I am in nursing school and My teacher is awful and I felt like I was drowning in pharmacology. You guys are basically teaching me pharmacology. You should get.a paycheck 😄 Thanks for the 95% on the last exam! ❤
Kristin, you must attend Bergen county community college, in New Jersey. (Joking... But my pharmacology professor is a horrible teacher too and she thinks she's the greatest) Thank you Michael for your explanation!
I've been watching your videos for 3 years! You got me through anatomy and physiology, pharmacology and the first year of nursing school. Thank you Dr. Mike!!
I don't know what to say!! you really saved my life!!! I have been suffering understanding this confusing process of Alpha and Beta receptors and you just solved it !!
Thank you so much for your time and effort explaining all these things in such amazing ways. You are a blessing to many nursing students!!!!!❤️❤️❤️❤️❤️
You're a straight up legend Dr Mike! I'm learning and reinforcing so much of my lecture content from you guys - thank you, thank you, THANK YOU for your channel!
Explained it way better than my professor at college, in the span of 10 minutes, this helped me learn about 1 and a half hours of my professor's material better. Thank you.
Glad I found your channel. Great teaching of these basic medical topics. Videos are very clear & easy to understand . Not just detailing of a particular topic but there’s explanations about how it’s relevant in a general medical sense. Best videos of this kind on RUclips & am surprised there not more views !
This was an amazing watch. So concise and just what I needed as a final revision. Looking forward to learn more from you, Doctor! Thank you for this wonderful, wonderful cheat sheet :)
Nice, lesson bro, I am a nursing student in Kenya, I love this presentation I am understanding it well. really teach exactly like my pharmacology lecturer.
Dr mike just wanted to thank you for all you do. I am in nursing school and I feel like lost from just listening to my instructor just reading the PowerPoint. Every time I needed to understand the pathology behand something or drugs I always watch your videos. Thanks to you I am passing my classes. You are wonderful Dr.
thank you thank you thank youuuuuu. i have been struggling for days to visualize the organization of this concept. you just made it click in 5 minutes.
Thank you for your teaching, reminded me of things. I want to say to all those complaining about their teachers, yes there are crappy ones, but most that are complained about are not, it is simply that you saw the material for the first time when the teacher showed it to you and you related that difficulty to the teachers teaching, in actuality it is simply cause the 2nd time your brain hears it being explained on youtube you already had an idea of it even if subconsciously, so it is not as hard the 2nd time and even easier the first, after 100x it becomes trivial cause of repetition. stop blaming the education system, the books are the same everywhere, unless you are in south korea then them books might just be communist that's why its hard hahaha. i am not a teacher, i am a doctor, and i use to think like that too until i realized it was me and i stopped blaming the teachers, ones i came to this revelation i started doing much better in school and feeling better about my situation cause i had control, not that the teacher had control (reason yall are blaming them is cause you feel like they control how and what you learn(yes the government controls education to a degree but that different, what they control is the content not how much of it your brain can remember), teachers are are guides that have been there done that 100x, nothing more)
I wish we used the terms "noradrenaline" and "adrenaline" here in the US instead of "norepinephrine" and "epinephrine". I think it makes it so much easier to remember and it helps to relate the "adrenal-ine" the adrenal gland.
Epinephrine has a similar clue, too. It is epi (above) the nephrine (nephron: the functional unit of kidneys, nephrology: the study of kidneys) I actually just realized the connection of both adrenaline and epinephrine to the adrenals and the nephrons while watching this video!
Thanks so much for your videos! I'm wondering why would an α2A alpha-adrenergic agonist cause a side effect of constipation? How would this be resolved?
Yes, I.e. we commonly see constipation with guanfacine and clonidine. Guanfacine is meant to target alpha 2 receptors. If constipation occurs, would it due to an unintended cross action on the alpha 1 receptor?
Non medical person, watching this amazing video to understand POTS and what pills to take :D But somehow i dont understand why Propranolol (B1,b2 blocker) is better than Cardio selective b1 blockers like Bisoprolol for post viral POTS leading with Orthostatic Hypotention, any ideas?
What is the role of sympathetic system for salivary gland? We get dry mouth in panic situations but its written in my book that alpha 1 and beta 2 stimulates salivary gland.
