😅😅
You are the best .. 😮😮
i need to say this but I LOVE YOU DOC OMGGG YOU HELPED MEEEEE!!!! 🤟🤟🤟 THANK UUUU
You are a ROCKSTAR!
Thank you very much for this, it has been very useful
everytime u ask me how the hell we gonna do that?? I smile. thanks
Thank you so much, you answered so many of my questions.
Super cool! Super high yield!!!!! 👍
Awesome 😎! Seriously, thank you! .
Can Someone Please Clear This Doubt For ME..
Why does buildup of acetyl CoA from failure of TCA cycle shunt towards Ketones and not gluconeogenesis? Acetyl CoA stimulates pyruvate carboxylase right
Thanks for explaining!
THANKS for this!
This is awesome!!
I'm late to the video but just in case you're still active and replying, I have a question. Is acetylacetyl CoA the same as acetoacetyl CoA? That's what I'm seeing in my textbook
this is amazing!
I wonder if his other topics are as good as his biochem series?
Please explain how ketone synthesis occurs when someone eats low curb high fat diet.
Amazing video!!!
Impeccable 💝
amazing good job!
Thank you very much ❤
u truly saved us
Can someone please explain how it is possible to use Ketones as an energy source? If it is actually formed due to oxaloacetate depletion or a NAD/NADH disbalance and if it's degradation would form acetyl CoA as a final product, how would it produce energy without undergoing TCA cycle?
He states when things are depleted and no oxaloacetate, our body will produce ketones as a result of a loss of ATP. The TCA cycle will not commence. Ketones will be the new source of energy.
That TCA cycle takes energy to go thru the whole process? Thus more energy short cut with ketones?
Ketones also release less free radicals, so less Glutathione needed?
My savior ❤️😍😍😍😍
So Keto-Diet is ?.. good/bad?
The high-level overview of the mnemonics doesn’t seem helpful to improving my conceptual understanding of how things actually work. Rather, it seems more like a memorization technique to pass a quiz. I’m just trying to understand how things work. I am not a medical student because I don’t accord with the Sociopolitical ideations of modern college and medical school. Aside: describing things that are important as “high-yield“ is silly and somewhat distracting. I appreciate the effort you put into this. I just don’t completely understand it. The subject matter requires deeper and more involved discussion than a 21 minute video. Do you have more videos to breakdown each of these components in slightly more detail? It would be nice to start with a high-level overview, then go into deeper discussion of bio chemical and physiological pathways, and then draw those pathways back into the high-level topic of discussion.
Thank you.
Great video for students but why does the body make 3 ketones? Surely one is enough?
😂
thank you very very much really you are amazing
Amazinng
Thank you so much
Sending love❤❤
Please make a video on harmful effects of ketone bodies.
Blood ph
If you're NOT DIABETIC ketosis is the preferred fuel of the body. BHB is what you want.
Did you mean starvation was equal to very low carbohydrate diet?
Yes
thank you
Wait a sec, statins are called hmg-Coa inhibitors. So basically statins will prevent you from building ketones.
Does that mean, byproduct of ketones synthesis is cholesterol? I'm not in medical school. Just learning for personal health.
@@sgill4833I don’t think so, cholesterol biosynthesis is a separate pathway from ketone metabolism. It’s just a coincidence that HMG coA is produced in both pathways
Statins = HMG coA reductase inhibitors
You are not starving, you are fasting.
You got a magic ocean potion advertisement on your video. Really pushing the agenda they are.
You are the best 😭♥️♥️♥️♥️♥️♥️♥️♥️♥️
Very well-done 🥰🤩
How is this free :'D Thank you sir!
Legend
Can't you talk about how the body uses these ketone bodies to fuel your life, if you are NOT diabetic.
GOAT!!!!
8:15
i gonna give the IFOM exam ...i hope this video helpful for me😍😍
Umakant Shinde Yes , extremely useful for IFOM , I recommend you all the videos for review
Good Luck