Mayo Clinic Minute: Signs and symptoms of syphilis

It's been referred to as "great pox," "great crippler" and "loues" (pronounced lou-ease) along with a number of names and references over the centuries. Syphilis has long been a global health issue affecting millions of men, women and children. After decades of decline due to treatment with penicillin, infection rates are on the rise. A recent report by the Centers for Disease Control and Prevention shows steady increases especially among women and their babies, and men who have sex with men.
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