Senolytics definitely have potential. At the moment the drive in the field is identifying senolytics that have greater specificity for targeting senescent cells without disrupting other cells, in addition to good drug properties and long-term safety. In addition (although havent read the paper yet) there is some concern over removing senescent cells without being able to replace the space with healthy cells (www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30241-2?rss=yes&.it&) and so delaying senescence , or using senolytics + activating stem cells, may have greater potential.
So currently in terms of reversal, this refers to the ability of a senescent cell to proliferate again and overcome the "irreversible cell-cycle arrest", not to become "normal" again. There does appear to be evidence of this, discussed briefly in this review [www.nature.com/articles/s41556-018-0249-2 ], but it raises the question of whether the cells were senescent in the first place or just quiescent, but is that more of an issue of semantics? Anyhow, understanding senescence "escape" is of interest since it may help us to understand early tumorigenesis.
Great video but the sound is very low. Could barely hear.
Really like this video. Awesome explanation and visuals
What is your opinion on senolytics, and its potential to possibly promote health and reverse aging?
Senolytics definitely have potential. At the moment the drive in the field is identifying senolytics that have greater specificity for targeting senescent cells without disrupting other cells, in addition to good drug properties and long-term safety. In addition (although havent read the paper yet) there is some concern over removing senescent cells without being able to replace the space with healthy cells (www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30241-2?rss=yes&.it&) and so delaying senescence , or using senolytics + activating stem cells, may have greater potential.
Very interesting!
Can senescence be reversed??
So currently in terms of reversal, this refers to the ability of a senescent cell to proliferate again and overcome the "irreversible cell-cycle arrest", not to become "normal" again. There does appear to be evidence of this, discussed briefly in this review [www.nature.com/articles/s41556-018-0249-2 ], but it raises the question of whether the cells were senescent in the first place or just quiescent, but is that more of an issue of semantics? Anyhow, understanding senescence "escape" is of interest since it may help us to understand early tumorigenesis.
Brilliant!
This is why we age.
Indeed