*ONE AMENDMENT (READ BELOW)* Videos on Studies: GlyNAC (Full Analysis): ruclips.net/video/6Lmc-mmqxyQ/видео.html Collagen (Full Analysis): ruclips.net/video/pM5LdJkjy9Q/видео.html OMAD (Full Analysis): ruclips.net/video/JKwC8sHEEjY/видео.html Reversing Aging/TRIIM Study: ruclips.net/video/rVoxfABoHh4/видео.html Obese & Autophagy: ruclips.net/video/F8arfpKri0M/видео.html Insulin vs Calories: ruclips.net/video/wJh98sNrBzM/видео.html LDL on Heart Disease (Full Analysis): ruclips.net/video/1t8rqfG1CMA/видео.html Urolithin A: ruclips.net/video/cJdAlp2new4/видео.html Omega-3 on Cognition (Full Analysis): ruclips.net/video/51sTitaUzJ8/видео.html Reversing Heart Disease (Full Analysis): ruclips.net/video/obD1GBU8gik/видео.html AMENDMENT: At 19:19, I say that there are a vocal minority of people who argue LDL is a cause of heart disease risk - that is reversed, it should be "a vocal minority of people who argue LDL is NOT a cause of heart disease risk" - thanks to @mkvalor for pointing it out.
I love your channel but I'm disappointed that you did not include research on nattokinase around its ability to remove arterial plaque. Also, berberine has been shown to remove arterial plaque. These are very important supplements to help people who can't exercise due to physical limitations or simply to help people who really struggle to get in shape. Many supplements can help people have an advantage until they can reshape all the other lifestyle factors needed for optimal health. They just give you an advantage even if you are healthy but you're older.
@@brianwnc8168 The evidence that berberine removes plaque is very early and needs more research - double blinded, case controlled study with enough participants. I do take it for that reason and it also does seems to lower blood sugar, BUT the only reason I take it without more evidence is that it does not seem to do any harm. So, I am hoping we eventually do get more robust/solid data. Nattokinase - not sure the evidence is there ... can you point me to some high quality studies? I AM SURPRISED HE LEFT OUT CREATINE MONOHYDRATE.
This is great analysis - independent, evidence-based and with context and nuance that is absent from the influencers and supplement sellers who are everywhere on RUclips. Much appreciated.
I am back in school finishing my Nursing degree at 50 partially because of this man. His videos help me stay fit by running to RUclips every time he posts. He's had me print out and read studies he's mentioned on here. It's like he's our own personal TLDR superhero. I trust his analysis.
Who wouldn't want to learn the 10 best tips for your health that a Ph.D. student has gleaned from reading 250 research reports? At the least, it can point up vitamins that you should look at more closely. Immense value in this channel!
Glynac has definitely been my Grandmother is 88. She was starting to show signs of cognitive decline and becoming increasingly frail. Started her on glynac 2.5g and 1.5g taurine twice daily, and the results have been astonishing. Moves faster gets up better, and her cognitive capacity and memory have come back to baseline.
I've been taking glynac since last summer and taurine since the fall and I must say it has vastly improved my energy levels and I think it's actually improving the speed of my thinking, no small feat, despite being under 50. I also think NAC generally acts as a detoxifier which is beneficial.
Your channel and nutrition made simple are the only 2 I trust. Independent non-biased clinical evaluation of data. and no products or gimmicks being sold to me! ❤
You should only get diet advice from a real Ph.D in nutritional biochemistry with awards and honors and or a Nobel Prize with a long term track record of being right such as Roger J. Williams, Frederick Gowland Hopkins, Fred Kummerow, George H. Whipple, William Parry Murphy, Edward Adelbert Doisy. All 6 would say the same that Linus Pauling said that meat, poultry, fish and eggs are good for you in moderation and that dairy is ok in small amounts if you like it and are not allergic to it. Gil Carvalho has zero experience in anything.
I am 48 and have suffered from severe chronic depression and anxiety for years. I have used all of the drugs, psychological treatment modalities and nothing ever gave me much relief until a couple of years ago I hears about glycine and NAC. I had seen a study somewhere that chronically anxious people were often found to be depleted in glutathione. Obviously this can lead to all kinds of problems. At the time, I started taking about 2 grams of NAC along with 2 grams of TMG daily. I started noticing after a few weeks everything was changing. It was like reality was becoming brighter. I could also breathe more deeply and freely (nac also helps the lungs) On top of that, my blood pressure normalized and my energy increased 10x. It was like getting my life back. I just wanted to point this out because I think people who have generalized anxiety even in their 20s and 30s could recover using glycine and nac. I think this needs more attention!
