Spermidine - autophagy & anti-aging research (2021)

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  • Опубликовано: 5 дек 2024

Комментарии • 142

  • @TheSheekeyScienceShow
    @TheSheekeyScienceShow  3 года назад +32

    Cool me a biochemist nerd, but my favourite fact from making this video was the hypusination :D ! What was yours?

    • @randenrichards5461
      @randenrichards5461 3 года назад +1

      Your accent lol, but I’m a yank and I dig it and to me it’s also soothing. On the spermidine, it’s so underrated there has been a lot of evidence that it’s effective yet there seems to be no market for it in the supplement area, at least I can’t find any and I was taking a lot of wheat germ to get an effective amount per day until I read some studies that wheat germ has a negative effect on testosterone. My ask is what else is there out there that can give a lot of bang for the buck on spermidine or a supplement I may of missed?

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 3 года назад +2

      @@randenrichards5461 Sprouts and microgreens can have a lot; see article by Kralj Cigic et al. 2020 in Foods. IIRC there is discussion of potentially undesirable constituents such as cadaverine and canavanine. From the video it seems it might be possible to get too much spermidine. I think it would benefit my daughter, but she has Celiac and multiple allergies so wheat germ and spermidine supps from wheat germ (there is one, I forget the name) are not suitable. The video reminded me I needed to add some frozen peas to my grocery order.

    • @ChillFantasticFive
      @ChillFantasticFive 3 года назад

      @@randenrichards5461 I'm reading studies that wheat germ increases testosterone

    • @abritrn
      @abritrn 3 года назад +3

      @@randenrichards5461 Primeadine and Spermadinelife are 2 brands. Very expensive and I think it would be pretty easy to get 1 mg (the amount in those supplements) in the diet- natto, tempeh, edamame, soy nuts, peas, mushrooms, nuts.

    • @Celtokee
      @Celtokee 3 года назад +1

      The hypusination aspect was enlightening, but also the suggestion that we should limit semen consumption.

  • @TonyT-fz8od
    @TonyT-fz8od 3 года назад +52

    you have the most underrated channel on youtube. amazing content and appreciate all the work you put in. All your videos about longevity and disaease prevention are amazing. thank you!

    • @Celtokee
      @Celtokee 3 года назад +1

      Agreed. Sheekey and Dr. Michael Lustgarten are the two best reviewers and presenters of relevant current literature, and advancing reasonable hypotheses based on same. But Sheekey gets the nod. Love the way she highlights in color salient sentences.

    • @jojoeleven8878
      @jojoeleven8878 3 года назад +1

      Sheeky Science Show about healthy lives => 20.000 Views ; Gangnam Style => 40.000.000.000 Views; Nuff Said

  • @MrStarchild3001
    @MrStarchild3001 8 месяцев назад +4

    Spermidine is a natural polyamine found in many foods like mushrooms, aged cheese, soybeans, and whole grains. As a polyamine, spermidine is attracted to negatively charged compounds like DNA, RNA and proteins, allowing it to be involved in various cellular functions ranging from growth to death.
    One key cellular process that spermidine activates is autophagy. Autophagy is a mechanism that removes unnecessary or dysfunctional cellular components. It acts as a recycling system to break down these components and generate new functional ones. The life extension seen in model organisms supplemented with spermidine seems to be autophagy-dependent (Eisenberg et al, 2009).
    In addition to activating autophagy, spermidine supplementation has shown other anti-aging effects in animal studies:
    - Dietary spermidine extends lifespan in yeast, flies, worms and mice (Eisenberg et al, 2016)
    - Spermidine improves cardiovascular function and reduces high blood pressure in aged mice (Eisenberg et al, 2016)
    - Spermidine reduces age-related motor impairment in flies
    Recent research has also investigated the effects of spermidine on cognitive function. A study by Schroeder et al (2021) found that spermidine supplementation improved memory in both flies and mice:
    - In aged flies, spermidine feeding for 10 days improved immediate recall memory by 50% compared to controls
    - In aged mice, 3 months of oral spermidine supplementation improved spatial memory, novel object recognition, and associative memory
    - Mechanistically, spermidine reduced age-associated brain inflammation and increased levels of the transcription factor TFEB in mice, which regulates autophagy
    To determine if these cognitive benefits translate to humans, the researchers analyzed data from a long-running population study. They found that higher levels of spermidine intake correlated with better cognitive performance on a memory recall test, even when controlling for age, sex, education and other factors (Schroeder et al, 2021). Those in the highest quartile of spermidine intake (7.89 mg/day) were 60% less likely to have poor memory scores compared to the lowest intake quartile (Schroeder et al, 2021).
    While these results are promising, clinical trials are still needed to directly test the effects of spermidine supplementation on human health and longevity. A small trial is currently listed on clinicaltrials.gov, but results are not yet available.
    In terms of dosage, nutritional data suggests average daily spermidine intake is around 7-10 mg per day from foods. Supplements are available but not necessarily recommended, as food sources are likely sufficient. There are also potential risks to consider with high-dose supplementation, as excess polyamines have been linked to conditions like cancer in some studies.
    In conclusion, spermidine is a promising compound for promoting longevity and healthspan. Its key mechanisms seem to be activating autophagy and improving cognitive function, as shown in animal models and preliminary human data (Eisenberg et al, 2009; Schroeder et al, 2021). However, more research, particularly clinical trials, are needed to confirm efficacy and determine optimal dosing in humans. For now, the safest approach may be to obtain spermidine from dietary sources like mushrooms, legumes, whole grains and aged cheeses. Future studies will continue to elucidate the full potential of this intriguing natural polyamine.

