Mechanism of NOTCH SIGNALING PATHWAY

The Notch signaling pathway is a highly conserved cell signalling system present in most multicellular organisms.[1] Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region.[2]
Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic development.
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[@hedayathabibzai6570]

Thank you sir but I think the third enzyme is gamma-secretase not alpha-secretase

[@hussainbiology]

pinned your comment... thanks

[@diksha6954]

Ur diagrams and explanation makes biology so easy to understand ...u've really helped me a lot during my graduation...keep up ur good work👍

[@hussainbiology]

Really makes me happy when i get to know that.... Thanks for appreciation....Keep sharing and supporting ✌️

[@BiologyRoots]

Half an hour topic explained in 2 mins 👍👍

[@aboutstudies123]

Easy to understand Sir. Thank you

[@michellew4634]

super helpful! thanks for making this!

[@IanMahetiMbano]

This is so good Hussain, thank you again Sir.

[@hussainbiology]

Thanks Ian for appreciation.....Glad to know that it helps..

[@learningskills483]

Thanks so much Sir seriously it's very helpful for me to understand #Notch signaling

[@hussainbiology]

Thanks Shivani for appreciation....... Really glad to know that it helps,,,

[@gopalkalwan7465]

Sir in place of alpha secretase it is gamma secretase otherwise i am a big fan of u

[@AnkeetKumar]

You speak like that of Shaukat Sir . .
I love you accent .

[@hussainbiology]

Shaukat Sir ,who??

[@AnkeetKumar]

@@hussainbiology He is used to teach me in my BSc at Doda

[@sanjaisrao484]

Thanks

[@austinkunch710]

What's the difference between differentiation and cell fate?

[@luluskeyni9090]

very clear thank you

[@hussainbiology]

Thanks Lulu for appreciation.....Keep sharing and supporting

[@Ali-kn1nk]

thank youuuuu!

[@hussainbiology]

thanks Alizeh for appreciation... Glad to know that it helps

[@Maelstroma666]

Very good sire.

[@hussainbiology]

Thanks bro.... excited to know that mine videos help others.....thanks again for support.....Do subscribe

[@aadilaif]

nice

[@vaishnavivaishu3313]

plz mention u r explaination in below box

[@ankitnegi8070]

Bhai pls video thodi slow bnawogy to thoda Shi rhgga thoda time consuming hogga bt pr smjny m asani hoggi🙂

[@hussainbiology]

Haan g bilkul....I will this in mind.

[@deekshasharma7598]

Can u plz name the proteins u mentioned in the end in nucleus? It's a bit unclear.

[@hussainbiology]

CSL protein ,(CBF1, Suppressor of Hairless, Lag-1)
and Mastermind proteins.

[@deekshasharma7598]

@@hussainbiology thanks.😊 I really like ur videos n it's great that u actually reply to queries of ur viewers. Thanks once again

[@hussainbiology]

@@deekshasharma7598 keep sharing and supporting ✌️

[@samiaaasim8964]

thanks sir

[@hussainbiology]

Welcome Samia............. and don't call me sir....i am still a student

[@Zetsuke4]

cant understand the sound

[@Aleezah143]

So this only happens in neural cells?

[@hussainbiology]

No no.. Notch signalling drives in Epidermal Stem cells , T cell lineages and many more....

[@concept_of_BiologyAS]

😊😊😊

[@ruchitanavade1217]

The content is top class and your way of explanation is also good, but your language is not very clear.....with this good content if the audience is not able to understand the topic, then whats the point of making the video, I hope you take it in a positive way.

[@hussainbiology]

Thanks for appreciation and feedback.....and surely i will work on my accent to make it understandable plus i will also add subtitles to make it easy.

[@hussainbiology]

@dobo okay..will make subtitles available in few days