It's like Prof Zack actually shrinks himself into a tiny being, drive into the body systems and studies whatever is happening there, comes back and give us a report... Because man this is sooo realistic... How many textbooks would i need to go through to understand this 🥲 God bless you Professor 🙏 You've saved a lot of people in the med sch
Dude, it's a joy to see you explain this, but it's even more of a joy to see you smiling with such passion about it all. I'm smiling with you in equal awe. It's inspiring my man, keep it up.
I'm constantly amazed by the quality of this channel. It's incredible to think that people voluntarily produce better lessons than my MedSchool. Congrats and thank you
I can't thank you enough for saving me comprehending this topic. You've helped so many students around the world and I hope you continue this unselfish act of teaching. Indeed, you're the gift to the medical education.
I am so impressed with your extensive knowledge. AND you are very good at communicating it in a very understandable way. For us auditory learners... all I have to do is listen to your lectures and everything makes total sense.
My pharma lecturer just confuses me, so I seek out your clips and I understand so much better than I did before. Thank you as always for making medical science easy to understand. I have learned so much from you over the years. Thank you again.
Hi man, I'm here for reviewing all important stuff for Step 1. Watched your videos while learning the stuff for the first time and now I'm back. Your channel makes 80% of a medical university irrelevant. Thank you for just being there, holding my back. Couldn't image where I would have been if your teaching skills weren't as perfect as they are.
Awesome video! Just to clarify, A1- in smooth muscles of blood vessels for contraction therefor inhibition and in organs for activating peristalsis such as in ejaculation. In addition to that they increase contraction in sphincters for inhibition, A2- in Beta, Alpha cells of kidneys, platelets, and neurons. B1- in JG cells, Nodes, and Ghrelin secretion. B2- opposite of A1, relaxes in smooth muscles of blood vessels in activated organs for fight or flight. And in organs it relaxes such as to prevent peristalsis. They are also for activation of organs that need to secrete stuff in fight or flight such as salivary glands and liver. B3- is for adipose tissure and bladder only. I hope someone clarifies this. Thanks!
Dude, you are incredibly intelligent. I learn more with you than with any teacher in College. Thank you so much for what you are doing to help us. God Bless!
Holy crap you are the light shining into the dark corners of my brain. You have solved the mystery of the receptors in the body for me. Why couldn’t a rest book simply tell me that beta 2 are inhibitory and alpha 1 excitatory. I cant believe how you made it logical for me. Thank you.
OMG!!!!! Why did they not teach this in my paramedic class!!!! I have a MUCH better understanding of adrenergic receptors now. My new goal now is to change the way paramedic students are taught. If they are taught the why rather than just rouge memorization we will produce much better medics and save many more lives. It makes me SICK when I am on shift studying and I hear a seasoned medic tell me you will never need to know that.
Simply said, you are outstanding in terms of energy and the wonderful way you teach! You are very much knowledgeable and passionate instructor I have ever seen. Thank you so much.
This video is more than enough sir. Your work is helping us here in Africa specifically Sierra Leone West Africa. Please continue to make the world a better place for the less privileged out there. Thank you very much and may God bless you and your team.
I’m a huge fan, currently doing my non medical prescribing course. When the tutor was explaining this my brain started to hurt. You communicate it better.
If I'd found this channel while I was still in medical school my grades would have been a lot better. Anyway happy to finally be understanding these things now. Keep it up!
Thank you SO much for these videos. These are important concepts that I really want to UNDERSTAND not just memorize and you make that possible while also making it interesting, engaging, and fun. As a paramedic studying for critical care, I have found several of these videos to be the PERFECT level of depth. I suddenly understand shock in my patients in a way I didn't before and this has set the stage for me to much more easily understand how various vasopressors work (via another one of your videos of course!). So thank you for producing these, thank you for providing such high quality education for free, and I'm off to check out your memberships because I'd love to support the work you do.
