NAC, N Acetylcysteine as Addiction Therapy
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- Опубликовано: 16 сен 2020
- N-Acetylcysteine as Addiction Therapy
by Khadiga Fouad
Peer Reviewers:
Emily Morgan
Shikha Jha
Introduction:
N-Acetylcysteine (NAC) is a precursor of cysteine, an amino acid. NAC is a known antioxidant and anti-inflammatory drug that is used to treat various diseases, such as acetaminophen toxicity, chronic bronchitis, asthma, Alzheimer’s, and Parkinson’s disease. (Mokhtari et al., 2016). Several studies have focused on NAC as a potential treatment for cocaine, heroin, nicotine, and alcohol use disorders. The studies have focused on understanding the neurological mechanism of NAC and its effects on reducing drug seeking behaviors, cravings, and withdrawal symptoms (Mcclure et al., 2014). NAC would be most beneficial “in preventing relapse after an individual has achieved abstinence” (Tomko et al., 2018).
Future Research:
1. Studies need to be conducted in regard to pregnant women and NAC treatment
2. Further research must be done to determine the effectiveness of NAC in promoting abstinence, both as a stand-alone treatment and as part of an addiction treatment plan.
References:
Acetylcysteine (acetylcysteine) dose, indications, adverse effects, interactions. from PDR.net. (n.d.). PDR.Net. www.pdr.net/drug-summary/Acet...
Back, S. E., McCauley, J. L., Korte, K. J., Gros, D. F., Leavitt, V., Gray, K. M., Hamner, M. B., DeSantis, S. M., Malcolm, R., Brady, K. T., & Kalivas, P. W. (2016). A double-blind, randomized, controlled pilot trial of N-acetylcysteine in veterans with posttraumatic stress disorder and substance use disorders. Journal of Clinical Psychiatry, 77(11), e1439-e1446. doi.org/10.4088/JCP.15m10239
Ershad, M., Naji, A., & Vearrier, D. (2020, June 28). N Acetylcysteine - StatPearls -NCBI bookshelf. National Center for Biotechnology Information. www.ncbi.nlm.nih.gov/books/NB...
Mcclure, E. A., Gipson, C. D., & Gray, K. M. (2014). Potential role of NAC in SUDs. CNS Drugs, 28(2), 95-106. doi.org/10.1007/s40263-014-01...
Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A Review on Various Uses of N-Acetyl Cysteine Citation: Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A review on various uses of N-acetyl. CELL JOURNAL(Yakhteh) Cell Journal (Yakhteh) Cell J, 19(191), 11-17. www.ncbi.nlm.nih.gov/pmc/arti...
NAC drug interactions. Drugs.com. www.drugs.com/drug-interactio...
LaRowe, S. D., Mardikian, P., Malcolm, R., Myrick, H., Kalivas, P., McFarland, K., Saladin, M., McRae, A., & Brady, K. (2006). Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. American Journal on Addictions, 15(1), 105-110. doi.org/10.1080/1055049050041...
Tomko, R. L., Jones, J. L., Gilmore, A. K., Brady, K. T., Back, S. E., Gray, K. M., & Author, C. P. (2018). N-acetylcysteine: A potential treatment for substance use disorders HHS Public Access Author manuscript. Curr Psychiatr,17(6), 30-55. www.ncbi.nlm.nih.gov/pmc/arti...
why this video is not viral really this is the most useful video i terms of addictions
Thank you for this video it’s putting out very relevant and helpful information and I think you’re doing a great job of narrating it for us! Bless you
Good job James in using the nac to help you.
The video is very good and informative, good job. Keep the videos up, you have a talent for them
Great information
Thank you!
Very nice presentation. Thank you
Thanks
Very nice presentation!
Risk of heart failure… awesome!
Great video. Bit hard to hear u speak tho
MARRY ME🥰
Good information but so boring, monotone voice and childish voice from the narrator, moved on.
Because as we all know, every video on RUclips has to be tailored to you and what you consider entertainment. We’re ever so sorry, your highness. 🙄
You’re doing a great job of putting forth the information for this very important topic. Thank you
@@TwoBs lmao! You tell em!