@@shahzamanhaque I try to take it on an empty stomach. I usually take a NOW 1G NAC pill with a glass of water mixed with glycine powder. Lately I have added 3 grams of Taurine to the mix as well as 2.5 grams of creatine.
@@oolala53 I think what the glycine/nac combination did for me was end the constant exhaustion, depression and edginess I experienced every moment of every day. It has given me space to work on the critical thoughts and destructive thinking patterns. Self enquiry and meditation have been extremely useful. anything that brings circulation to the prefrontal cortex. I really like the meditation devices like the Muse 2 and the Mendi.
Thank you @Physionic for being a voice of reason. I LOVE your videos! I'm so glad I found you and now I can stop wasting hours of my time watching all the others debate. Please never stop what you're doing! We need you!
Excellent Nic! Well done sir! I enjoy your more in depth analysis but this sort of summary overview is also very useful. I like the way that you give references and allow the listener to dive deeper with some of your other videos if they choose to. Please keep up the great work!
You have so many views nowadays!! Awesome! I've not followed anything nutrition related in a while because I started working in politics lol! But I'm so glad to see your current success!
Love your humor (and you too), my good young man! Stay well, stay healthy, stay wise, and keep sharing the goodness of your heart! May the universe bless your good life!
You’re totally awesome! I so really appreciate all the unbelievable hard work you’ve put in. I can’t imagine doing 5% of what you manage. I can blame my ADHD, but I’ve met too many highly productive people with ADHD to feel I have an adequate excuse.
RE: Human growth hormone ("Reversing Aging/TRIIM Study) Studies indicate that betaine [anhydrous] (aka, trimethylglycine (TMG)) at c. 3g a day (in split dosages, morning and evening, with meals) increases serum HGH naturally. (Glycine, in its various forms [like glynac], appears to be very actively important to maintaining/optimizing health.)
By day two of a water fast you will feel HGH in your body. So if you can do a 3 to 5 day water fast you will generate your own HGH. In my opinion the most efficient way to maximize water fasting is 7 days but it's not easy for a lot of people. The key here is that when you come off of the water fast your body will make up for the protein deficit by maximizing efficiency and rebuilding once you start adding protein as it leverages the HGH that was used to preserve muscle mass during the fast to build up even further; it might be 3 days of water fasting @ a minimum to see the HGH effect, I don't usually pay attention until I start feeling it in the morning and that's not until I'm already well into the fast.
The thing is can you produce any HGH when you're 50+ ? or Testosterone ? No... not really, the charts crash badly. You produce very little, there's not much to stimulate "naturally". You have to supplement.
Thanks so much for this, Nic! As a student I’m grateful for the lessons in research literacy, and I so appreciate the way you approach analysis with equal parts intelligence, tenacity and humility. From a student’s perspective that is rare in both academia and wellness communication spheres, and highly worthy of emulation. 🙏
Thank you Nic, I really appreciate your sharing all this info to me as an aging young person, keep them coming. Its definately helping to educate me making my decisions.
I remember when I first came to your site I think 3 years ago and if I recall yours was one of the only ones that was very heavy into statistical analysis and broader cross study analysis. But more importantly, a broader respect for the lack of information and or the oversimplification as well as just the general lack of respect for science and most of these style of youtube informationals. I'm really glad to see that you are blowing up as I really think that your style of information is really helpful as the granular detail on this type of stuff is really what makes a difference & what makes you different because real results are always made in margins of 2 to 5% if you're lucky and anything promising more than that needs to be taken with a massive, massive grain of salt!! Congratulations dude, good on you!! P.s I'm currently struggling with type 2 diabetes. As a result to get my blood sugar down, I massively reduced my carbs for the obvious reason. However, as a result of the initial diabetic cannibalization of my muscle mass as well as my fat, I went from 240 lb to 155 lb is less than ideal for the obvious reasons of not just being considerably less strong. But as we will continue to lose muscle mass over time, it will be an issue moving forward as I am 48 years old. I guess all that being said, is if you end up coming across anything about how to maintain or keep muscle mass as a aging type 2 diabetic I would super appreciate it. Mostly, because everything is geared towards losing weight, but I actually just stopped eating. I'm mostly carb diet and switch to primarily protein, greens that don't add any carbs and then low and glycemic index vegetarian carbs. Obviously this will need to be. How is the consideration overall? But I would love to hear some strategies on building if not, at least maintaining muscle mass as a type. 2. Diabetic. Everything I've read about building or maintaining muscle mass is about carb intake which is not going to work for me. No worries if this isn't anywhere close to your wheelhouse, but I couldn't help but shake the feeling that you might have ran across some research that would be relevant to my situation. I can't imagine but I'm the only skinny type 2 Diabetic!! We're not all fat, some of us got this way cuz you were either just lucky or drunks 😉
Thanks for the Roundup! .. Maybe when you get time maybe you could analyze the literature on Aspirin/Salicylic Acid's benefit for CVD & Cancer treatment
You might do a segment on the following relationship: Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
Wow. I don’t know why the algorithm suggested this video (though I suspect you do), but I am sure glad it did. Thank you for the wealth of trustworthy information.
