Hedgehog Signaling Pathway in Vertebrates | Purpose and Mechanism

Introductory lesson on the Hedgehog Signalling Pathway in Vertebrates. The Hedgehog signaling pathway is important in embryological development of both invertebrates and vertebrates. Hedgehog proteins facilitate the activation of the hedgehog signalling pathway, inducing target gene expression in a graded and tissue-specific fashion. Activation of the hedgehog signalling pathway is critical for the proper embryological development of vertebrate species and has roles in tissue growth and mitogenesis of the cerebellum and retina, as well as roles in axonal development and homeostasis and tissue repair of adult neural stem cells.
In this lesson, you will learn about the importance of the hedgehog signalling pathway in vertebrate development, the mechanism of the hedgehog pathway and genes that the hedgehog pathway induces.
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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JJ

[@mariamjen5353]

No one, I say no one can explain this better than you did !
Thank you so much for sharing !

[@himynameisjakeable]

MATE, BLESS YOU!!!! After HOURS of searching a clear way to learn this goddamn signalling pathway, you made it so understandable to write my essay. Bless you man...

[@Gracie-gf7lo]

No need to drop gd 🫤

[@christopheryen5377]

Great explanation of the intricacies.

[@Ala22223]

best utube channel for these pathways thanks alot

[@a.7325]

Thank you very much for your helpful, easily understand video :)

[@eduardoviniccius]

Really nice. Saudations from Brazil!

[@alexataupin8052]

Thank you for this clear explanation :)

[@rajabilawal4002]

Thank you so much
you are a great teacher. 😍

[@anleyteferra7846]

Thank you so much!

[@seeshellslife7273]

I was born in 1968, preaxial polydactyly . I have many associated anomolies also associated with my birth defect , yet not a named syndrome. Teeth abnormalities, unbalanced hormones , slightly tongue tied, small mouth and jaw . About 5 years ago, my healthy, happy , active, lifestyle came to a screeching halt! Literally, like the light switch got turned off. My doctor's do not want to believe that any of my symptoms could possibly be what so ever related to my birth defect . In November I was diagnosed with hoshimotos disease, hypersomnia, depression. If you have an interest , I would so truly appreciate any videos .

[@HadasLL]

Get a full DNA sequence.

[@valentine-lr8kv]

thank you very much

[@darvinggonzalez841]

best video ever

[@charlesnelthorpe9252]

Now I can master Green Hills zone 2

[@abdullahgam33]

thanks a lot ♥

[@martinmcr83]

Nice

[@LordBurningStuff]

Why are gli proteins not phosphorylated in the primary cilium, and what's to stop them from being phosphorylated on the way to the nucleus, from the primary cilium?

[@kaitlynjackson3767]

Citations would be very helpful. Did this all come from a specific text/review article?

[@valentine-lr8kv]

Hello,
Are GLI 1 and GLI 2 activators and GLI 3 a repressor ? I have that in my lesson but I don't know
Thank you

[@dr.bidiingalah4317]

Well explained... Figuring out how my candidates genes affect Hedgehog pathway in familial cancer.

[@carliehowe8277]

Great video, is there any citation?

[@Confession23]

Let's discuss

[@hannahwilkinson347]

Which pathway is canonical and non-canonical?