Dr. Sinclair’s New Theory of Aging, Explained.
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- Опубликовано: 21 июл 2024
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#drsinclair #agingresearch #healthscience
![Fasting and Overeating - How you Change your Mitochondria. [Study 32]](http://i.ytimg.com/vi/KQBmtzT4VTU/mqdefault.jpg)
Petition for a video on demon possession and longevity in mice.
No problem. :)
😜
Sinclair is just into making money as far as I am concerned. I now ignore everything he says.
He touted resveratrol which was discovered in 1939, pumped it as effective, and then dumped it through his private manufacturing and sales company. Now more research has questioned it's efficacy.
NMN, he seems to have done the same. In the case of NMN, I believe he has successfully got FDA involved so to gain exclusive rights to the sales of NMN. He's using the Harvard brand to publicly promote research which he then turns into private profits.
We've just got a slicker snake oil salesman now. But it's the same game. Miracle treatment for sale at a "cheap" price.
Fool me once shame on you. Fool me twice shame on me. I'll wait for reputable researchers before I buy what he's pumping and dumping.
@@Physionic so, what happened with mouse who ate toxic drugs which damaged DNA? And what happened after that mouse became grayed forever or reverse his age?
Where is the line to get my micr demonically poessed
I'm glad to see you give credit to how hard molecular biology is. When I was in undergrad for biology, it was the most challenging course.
This is a fantastic study and thanks for your breakdown analysis. I totally agree - and this now explains past studies that indicated that only 5-10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90-95% have their roots in environment and lifestyle eg smoking, diet, alcohol, UV, pollutants, infections, stress, obesity, physical inactivity. Looking fwd to more on human studies too and your analysis. I will share this with my friend who is a genomics principal scientist.
100%, I thought everyone knew that most cancers are caused by external means more so than internal aspects like your family genetics.
thanks for sharing. somehow someday, this information is going to fall in the right hands. maybe not for you or i, but for the bettering of humanity!
" and this now explains past studies that indicated that only 5-10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90-95% have their roots in environment and lifestyle " This is nonsense. The Study never explain this.
@@markiv2942 it is based on previous research long before this one. It's actually old news made new
Look into the Warburg effect and the metabolic theory of cancer. Two good books are Sam Apple's 'Ravenous' and Travis Christofferson' 'Tripping Over the Truth'. This was understood going back to before WWII, but research over time has brought ever more supporting evidence and explanations of causal mechanisms.
Put a lot of work into this one - hope it’s clear and informative. If you have related questions, feel free to ask.
Also, I know nothing about the NMN situation and Dr. Sinclair. This is merely an evaluation of his largest scientific work.
firtst thanks, second i would like to ask you can i make IPSCs research at home to make reverse aging, Just i would like to be reverse aging to be my home game
These new videos that you breakdown the science are the best!! Please keep doing it!!
Thank you, Draziell! I've been working hard over the last several weeks to improve the quality of my work. Much appreciated.
This was fantastically presented. Thank you for the information presented in a clear way.
Kind of you, Ivanna. Thank you.
Concise as always, highly informative, captivating delivery and graphics. Great video
Thanks, Mark - always thankful for you!
Great video mate, you definitely have a unique style amongst the many health youtubers. Keep up the good work!
Thanks!
Your presentation was outstanding. Just as my head began to hurt, you injected a bit of comic relief, then got right back into it. I appreciated the conclusion where you informed us that we should keep doing what we already know we should be doing to maintain our health. As is your practice you left me wanting more, much more.
Thank you, Wilmer. I appreciate the feedback, too. Hopefully your head doesn't hurt anymore.
These subjects are soo hard to explain, even to stem field students. I admire how you wanted to share this information in a more "people in general friendly" manner. Amazing how many aspects of aging is in our hands. I wonder how technology, if any, have a impact in our epigenome, the constant use of our phones and social media I think can make a impact in some way. what a great video
Hey, thanks. Kind of you to say.
In what way can it be impactful? How is technology gonna change anything in our epigenome?
@@milesmorra5910adrenaline and stress maybe?