Watta detailed and thorough explanation on why there is a specific location for each receptor! Amazing ! Tremendous patience you have ! It's such a great feeling to find out at the end of each video that it was so logical and easy to remember! Thank you for such wonderful videos! You are a Great Teacher !
I really enjoy your lectures. You are fantastic.I learn from You a lot. Im a beginner in teaching in UNI in Baltic States, so you can say, that your lectures are used worldwide. Please never stop!!!! Best regards, Hedi
Gosh- you are amazing. I have pretty much started watching your videos instead of my class' insanely boring and long lectures then studied my teachers' powerpoints and written material. You make it come alive and make sense. I hope youtube pays you well.
Can’t thank you enough! You’re the only one capable to enlighten my doubts at once, as given me hope to understand all this.Please, keep doing it! You’re the best teacher ever! 🙏🙏🙏🙏
First of all thank you for your wonderful lectures. I think there is a small mistake in this lecture. N.E has higher affinity to alpha receptors than EPI.
I just checked the book, it says, NA is equipotent to Adr, on alpha receptors, but it is shown to be less potent as in the test systems as it is reuptaken faster.
Zviizaks, you are right. N. E. stimulates only the Alpha receptors, 100% Alpha. It has no Beta stimulation at all. Epinephrine has 50% Alpha and 50% Beta stimulation. So it can stimulate both Alpha and Beta receptors. Epinephrine and N. E. are both naturally occurring catecholamines. But there is a synthetic catecholamine called Isoprenaline, which is 100% Beta receptor stimulant. To sum up N. E. - 100% Alpha Epinephrine - 50% Alpha + 50% Beta Isoprenaline - 100% Beta
I find it fascinating how differently human brains are created. I'm struggling to follow along with the general direction of this lecture. But the joy this guy derives from every little detail here is apparent!
I don’t have the words to express how grateful I am for you and your videos. Thank you kindly and God bless you for making this most helpful tutorials ❤
Tommrow I’ll have exam on adrenergic receptors , this video really gave me a much more informations and those new research points ; probably no one in my class knows it actually, it gonna give me extra credits to my exams
Haha my favorite part of your videos are when you fight with your markers 😂… thank you for sharing all your knowledge the way you do! Helps a lot for the visual learners!
bro well done! you earned a new subscriber 3 seconds into the vid! you jump right into it, no time wasted and basically summarized what I hours reading in Costanzo phys book in just 1 hr with a great visual display. thank you!
Omg thank you very much for the amazing lecture that must have been pretty tiring. That has made understanding mechanism of action of drugs related to the ANS much easier. Bless you!
Hi there, I really enjoy your videos. I wanted to mention that activation of Gi protein-coupled receptors leads to activation of phosphodiesterase (PDE), which breaks down cAMP to AMP. You mention inhibition of adenylate cyclase. I wanted clarification over that.
These organs have parasympathetic control and sympathetic control by direct innervation as well. The direct innervation will produce a response faster than the hormonal regulation. So the effect of the nerves will happen first, the hormones second. For example the arterioles controlling the capillary beds are innervated. So are these sphincters. There is no benefit to keeping urine inside in a crisis. Same for fecal matter. They consume energy to keep warm. So you expel them under neuroligical control (instant) and then shut the door under hormonal control (gradual)shortly after. This even explains why epinephrine and norepinephrine act on alpha 2 receptors to inhibit the preganglionic nerves. The hormonal system is taking over from the nervous system. In addition the adrenal glands have much larger amounts of stored norephinephrine compared to those nerves. They would run out of neurotransmitters if their output wasnt suppressed through the activity of alpha 2 receptors. By being surpressed this allows the takeover by the adrenal gland which is better equipped to mass produce these hormones for a prolonged fight/flight. Its important to remember that not only is the sympathetic nervous system helping you win the fight or escape the danger. It is preparing your body to survive the aftermath. Massive blood loss? The kidneys preemptively started preserving water and salt and the hormone that will continue this trend (renin) is s being activated. Renin is not quick enough to help during the crisis but will help after and the earlier it is activated the better. Erector pilli?? Keep you warm so you don't die of hypothermia from blood loss. Central blood shunting? Lose less blood from a wound. Platelet activation by alpha 2? Lose less blood. Ghrelin??? After the battle you need to eat. Its fight and flight AND preparation to survive trauma.m