  • @hannabaal150
    @hannabaal150 3 года назад +6

    You move right through this information, which requires actually paying attention. My first look at your channel is impressive. Thanks!

  • @manuelojeda9144
    @manuelojeda9144 3 года назад +8

    Your deligence in this area is remarkable. I have learned a lot. Thanks.

  • @ericcigs5425
    @ericcigs5425 2 года назад +4

    You are INCREDIBLE.... i hope u get proper recognition!! THANKYOU

  • @peterz53
    @peterz53 3 года назад +15

    Thanks for another excellent and detailed review. Given the amounts in food, one wonders why supplement makers are charging high $ for 1 mg doses.

    • @manmoth4
      @manmoth4 3 года назад +6

      I just add chlorella powder to food. It's basically dried algae standardised to about 1mg spermidine per gram, packet says a couple of level teaspoons would give you 5mg. Doesn't taste bad, but makes things look a bit Chernobyl. I add to food rather than drink.

    • @ctguitarguy8510
      @ctguitarguy8510 3 года назад +1

      @@manmoth4 which supplement is this? Because every chlorella supplement I've seen shows it takes nearly a kilogram of chlorella to get about 1 gram of spermidine. That's a lot.

    • @manmoth4
      @manmoth4 3 года назад +1

      @@ctguitarguy8510 Yeah, but you only want mgs of spermidine, not grams lol

    • @ctguitarguy8510
      @ctguitarguy8510 3 года назад +1

      @@manmoth4 No, I want grams.

    • @manmoth4
      @manmoth4 3 года назад +1

      @@ctguitarguy8510 Well, standard supplements are pills of 1mg each, so chlorella are still cheaper per mg either way

  • @normjohnson4629
    @normjohnson4629 3 года назад +5

    Very nice. Thanks for not using a robot voice.

  • @AdamT2
    @AdamT2 3 года назад +7

    Great science communication, you have made me love biochemistry!

  • @SeganHealthHacker
    @SeganHealthHacker Год назад +2

    Talking about spermwhatever in this English accent n omg-so-cute feminine voice. Learned/understood nothing (n I lived in London) aside from the fact that I'm in love. Cuteness over 9000. Pleasant voice 2 study with.

  • @AshrafAli-mr9pz
    @AshrafAli-mr9pz 3 года назад +5

    Clear explanation. If you've a research done on Olive leaf extract and polyphenols. Could you share a link?

  • @Lexington101
    @Lexington101 Год назад +3

    Great video, explained a lot of high science stuff to lay people like me, well done! And great style, I second what Tony T below said.

  • @mickmack9333
    @mickmack9333 Год назад +2

    hi ms sheekey, i just watched this video on spermidine. u said there could b a correlation of spermidine and cancer. I checked out a couple of papers online and found that spermidine is in fact a mtor inhibitor. in this way spermidine would prevent cancer, right?

  • @brewhog
    @brewhog 3 года назад +6

    Awesome! Thanks for the upload. Do you mind sharing what software you are using for the whiteboard and the video editing? I love what you are doing!

    • @MrDani695
      @MrDani695 3 года назад +1

      I second this question, it looks really user-friendly and easy to use!

