I made this video more for a bit of fun, these are just my opinions, *not recommendations* and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it! Do my top 5 match yours?
Matches most of mine. I’ve been following spemidine and it’s found in concentration wheat germs. However would it be safe to take a small mg dose 2-3mg from this? Spermidine Free Base, 25 Grams smile.amazon.com/dp/B0771PZQ62/ref=cm_sw_r_cp_api_glt_fabc_NHJ2FbKHX9G2D
These are the supplements I take; -NAD - Resveratrol - Glutathione - alpha lipoic acid - D3-K2 - Turmeric-Ginger compound - Multi-vitamin - Vitamin C 1000 mg - CoenzymeQ10 200 mg I'm 68 years old and bench press 36kg+36kg dumbbells 3 sets 12 reps. This formula is working quite well for me.
@@bluellamaslearnbeyondthele2456 I think the dosage is the key factor. Too much of every supplement is harmful for the body. I have my liver functions checked now and then. I personally didn't come across any problem.
My Top Five Anti-Ageing Supplements 1. Sirolimus (Rapamycin) 2. NR + Niacinamide (Not MNM) 3. Lithium Orotate 4. Melatonin 5. Resveratol (Regular exercise is by far the most proven healthspan extender. Number 2 is time-restricted eating.) The reason Metformin does not make the list is that while an excellent supplement for younger people it is very problematic for older people. I am 80 yrs. old and do not take it. I think melatonin is an extremely underrated and underappreciated healthspan and life extension supplement. I have been using it for 40 yrs and long before I started taking the other supplements. I am in excellent health and epigenetic age tests claim my epigenetic age is 64. I go to the gym 3 to 6 times a week. My BMI is 22.
I’m 64.....My top 5....bio-identical HRT, marine collagen, biotin, NAD, vitamin D. What I don’t consume......sugar, omega 6 oils, artificial sweeteners flavours and colours, refined carbohydrates. Love from Australia 🇦🇺
@@GuidetteExpert "Sunscreen and max 10 minutes a day out in the sun." Er, no. You are confusing sunshine and sunburn. Sunshine has cardiovascular benefits - and these quite apart from vitamin D3, and cardiovascular benefits that are not trivial. Remember the principle advised by natural medicine cardiologist Dr Jack Wolfson of "Sunshine good, sunburn bad" and you can't go far wrong. Also, sunscreens have chemicals that are not part of humans' natural environment, for which there is no physiological requirement or known deficiency disease, and which could be toxic; a few of these are. The foregoing stated without frivolity or vexatiousness.
@@JahreadyKnow Sad truth is that humanity evolved within the shelters they built. Their DNA got corrupted by false environment. If humans never stayed inside homes and always outside and let the environment decide their evolution, then they'd be genetically superior species today. Skin would've evolved protective layers to screen from harmful radiations as well.
Thanks! Dosing, synergistic response (with other compounds, supplements, medication, diet, etc), medical pre-conditions, , age at which administered, etc, are among key issues if one chooses to go the compound route, 1: AKG 2. Metformin 3. NAD+ precursors 4. Resveratrol 5. Rapamycin
@@jimtempleton4312 This is just my stack and not what you should be taking for example Nicain B3 with flush, I increased slowly. 1. Nac. --> 3000mg per day in 2 doses 2. niacin. --> 500mg per day and every few days 750mg in 500mg + 250mg 3. resveretrol --> 500mg trans resveratrol in yogurt with olive oil 4. apigenin --> from dried parley added to Yogurt. 2 table spoons in a cup of yogurt 5. D3 & C --> D3 is combined with K2-MK7 --> that I use once a week 5000UI of D3 and 200 mcg this is every few days loosely every 3'd day or so. C I take 2 times a day 500mg each.
Thank you, epic content ! Keep it coming! "On" brocolli / avos / fish / berries for years now, never felt better, occasional NR / resveratrol... Let's see where this is going :D
1.) 3:10 Alpha-Ketoglutarate. (AKG) Particularly good if you are a black mouse. 2.) 6:16 Metformin. 3.) 8:54 NAD+ precursors (NMN, NR, Niacin) 4.) 11:30 Resveratrol. Not just for mice. Also good if you are a fruitfly. 5.) 12:50 Rapamycin Excellent sensible commentary and details along the way.