great video , I particularly like your rational -- when you place receptors at sites with the ultimate goal of flight/fight response --> it makes working from first principles feasible and interesting. thank you heaps
a1 & b1 = Stimulatory | a2 & b2 = Inhibitory. a1 acts on all smooth muscles and organs and glands. (Stimulus, Constriction, Contraction) b1 acts only on heart and JGC of kidney. --------------------------------------------------------------------------------------------- a2 acts to pre-synaptic membrane (Post ganglion). b2 acts on all smooth muscles and organs and glands. (Dilatation, Relaxation)
It's like Prof Zack actually shrinks himself into a tiny being, drive into the body systems and studies whatever is happening there, comes back and give us a report... Because man this is sooo realistic... How many textbooks would i need to go through to understand this 🥲
God bless you Professor 🙏
You've saved a lot of people in the med sch
Dude, it's a joy to see you explain this, but it's even more of a joy to see you smiling with such passion about it all. I'm smiling with you in equal awe. It's inspiring my man, keep it up.
Great explanation. Thank you
Its his passion!
0:00 is where he defines the alpha/beta receptors
14:54 is where he starts discussing the location of adrenergic receptors
Thanks 👍 that was helpful ☺️
finding your channel was hitting the jackpot ! I LOVE YOU
He's a star.
True
What is the mean of jackpot?
@@rayanthabit3489 like big prize
Very true... I m a Indian... And english is not my first language but his videos are still better than my college proffessors....
I'm constantly amazed by the quality of this channel. It's incredible to think that people voluntarily produce better lessons than my MedSchool. Congrats and thank you
I can't thank you enough for saving me comprehending this topic. You've helped so many students around the world and I hope you continue this unselfish act of teaching. Indeed, you're the gift to the medical education.
You are a hero ...
Putting an end to commercial doctors thst dont have time for you.
Wish you health and wealth...keep it up
I am so impressed with your extensive knowledge. AND you are very good at communicating it in a very understandable way. For us auditory learners... all I have to do is listen to your lectures and everything makes total sense.
Such a gifted teacher, and I would say the same is likely for his behind the scenes partners. Thank you so much for your contributions.
My pharma lecturer just confuses me, so I seek out your clips and I understand so much better than I did before. Thank you as always for making medical science easy to understand. I have learned so much from you over the years. Thank you again.
Ditto!
YOUR CHANNEL IS ABSOLUTE GOLD !! your videos were so helpful for my physiology exam!!
Thanks a lot, you are awesome ! just one comment to add at 4.37 it is norepinephrine which has higher affinity to Alpha-1 receptor than Epinephrine.
Not at all epinephrine >norepinephrine
Source? @@clintonodinaka6737
@@clintonodinaka6737 No. The guy's right. It's in the textbooks. NE has higher affinity to alpha-1 and epinephrine has higher affinity to alpha-2
by far the best and most detailed adrenergic lecture I've experienced, even professors in med schools stumble through these
Hi man, I'm here for reviewing all important stuff for Step 1. Watched your videos while learning the stuff for the first time and now I'm back. Your channel makes 80% of a medical university irrelevant. Thank you for just being there, holding my back. Couldn't image where I would have been if your teaching skills weren't as perfect as they are.
Thank you so much! Would love to see more pharmacology content though!
I would say that no one teaches Physiology better than you do! Thank you soooooooooo much!!
What a gifted person. He's probably the ones teaching his own professors!
Awesome video! Just to clarify,
A1- in smooth muscles of blood vessels for contraction therefor inhibition and in organs for activating peristalsis such as in ejaculation. In addition to that they increase contraction in sphincters for inhibition,
A2- in Beta, Alpha cells of kidneys, platelets, and neurons.
B1- in JG cells, Nodes, and Ghrelin secretion.
