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Mmmm caloric restriction is not so hard. we are now used to eating huge anounts. In my youth in the 50's I knew many who ate far far less,, very simply, worked hard as farmers and were very very thin. No one was hungry and no one was a big eater. Mum was the same. All three i know of lasted into their 90's and were still active. Country towns in Oz have a lot of funerals for 90 year olds. I know a farmer still farming and driving in his 90's and looking 70.
I had the same thought whilst watching this video. Caloric restriction is not hard, once you do regular fasting it's just another way of living. Over eating is like a drug addiction.
There is a slide at 2:37, which mentions "Cellular Communication". That triggered something from my past. I am tempted to go back in time, and check something. Maybe some of you will beat me to it. I was for a while acquainted with a saccharide supplement product called "Ambrotose", and they used to spell out which rare saccharides it contained. (It's hard to find that list now). I should like to compare that list with Glycans & Glycan components, as published in some reliable, standard list, and see if there are any "hits". Sourcing details of the Ambrotose formula have been published and can be located, so the rarity of the specific saccharides can be overcome with effort. Still, I want to see if there is some connection between this video, and the contents of an old product in my history, said to promote "Cellular Communication" (like the slide at 2:37 ). I know this: Mannose, easily available from Aloe, is a building block of some Glycans, and enjoys some anecdotal endorsement in the natural health community. As always, be careful !!
I ate a bottle for $100 in the 2000's and figured it wasn't worth it if i could get these glycans from the diet and cheap mannose. Nothing subsequently came along to pursue this glycan supplementation (other than bladder infections, which as a man, I don't get), but the story is still compelling. "Ambrotose is a glyconutrient supplement that contains glycans, which are plant sugars linked in chains. Glyconutrients are sugars that the body can use as nutrients. What is Ambrotose? Ambrotose is a combination of sugars that the body uses to make glycoproteins Ambrotose is marketed as a supplement that can improve immune function, sleep, memory, and more Ambrotose is a product of Mannatech What are glycans? Glycans are plant sugars linked in chains The body breaks down glycan chains into simple sugars Glycans are like a five-course meal at the cellular level Healthy cells have better cell-to-cell communication when they can send and receive signals to each other What is the evidence for Ambrotose's health benefits? There is no good evidence to support the health benefits claimed for Ambrotose There are no clinical studies in the PubMed database that support the use of Ambrotose for any clinical indication" "Glyconutrient Sham", looks like a good read.
Ambrotose ingredients: Arabinogalactan, Rice starch, Aloe Vera extract, Glucosamine HCl. I think there's more to this than just mannose. Probably mannose specifically bound to some other sugar or sugars. This concoction is very expensive. You can get Aloe Vera from NOW that's not expensive. I suspect that's most of the magic here.
@@incognitotorpedo42This sounds like a manotech company product. They did a lot of research out of Texas a&m with aloe vera. They grew their own aloe vera and developed a product for severe burn victims that actually incorporated colloidal silver in the bandage. It was actually used in hospitals.. Reg McDaniels, a great researcher help develop these products .
Love the content. Been listening for a long long time. I always turn the volume down cuz The intro and outro music is like fingernails on a blackboard. Best of health to everyone. :-)
Gene therapy for epigenetic reprogramming or senolytics will likely be first generation age reversal therapeutics, i.e. therapeutics that specifically remove accumulated aging damage in a meaningful way.
When the CO2 concentration is low, plants have to open their stomata to get more CO2 and end up consuming more water in the process. So we have to consume more from the food desert to get the nutrition we need. Nutrient dense food leads to less hunger??
Ok so far just a diagnostic tool. I wonder if there are any glycome specific treatments other than mild/gradual exercise and losing weight or being thin.
He mentioned the importance of gut microbiome, so there are numerous ways to work on that. From eliminating alcohol to taking probiotics. But I see what you mean, he wasn't very prescriptive. We really have to work to extract the information about treatment.
Genes are still at the basis of everything in our bodies, with the most important part of it being the epigenome. And that is where aging, in the end, will be stopped. But I do not want to discount his research, he is right in saying that we must understand everything about glycans, because only if we understand the products of our genes, like proteins or glycans, we have the knowledge to change our genes to improve them
I believe much of our ageing process is driven by genetic signals that progressively downregulate bodily functions, leading to increasing damage over time.
Coupon CODE: REVERSE ☑ ProHealth, RENUE, DoNotAge, StemRegen, N1O1, NOVOS ☑
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**N1o1 will donate a bottle of lozenges to the firefighters in California for every order placed on the site!
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🌏ProHealth Longevity 15% OFF, Subs UPTO 45% OFF 🔖Pure NMNH prohealth.pxf.io/NMNH NAD Triple Boost prohealth.pxf.io/NADTripleGlycine & NAC Pack prohealth.pxf.io/GLYNAC
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🩹NOVOS novos.sjv.io/REVERSE US$5 OFF Every Purchase
🔖Swanson Full Spectrum Ashwagandha 5% OFF iherb.co/NY9KvCRp
Mmmm caloric restriction is not so hard. we are now used to eating huge anounts. In my youth in the 50's I knew many who ate far far less,, very simply, worked hard as farmers and were very very thin. No one was hungry and no one was a big eater. Mum was the same. All three i know of lasted into their 90's and were still active. Country towns in Oz have a lot of funerals for 90 year olds. I know a farmer still farming and driving in his 90's and looking 70.
I had the same thought whilst watching this video. Caloric restriction is not hard, once you do regular fasting it's just another way of living. Over eating is like a drug addiction.
