G Protein Coupled Receptors (GPCR) & G Proteins

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Video Summary:
G protein-coupled receptors are transmembrane proteins with 7 transmembrane segments. They are also called 7 pass receptors or serpentine receptors. As per the name, they are coupled with G proteins. G proteins have GTPase activity and they bind with GTP or GDP. Heterotrimeric G proteins have α, β, and γ subunits with α subunit having GTPase activity. Different trimeric G proteins are Gs, Gi, Go and Gq. This group mediates the response to a wide range of signal molecules. Monomeric G protein is similar to the α subunit of heterotrimeric G protein. They include Ras, Rho, Rab, Arf, and Ran families of G proteins. They regulate gene expression and cell proliferation, differentiation, and survival. Now the cycle of subunits of heterotrimeric G proteins during signaling. Under resting state, the complex is associated with the receptor and the α subunit is bound to GDP. The binding of a ligand with the receptor causes the release of GDP and binding of GTP. This in turn causes of release of the free α subunit and βγ complex. They both affect different downstream signaling molecules. Eventually, the GTPase activity of the α subunit causes hydrolysis of GTP into GDP and phosphate. The inactive α subunit then dissociates from the effector molecule and re-associates with the βγ complex bringing the system back into the resting condition.
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@Priya-wf5nz]

........you saved me.........best explanation ever

[@ammarasattar7809]

Now for the first time I completely understand (GPCR) & G proteins thank you 💚🤍

[@amjr7105]

better than Dr.Najeeb and Ninja good job

[@user-assalav]

thank u so much it helps me a lot

[@zahidgul1322]

Thanks for easy explaination

[@user-tq2ig7zo5l]

Amazing explanation till date ! 💯

[@uttamghosh503]

Awesome ❤ very helpful

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Most useful channel👍👍well explained and convey the topic meaningfully👌👌👌Thank you very much sir🙏🙏🙏

[@user-nt7ex7ub9w]

Great . Thank you so much

[@devdharpanchal9693]

Very good explanation 👍👍👍👍

[@malakarmakar1696]

Upload more videos please.... The way you teach is really beneficial..Best wishes 💗

[@NonstopNeuron]

Yes. We are regularly uploading videos. Keep checking back.

[@monaalbazi8532]

Very true

[@rashim.jbajaj]

Amazing channel

[@ndmshah]

Very good explanation sir

[@mariyajacob4107]

Thank you so much sr

[@devesh3724]

Awesome explanation 🙏

[@NonstopNeuron]

Thank you 😊

[@MarathiPharmacy-123]

you are awesome sir

[@KimiaHaseli-yn9uz]

Perfect

[@smkishtiak]

Thanks

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MAY ALLAH GIVE YOU A LOT OF STRENGTH INSPIRATION TO GO AHEAD

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Nice bro

[@Lusungumsimuko5816]

Thank you very much
Best way explained👏👏

[@koushikaditya7580]

need some about protein regulation

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Tesekkurler in Turkish :) , thanks so much in English :)

[@pyndaplangryngkhlem5485]

Wow 👌

[@shishirbain3615]

Really helpful 👍 thanks 😊😊😊 superb amezing 😊😊 great 😁

[@NonstopNeuron]

Most welcome 😊

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Please 🙏🙏🙏🙏🙏 upload as much possible to you ❤️☺️❤️❤️💞💞💞💞💞

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love from france

[@NonstopNeuron]

Thank you

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May god blessed you

[@NonstopNeuron]

Thank you

[@sandhyasandy4884]

Suprb upload more videos sir

[@NonstopNeuron]

Yes... Will resume uploading soon

[@sirishasrisailapu7303]

Revise @ 4.50

[@gamagarcia3037]

is there an error in the process at that time? I'm taking notes and i want o make sure I have the right information

[@saiteja6742]

Hiw much time does it take for u to make this animation lecture sir??🙄

[@NonstopNeuron]

a lot. When I was learning animations, it took 7-10 days for 5 minutes of animation. Now it takes average 3 days. And I spend almost all the time of day on this work. At college or at home, I am working on this whenever I am free which I am most of the time. But I love this so I enjoy it.

[@saiteja6742]

@@NonstopNeuron in which software ur current doing these animation sir..
I got good rank NIPER bcz of ur lectures sir..❤️❤️

[@NonstopNeuron]

That's great. I use multiple software.

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@@saiteja6742 what is your niper jee rank ? And subject for m pharm

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