NAC definitely has a difference for people above 60, based on my own experience. My joints are less achy, my slight pre diabetic signs disappeared, I’ve noticed more strength as well. I’ve also got Covid recently, and unlike all my previous flu and lung infections, I had the least symptoms, and lasted only 5 days, which is phenomenal based on how I suffered every time I get some kind of lung infection. Still working and learning as I go. My eyesight seems a bit better, although my optician said it’s no change from my last eye examination.
@@littlevoice_11 Initially I bought 600mg capsules and I had 1 in the morning and 1 in the evening. Now I have them as 400mg, and still trying 1 morning and 1 evening. I'm usually giving it a little break every 2 week cycle. 2 days off it every 2 weeks for now. I'm thinking of 3 times a day at the moment.
Love all the content you put up, been following for a while and the sheer amount of work you put into your videos is astounding. Keep it up, we really appreciate you! Lum S.
This is an awesome analysis. I wish you could update this once a year and make it an event we look forward to. Then the title needs a bit adjustment: It needs an edition marker, such as "2024 Edition".
Hi. For the Thymus rejuvenation, have you seen Brian Johnson talk about him trying this? He mentioned on Dr Mike’s podcast that it had the most negative health effects of anything he’s done due to the human growth hormone because of increased intracranial pressure and maybe some other negative health effects that I’ve forgot.
I listen to my own body. Period. As we all should. My triglycerides went way up when I was eating more carbs and experiencing stress. And I became pre-diabetes. Now I’m none of those on a low carb diet. LDL is high, but HDL is higher. You did no talk on stress or herbs such as tumeric . Listen to your body people….and I’m an RD. I also exercise as well
LMAO on your charming sense of humor. Yes Nick your charming. Thanks for sharing your research with us & most important explaining it for the non nerdy tribe.
Regarding the insulin versus total calorie argument, I would really like to see an explanation of the differences of efficiency of conversion of molecule type into body fat disposition. Meaning, for a given calorie content of carbs versus same calorie content of fats, which results in the greater amount of resultant body fat. Is there some % metric of conversion to body fat? There is an argument amongst keto participants that dietary fat is less efficient at creating body fat then the same calories ingested as carbs. Can of worms here perhaps? Invigorating to hear discussions about cell/molecular biology. Studied this way back in the day but never went into the field. You never lose the passion for the science. Great work.
Wow I just saw a video you did 3 years ago on that old anecdote of a carnivore guy in GB a hundred years ago. You appear much heathier now in weight and confidence. However now you appear pasty white and puffy under the eyes. maybe dial back the sodium and creatine intake and ingest more potassium for less water retention and get more sleep. It could be the lights/lighting but I do recommend getting more sun, sleep and a little less sodium/creatine. Also eating more carotenoids will give your skin more pigmentation and UV protection. Great info BTW and thanks for the synopsis of your due diligence. I commend your efforts. We need more people like you as influencers.
Great video! New sub here! I’ve been feeling defeated by post menopausal hashi hypo 25 lbs. Im not sure where I go next as I feel I’ve tried sooo many diets, coaches, purchased food, FMD, omad, keto, vegan, it’s been exhausting! I think I could seriously become a nutritionist which it shouldn’t be that hard. I’m going to give low carb, adding macadamia nuts for good fat, sardines and see how that works. Thank you ❤
14:50 I think that calories matter the most to loose fat, but a low carb diet with low insulin levels makes it easier since you do not starve as you would a regular high carb diet in a calorie deficit. Also, protein and fat is like 🪵 for our body, it takes more time and energy to burn. On the other hand carbs are like hay, they burn fast and easy and you need more right away to keep moving.
Hi Nicholas, I really enjoy your videos and learned a lot. One question: I’ve heard many times the most important information in a study is, who provided the funding. 😉 What’s your take on that? Thx from Germany 👍
I cover funding in my analyses. I agree that funding is important, but it's often overblown in importance as if it is *the* deciding factor to believe or not believe a study, and I disagree with that notion.