  • @littlevoice_11
    @littlevoice_11 3 года назад +7

    Was I the only one who was very relieved to hear the sources of spermidine weren't as grim as I initially feared 🤮

  • @hkw53
    @hkw53 2 года назад +5

    Out of all your research 🧐 what is the best supplement you have tried that gave you the best hair growth results?

    • @NASkeywest
      @NASkeywest Год назад

      You can get finasteride and other hair supplements online.

    • @hkw53
      @hkw53 Год назад

      @@NASkeywest Where can I get Finasteride from? How much to take? Thanks

  • @elliottrubenstein1746
    @elliottrubenstein1746 3 года назад +2

    Very informative. Love graphics and your accent. Keep up good work.

  • @bogrunberger
    @bogrunberger 3 года назад +4

    I suggested to my wife that she should be supplementing with spermidine, and she thought I was randy.

  • @TheShazExperience
    @TheShazExperience Год назад +2

    I love Sheekey Science Show ❤ A question for you… If you had to choose between taking Spermadine, or doing a Fasting Mimicking Diet what would you choose?

    • @adopenmindiswhatyoullfind5305
      @adopenmindiswhatyoullfind5305 6 месяцев назад

      I do both. Started the supplement. Stopped to do the fast mimicking diet and then started taking it again. There are other benefits of fasting besides autophagy. I do the diet to lower blood sugar. Some use it for weight loss.

  • @dr.julia-heyakarcic8862
    @dr.julia-heyakarcic8862 3 года назад +4

    Thank you for sharing the reference articles.

  • @manuelojeda9144
    @manuelojeda9144 3 года назад +3

    I take QUERCETIN and Fisetin supplements. I eat a lot of ARAGULA and broccoli

  • @brewhog
    @brewhog 3 года назад +5

    Is there more info on specific dose levels that would be considered dangerous (Cancer potential)? (Just looking for more reading related to spermidine supplementation)

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 года назад +5

      The links I provided in the description (particularly the reviews) are best!

  • @sergicatala3937
    @sergicatala3937 3 месяца назад

    I love your videos! you are great!!

  • @OneDayIMay91Bil
    @OneDayIMay91Bil 11 месяцев назад +1

    I love your channel I hate that I only just found it

  • @luisfernando55
    @luisfernando55 3 года назад +2

    Subscribed ! Do you have a video where you explain what kind of tools(software) for making a regular video on your channel ? Thanks !

  • @bleu27
    @bleu27 Год назад +1

    Thank you for the nice illustration! Is there a max dose of Spermidine/day suggested by scientists or nutritionists?

  • @andrewchristie3139
    @andrewchristie3139 3 года назад +6

    Interesting! Curious - why would anyone spend 90 dollars on a Spermidine supplement when you can get it from a single serving of Wheat Germ?

    • @theeclectic2919
      @theeclectic2919 3 года назад +1

      Good question. I put wheat germ in my yogurt every morning. I have ZERO age related issues.

    • @abritrn
      @abritrn 3 года назад +1

      Wheat germ contains gluten so a person with celiac disease would not be able to tolerate it. But they can get spermidine from other food sources like soy beans, peas, mushrooms.

    • @ctguitarguy8510
      @ctguitarguy8510 3 года назад +5

      The variability in wheat germ is dramatic. They use wheat germ extract, essentially, in these supplements. Only specific types of wheat have high levels and they dont like to share which ones. Wheat germ also goes rancid rather quickly too, unlike the supplements. What would be best is a higher dose product to meet what is consumed naturall but optimal diet like 10-25 grams.

    • @luisfernando55
      @luisfernando55 3 года назад

      @@ctguitarguy8510 what kind of food contains it ? Thanks

    • @ctguitarguy8510
      @ctguitarguy8510 3 года назад +2

      @@luisfernando55 The highest known food source is wheat germ.

  • @titititi2022
    @titititi2022 3 года назад +1

    I wonder what would be the human equivalent of 3 mm dose for mices? Any idea? Some supplement manufacturers recommend 1mg per day.

  • @Aryeh-o
    @Aryeh-o 3 года назад +1

    sounds pretty weak compared to the price of the compound and the difficulty of regularly eating wheat germ.

  • @TerryRGraham
    @TerryRGraham 2 года назад +2

    Is Spermidine Trihydrochloride toxic?

