Hedgehog Signaling Pathway

This video unravels the intricate dance of the Hedgehog Signaling Pathway, a master controller in animal development!
Ever wondered how a single pathway orchestrates the growth of organs and tissues? Here, we'll witness the key players - Hedgehog, Patched, Smoothened, and Ci - working in concert.
Without the Hedgehog signal, it's all quiet:
Ci, a gene activator, gets constantly broken down.
Proteins like Fused and Costal2, along with kinases, tag Ci for destruction, keeping Hedgehog target genes off.
Patched, a receptor, holds Smoothened, another protein, inactive.
But when Hedgehog arrives, the music starts!
Hedgehog binds to Patched, freeing Smoothened.
Phosphorylated Smoothened interacts with the Fused-Costal2 complex, releasing Ci.
Unbound Ci travels to the nucleus, activating Hedgehog target genes.
These genes control critical processes like:
Cell destiny - choosing the right path for each cell!
Tissue organization - building structures in the right place.
Growth - ensuring proper development.
Join us as we explore the fascinating world of Hedgehog signaling!
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Leave a comment below with your questions about this amazing pathway!