I recently came across something saying basically that if you are overweight and insulin resistant you have a hell of a time switching to fat burning(meaning that when you try to exercise to burn fat you end up out of energy because you cant make the switch and you feel like crap)...I experienced this when I started getting back in shape 3 years ago. I couldnt lose weight my old school way of training hard first then having my body ask for a better diet...Instead I had to eat once per day and go walking for my exercise. Once I dropped about 8 kilos in two months I was able to exercise normally and off I went. I can now eat reasonably and train hard....like a psycho. To me eating once a day is a good way to get the weight lose going but once you are in decent shape you can expand the window..and have to in order to build some muscle and train properly. Just my experience and thoughts
i used to eat once a day for years and was 140kgs and miserable when i started eating 3 to 5-6 times a day in an 10h interval since waking up with 14h pause i got down to 100kg and felt amazing, no gym or exercise, just doing basic stuff + work. for reference i am also 1.95m tall
I think it really depends. I can see the point in not eating for a long time as kind of exercise in restraint. But I lost 20 kg last year with frequent small meals. Often just a protein shake as snack at work. I feel that helped shrink down my stomach making me feel full being less full. Couldn't have happened with Giant 1-2 meals
Hello, thanks for the in-depth video. Can you do a supplement special on autoimmune diseases? I have Long Covid and am trying to figure out how to recover. Studies are few and far between, so it's tough to get your hands on useful information. Maybe some general strategies that work for autoimmune could work with LC? Who knows. I'm gonna try Glynac in any case, as LC is supposed to at least partly be due to oxidative stress
I took Omega 3 for the advertised reasons for years (and still do). What kept me taking it was how much it calmed my psoriasis. I had no idea that it could do that. I suppose it calms the inflammation down? It's the only reason I keep taking it.
![Can we reverse Atherosclerosis? [Study 241 - 246 Analysis]](http://i.ytimg.com/vi/obD1GBU8gik/mqdefault.jpg)
![Can we reverse Atherosclerosis? [Study 241 - 246 Analysis]](/img/tr.png)
*ONE AMENDMENT (READ BELOW)*
Videos on Studies:
GlyNAC (Full Analysis): ruclips.net/video/6Lmc-mmqxyQ/видео.html
Collagen (Full Analysis): ruclips.net/video/pM5LdJkjy9Q/видео.html
OMAD (Full Analysis): ruclips.net/video/JKwC8sHEEjY/видео.html
Reversing Aging/TRIIM Study: ruclips.net/video/rVoxfABoHh4/видео.html
Obese & Autophagy: ruclips.net/video/F8arfpKri0M/видео.html
Insulin vs Calories: ruclips.net/video/wJh98sNrBzM/видео.html
LDL on Heart Disease (Full Analysis): ruclips.net/video/1t8rqfG1CMA/видео.html
Urolithin A: ruclips.net/video/cJdAlp2new4/видео.html
Omega-3 on Cognition (Full Analysis): ruclips.net/video/51sTitaUzJ8/видео.html
Reversing Heart Disease (Full Analysis): ruclips.net/video/obD1GBU8gik/видео.html
AMENDMENT: At 19:19, I say that there are a vocal minority of people who argue LDL is a cause of heart disease risk - that is reversed, it should be "a vocal minority of people who argue LDL is NOT a cause of heart disease risk" - thanks to @mkvalor for pointing it out.
I love your channel but I'm disappointed that you did not include research on nattokinase around its ability to remove arterial plaque. Also, berberine has been shown to remove arterial plaque. These are very important supplements to help people who can't exercise due to physical limitations or simply to help people who really struggle to get in shape. Many supplements can help people have an advantage until they can reshape all the other lifestyle factors needed for optimal health. They just give you an advantage even if you are healthy but you're older.
@@brianwnc8168 The evidence that berberine removes plaque is very early and needs more research - double blinded, case controlled study with enough participants. I do take it for that reason and it also does seems to lower blood sugar, BUT the only reason I take it without more evidence is that it does not seem to do any harm. So, I am hoping we eventually do get more robust/solid data. Nattokinase - not sure the evidence is there ... can you point me to some high quality studies? I AM SURPRISED HE LEFT OUT CREATINE MONOHYDRATE.
New subscriber. Just found your channel. Love it!🙂
This is great analysis - independent, evidence-based and with context and nuance that is absent from the influencers and supplement sellers who are everywhere on RUclips. Much appreciated.