  • @ctguitarguy8510
    @ctguitarguy8510 3 года назад +1

    What are the dosages for human trials? 1mg strikes me as rather low, does it not? That is what is available in supplements at the moment.

  • @MT-sq3jo
    @MT-sq3jo 3 года назад +2

    Being a chemist who knows more about the high toxicity of small poly amine molecules than any health benefits specific polyamines have, I was shocked to see these polyamine molecules highlighted in this video. I’m intrigued but not ready to jump in taking a spermidine supplement. I’ll just eat healthy food and let nature to decide how much my intake will be.

  • @mylesl2890
    @mylesl2890 3 года назад

    so any nice links to where we can purchase some ??

  • @DheerajBhaskar
    @DheerajBhaskar 3 года назад +1

    What was my takeaway from this video? Nothing was actionable.

  • @mooinabc1
    @mooinabc1 2 года назад

    How many mg are there in Broccoli sprouts and broccolli seed?

  • @clairebradbury11
    @clairebradbury11 3 года назад

    Thank you, very clear and interesting

  • @luckssj
    @luckssj 2 года назад +1

    Have you looked at Glycocalyx Structure and it's effective on death

  • @showkatkhan8461
    @showkatkhan8461 3 года назад +1

    hi, if i eat peas, mushroom, hard cheese, broccoli do i still need to take spermidine supplement? thank you.

    • @larryc1616
      @larryc1616 2 года назад

      I just make my own whenever I visit a porn site 💋

  • @blindandlearning9379
    @blindandlearning9379 3 года назад +1

    I have a pair in an apple every day do you think that’s enough?

  • @jacklan4103
    @jacklan4103 2 года назад

    I think I'll pass on this one and just take fish oil instead. What am i suppose to tell people if they found out i take spermidine?

  • @victorchan5456
    @victorchan5456 3 года назад +1

    Can you upload english subtitle ?

  • @rhyothemisprinceps1617
    @rhyothemisprinceps1617 3 года назад +1

    re: sex differences - men are more susceptible to high altitude pulmonary edema, but can achieve higher VO2 max than women. Women are more susceptible to pulmonary arterial hypertension. hmmm ...

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 3 года назад

      Male babies are also more susceptible to SIDS. I mentioned this and possible relationship to SOX9 above, but there is a recent article that reports a link between SIDS and MAO-A, which is on the X chromosome and is also regulated by SRY (the sex determining gene on the Y chromosome).

  • @asmadak
    @asmadak Год назад

    Is it safe to take for people who have Cancer?

  • @ChrisGroggyCreaser
    @ChrisGroggyCreaser Год назад

    - I've been Taking it Approx 2 Weeks & I Havn't felt one iota of difference to my ULTRA-TIREDNESS/BRAIN FOG!!... :(

    • @gicuneagu
      @gicuneagu Год назад

      try this : electrolyte renewal, you might be having low electrolytes, supplement magnesium, NU salt (salt with potassium chloride) for all meals then reply here if it worked ;)

  • @ArticBlueFox96
    @ArticBlueFox96 3 года назад +5

    This is great

  • @curadamortecomespermina
    @curadamortecomespermina 2 месяца назад

    People are taking spermidine via the wrong route, the wrong way, and using a weaker version of the substance, as SperMINE is more efficient at preventing oxidative damage than spermiDINE. The substance must be absorbed into the blood as a liquid crystal by the intestinal mucosa and by tooth cavities left open but treated by your dentist. And there is only one source, for liquid crystalline spermine = s*men. And that is only half of the equation...because then there is also the problem of deficient nutritional absorption ... That is why I am the only person in the world getting 100% benefit from spermine supplementation. Everyone else is clueless.

  • @sirt1353
    @sirt1353 3 года назад +1

    Could this help with hair regrowth in males as well? If no, is there any other anti-aging supplement that may be good for that?

    • @daniellem1838
      @daniellem1838 3 года назад +1

      Check out More Plates More Dates channel for men and hair loss.

    • @sirt1353
      @sirt1353 3 года назад

      @@daniellem1838 what is the summary of the things he say?

  • @cliffmode2000
    @cliffmode2000 3 года назад +1

    So if I read that table correctly the best food to eat is whole wheat bread? I'm a dumb ape. Help me. 🙏

    • @george6252
      @george6252 3 года назад +1

      I'm going to try mixing wheat germ in yogurt. Wheat bread will cause serious weight gain.
      The Spermidine supplements on Amazon are wheat germ capsules costing 59 dollars a bottle.