So true! Even “healthy” gym junkies over eat in the pursuit of getting big muscles
There is a slide at 2:37, which mentions "Cellular Communication". That triggered something from my past. I am tempted to go back in time, and check something. Maybe some of you will beat me to it. I was for a while acquainted with a saccharide supplement product called "Ambrotose", and they used to spell out which rare saccharides it contained. (It's hard to find that list now). I should like to compare that list with Glycans & Glycan components, as published in some reliable, standard list, and see if there are any "hits". Sourcing details of the Ambrotose formula have been published and can be located, so the rarity of the specific saccharides can be overcome with effort. Still, I want to see if there is some connection between this video, and the contents of an old product in my history, said to promote "Cellular Communication" (like the slide at 2:37 ). I know this: Mannose, easily available from Aloe, is a building block of some Glycans, and enjoys some anecdotal endorsement in the natural health community. As always, be careful !!
Moment you started i thought of the mannose mix too.
I ate a bottle for $100 in the 2000's and figured it wasn't worth it if i could get these glycans from the diet and cheap mannose. Nothing subsequently came along to pursue this glycan supplementation (other than bladder infections, which as a man, I don't get), but the story is still compelling.
"Ambrotose is a glyconutrient supplement that contains glycans, which are plant sugars linked in chains. Glyconutrients are sugars that the body can use as nutrients.
What is Ambrotose?
Ambrotose is a combination of sugars that the body uses to make glycoproteins
Ambrotose is marketed as a supplement that can improve immune function, sleep, memory, and more
Ambrotose is a product of Mannatech
What are glycans?
Glycans are plant sugars linked in chains
The body breaks down glycan chains into simple sugars
Glycans are like a five-course meal at the cellular level
Healthy cells have better cell-to-cell communication when they can send and receive signals to each other
What is the evidence for Ambrotose's health benefits?
There is no good evidence to support the health benefits claimed for Ambrotose
There are no clinical studies in the PubMed database that support the use of Ambrotose for any clinical indication"
"Glyconutrient Sham", looks like a good read.
Ambrotose ingredients: Arabinogalactan, Rice starch, Aloe Vera extract, Glucosamine HCl. I think there's more to this than just mannose. Probably mannose specifically bound to some other sugar or sugars. This concoction is very expensive. You can get Aloe Vera from NOW that's not expensive. I suspect that's most of the magic here.
@ Great start!
@@incognitotorpedo42This sounds like a manotech company product. They did a lot of research out of Texas a&m with aloe vera. They grew their own aloe vera and developed a product for severe burn victims that actually incorporated colloidal silver in the bandage. It was actually used in hospitals.. Reg McDaniels, a great researcher help develop these products .
Excellent points!
I shall look more on this topic, thx for the info!
The only Glycan I’ve read of is the Glycocalyx which protects the vascular endothelium. Is degradation of the Glycocalyx also an indicator of aging?
I wonder how much this is affected by the microbiome, causing aging effects?
well presented , fascinating topic
Love the content. Been listening for a long long time. I always turn the volume down cuz The intro and outro music is like fingernails on a blackboard.
Best of health to everyone. :-)
So, what are we supposed to do? Eat more mushrooms for the beta-glucans?
No, you go to his Glycanage website, pay for the test and follow their advice after getting test results.
when will get get the 1st products that actually reveres are age ?
I know what you mean. Maybe there is a clue in my own post-up.
It is at your grocery. It is sold as beef, butter and eggs. Mainly the beef.
Gene therapy for epigenetic reprogramming or senolytics will likely be first generation age reversal therapeutics, i.e. therapeutics that specifically remove accumulated aging damage in a meaningful way.
Malnourishment drives hunger, its about quality vs quantity..
When the CO2 concentration is low, plants have to open their stomata to get more CO2 and end up consuming more water in the process. So we have to consume more from the food desert to get the nutrition we need. Nutrient dense food leads to less hunger??
Interesting, it seems an underrated factor of aging.
The most important slide is at 11:09. He glossed over it. Why? I do research in this field.
What points did he miss?
So, Exactly what can we do to make this glycan stuff work for our own longevity?
Just use taurine, glycine, nac for longevity
@@larryc1616
Where was that in the video?
What about exercise, diet, and "lifestyle changes" that were mentioned slightly?
@@larryc1616 do you have quantity recommendations?
What is important is Health Span and NOT Life Span.
So balance the 8 major hormones, lose weight, and build muscle progressively over time.
There is no health span without life span. Life before health
@@larryc1616An unhealthy life is no life at all. I know from hard experience, as so millions of others.
@@larryc1616 Lifespan without healthspan is useless.
And neither one is useful without brainspan. Nor friends and family to enjoy it all with.
Rumor has it this guy is actually 120 years old 👀
Is that why he talks so slow?
@Bozemanjustin 😂😂😂
Did he get The Guinness World Record ?
If not, then it is real rumor.
Ok so far just a diagnostic tool. I wonder if there are any glycome specific treatments other than mild/gradual exercise and losing weight or being thin.
He mentioned the importance of gut microbiome, so there are numerous ways to work on that. From eliminating alcohol to taking probiotics. But I see what you mean, he wasn't very prescriptive. We really have to work to extract the information about treatment.
Don't have to be hungry to eat less. Intermittent fasting paired with ketogenic diet keeps the hunger hormones low. You feel tired instead of hungry.
Genes are still at the basis of everything in our bodies, with the most important part of it being the epigenome. And that is where aging, in the end, will be stopped. But I do not want to discount his research, he is right in saying that we must understand everything about glycans, because only if we understand the products of our genes, like proteins or glycans, we have the knowledge to change our genes to improve them
I believe much of our ageing process is driven by genetic signals that progressively downregulate bodily functions, leading to increasing damage over time.
GLYCAN age
.😮
al ti si se pelcovao zbog papira kak si rekao :)
So much talking about nothing...
Maybe you just didn't understand it. I think that the information he presented is important.
Actually he is 600 years old.
😅 Lol 😅