Thanks, Mark
I second this.
I third this.
He’s buying the lipid hypothesis, but hiding behind “one of the contributors…”, otherwise excellent summary.
A minority also thinks that males can be females, and females can be males. So take that with a grain of soy😂
I am back in school finishing my Nursing degree at 50 partially because of this man. His videos help me stay fit by running to RUclips every time he posts. He's had me print out and read studies he's mentioned on here. It's like he's our own personal TLDR superhero. I trust his analysis.
Who wouldn't want to learn the 10 best tips for your health that a Ph.D. student has gleaned from reading 250 research reports? At the least, it can point up vitamins that you should look at more closely. Immense value in this channel!
Glynac has definitely been my Grandmother is 88. She was starting to show signs of cognitive decline and becoming increasingly frail. Started her on glynac 2.5g and 1.5g taurine twice daily, and the results have been astonishing. Moves faster gets up better, and her cognitive capacity and memory have come back to baseline.
I've been taking glynac since last summer and taurine since the fall and I must say it has vastly improved my energy levels and I think it's actually improving the speed of my thinking, no small feat, despite being under 50. I also think NAC generally acts as a detoxifier which is beneficial.
I have a 95 year old aunt who I am going to try this on.
let us know your anecdote @@SkyRiver1
@@SkyRiver1 Please let us know how it goes! Well wishes!
MDMA works wonders on pensioners too.
Your channel and nutrition made simple are the only 2 I trust. Independent non-biased clinical evaluation of data. and no products or gimmicks being sold to me! ❤
Gil is awesome. Humbled to be in his company.
You should only get diet advice from a real Ph.D in nutritional biochemistry with awards and honors and or a Nobel Prize with a long term track record of being right such as Roger J. Williams, Frederick Gowland Hopkins, Fred Kummerow, George H. Whipple, William Parry Murphy, Edward Adelbert Doisy. All 6 would say the same that Linus Pauling said that meat, poultry, fish and eggs are good for you in moderation and that dairy is ok in small amounts if you like it and are not allergic to it. Gil Carvalho has zero experience in anything.
What a great video! The fact that people can get acces to this kind of useful knowledge for free and with so little effort is awesome
You are a gifted teacher. Great dissemination of useful information!
I am 48 and have suffered from severe chronic depression and anxiety for years. I have used all of the drugs, psychological treatment modalities and nothing ever gave me much relief until a couple of years ago I hears about glycine and NAC. I had seen a study somewhere that chronically anxious people were often found to be depleted in glutathione. Obviously this can lead to all kinds of problems.
At the time, I started taking about 2 grams of NAC along with 2 grams of TMG daily. I started noticing after a few weeks everything was changing. It was like reality was becoming brighter. I could also breathe more deeply and freely (nac also helps the lungs)
On top of that, my blood pressure normalized and my energy increased 10x. It was like getting my life back.
I just wanted to point this out because I think people who have generalized anxiety even in their 20s and 30s could recover using glycine and nac. I think this needs more attention!
Thank you for this. When you take this ? During or after meal ?
So you are now less bothered by critical thoughts about yourself and the world, past and future?
@@shahzamanhaque I try to take it on an empty stomach. I usually take a NOW 1G NAC pill with a glass of water mixed with glycine powder. Lately I have added 3 grams of Taurine to the mix as well as 2.5 grams of creatine.
@@oolala53 I think what the glycine/nac combination did for me was end the constant exhaustion, depression and edginess I experienced every moment of every day. It has given me space to work on the critical thoughts and destructive thinking patterns. Self enquiry and meditation have been extremely useful. anything that brings circulation to the prefrontal cortex. I really like the meditation devices like the Muse 2 and the Mendi.
Where did you buy it?
That’s some great stuff Nic, really proud to see how far you’ve come and happy to have been here since the start.
Keep up the awesome work…Richard
Thanks so much for the kind words, Richard. :)
Thank you @Physionic for being a voice of reason. I LOVE your videos! I'm so glad I found you and now I can stop wasting hours of my time watching all the others debate. Please never stop what you're doing! We need you!
Excellent Nic! Well done sir!
I enjoy your more in depth analysis but this sort of summary overview is also very useful. I like the way that you give references and allow the listener to dive deeper with some of your other videos if they choose to.
Please keep up the great work!
Glad to see how much your channel has grown and you are getting better and better each year with the delivery 👊 Brilliant vid bro🤙🔥
An abundance of information using minimal words. No flashy intro, no yo yo music, just the facts and nothing but the facts. Information at it's best.