I have Long Covid. A lot of recent literature points to this system being affected by covid causing molecular mimicry in B cell antibodies, so we get self destructive autoantibodies that clog up these receptors and down and up regulate them and fuck everything up. You have helped me understand my disease very well thank you
I can watch your videos for ever without being bored but believe me I can’t focus on the subject because you’re so charming Next time cover your face 😂❤
I understand the relaxing of vessels to improve blood flow, but what purpose does the negative feedback response in alpha-2 serve during flight or fight? (Amazing video!)
I would say in an extreme situation of overstimulation, it can help prevent an exaggerated response that can be even more dangerous than the threat itself. An example may be extreme tachycardia leading to cardiac arrest.
Hi, doctor Mike, student here. Based on RANG & DALE's book, if alfa-2 receptors promote vasodilation it promotes constriction of smooth cell muscle at the same time. How is it possible if vasoconstriction is made after alfa-1 stimulation?
Not sure , but I think you forgot to mention that alpha one adrenergic receptors in all glands except sweat gland , since it gets stimulated by acetyl choline in sympathetic outflow
Hello, I have a question as a1 and b2 both are present on smooth muscles so why b2 do not show action of relaxation during sympathetic nervous system and relaxes muscles. Why a1 is only working there to vasocontrition
Simple question, but for some reason, I'm having trouble finding the answer online. Does norepinepherine have a higher binding affinity for its excitatory receptors than the alpha-2 inhibitory receptors? I'd assume so, as that is the only way it would be able to produce a response while still running the negative feedback loop. Am I asking the right question? I'm just unsure as to how the negative feedback loop is managed (ie what level of stimulus the sympathetic nervous system will reach before that inhibition kicks in, and how this is controlled). Thanks for the great video!
These types of physiological function are usually not all-or-none, which is to say there is no complete inhibition or activation of something. There is a constant homeostasis that is regulated constantly by several factors and mechanisms.
![Blox Fruits Dragon Rework Update [Full Stream]](http://i.ytimg.com/vi/EqDAp8udhm0/mqdefault.jpg)
I am in nursing school and My teacher is awful and I felt like I was drowning in pharmacology. You guys are basically teaching me pharmacology. You should get.a paycheck 😄 Thanks for the 95% on the last exam! ❤
Me too!!. Starting pharmacy now that I’m in my second year and I’m struggling sooo much
Same!! I use their videos that address Fundamentals topics!!
@@Misskirty where are you located? We started Pharmacology from 1st semester
Kristin, you must attend Bergen county community college, in New Jersey. (Joking... But my pharmacology professor is a horrible teacher too and she thinks she's the greatest) Thank you Michael for your explanation!
@@Misskirty are u a Ghanaian???
This is first time i REALLY understood the alfa 2 receptor! Great video!
I've been watching your videos for 3 years! You got me through anatomy and physiology, pharmacology and the first year of nursing school. Thank you Dr. Mike!!
For someone who needs to grasp all this and has ADHD on top of it, your lectures are a savior! Thank you 🥰🥰🥰🥰
I wouldn’t have passed my exam without this video! You literally saved me! Thank you so much for the clarity of either your explanation and schemes!
I don't know what to say!! you really saved my life!!! I have been suffering understanding this confusing process of Alpha and Beta receptors and you just solved it !!
Thank you so much for your time and effort explaining all these things in such amazing ways. You are a blessing to many nursing students!!!!!❤️❤️❤️❤️❤️
You're a straight up legend Dr Mike! I'm learning and reinforcing so much of my lecture content from you guys - thank you, thank you, THANK YOU for your channel!
Explained it way better than my professor at college, in the span of 10 minutes, this helped me learn about 1 and a half hours of my professor's material better. Thank you.
I am newly in paramedic class and I have enjoyed watching your videos to get a better understanding! Thanks you!!
I'm just a biohacker on a mission to end adhd lethargy without drugs I can't drive a semi on. This has really helped me in my path.
Glad I found your channel. Great teaching of these basic medical topics. Videos are very clear & easy to understand . Not just detailing of a particular topic but there’s explanations about how it’s relevant in a general medical sense. Best videos of this kind on RUclips & am surprised there not more views !
Go bless you my brother. Showing love here all the way from Papua New Guinea. Love your content. Thanks for your tireless efforts!
THANK GOD SOMEONE WHO MAKES IT MAKE SENSE
Ok ,imean for arab medical students, Dr Mike is an actual blessings!!!!!! Thanks alot dr
This was an amazing watch. So concise and just what I needed as a final revision. Looking forward to learn more from you, Doctor! Thank you for this wonderful, wonderful cheat sheet :)
Your gift is clarity. Was ready to give up on adrenergic receptors. THANK you.