B2- opposite of A1, relaxes in smooth muscles of blood vessels in activated organs for fight or flight. And in organs it relaxes such as to prevent peristalsis. They are also for activation of organs that need to secrete stuff in fight or flight such as salivary glands and liver.
B3- is for adipose tissure and bladder only.
I hope someone clarifies this. Thanks!
a little mnemonics technique: B1 = Heart (1 heart), B2 = Lungs (2 lungs)
@@paulafunesgroverman5179 nice lol
Dude, you are incredibly intelligent. I learn more with you than with any teacher in College. Thank you so much for what you are doing to help us. God Bless!
Holy crap you are the light shining into the dark corners of my brain. You have solved the mystery of the receptors in the body for me. Why couldn’t a rest book simply tell me that beta 2 are inhibitory and alpha 1 excitatory. I cant believe how you made it logical for me. Thank you.
OMG!!!!! Why did they not teach this in my paramedic class!!!! I have a MUCH better understanding of adrenergic receptors now. My new goal now is to change the way paramedic students are taught. If they are taught the why rather than just rouge memorization we will produce much better medics and save many more lives. It makes me SICK when I am on shift studying and I hear a seasoned medic tell me you will never need to know that.
First year PA student here, you're saving my (academic) life. Thank you for making this material engaging and entertaining!!
Can i save your personal life?
Simply said, you are outstanding in terms of energy and the wonderful way you teach! You are very much knowledgeable and passionate instructor I have ever seen. Thank you so much.
This video is more than enough sir. Your work is helping us here in Africa specifically Sierra Leone West Africa. Please continue to make the world a better place for the less privileged out there. Thank you very much and may God bless you and your team.
You are gifted to teach things that most of the people can't. Thanks for the videos.
CRNA interview today! Lets go! Been binging your videos for months now. Last minute touch ups. Thanks Zach.
I’m a huge fan, currently doing my non medical prescribing course. When the tutor was explaining this my brain started to hurt. You communicate it better.
If I'd found this channel while I was still in medical school my grades would have been a lot better. Anyway happy to finally be understanding these things now. Keep it up!
Why what happened did you get kicked out? Cz if you are already a doctor, you should know this.
Thank you SO much for these videos. These are important concepts that I really want to UNDERSTAND not just memorize and you make that possible while also making it interesting, engaging, and fun. As a paramedic studying for critical care, I have found several of these videos to be the PERFECT level of depth. I suddenly understand shock in my patients in a way I didn't before and this has set the stage for me to much more easily understand how various vasopressors work (via another one of your videos of course!). So thank you for producing these, thank you for providing such high quality education for free, and I'm off to check out your memberships because I'd love to support the work you do.
Been studying for a week pharm drugs and now... in less than an hour... they all make sense! Keep doing what you're doing! Thanks!
You deserve all the success in the world❤️.......GOD BLESS YOU ZACH
Watta detailed and thorough explanation on why there is a specific location for each receptor! Amazing ! Tremendous patience you have ! It's such a great feeling to find out at the end of each video that it was so logical and easy to remember! Thank you for such wonderful videos! You are a Great Teacher !
Brilliant! You turn the complicated things into the simple ones.Your passion brings mine back to life! Thank you a lot!
I really enjoy your lectures. You are fantastic.I learn from You a lot. Im a beginner in teaching in UNI in Baltic States, so you can say, that your lectures are used worldwide. Please never stop!!!! Best regards, Hedi
I know ive said this before in previous comments, but THANK YOU for providing such amazing lectures. You have a real gift!!
this is going to save my pharmacology module grade THANK YOU
Soo easily clear in my mind, amazing tutor by Dr.Zach
From INDIA 🇮🇳
Thank you!!!! You are doing an amazing job for medical students!!!!!
Gosh- you are amazing. I have pretty much started watching your videos instead of my class' insanely boring and long lectures then studied my teachers' powerpoints and written material. You make it come alive and make sense. I hope youtube pays you well.