You have so many views nowadays!! Awesome! I've not followed anything nutrition related in a while because I started working in politics lol! But I'm so glad to see your current success!
Hope things are going well on your end. :)
Thanks for your summary. Terrific content as usual.
Love your humor (and you too), my good young man! Stay well, stay healthy, stay wise, and keep sharing the goodness of your heart! May the universe bless your good life!
You’re totally awesome! I so really appreciate all the unbelievable hard work you’ve put in.
I can’t imagine doing 5% of what you manage. I can blame my ADHD, but I’ve met too many highly productive people with ADHD to feel I have an adequate excuse.
So take glynac and omega 3 if you are over 60 and do the usual (weight,exercise,whole foods) for heart health.
Toss in taurine and creatine monohydrate.
RE: Human growth hormone ("Reversing Aging/TRIIM Study)
Studies indicate that betaine [anhydrous] (aka, trimethylglycine (TMG)) at c. 3g a day (in split dosages, morning and evening, with meals) increases serum HGH naturally. (Glycine, in its various forms [like glynac], appears to be very actively important to maintaining/optimizing health.)
By day two of a water fast you will feel HGH in your body. So if you can do a 3 to 5 day water fast you will generate your own HGH. In my opinion the most efficient way to maximize water fasting is 7 days but it's not easy for a lot of people.
The key here is that when you come off of the water fast your body will make up for the protein deficit by maximizing efficiency and rebuilding once you start adding protein as it leverages the HGH that was used to preserve muscle mass during the fast to build up even further; it might be 3 days of water fasting @ a minimum to see the HGH effect, I don't usually pay attention until I start feeling it in the morning and that's not until I'm already well into the fast.
I am going to check you on the TMG, but thanks in advance for the info if it checks out.
The thing is can you produce any HGH when you're 50+ ? or Testosterone ? No... not really, the charts crash badly. You produce very little, there's not much to stimulate "naturally". You have to supplement.
@@pavman42how does one feel HGH?
appreciate your insights and opinions. Good to see the science community come out on these hot topic items circulating today.
Thanks so much for this, Nic! As a student I’m grateful for the lessons in research literacy, and I so appreciate the way you approach analysis with equal parts intelligence, tenacity and humility. From a student’s perspective that is rare in both academia and wellness communication spheres, and highly worthy of emulation. 🙏
That was a quick review of past videos. It was beneficial for me.
Thank you Nic, I really appreciate your sharing all this info to me as an aging young person, keep them coming. Its definately helping to educate me making my decisions.
Thanks for your work.
Thanks!
I remember when I first came to your site I think 3 years ago and if I recall yours was one of the only ones that was very heavy into statistical analysis and broader cross study analysis. But more importantly, a broader respect for the lack of information and or the oversimplification as well as just the general lack of respect for science and most of these style of youtube informationals. I'm really glad to see that you are blowing up as I really think that your style of information is really helpful as the granular detail on this type of stuff is really what makes a difference & what makes you different because real results are always made in margins of 2 to 5% if you're lucky and anything promising more than that needs to be taken with a massive, massive grain of salt!!
Congratulations dude, good on you!!
P.s I'm currently struggling with type 2 diabetes. As a result to get my blood sugar down, I massively reduced my carbs for the obvious reason. However, as a result of the initial diabetic cannibalization of my muscle mass as well as my fat, I went from 240 lb to 155 lb is less than ideal for the obvious reasons of not just being considerably less strong. But as we will continue to lose muscle mass over time, it will be an issue moving forward as I am 48 years old.
I guess all that being said, is if you end up coming across anything about how to maintain or keep muscle mass as a aging type 2 diabetic I would super appreciate it. Mostly, because everything is geared towards losing weight, but I actually just stopped eating. I'm mostly carb diet and switch to primarily protein, greens that don't add any carbs and then low and glycemic index vegetarian carbs. Obviously this will need to be. How is the consideration overall? But I would love to hear some strategies on building if not, at least maintaining muscle mass as a type. 2. Diabetic. Everything I've read about building or maintaining muscle mass is about carb intake which is not going to work for me.
No worries if this isn't anywhere close to your wheelhouse, but I couldn't help but shake the feeling that you might have ran across some research that would be relevant to my situation. I can't imagine but I'm the only skinny type 2 Diabetic!! We're not all fat, some of us got this way cuz you were either just lucky or drunks 😉
Best health channel by far!
Thanks Nic!