Wow fascinating! Thanks for the breakdown. Love your videos
Finally a very clear explanation of what an epigenome is for me!
I wish all of my college professors were as humorous as you are. I appreciate your clever and concise delivery!!
Very understandable summary of dr Sinclair's new theory. Thank you!
You're very welcome!
Thanks I was looking for this kind of video instead of those shorts spitting the title of the article at you and leaving you mostly confused haha. Really great to have more context.
Thanks for covering this topic and David.
Thank you for chiming in, Griffin.
It's been pretty well understood for a while now that getting the wrong histones in a cell for that cell type is a major cause of aging, especially as it relates to health span. Epigenetics is very important.
Brilliant break down of the study mate fascinating stuff
Thanks, Jonathon - hope you've been well.
Great presentation as always nicolas. It makes sense now that the "epi-" in front of genetics meaning on top - may actually refer to these "tags" you refer to.
I am always ambivalent on topics involving NAD precursors supplements. While my biochemistry is admittedly pedestrian, there appears to be perplexed findings on their use on present literatures (particularly B3/NMN/NR and or even Metformin). Perhaps food for thoughts in the future?
many thanks. live-it-forward, AW.
Thanks, Andrew.
It seems to be a hot topic at the moment, which is why I released a poll to the Physionic Community to see if people would be interested in me covering it. I’ll have to spend some time on it, we’ll see.
Thanks, as always!
Very nice explanation. Thank you!
I just subscribed to your channel after watching this video. I will also try fasting. Thank you so much 😊
Thank you, Praveen - kind of you. All the best!
This is the first video I've seen from you. Great stuff! Also, I begrudgingly acknowledge your "cell-ves" joke
Thanks, Kyu-Hun. 😋
Thank you, Nicolas, one of your best reviews!
Thank you!
Fantastic summary. Thanks!
Thank you, Paulo!
Impressive analysis of the study, and so easy on the eyes, what a blessing
Thank you for the summary!
My pleasure!
Interesting educational and understandable....PERFECT...thanks much 🎉
Glad it was helpful!
Excellent video, sub'd. Great presentation and explanation
Welcome aboard!
Linking the study in the bio would be great!
Rumour has it that only three mice were used. In addition to visibly increasing their ability to run (in two separate observations) and reversing their blindness, it was also found possible to regenerate their tails, which had been surgically removed in an agricultural confrontation.
Clever, StepDub.
fascinating!!!!! even knowing how of an effect methylation has on gene expression after damage it would appear fixes to our "software" will be super beneficial in a variety of ways not just for aging
Also, what about the phenotype of that ICE+OSK mouse(mice)? did they get rid of that grey hair in the slightest? became more sturdy and frisky after applying Y F?
There is a key detail about the yamanaka factor, that is important to know: They just used 3 of the four available switches and this has to do with the devastating consequenses, you mentioned at the end of your video.
Highly underrated comment
Has Sinclair not been shamed out of science yet, as a low rate salesmen? He sold his research for a huge sum to GSK which then couldn’t be replicated by any of the other researchers. which tells me he had bias and ego leading his research. He also lied about other researchers not consulting him before they started which was not true. I take everything from that man’s mouth with a pinch of salt! Love your videos though 😊
I've been taking NMN for a while now. Do you have specific thoughts on this supplement?
What I would love to see from you is a stack of 'anti-aging' supplements and some research on why each are chosen.
Literally just finished a script on exactly that.
@@Physionic Hallo. It means that we must buy your Script? Or, can you put it Video wich supplements is ok? You was made very nice Job, thank you for that, but please, where is a solution? Is it too much to say this? Thanks Man. Best regards.