I have my pharmacology final for my first year of Vet Med next week. Thank you so so so much for this explanation!!
Nice, lesson bro, I am a nursing student in Kenya, I love this presentation I am understanding it well. really teach exactly like my pharmacology lecturer.
I can always count on your videos to help me study for paramedic college
Thank you so much for the dedication , been struggling for days to understand this concept, all thanks to you❤😇
Med student here! Thank you, very easy to understand. You're a great teacher!
Thank you for this free video. Im not skipping ads, this is my little way for my payment. :)
Dr mike just wanted to thank you for all you do. I am in nursing school and I feel like lost from just listening to my instructor just reading the PowerPoint. Every time I needed to understand the pathology behand something or drugs I always watch your videos.
Thanks to you I am passing my classes. You are wonderful Dr.
Thanks Dr for your hard work and time. You help make lessons understandable
thank you thank you thank youuuuuu. i have been struggling for days to visualize the organization of this concept. you just made it click in 5 minutes.
Grateful to you for you great explanation...I was so confused about these stuff & you have brought a light to darkness in my medicinal world
I was struggling to learn this topic, but this video makes it so much clearer, thank you so much!
you saved me, this made so much sense!!! i couldnt figure it out from the websites i was reading!!
Honestly, you are amazing in the way of simplifying complex concepts 😊
Great video ,I’m medical student from Iraq and I understood that very good thank you a lot.
Yankee here.. You pronounced Norepinephrine perfectly , don't worry about it
Thank you so much for the very intelligent ideas from your lectures that you've shared. God bless you.
always saving my time :( BEST TEACHER ON RUclips!!!!!!
Thank you so much, no words could be enough to express my gratitude
Thank you for your teaching, reminded me of things. I want to say to all those complaining about their teachers, yes there are crappy ones, but most that are complained about are not, it is simply that you saw the material for the first time when the teacher showed it to you and you related that difficulty to the teachers teaching, in actuality it is simply cause the 2nd time your brain hears it being explained on youtube you already had an idea of it even if subconsciously, so it is not as hard the 2nd time and even easier the first, after 100x it becomes trivial cause of repetition. stop blaming the education system, the books are the same everywhere, unless you are in south korea then them books might just be communist that's why its hard hahaha. i am not a teacher, i am a doctor, and i use to think like that too until i realized it was me and i stopped blaming the teachers, ones i came to this revelation i started doing much better in school and feeling better about my situation cause i had control, not that the teacher had control (reason yall are blaming them is cause you feel like they control how and what you learn(yes the government controls education to a degree but that different, what they control is the content not how much of it your brain can remember), teachers are are guides that have been there done that 100x, nothing more)
Holly molly, that was a fantastic video!
Now I can easily remember the function of each receptor.
Keep it up doctor you are the best😘😘🌷🌷🌷
Beautiful explanation, It is actually a cheat sheet to remember the receptors, thank you for making it so easy. :)
I wish we used the terms "noradrenaline" and "adrenaline" here in the US instead of "norepinephrine" and "epinephrine". I think it makes it so much easier to remember and it helps to relate the "adrenal-ine" the adrenal gland.
Epinephrine has a similar clue, too. It is epi (above) the nephrine (nephron: the functional unit of kidneys, nephrology: the study of kidneys)
I actually just realized the connection of both adrenaline and epinephrine to the adrenals and the nephrons while watching this video!
Best explanation it is been years I watching your videos
Thank you Dr. Mike. Your lectures are the best...
Wow I am nursing student and this video really help me ❤❤🎉🎉
And that is how my brain works.. amazing! Got it now! thank you!
Thank you for clearing the concepts... Very helpful video
Love these videos. Spoken in plain English to drive the point home. 👍🏼.
thank you Dr Mike , crystal clear
Man was this helpful. Thank you!
Thank you sooo much finally I got it ❤
u really becoming my life savor thanks so much
i have exam next week
An actual fact - you are the best!!!!
Thanks so much for your videos! I'm wondering why would an α2A alpha-adrenergic agonist cause a side effect of constipation? How would this be resolved?
Alpha2 agonist? Like what? Or did you mean alpha-adrenergic agonists in general?
Yes, I.e. we commonly see constipation with guanfacine and clonidine.
Guanfacine is meant to target alpha 2 receptors. If constipation occurs, would it due to an unintended cross action on the alpha 1 receptor?
I saw a lot of pictures and videos bt i can't understand what is a alpha 1and 2 ..but sir your videos gives me a better explanation.
