Besides the VERY MINOR flaw in remaining zoomed in during a certain segment this was a very succinct and well presented lesson on GPCRs. Thanks for posting it up, it's been a great overview to revising the key concepts.
This was perfect! The only thing this video missed was that after ATP is converted to CAMP, CAMP then goes on to activate Protein Kinase A to THEN produce the physiological effects.
Thank you so much. I went through my lecture slides, recording but still not understanding a piece of information like you did in 12 minutes. I am so grateful to be here with other students.
How hours of boring lectures are made into a 12 min riveting knowledge is always going to be a mystery to me #Khanacademy. Thank You for saving my life btw
Great clear explanation. I studied this back in undergrad and want to carry out an experiment now in my PhD where I inhibit G-alphaS and see downstream function. I need a quick re-fresher and this hit the spot! Thanks!
I'm overwhelmed with joy, I finally passed my NCLEX RN after three trials and I almost gave up until I met this God sent. Please join me celebrate my helper Dr Brooks for his consistent assistance showed to me during my preparations for this exam. If you want nclex to be history to you, contact Dr Brooks via text or whatsapp on +12404085402.
Wow , very well explained 👏👏 i always get scared when i hear g protein coupled receptors (sounds scary right) but now that ive tried to understand its so simple thanks khan academy
I get that the alpha subunit of the g protein acts s a regulaator after it's activted. But wht do the bet and gmma subunits do? Is their only functtion to block the alpha subunit from being activated all the time?
Greetings from Sweden! Thanks for a great video! Dont know if it really matters, but it's an adenylyl cyclase (not adenylate) according to my biochemistry book.
Both terms are used. I just checked two of my danish textbooks. Biochem-book says 'adenylate' and Pharma-book says 'adenylyl'. But I also seem to recall that previous english textbooks I've read uses 'adenylate'. I guess it's just a 'cultural' thing, regarding what system you use to name the functional groups.
Both terms are used, adenylyl is kind of an old fashioned name, some of the pictures of researches my lecturer shown us use adenylyl, but adenylate is used in most universities in London as as far as I know.
This guy taught me better in 12 minutes than my professor did in a 45 min class. Kudos dude.
and my one took more than an hour.
@@naveedkhankakar144 and mine took more than five hours 😫.
Hahahhaha we are in same category
@@fizazainab1526 hahahaha yup we are.
@@naveedkhankakar144 good luck for your future
Besides the VERY MINOR flaw in remaining zoomed in during a certain segment this was a very succinct and well presented lesson on GPCRs. Thanks for posting it up, it's been a great overview to revising the key concepts.
Bruh, it's been 9 years, this video needs a re-edit for those precious minutes gone while it was zoomed in
I HAVE SPENT 2 YEARS IN MED SCHOOL MANEUVERING MY WAY THROUGH COUJTLESS EXAMS AND VIVAS WITHOUT EVER REALLY UNDERSTANDING THIS! UNTIL TODAY! THANK YOU
this is me right now haha
thats kinda sad
Did you graduate yet? If so, congratz!
How far
I need a mentor. I just got into my first year of medical school
This was perfect! The only thing this video missed was that after ATP is converted to CAMP, CAMP then goes on to activate Protein Kinase A to THEN produce the physiological effects.
Thank you for your contribution
to talk about this would be a specific video about the second messengers
why did the video zoom in so much i can't see~~!!
This is the best video explaining GPCRs out there. Tysm
Except for the zooming error, this video was a spot on. Thank you. I heard that it was called "adenylyl cyclase" though.
+Jai A Meyrick Thanks. I'll have to remember that.
Daniel Bundrick g
Adenylate cyclase
It does the same thing ,but it’s an amplifier enzyme so I think there must be a difference
Adenylate cyclase, adenyl cyclase, & adenylyl cyclase are all the same enzyme. Confusing redundant names, that's science.
Great video! FYI the zoom only lasts for like 30 seconds yall ;)
more like 1 -minute......
It goes from 4:03 to 5:23 for a total of 1:20 or 1 minute and 20 seconds, plus or minus a few seconds.
well with subject like this, every second is crucial, the dude fucked me up
This video helped the concept of G proteins finally click in my brain. Thank you!
Jocelyn Justice go for The Great Dr.Najeeb if you really want to build your concept
This guy taught me better in 12 minutes than my lecturer did in a 2 hour class. Levels, thanks dude.
Or maybe you don’t pay attention😊
Thank you sir, it helps me a lot for my final exam
Thank you so much. I went through my lecture slides, recording but still not understanding a piece of information like you did in 12 minutes. I am so grateful to be here with other students.
Same here, the lecture and audio from my boring lecturer was always inducing sleep
How hours of boring lectures are made into a 12 min riveting knowledge is always going to be a mystery to me #Khanacademy.
Thank You for saving my life btw
This video saves my 1st year as a medical student!!!!! Thank you so much!!!!!
Great clear explanation. I studied this back in undergrad and want to carry out an experiment now in my PhD where I inhibit G-alphaS and see downstream function. I need a quick re-fresher and this hit the spot! Thanks!
I tell you am wid u on this one same here am good to go now😅
I like the way you explain this 5-full-pages theory in a simple way. Thank you! This helps me for my tomorrow exam ehehehe
Greatest video ever. loved it. Thank you for being alive.