@@bokigitara1 Pretty sure he means a video script (free)
So 20 years ago after the phase of speaking of telomere shortening, I came across another method of anti-aging. This method had to do with senescence cells. Cells that live on are the benefactor of a statistical probability of more and more senescence cells become populated so that aging processes are pretty standard at a specific age because the senescence cells gain a higher and higher percentage. So what the researchers did was find a method of killing the senescent cells leaving the regular cells alone. They did this with two drugs. One drug was quercetin and the other drug was Dasatinib. A powerful leukemia medication. The dosage was quite high to human standards and the mice responded very well and in some cases doubled their life expectancy. This experiment was not carried out on humans you can imagine. It would be interesting to dose myself with this cocktail and may some day try it. People quadrupling their Dasatinib intake had problems of anemia and other effects as they were fighting chronic leukemia, cll, and did not at the same time in any case take quercetin. I would need a 400 dollar dose of Dasatinib and half a bottle of quercetin. This might be extremely life threatening. But when exposed to flue or covid many more cells are killed by the infection than this, But one has no idea what your personal lethal dose is.
Your content is very nice, thanks. And I hope you download the latest content of Dr. David Sinclair.❤❤
400+ videos and I found you today ?
Amazed with the horrible RUclips suggestions/algorithm despite searching for health based videos all the time.
Well, abc - to be fair, I actually had about 800 videos up and took half of them down, because they were horrible quality. While I'd love to get more exposure, I should blame myself for sticking to antiquated ways of creating videos. It seems things are picking up since I've defined my style a bit more. I appreciate the kind words!
@@Physionic I loved how composed, articulate, calculated speech you have ! Accurate pitch, intricate details, everything is phenomenal! I wished if you had Phenomenal as your channel name instead of just Physionic.
Best wishes from India !
(Btw, you have a gorgeous smile as well. I hope this doesn't sound creepy).
The Epigenetic cause of aging has been shown in multiple ways. Working with fish, this evidence has become more specific. Even perfect RNA cannot make protein/peptides/hormones without having all necessary amino acids. The current evidence points to a lack of amino acids due to changes in the microbiome. It looks like their may be a universal overgrowth of parasitic bacteria over time. Humans can have trillions more of specific gut bacteria as they grow older. After all, old people appear to be starving...
Where can I read these studies on the microbiome's impact on health? DOIs would be appreciated
@@chosenrubric7308 Links keep being removed... Epigenic cause is now a standard view. I do post on Quora!
" old people appear to be starving"
Great comment. I'm using Mott c for better mitochondrial metabolism and supplement with EAAs, do weight training and go cycling three times a week for 30 miles or so.
With aging, I think the common denominator is mitochondrial dysfunction. As someone in her 60s, on no medication, working to keep muscle mass, and a body fat lower than 20% in the 17% range in fact, I'm going to tell you the struggle is real. I definitely feel slower now than I did in my 20s.
And I agree that the focus should be on mitochondrial health and DNA protection, after studying this for about 40 years.
@@tracymullane8818Yes! At 60, I'm not seeing the quick results of diet and exercise that I did when I was in my 30's and 40's. It's requires so much more work and time now!= even more self discipline, no cheat days.
Great study, but honestly I would rather age than mess with my 😢dna, I swear by saunas and fasting for maintain a youthful appearance 😢 would you do a natural follow up on aging looking at what I’ve mentioned plus other scientific backed research 🔬
Great video, thanks. So the primary takeaway is that David Sinclair has demonstrated that epigenetic damage is more likely to be causing gradual aging than gene damage.
The secondary takeaway is that Yamanaka factors can potentially reverse some of this epigenetic damage, but are too dangerous to use, presumably because if you overshoot, you end up converting everything to stem cells..?..
So, a few questions:
1. How were the Yamanaka factors controlled in the experiment, so as to unwind the epigenetic damage without damaging the mice?
2. How will this affect the direction of research? Will it focus on how to safely use Yamanaka factors, perhaps by only using some of them? Or are there other methods that show promise?
From reading some of David’s book I can provide some explanation from my basic understanding:
The expression of the Yamanaka factors in mice were under the control of an inducible drug like seen with the expression I-Ppol in the ICE mice.
In mice where there was constant over expression of these Yamanaka factors it lead to the development of benign tumours and actually decreased the lifespan of the mice. Studies now are essentially looking at how they can find the happy medium, where you get the amount of Yamanaka factor of expression that can reduce hallmarks of aging while not developing these benign tumours.