Oh my god what a wonderful video that helps you understand it simply!! Thank you :)
Glad it was helpful!
Non medical person, watching this amazing video to understand POTS and what pills to take :D But somehow i dont understand why Propranolol (B1,b2 blocker) is better than Cardio selective b1 blockers like Bisoprolol for post viral POTS leading with Orthostatic Hypotention, any ideas?
finally understood the mechanism. thank you so much
What is the role of sympathetic system for salivary gland? We get dry mouth in panic situations but its written in my book that alpha 1 and beta 2 stimulates salivary gland.
Thank you sir
I found your lecture so beneficial for med chem and cology studies🙏🙏🇮🇳🇮🇳
Thanks for the video man, your a real one
You are a good one!
Glad I found your channel♥️
Very good little heuristic. I’m upping my biohacking game on detoxing from catecholamines.
in pharm school now, thanks for these life lines during grad school!
This was wonderfully helpful. Thank you so much ♥
You are very explicit, Thanks so much.
Thank you Dr. Mike
Thank you so much sir, this is going to be extremely helpful...
Doc … you are amazing… thank you sooooooooo much ❤
Thank you for this!!!
I needed to hear this. Thank you so much.
I have Long Covid. A lot of recent literature points to this system being affected by covid causing molecular mimicry in B cell antibodies, so we get self destructive autoantibodies that clog up these receptors and down and up regulate them and fuck everything up. You have helped me understand my disease very well thank you
Any treatments work?
Thank u so much, your explanation helped me lot💓
Well explained Dr. 👌👌👌
I can watch your videos for ever without being bored but believe me I can’t focus on the subject because you’re so charming
Next time cover your face 😂❤
Since you said the Alpha 2 is present at the pre-synaptic terminals. Are PRE-SYNPATIC in both PANS and SANS not Nicotinic receptors?
Good stuff Dr. Mike, very helpful indeed
I understand the relaxing of vessels to improve blood flow, but what purpose does the negative feedback response in alpha-2 serve during flight or fight? (Amazing video!)
I would say in an extreme situation of overstimulation, it can help prevent an exaggerated response that can be even more dangerous than the threat itself. An example may be extreme tachycardia leading to cardiac arrest.
Hi, doctor Mike, student here. Based on RANG & DALE's book, if alfa-2 receptors promote vasodilation it promotes constriction of smooth cell muscle at the same time. How is it possible if vasoconstriction is made after alfa-1 stimulation?
Thank you so much! For the great explanation .
Thank you so much it’s helpful
Not sure , but I think you forgot to mention that alpha one adrenergic receptors in all glands except sweat gland , since it gets stimulated by acetyl choline in sympathetic outflow
Thank you so much, this was amazing.
❤❤❤❤dr Mike from India....iam pharmacology professor ❤❤❤
Thanx Dr Mike appreciato💪
Well explained. Thank you
Hello, I have a question as a1 and b2 both are present on smooth muscles so why b2 do not show action of relaxation during sympathetic nervous system and relaxes muscles. Why a1 is only working there to vasocontrition
B2 only causes vasodilation of skeletal and coronary blood vessels
Thank you for your video and also nice looking to watch
Such an amazing video Thx😍😍😍
I can't thank you enough for your amazing videos ❤️❤️❤️❤️ good luck 🤞
Dr can u do a video about Tension stress and the common medications to treat it
it would be a great if u explained it .
Thank you, for the videos Dr. 🙏
Simple question, but for some reason, I'm having trouble finding the answer online. Does norepinepherine have a higher binding affinity for its excitatory receptors than the alpha-2 inhibitory receptors? I'd assume so, as that is the only way it would be able to produce a response while still running the negative feedback loop. Am I asking the right question? I'm just unsure as to how the negative feedback loop is managed (ie what level of stimulus the sympathetic nervous system will reach before that inhibition kicks in, and how this is controlled). Thanks for the great video!
These types of physiological function are usually not all-or-none, which is to say there is no complete inhibition or activation of something. There is a constant homeostasis that is regulated constantly by several factors and mechanisms.
Thank you so much
You are amazing. I love your teaching style.
Kudos🙌🏽
Perfect
Thank you so much ✨️
Thank you this is so helpful!!!
thank you so much you're a life saver!
very smart. thank you so much!
THIS IS AMAZING, THANK YOU
Thank you for this ❤
Very helpful 💯
Thank you 💕
besides airway and bronchial relaxation, what do i want to relax (a2) in the ACLS algorythm?