Thanks for the Roundup! .. Maybe when you get time maybe you could analyze the literature on Aspirin/Salicylic Acid's benefit for CVD & Cancer treatment
You might do a segment on the following relationship: Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
This is great! Thank you so much Nicholas! QUESTION: can you do (or, did you do) a video on CA-AKG?
Thank you! I appreciate your hard work and no BS approach.
Wow. I don’t know why the algorithm suggested this video (though I suspect you do), but I am sure glad it did. Thank you for the wealth of trustworthy information.
I just got this recommended. Idk why not earlier, but at least I got it within a year.
I really like these recap videos you do, please keep doing them!
Love your channel. Keep up the good work!
Thank you for your hard work. I really enjoy your videos!
You deserve way more subscribers ! !
NAC definitely has a difference for people above 60, based on my own experience. My joints are less achy, my slight pre diabetic signs disappeared, I’ve noticed more strength as well. I’ve also got Covid recently, and unlike all my previous flu and lung infections, I had the least symptoms, and lasted only 5 days, which is phenomenal based on how I suffered every time I get some kind of lung infection. Still working and learning as I go. My eyesight seems a bit better, although my optician said it’s no change from my last eye examination.
How many grams per day do you use?
@@littlevoice_11 Initially I bought 600mg capsules and I had 1 in the morning and 1 in the evening. Now I have them as 400mg, and still trying 1 morning and 1 evening. I'm usually giving it a little break every 2 week cycle. 2 days off it every 2 weeks for now. I'm thinking of 3 times a day at the moment.
Nic is the best! LOVE this channel.
Thank you so much for your great content!!
I love how this man embraces his nerd, and I am here for it!
Saw the title... clicked immediately! This is THE Physionics video I've been hoping for.
Thank you
So clear and well explained…thank you 😊
great analysis, mate! 🙌 thank you so much 🤩🤗
Top Drawer commentary - thanks!
I was legitimately expecting you to discuss high dose Vitamin K2 and reversing atherosclerosis at the end.
And boron
Nattokinase can do that
Because it's high in k2, right? I've heard it is not tasty 😂
That was awesome info! Thank you!
Thx yet again, you are doing your fellow man a great service! Cheers, to our health, and to science!
This is so informative. Thank you very much. This is one of the best and most comprehensive videos out there.
Love all the content you put up, been following for a while and the sheer amount of work you put into your videos is astounding. Keep it up, we really appreciate you!
Lum S.
Can you share your workout & nutrition routine?
Thank for putting in the hard work to make this easy to understand.
Merci beaucoup pour cette synthèse.
De rien, Pierre.
Exactly what ive been waiting for.
A Perfect video.
This is an awesome analysis. I wish you could update this once a year and make it an event we look forward to. Then the title needs a bit adjustment: It needs an edition marker, such as "2024 Edition".
Great video. Thanks for sharing.
Awesome. Thankyou for making me double check my routine.
Thanks I really appreciated all of your analysis . Looking forward to the one on CVD.
Been watching your vids this one earned a sub. Great work 👏
Excellent summary .. thank you
Thx for all your hard work...very much appreciated!
Do you have any idea what a suitable dose would be for GlyNAC? Thanks for your great videos!
3 gm/day(min)
Thanks for respecting truth
Excellent work, brother. 👏🏻👏🏻👏🏻👏🏻👏🏻🫶🏻
Hi. For the Thymus rejuvenation, have you seen Brian Johnson talk about him trying this? He mentioned on Dr Mike’s podcast that it had the most negative health effects of anything he’s done due to the human growth hormone because of increased intracranial pressure and maybe some other negative health effects that I’ve forgot.
excellent work!
I listen to my own body. Period. As we all should. My triglycerides went way up when I was eating more carbs and experiencing stress. And I became pre-diabetes. Now I’m none of those on a low carb diet. LDL is high, but HDL is higher. You did no talk on stress or herbs such as tumeric . Listen to your body people….and I’m an RD. I also exercise as well
Fantastic video. Bravo.
LMAO on your charming sense of humor. Yes Nick your charming.
Thanks for sharing your research with us & most important explaining it for the non nerdy tribe.
Excellent video. Thank you!
This was a great analysis
You should do a video on ellagic acid and osteoclast differentiation. If pomegranates can build bone, everyone needs to know about it!
It’s be super helpful to place your videos linked in a playlist so it just plays one after another. Thanks!!