In one of David’s studies, they removed 1 of the 4 Yamanaka factors they believed were causing benign tumour development. Using this strategy, they managed to successfully restore optic nerve damage in mice.
I imagine all going well in the future all going well with these studies we could deliver these Yamanaka genes to cells through a virus a trigger their expression when needed with a drug to possibly reverse aging and help restore movement in people with paralysis
@@killianscanlon7031 Thanks for the reply. I've since read David's book, so I'm much more informed than previously. And yes, the optic nerve damage reversal in mice was very impressive. The research involving utilizing the Yamanaka factors is going to be a long research path, but it promises to be able to arrest or even reverse many types of aging rather than slowing them down as most currently available interventions do (not that that's a bad thing though).
awesome review
Thank you!
What anti aging supplements are ineffective?
When was this experiment done? Thank you!
Specific actionable takeaways or suggestions would be helpful.
The content was dense but you speak clearly, talk slow, and have a very calm demeanor so it was easy to digest. Awesome video!
Thanks, Tommy!
New to your channel and already subscribed. Is there any research into the benefits of peptides outside of Russia?There are some with claims of enhancing epigenetic expression and even extending telomeres, Aloha.
Avoiding radiation? I am physics teacher and one day one day looking at a Wilson Cloud chamber i was surprised at how much activity i was see since there was no radioactive source in it.its background radiation mostly cosmic rays. This led me to consider is there something we could do to reduce reduce it. Surround the house with water not possible but what about something that is 50% water. Trees shrubs and climbing plants
Good summary of similar videos.
So is increasing/maintaining NAD levels in the body is still a valid strategy to promote longevity?
❤ love what you do..live well sir
Not sure why the downregularion of yh2ax means the damage was fixed. Explain maybe, how long is this expressed after DNA damage? Maybe it's only after acute damage but then is downregulated over time.
Fascinating.
Fascinating indeed! Can I ask questions?…
Firstly, your brief mention of a virus compared one with genes. I wonder if you could elaborate?… Are they something like a program that gets recreated by the cells?
And secondly, does epigenetics refer to gene expression, or not? I didn’t know about the tags and I’m wondering about their role. Is “irregular genetic tagging” a definition?…
The dog behind the laptop looks too familiar... Almost embarrassing
P.S. the presentation is impeccable.
we will live for ever
How big of a roll does epigenetic tagging play with cancer versus genetic mutation. I worked as a health physicist and our story was the cancer being caused by generic mutations. But the fact that many people get the same types of cancers means it could not be due to strictly random mutations. Epigenetic differences could be a better explanation for how cancer types are so reproducable.
The rate of genetic mutations in an organism, especially the rate of somatic mutations, scales according to lifespan in different species (a mouse's rate of mutations is many times higher than a human's) and the background rate of somatic mutations is the same from conception to death, no changes with age. So it is very much a feature not a bug, the damage is under way from birth (or before) and once the mutations are present in the body they are pretty much there to stay. They are a main driver (though not the only component) of aging. These mutations' accumulations in virtually every part of the body are a main cause of loss of organ reserve, immune dysfunction, and of course, cancer.
CRISPR therapies could potentially address these eventually (since virtually all cancer is a result of these mutations as well, there's plenty of research in this direction) but until something can effectively revert these mutations to their original state, all the epigenetic reprogramming in the world isn't going to budge our maximal lifespan much or at all. It also stresses the importance of doing all you can to reduce your DNA damage rate from as early an age as possible.
Would you consider a video on a common age associated disease such as osteoarthritis?
I'd be very interested to know effect diets (such as anti-inflammatory, sugar-free)
Supplements (collagen, UC-ii, boswellia, glucosamine, vit d, turmeric, etc)
Red light therapy
There's a lot of information online. But I wonder how much is back by science.
I'm desperate to help my mother who is struggling with hip pain from osteoarthritis
Sure, as with almost all suggestions, I'm extremely excited to tackle any of the topics, but something like osteoarthritis in relation to all these supplements and diets would be about 6 months of full time work, which I can't afford to do.
However, in my Dr. Stanfield video I expect to release in a few weeks, I do discuss osteoarthritis and a few potential treatments. I hope it'll help!