  • @andreycham4797
    @andreycham4797 3 года назад +3

    Now I see why women live longer

  • @GGschanel94
    @GGschanel94 Год назад

    Best spermidine supplements name ?

  • @manuelojeda9144
    @manuelojeda9144 3 года назад

    There is a recall on METAFORMIN FOR IMPURITY.

    • @panama2468
      @panama2468 2 года назад +2

      Berberine is a great replacement for metformin

  • @mik19mazz
    @mik19mazz Год назад +1

    It would have been nice if this was explained more in Layman Terms.

  • @-w-.
    @-w-. 3 года назад +2

    And here I was thinking that eating -sperm- is good for longevity.

    • @-w-.
      @-w-. 3 года назад

      Then again...... It is found in sperm 🤔

    • @ThatCatCameBack
      @ThatCatCameBack 2 года назад +1

      rub it on your face to prevent wrinkles =:3

  • @garroshhellscream8069
    @garroshhellscream8069 3 года назад

    so, can male ejaculation increase longevity while in a fasted state 24+ hours?
    because i only have sex in a fasted state because i have a better prefformance.

  • @andyz.5431
    @andyz.5431 3 года назад +3

    I simply integrated 30g of wheat germs into my breakfast.

    • @Michael_RareZebra
      @Michael_RareZebra 3 года назад +1

      Does roasted wheat germ still have spermadine intact?

  • @charlessavoie2367
    @charlessavoie2367 2 года назад

    similar to fisetin (strawberries)

  • @susymay7831
    @susymay7831 3 года назад

    Is it best to cut out dinner rather than breakfast if we are trying to eat all our calories within right hours?
    Or visa versa?

    • @FatumAedifico65
      @FatumAedifico65 3 года назад +1

      I find I'm more alert and less hungry when I don't eat breakfast than when I do. So cutting out breakfast comes easy for me. But others may have a very different response to breakfast. Listen to your body.

  • @DBCooper3
    @DBCooper3 Год назад

    You talk way to evenly and mono the whole time, that all of what you say blurs together

  • @melodymoore2943
    @melodymoore2943 3 года назад +1

    Maybe you should research fast hair growth shampoo to double hair growth.

  • @acousticmotorbike2118
    @acousticmotorbike2118 2 года назад

    Brilliant

  • @ManoBengaluru
    @ManoBengaluru 3 года назад +3

    Semen Retention

  • @ketokarbs3671
    @ketokarbs3671 2 года назад +1

    It's in MEAT

  • @yosefsugi1808
    @yosefsugi1808 Год назад

  • @gravelman5789
    @gravelman5789 3 года назад

    ONATO RULES!!!

  • @ts6070
    @ts6070 3 года назад +4

    First

    • @tomsport4537
      @tomsport4537 3 года назад +1

      I wonder if you are 9 years or older 😂😂😂

    • @ts6070
      @ts6070 3 года назад +3

      @@tomsport4537 Friend I’m definitely older than you that I’m very sure of as I do remember second boer war..😉

    • @theeclectic2919
      @theeclectic2919 3 года назад +2

      @@ts6070 I remember Lincoln!

    • @ts6070
      @ts6070 3 года назад +4

      @@theeclectic2919 I was at school with his dad..

  • @jedlimen123
    @jedlimen123 3 года назад

    Sorry, does not sound very appetizing.

  • @dieudonnecorstjens4138
    @dieudonnecorstjens4138 2 года назад +1

    If you translate somsing than do it proppely, the translator don't speak british or dutsh or both not ,it is bad.

  • @StevieWonders2020
    @StevieWonders2020 2 года назад

    Interesting---if only it was narrated in English.

  • @benv.5170
    @benv.5170 2 года назад

    Your accent is too strong

  • @stephanszwajcar2287
    @stephanszwajcar2287 3 года назад +1

    What is this accent.. i hardly understand a word 😉

    • @mayahobsbawm415
      @mayahobsbawm415 3 года назад +5

      It is Oxford English, the kind that educated people (and also upper class) is speaking!

    • @adespade119
      @adespade119 2 года назад +1

      @@mayahobsbawm415 like what I do too.

    • @theodorephillipgideon2747
      @theodorephillipgideon2747 2 года назад

      @@mayahobsbawm415 Sounds more like a black sales assistant from our local B&Q.