Thanks very good
Regarding the insulin versus total calorie argument, I would really like to see an explanation of the differences of efficiency of conversion of molecule type into body fat disposition. Meaning, for a given calorie content of carbs versus same calorie content of fats, which results in the greater amount of resultant body fat. Is there some % metric of conversion to body fat? There is an argument amongst keto participants that dietary fat is less efficient at creating body fat then the same calories ingested as carbs. Can of worms here perhaps? Invigorating to hear discussions about cell/molecular biology. Studied this way back in the day but never went into the field. You never lose the passion for the science. Great work.
Wow I just saw a video you did 3 years ago on that old anecdote of a carnivore guy in GB a hundred years ago. You appear much heathier now in weight and confidence. However now you appear pasty white and puffy under the eyes. maybe dial back the sodium and creatine intake and ingest more potassium for less water retention and get more sleep. It could be the lights/lighting but I do recommend getting more sun, sleep and a little less sodium/creatine. Also eating more carotenoids will give your skin more pigmentation and UV protection. Great info BTW and thanks for the synopsis of your due diligence. I commend your efforts. We need more people like you as influencers.
Great video! New sub here! I’ve been feeling defeated by post menopausal hashi hypo 25 lbs. Im not sure where I go next as I feel I’ve tried sooo many diets, coaches, purchased food, FMD, omad, keto, vegan, it’s been exhausting! I think I could seriously become a nutritionist which it shouldn’t be that hard. I’m going to give low carb, adding macadamia nuts for good fat, sardines and see how that works. Thank you ❤
Youre doing great work
Good stuff!
Good one man! 🎉👍
Thanks for these videos
Dude this is excellent
I'm glad you like it!
Thanks, Nic
You remind me of a proto Huberman, keep up the good work!!
Humor with mild snark works great Nic. Never change.
The more I watch your videos, the more I realize simple things are the best - weight loss, exercise and nutrition.
This is good stuff! Thanks for sharing. 👍
14:50 I think that calories matter the most to loose fat, but a low carb diet with low insulin levels makes it easier since you do not starve as you would a regular high carb diet in a calorie deficit.
Also, protein and fat is like 🪵 for our body, it takes more time and energy to burn. On the other hand carbs are like hay, they burn fast and easy and you need more right away to keep moving.
Hi Nicholas, I really enjoy your videos and learned a lot. One question: I’ve heard many times the most important information in a study is, who provided the funding. 😉 What’s your take on that? Thx from Germany 👍
I cover funding in my analyses. I agree that funding is important, but it's often overblown in importance as if it is *the* deciding factor to believe or not believe a study, and I disagree with that notion.
Amazing! Thank you for this! Still unsure about Urolithin A - think I’ll wait for further studies as it’s quite an expensive supplement.
Really important video. Nic deserves Huberman level of audience.
Hope you will look at future research on LDL increases post-COVID infection. 21:31
I recently came across something saying basically that if you are overweight and insulin resistant you have a hell of a time switching to fat burning(meaning that when you try to exercise to burn fat you end up out of energy because you cant make the switch and you feel like crap)...I experienced this when I started getting back in shape 3 years ago. I couldnt lose weight my old school way of training hard first then having my body ask for a better diet...Instead I had to eat once per day and go walking for my exercise. Once I dropped about 8 kilos in two months I was able to exercise normally and off I went. I can now eat reasonably and train hard....like a psycho. To me eating once a day is a good way to get the weight lose going but once you are in decent shape you can expand the window..and have to in order to build some muscle and train properly. Just my experience and thoughts
I love your videos
i used to eat once a day for years and was 140kgs and miserable
when i started eating 3 to 5-6 times a day in an 10h interval since waking up with 14h pause i got down to 100kg and felt amazing, no gym or exercise, just doing basic stuff + work. for reference i am also 1.95m tall
I think it really depends. I can see the point in not eating for a long time as kind of exercise in restraint. But I lost 20 kg last year with frequent small meals. Often just a protein shake as snack at work. I feel that helped shrink down my stomach making me feel full being less full. Couldn't have happened with Giant 1-2 meals
Can you do a video about the new Niacin study that just dropped?
Monday
Hello, thanks for the in-depth video. Can you do a supplement special on autoimmune diseases? I have Long Covid and am trying to figure out how to recover. Studies are few and far between, so it's tough to get your hands on useful information. Maybe some general strategies that work for autoimmune could work with LC? Who knows. I'm gonna try Glynac in any case, as LC is supposed to at least partly be due to oxidative stress
I took Omega 3 for the advertised reasons for years (and still do). What kept me taking it was how much it calmed my psoriasis. I had no idea that it could do that. I suppose it calms the inflammation down? It's the only reason I keep taking it.
Can you share with us the supplements routine and specific brand you use or would be greatly appreciated! Great video!