@Little Voice
I'm gambling on that strength exercise and some supplements will keep my joints healty. So far (age 74) it has worked.
Magnesium, at least 250 mg.
Vitamin D3 5000 IU (125 ug).
Vitamin K2, MK7 400 ug.
Hydrolyzed Collagen 4 g.
You might belive that Calcium and Phosphorus are more important. But I belive we get enough of those from food.
Joints are repaired very slowly. So I wouldn't expect much change in a year.
Glucosaminesulphate increases the synovial fluid, and that might make a more rapid perceived change. Although no one has proved that it actually repairs anything.
Collagen tastes terrible, as all isolated amino acid does. And nothing hides that taste!
And capsules are too expensive.
I wonder if putting it into a gelatine cube flavored by some berries would work.
I developed a flair up of OA last year out of the blue in my left thumb. Sharp, stabbing pains and development of calcium deposits causing the start of disfigurement. I researched what could cause it, medicine doesn't know. I called bullshit. I researched what triggers the immune system and what calms it. Found studies on PROBIOTICS that were stopping OE of the knee. Have her take Lactobacillus strain Shirota. It's in supermarkets and is called Yakult. It's those little bottles of fermented milk. It's delicious. It causes antiinflammatories in the gut. That and i bombed my gut with huge varieties of PROBIOTICS. I also cut out cottage cheese and cow's milk and THE OA STOPPED COLD. It took a few days but it almost totally disappeared and stayed that way.
Exceptionally clear.l
Great - thank you, Robert.
A huge part of aging is bluntly said, laziness, lack of exercise doin less and less. the couch and watching tv are silent killers
I'm wondering if liposomal distribution of the Yamanaka factors has been tried.
As a 23 year Firefighter/Paramedic, with all the toxins I’m constantly exposed to, along with the lack of consistent sleep, this tells me I’m screwed. Great info to know, though. Thanks for putting this kind of cutting edge material out. It’s very informative and much needed.
Your service doesn't go unnoticed, and hopefully some reversal can still be had. Thank you, Brian.
@@Physionic Thanks, brother. I know that watching informative videos like yours helps me better repair the damage that can be done to my health on the job. And, with knowing much of my genetic makeup, I’m able to better optimize my methylation with certain vitamins like B-12 and 5-MTHF, along with taking high doses of important minerals like magnesium and other essential nutrients.
Thanks for your very informative content. I always look to forward to learning more about what my brother and sister firefighters can do to better preserve our health, so I appreciate you sharing your wealth of knowledge.
Get a new job
@@michelles2299 Someone has to do the job.
Take heart in knowing that at least one study claims to have found that fire-fighters live longer than most other people; for some reason.
I like the demon possession theory of aging.
Implies that all we need to live forever is an exorcist.
I believe it has to do with the thymus gland shrinking
is there a traduction somewhere ?
How's your healthy diet progressing? In 2022, you shared some plans. Will there be a 2023 update?
Oh, I switched to gaining weight back in October or so. I'll be slimming down again in March or April. I may make another video in that series, but it isn't high on the priority list.
Epigenetics is still a new word, a new idea for a lot of us, I just heard of the word about a year ago ,it fits in with many of our beliefs ,whether science or religion, a healthy lifestyle and healthy beliefs and memory leads to a healthy future, the memory part is in your young stem cells, that your parents forgot to freeze ( cryogenics) when you were young born, if you want to stay young, think young, how do you think placebos work, a positive mind is a young mind, Epigenetics, your genes are carryovers from your grandparents ,ancestral and environmental, The environmental part and that of the mind included, brings us closer to moments of notice to change in epigenetics, What is the epigenetics of a virus in terms of time compared to us humans, viruses are us, evolution, nature and memory, and then there’s biology ,virology and gene editing, we can actually tweak epigenetics in our favor, but the virus is faster, mutation, that’s epigenetics in a heart beat, you can’t beat nature, you can work with it, it’s in the genes, memory, fractal memory, does the spike carry the memory of the whole virus, mRNA to the host cell? Your playing epigenetics when you take the vaccine, pay attention to the telomeres, epigenetics
Word salad gobbledygook
The complete opposite of word salad gobbledygook. All of what you mentioned is being shown in research. Not only do microbes have their own epigenomes and, because of their short lives, make changes more quickly. Indeed, viruses are amazing organisms. Also, microbes have been shown to alter the human microbiome. It's a complex web of factors. And it has affect on every aspect of the human mind-body. The microbe reuteri, for example, alters neurocognitive functioning related to oxycontin. And it's only been recently that reuteri has disappeared from most Westerners, having been central to mammalian evolution. Considering that both epigenetics and microbiome get passed on, it's clear we are on the edge of a scientific revolution. Some of the research on transgenerational epigenetics is mind blowing, where certain behaviors (e.g., being trained to jump in response to a specific scent) have been demonstrated to pass across upwards of 7 generations of rodents.
