Notch Signaling Pathway | Purpose and Mechanism

Lesson on the Notch Signaling Pathway. The Notch signaling pathway is a highly conserved and critically important pathway in homeostasis and the development of sensory hair cells and branched arterial networks. The Notch signaling pathway derives its name from the NOTCH receptors, which are activated through ligands located on the cell membrane of other cells (sending cells). The NOTCH receptor is composed of three domains, the extracellular domain, a single transmembrane domain, and a notch intracellular domain (NICD). Upon ligand binding to the Notch receptor, the Notch receptor undergoes cleavage reactions, releasing the NICD into the cytosol. The NICD binds to the complex of proteins, which translocate into the nucleus and activate Notch target genes involved in cellular proliferation, differentiation and apoptosis.
Hey everyone! Here is a lesson on the Notch signaling pathway. In this lesson, you learn what the Notch signaling pathway is, why it is important in development and homeostasis, what ligands activate the Notch receptors and the Notch signaling pathway, and how the Notch pathway leads to the expression of Notch target genes.
I hope you all find this video helpful! :) If you found this video helpful, please like and subscribe for more videos like this one.
Subscribe for more free medical lessons / @jjmedicine
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ / jjmedicine
Follow me on Twitter! ➜ / jj_medicine
Come join me on Facebook! ➜ / jj-medicine-1006426481...
Start your own website with BlueHost ➜ www.bluehost.com/track/jjmedi...
Check out the best tool to help grow your RUclips channel (it’s helped me!)
www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - ...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis P...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signalin...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and S...
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formati...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautop...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@Brickkzz]

Brilliant concise video! I think the cleavage of intracellular domain of Notch is usually called gamma-secretase.

[@Endymion5000]

Excellent! Clear, concise, and very understandable. Just subscribed!

[@roabashmail8433]

Thaank you soo much it is more than helpful it is treasure !! thanks a gain

[@michellew4634]

so helpful! thanks for making this!

[@christopherchen6937]

Wow!!! It's very brilliant!!!!! Thanks!!!!

[@madihaahmad5992]

very informative and helpful

[@bluemug111]

Thank you so much

[@animatedbiologywitharpan]

Nice explanation

[@user-im5lj4be8p]

great explanation, thanks!

[@mohammedelberawi8440]

Thanks very much

[@marwaali4821]

Thank you

[@victorf.martins8296]

JJ Medicine make a video explaining the erbb4 signaling pathway please

[@elizabethhu4508]

From what I read, I thought the NICD translocates into the nucleus first and then binds CSL? Am I wrong?

[@jazminefulgencio1543]

you're right. NICD translocates to the nucleus where it interacts with CSL

[@sanjaisrao484]

Thanks

[@woodbinson457]

Love of my life

[@danielgladish2502]

4:38 by p21 are you referring to RAS or CDKN1?

[@ezfit3367]

1:27

[@lifestylesocial2966]

4.57 what is the name of ligand?

[@nasranaizi2714]

what does the NOTCH acronym stand for?

[@SeeWoelfin]

It is not an acronym. It comes from Drosophila research: the phenotype which showed a little 'notch' in the wing. As this is a highly conserved pathway, similar genes are found in humans.

[@dukherdohonekorunrodone6346]

mind bomb!!

[@alexkmile]

the whole video is a mind bomb!!