The hedgehog signaling pathway - Part 1: Normal situation

In normal cells, activation of the hedgehog signaling pathway begins with the binding of the extracellular hedgehog protein to the membrane receptor Patched. The activation of Patched overcomes the blockage of the membrane receptor Smoothened. Active Smoothened is able to activate Gli2, which translocates into the nucleus, where it induces the expression of CCND1 and other genes activating proliferation.
#onkoview, #hedgehog, #proteins, #membrane, #receptor, #gli2, #ccnd1, #pathways

[@bonniesaha]

Excellent Explanation. A marvelous simplified demonstration of a complex process

[@amirkarra847]

Very good presentation of HH signaling pathway. thank you for this video !

[@ChinchillaHappyLife]

Great Explanation! Thanks

[@jasmeenkaurlamba5478]

Great explanation. understood so easily, thanks a lot

[@SarrahNikki]

LOL @ "homogolous" rather than "homologous." Feels like when Bush says "nucular" instead of "nuclear." ....Otherwise a very helpful video xD
Thank you!