Are we closer to longevity escape velocity?
Ran into Dr Sinclair while in line for Dinosaur at Animal Kingdom on NYE.
Did he look young;)
that was good , but we need an up date, on his book, I was hoping for more info. so far there has not been enough info of the influence of excerice and the interaction of the eppgentic system, and sirutins ,revitalization, ie muscle development influence on the systems, and protein, the mice ran there ass off ....and so do I....(bike ride)....and whats is now the roll of Revertrol
What do you take?
Thanks!
Thank you for the generosity, Richard!
I'd like to see more information on why we can't use the Yamanake factors ourselves?
That's a great question, Nick.
The reason is because if all of our cells were to be introduced to Yamanaka factors, there can be potentially scary side effects, because these factors make the cell go from an "adult" cell back to a "baby" cell. I'm simplifying, but they essentially revert to a less mature version of themselves, which can mean the cells no longer function the way they are supposed to, or may not develop the way they are supposed to (because the maturation process takes many inputs). So, it's a risk. Would it be possible in the future, when we know more, or we can have more control over these factors? Sure. But, for the time being, we don't have enough information.
This 44-year-old man with a bad back and knees is cautiously optimistic.
IV-therapy NAD+ has really helped me though.
Hang in there. :)
Anyone knows how these Y T F (Yamanaka transcription factors) work? I mean what do they do, mechanistically? If they remove wrong epigenetic tags and (I assume) add original/healthy/correct ones to a) curb incorrect gene expression b) re-iniciate a robust/right/base gene expression - then- how do "they" (these 3 proteins) know how to do it? I mean how do "they" know which tags are supposed to be corrected? "they" must reach for some kind of a base "template" where that information is being stored...
They're expressed and generate a set of proteins that act as signaling molecules (known as transcription factors) that bind quiescent genes, leading to their re-expression. These downstream genes are related to stemness, an earlier stage of the cell's development, thereby reversing the cell's "adulthood" and reverting it back to being a "teenager", or beyond.
Then, I'm not understanding the question. Can you re-write it, Albert?
If the DNA sometimes makes a mistake Could it not be due to a nutritional deficiency factor?
Loved the humor :D
Thanks, Vincent. :)
@@Physionic Ha! No please don’t give up your day job, great to add some humour still 😊
Did NMN do the same thing?
Did i just hear Tamoxifen right? Dunno if there's another drug called Tamoxifen, but the one i know, is an estrogen inhibitor.
And if that's the case, this would make youth pretty much available for everyone, since Tamoxifen is a widely spread and used drug in the industry.
Can someone clear things up for me on this one, please?
Thanks for the excellent breakdown. It was very interesting, indeed. I wonder what will happen when ageing becomes reversible. Imagine what would happen to the world's population. Or will the magic only be available for the happy few? Food for thought surely! Keep up the good work!
I think we have to make sure this kinds of technology become widely available for everyone once we create it bc the rich are going to get greedy.
Earth is vast. Technology will allow us surface dwellers to go inner earth, conquer more surface space and to go off planet creating more space.
Well then the super rich will rule forever with their advanced private armies and death among the lesser riches will mostly occur by defenestration.
If Sinclair belives that he can make mice younger. Why does he have to damage them first?
Why not just make naturally old mice younger?