MY PROFESSORS COULD NEVERRR. THANK YOUU 🥹🫶🏼
What would I do without Khanacademy?? Great explanation, as always😁👌🏼
Please fix the zooming issue!
You have to change it to full screen, it worked for me :)
@@oxysmoxy1977 doesn't work
for the first time iunderstand the concept of GPCRs. Thank you
Your speech was so clean that despite my poor english i could have understood you well. thank you :)
Amazing I love it ❤❤❤
5:23 continued from zoom out
Brilliant. Really helpful.! Thanks a lot
This helps us so much even if it was made 8 yrs ago
You have just activated my G-Protein awsm Khan Academy Simple Smart and Conceptual what else do we need
EXACTLY what i was looking for!! thank you!!
Thank you for the simplest , you explain better than my professors at the collage and for free
Finally got the concept of g protein ,thanku for this work 👍
Very helpful! Thank you. The visual really helped.
please help me with the kind of textbook
that you guys use
its really very well understood
thank you so much, i learned more from this video than i did in a 2 hour college lecture..
great job . thanks from Syria
wow. so nice. however i haven't understood the connection between the heterotrimeric complexes and the GPCR. Would you explain please? thank you
Thank you, i finally understood this!
WONDERFUL!!! I learned more from this video than my 3-hour-long graduate class!!! THANK YOU VERY MUCH!!!
So good. Worth my time
Made this sooo much easier to understand!
Woow thank u so much, u explained such a hard tissue sooo easily and clearrrr, ur greattt
Excellent explanation!! Thank you
Wow this is SO helpful!!!!! Thank you
i couldnt get the topic on my lecture but now it is all clear! thanks a lot! Thumbs up :)
This is a savior 👏
This video is my lifesaver. Thank you so much!
Any thoughts on fixing this video? It is a wonderful explanation worthy of an unspoiled presentation in true KA style.
Omg! I love this channel
Thank god for Khan Academy
I’m so thankful ❤️❤️❤️❤️❤️ for this video
I'm overwhelmed with joy, I finally passed my NCLEX RN after three trials and I almost gave up until I met this God sent. Please join me celebrate my helper Dr Brooks for his consistent assistance showed to me during my preparations for this exam. If you want nclex to be history to you, contact Dr Brooks via text or whatsapp on +12404085402.
Does the GTP replace the GDP? Or does a phosphate bind to the already-bound GDP creating GTP on the alpha subunit?
Amazing explanation, simple and straight to the point. thank you!!!
Thank you. Absolutely amazing! :)
Helped me through my exams!! Thanks!!
This kind of videos doesn't even deserve 1 dislike ❤️❤️
Way of teaching adorable...
Wish harper's was easily understood as this........
Thank you :) You've made final year physiology a little easier.
what! you were whatching this on your final year?
we read this on first year
Great video ... Alpha-Omega
Informative video... thnx a lot
Thank you so much I am forever grateful.
What an excellent explanation
Doesn't cAMP have to activate Protein Kinase A (PKA) first before those physiological responses occur?
tHIS MAKES SO MUCH SENSE
Thank you very much that’s help me more 🙌❤
Thank you😭😭😭
Great video! Thanks so much!
Thank God for you
Thank you so much for this!
Wow , very well explained 👏👏 i always get scared when i hear g protein coupled receptors (sounds scary right) but now that ive tried to understand its so simple thanks khan academy
wtf man
Cabero lol whatcha sayin‘
too good! 👍🏻
Perfect explanation... thank you alot!
I really thank you sir for this great video, tomorrow I’m taking a physiology exam
excellent presentation. perfect. thanks from Greec
Super helpful video!
Thank you so much for this. Really clear and helpful. God bless you❤❤❤❤❤❤❤
This video was amazing.
I get that the alpha subunit of the g protein acts s a regulaator after it's activted. But wht do the bet and gmma subunits do? Is their only functtion to block the alpha subunit from being activated all the time?
It helps me a lot!! lots of thanks.. it's very clear and simple.
Wonderful and clear! Thank you!
Great video; liked it. But question, can you call the beta & gamma subunits a dimer if they are not identical molecules?
That was a very useful and helpful video
Thanks. I like your hand writing
such a good video and explanation on GPCR. Great 👌👌
Thank you soo much for this video man....
thanku for teaching,its awosome....
Great video! Especially helpful if followed by Moof University's video "PIP2, IP3, DAG Signaling Cascade - GPCR - General Scheme" :)
Great Video! Thank You
Greetings from Sweden! Thanks for a great video! Dont know if it really matters, but it's an adenylyl cyclase (not adenylate) according to my biochemistry book.
Both terms are used. I just checked two of my danish textbooks. Biochem-book says 'adenylate' and Pharma-book says 'adenylyl'. But I also seem to recall that previous english textbooks I've read uses 'adenylate'. I guess it's just a 'cultural' thing, regarding what system you use to name the functional groups.
Both terms are used, adenylyl is kind of an old fashioned name, some of the pictures of researches my lecturer shown us use adenylyl, but adenylate is used in most universities in London as as far as I know.
they use both here at the University of Otago :)
thank you for clearly explaining things.
Thank you! Good video
Thnx for the explaination 👍
Extremely helpful. Thank you!
very good video, thank you very much!
Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists?
Awesome video sir 😍😍😘😘👌👌👌tx sir🙏🙏
Very Helpful explanation. Thank you.
You are awesome! thank you so much!!
Very well explained!
thank u so so much. This video is very great!