As someone interested in the topic but not having the background in this field it would be a lot easier to understand just by adding some natural retorical pauses (as we normally do when we talk) 😀 It is better better to speed up the video pase than to slow it down since the quality differs. Just a tip! Thanks for making this information available! (even though I only grasp half of it just because some retorical details 😉)
But is it necessarily a bad thing that SIRT1 gets degraded within a cell that is already senescent? It would be important to know if autophagy degrades SIRT1 in a normal cell which would be bad. My takeaway is that activating/upregulating SIRT1 with resveratrol etc may prevent the onset of senescence, but once senescence has set in, I don't see how rescuing SIRT1 in those senescent cells helps with anything at all.
Hello, so it has always been stated that deacetylation of p53 reduced its dna binding ability, so short answer yes. But, i am certain the situation is a lot more complex and given that p53 has >300 PTMs i doubt it would be that simple!! This question bugs me a lot!
Please help me answer this .., why would Sirt1 have a higher expression in high fat diet than in mice fed with NMN ? Would really appreciate your response Thankyou
You are quickly becomming my favorite PhD health youtuber. You and FMF.
I just discovered your channel and I really like it. It seems sincere. Looking forward to watching more of it!
I studied this in the book "Lifespan" by Dr.David Sinclair....Love from India....❤
As someone interested in the topic but not having the background in this field it would be a lot easier to understand just by adding some natural retorical pauses (as we normally do when we talk) 😀 It is better better to speed up the video pase than to slow it down since the quality differs. Just a tip!
Thanks for making this information available! (even though I only grasp half of it just because some retorical details 😉)
this one is important...full attention...
phenomenal and clear explanation, really good teacher thank you sm
looks like the induction of a mechanism to clear out senescent cells via autophagy.
But is it necessarily a bad thing that SIRT1 gets degraded within a cell that is already senescent? It would be important to know if autophagy degrades SIRT1 in a normal cell which would be bad. My takeaway is that activating/upregulating SIRT1 with resveratrol etc may prevent the onset of senescence, but once senescence has set in, I don't see how rescuing SIRT1 in those senescent cells helps with anything at all.
Very nice video! Help me a lot in some doubts I had int sirt expression!
Awesome. Thanks for that insightful lecture
What anti aging Supplements are you taking currently?
Hey! Quick question, isnt deacetylation of p53 a bad thing?
Hello, so it has always been stated that deacetylation of p53 reduced its dna binding ability, so short answer yes. But, i am certain the situation is a lot more complex and given that p53 has >300 PTMs i doubt it would be that simple!! This question bugs me a lot!
Great video! With the least meaningful thing I could add: sirtuins are named after SIR2, so should probably be pronounced closer to "sir two ins" :)
Please help me answer this .., why would Sirt1 have a higher expression in high fat diet than in mice fed with NMN ? Would really appreciate your response Thankyou
a recent paper shows that RVS is not a direct activator of SIRT1...
Can I have the source to paper for cross reference? Thank you.
As far as I remember, David Sinclair proves otherwise regarding RVS to SIRT1
Would love to have a look at the papers that you read
We want to activate a autophagy, but it is going to degrade the sirt1?
Maca can do this..check it out..