And if he damage some mice and repair them. Does they live longer than damaged but not repaired mice?
I like these thoughts, well done!
Because he wanted first to know if DNA damage causes aging by mutations or not and after this he tested if he could reverse there aging by OSK because he used OSK before and so it was more like an by product and not the main goal
I haven't seen if you commented on Bryan Johnson or Dave Asprey. Neither of these 2 guys look very healthy to me. I have followed many good recommendations from the Bulletproof Diet for a long time except nootropics. I would love to see what you have to say about these guys recommendations.
Great !
sinclair has me researching constantly in my spare time about longevity. Theres not a TON of things you can do, but ive come to the conclusion that carnivore diet, and exercise is the best thing for now
he never said carnivore is good
Sinclaire literally said you need to LOWER protein intake for longevity.
@@Unbelishitable that is based on mtor response
Would love to hear more on point 2. I mean it seems obvious to me the basic nut has been cracked and it also seems silly a 98 year old can't just roll the dice if he chooses to do so, but that's what regulatory capture will get for you. Gotta love corruption!
I have not read into this topic for a few years but i thought one of the ageing concepts was the free radical ageing theory? 1:24 free radical damage causing the cancer in the first place
The idea that epigenetic change has something to do with aging is of course immediately suggested by the existence of all those epigenetic clocks.
Why would Yamanaka factors not be made available in a CLINICAL setting? I understand that ODing on them would turn you into something out of a John Carpenter movie, but surely we could use them with proper medical supervision.
By the disasterous effects you mean possibility of causing cancer by Yamanaka factors? There's one more thing that intrigues me: I've read about using stem cells in an experiment of fixing a nerve tissue damage in mice. AFAIR it was successful, it was like 10 years ago and it was the last time I've read of anything similar. Nothing about testing that on humans. Did something go wrong? It's understandable that promising studies are published to increase funding, which is great. But what happens next? It just doesn't work, or are there other difficulties to overcome? I'm just curious.
Is this regarding cell DNA or mitochondrial DNA?
Cell.
Is this new data discovered since the publication of Sinclair's book Lifespan?
Yamanaka tried hundreds of factors affecting the epigenetics, before finding the four which compleatly reverses cells into stemcells.
Now when we want to reverse epigenetic aging less drastically, it might be interesting to look more closely into what all those other factors does.
I'm always wondering how systematic epigenetic changes with age is. If it's chaotic, it would be difficult to control aging with it.
How about finding factors which doesn't reverse epigenetic aging. Instead, factors which slow down further changes, if any such factors exists.
It still boggles me that these Yamanaka factors can somehow revert the epigenetic information back to the correct status. I can image a complete erase or something but how does the cell know the correct youthful epigenetic configuration?
Did you ever read about Tsutomu Yamaguchi? He received radiation poisoning from both bombs dropped on Japan at the age of 29. He lived to be 93.
13:35 summary/takeaways
15 minutes AND heavy molecular biology??? That's gold!!!!! lol
Ride the spiral till the end,
we may just go where no one's been
So it's not telomere shortening that ages you anymore?
Its also telomere shortening
Yes, it’s a combination lock that needs to be opened and it’s telling mirrors for sure DNA damage, mutations, and cellular damage, mitochondria dysfunction. Old age disease is the worst thing I’ve ever seen.
You are going to make a great Dad with your jokes 😅
Your exposition of Sinclairs ideas and approach is very clear.
I like to see more from you with this quality.
The thing I wondered about is how equal the epigenetic changes of aging and the experiment were.
And how equal the result of "repairing" those was to the none-aged ones was.
What's unclear to me is if the epigenetic clock is a systematic change. Or if it's just a gross chaotic change in one direction.
So, a video about that would be appreciated, if this is someting the researchers even know. I suspect they don't really know, or they would have been more clear about it.
I noticed that you said nothing about that the mice being treated with anti-aging looked younger. And if they lived longer than damaged mice which didn't receive treatment. (Of course there would be some of those?)
Until I see some mice actually getting younger, I don't really belive that Sinclair has proved his thesis. Making mice older isn't really the problem!