Can’t thank you enough! You’re the only one capable to enlighten my doubts at once, as given me hope to understand all this.Please, keep doing it! You’re the best teacher ever! 🙏🙏🙏🙏
First of all thank you for your wonderful lectures.
I think there is a small mistake in this lecture.
N.E has higher affinity to alpha receptors than EPI.
I just checked the book, it says, NA is equipotent to Adr, on alpha receptors, but it is shown to be less potent as in the test systems as it is reuptaken faster.
Zviizaks, you are right.
N. E. stimulates only the Alpha receptors, 100% Alpha. It has no Beta stimulation at all.
Epinephrine has 50% Alpha and 50% Beta stimulation. So it can stimulate both Alpha and Beta receptors.
Epinephrine and N. E. are both naturally occurring catecholamines. But there is a synthetic catecholamine called Isoprenaline, which is 100% Beta receptor stimulant.
To sum up
N. E. - 100% Alpha
Epinephrine - 50% Alpha + 50% Beta
Isoprenaline - 100% Beta
Sir .... I don't have words.... Literally... You are genius....
Love from India❤️❤️❤️
I find it fascinating how differently human brains are created. I'm struggling to follow along with the general direction of this lecture. But the joy this guy derives from every little detail here is apparent!
I don’t have the words to express how grateful I am for you and your videos. Thank you kindly and God bless you for making this most helpful tutorials ❤
You know this content in and out! Thank you, thank you and thank you for sharing!
Good quality content and rich detail, nice drawing skills too! I'm studying for the ACEM primary and this stuff is gold.
This is better than my current medical school lecturing 🥰🥰
Tommrow I’ll have exam on adrenergic receptors , this video really gave me a much more informations and those new research points ; probably no one in my class knows it actually, it gonna give me extra credits to my exams
Haha my favorite part of your videos are when you fight with your markers 😂… thank you for sharing all your knowledge the way you do! Helps a lot for the visual learners!
bro well done! you earned a new subscriber 3 seconds into the vid! you jump right into it, no time wasted and basically summarized what I hours reading in Costanzo phys book in just 1 hr with a great visual display. thank you!
Thank you Ninja Nerd. Your videos are making a huge sense in my education.
I really can't explain how much of a lifesaver you are. Tmrw's a test and this helps me so much than reading just the textbook!!
You are one lucky person if you have this guy as your professor. I am like a sponge whenever he speaks
There has been no one that have been this useful for medical students in the history of college of medicine .
Amazing lecture. Thank you, friend. (A depression patient always interested in deepening his understanding of the brain!)
Fantastic lecture! Please keep them coming.
Excellent fight or flight organ recital! Perfect ending with how chronicity effects dangerous risk factors for emboli…😎👍
The video is amazing, everything is dealt so lucidly and precisely. Heartly reverence to ninja Nerd Lecture for such great content.
From the bottom of my heart
Thank you 🫶🏻
Thank you for such a wonderful video! You are a Great Teacher ! We really need teachers like you !!❤
Your are gifted to be such an impressive extraordinary teacher🌟🚀🥇 and I am also gifted to find your channel ❤️❤️
thank u! finally understood and cleared my confusion.. love your videos!
Omg thank you very much for the amazing lecture that must have been pretty tiring. That has made understanding mechanism of action of drugs related to the ANS much easier. Bless you!
Loved it. Your videos have helped me pass biomedicine exams! 🙌
Nice video!! Way you explain one thing after other in perfect sequence is best!!
Beta 2 receptors for the heart/ sympathetic system? My professor said Beta 1 receptors for the heart. Beta 1 for the heart and beta 2 for the lungs.
It has both and Beta 1 .. I think he forget to write it
You are a great teacher, keep it up.
Your lectures give us inspiration ! 🌷
Let us all take a moment to appreciate how that heart was perfectly drawn haha
I’m glad that I found out your channel. Thank you so much for very clear explanation
You are saving my life! Thank you so much from a grateful medical student :)
I am soooo thankful to you and your team for this video bc I was having a real bad time understanding this during my class!
These videos are gold!
Thank You Zach! Thank You Rob! Thank You Kristen!
Thank you Zach you are a boss! Happy New year to you and your family
This is awesome! Side note: that would be great if you could put timeline of your videos in description .
Many thanks for your time and effort. Very easy to understand, Your notes are very helpful as well.
I've learnt so much, a lot of my pharmacology is making sense, thank you so much NNScience!
Thank you so much for the lectures. They really benefit us alot
Thank you so much for the great effort that you put all the time.
Very useful in making clear concept throughout medical studies and also after that ... Thanks urgr8...
Wow. You have made this concept amazingly easy. Asante sana!😊
You absolutely an excellent teacher. Thank you so much.
connecting knoweledge througout the world! thank you so much for existing 😍
May Lord bless this man the happiness of the entire world , THANKYOU SIR❤😭
Best video over receptors explanation. Watching in 2024
U r true hero ...our life saviour.. thanks a lot man
i wish i knew you when i was in med school You are extra ordinary and your videos are helpful more than you think
Hi there, I really enjoy your videos. I wanted to mention that activation of Gi protein-coupled receptors leads to activation of phosphodiesterase (PDE), which breaks down cAMP to AMP. You mention inhibition of adenylate cyclase. I wanted clarification over that.
I would love to see more pharmacology content from you! Thank you for this: )
your videos are gold. thanks man! stay healthy and safe
I have a question. If sympathetic system inhibits micturition and defecation then why do some people go to pee or defecate in stressful situations
Same doubt
These organs have parasympathetic control and sympathetic control by direct innervation as well. The direct innervation will produce a response faster than the hormonal regulation. So the effect of the nerves will happen first, the hormones second. For example the arterioles controlling the capillary beds are innervated. So are these sphincters. There is no benefit to keeping urine inside in a crisis. Same for fecal matter. They consume energy to keep warm. So you expel them under neuroligical control (instant) and then shut the door under hormonal control (gradual)shortly after.
This even explains why epinephrine and norepinephrine act on alpha 2 receptors to inhibit the preganglionic nerves. The hormonal system is taking over from the nervous system.
In addition the adrenal glands have much larger amounts of stored norephinephrine compared to those nerves. They would run out of neurotransmitters if their output wasnt suppressed through the activity of alpha 2 receptors. By being surpressed this allows the takeover by the adrenal gland which is better equipped to mass produce these hormones for a prolonged fight/flight.
Its important to remember that not only is the sympathetic nervous system helping you win the fight or escape the danger. It is preparing your body to survive the aftermath. Massive blood loss? The kidneys preemptively started preserving water and salt and the hormone that will continue this trend (renin) is s being activated. Renin is not quick enough to help during the crisis but will help after and the earlier it is activated the better. Erector pilli?? Keep you warm so you don't die of hypothermia from blood loss. Central blood shunting? Lose less blood from a wound. Platelet activation by alpha 2? Lose less blood. Ghrelin??? After the battle you need to eat.
Its fight and flight AND preparation to survive trauma.m
Some of the things Ive learned from ninjanerd: Lincoln log, doo doo hole, Hershey squirt
U hav a gift to teach beyond words🤩
You are the best. Better than my profs at med school for sure.
Watching from nepal, i loved it, a beautiful and clear concept .
great video , I particularly like your rational -- when you place receptors at sites with the ultimate goal of flight/fight response --> it makes working from first principles feasible and interesting. thank you heaps
God blessed all of us giving u to this world, thank u guys, u r lifesavers
you are just a star, i am getting ready for second year, thank you
You got this! - TG
a1 & b1 = Stimulatory | a2 & b2 = Inhibitory.
a1 acts on all smooth muscles and organs and glands. (Stimulus, Constriction, Contraction)
b1 acts only on heart and JGC of kidney.
---------------------------------------------------------------------------------------------
a2 acts to pre-synaptic membrane (Post ganglion).
b2 acts on all smooth muscles and organs and glands. (Dilatation, Relaxation)