Great Video. I'd definitely think about adding Urolithin A to the list due to it's ability to induce mitophagy. Plus maybe Nobiletin as it's a potential clock enhancing molecule and circadian dampening is highly associated with ageing and disease progression.
I follow all the main people involved in anti aging and after seeing Dr Nichola Conlon speak at the main anti aging conference (RAAD I think) two years ago , I was looking forward to the NAD+ product Time , which I now use. The data is on the website, but they appear to have boosted NAD levels 4x over the other NMN and NAD products. There are many great NAD , NMN products so I am not trying to sell lol, it just should be looked at by anyone looking for the best boost without IV infusions !
Hey Sheekey! wOw I love your content. I have been looking for this sort of thing for a while and thought it just might not exist. As someone who is trying to get into cellular therapies and the field of aging I really appreciate you following the science and not jumping to conclusion or making exaggerated claims!!! Please keep up the good work.
Metformin is difficult to obtain without a prescription, even on the Internet. An alternative is berberine ("poor mans" metformin) which can be purchased.
I think that the TAME study will change all that. Nils Barzilai predicts that in a few years once you turn 60/65 metformin will automatically be given out by gps.
Lots of Indian pharmacies on the internet that will send you metformin. Had good luck with alldaychemists. The online order from will ask for a prescription, but as long as you make a valid payment, they will send your order anyway.
Great upload! Tip for the future though, always do Top 5s or 10s starting at the bottom and working your way up to the Number 1 ( best thing ) last. It keeps people hooked and builds excitement ; - )
Please make this video a habit? Maybe once or twice a year? or whenever you feel their are changes worth updating? TY for all your excellent videos :-)
1. “Mediterranean Keto” Diet. 4 liters EVOO, fiber, green veggies, fatty fish, eight cloves garlic, polyphenols, Italian spices, Natto, 2. Six hour time restricted eating window and quarterly 48 hr fasts 3. Berberine taken with milk thistle. 4. Theracummin or Longvida Curcumin 5. HITT and resistance training
If you aren't pre-diabetic or diabetic drop berberine/metformin. Recent studies have shown no benefit over excercise alone and in fact they reduce exercise performance.
For skin anti aging, I would say sunscreen and vitamin A. And for hair, I would say 5-alpha-reductases and minoxidil. Pterostilbene may be another honorable mention.
Brilliant, thanks for the info. My Top 5: NR, Fisetin, Quercetin, Tumeric, Gamma E and as a bonus: C, D3-K2 ;) p.s. Intermittent fasting and I HIGHLY recommend reading The Phoenix Protocol Dry Fasting for Rapid Healing and Radical Life Extension: Functional Immortality it's an eye opener. Would love to get your take on it.
Great list and info as always, Eleanor! Glucosinolates also come to mind. Are you familiar with DR Jed Fahey's work? I know Rhonda Patrick is a huge fan!
I agree, the list can change so quickly now, the exponential growth in computing power is coupled with an ever increasing number of people researching year after year and it now seems like there's always something new being announced. A very exciting time to be alive...
I've divided my anti-aging/bio-hacking into three levels. Level 1. Lifestyle such as IF, CR, sleep, HIT/HIIT ie. Level 2. Hormon level. Level 3. Pathways and cells. My number one go to is dr. Khavidson protocol on Epitalon. Then d3/K2, B12, C, Magnesium, GlyNAC, DHEA/7-keto DHEA, Omega-3, fermented broccoli sprouts - some...
If you take all these expensive and weird supplements yet continue to consume processed foods, refined carbohydrates, animal products, and seed oils, then you're canceling the benefits, I think. Why not just eat a whole-food plant-based diet with plenty of omega-3 fatty acids and green vegetable juices and so on. You'll stay young that way.
If you want to enjoy a disease free life just eat foods that don't have a label, drink unfluorodated water and get plenty of fresh air and sunshine. If there's a lack of sunshine then vit D but no need for loads of other supplements. Also avoid doctors, big pharma and above all the va##ines.
Thanks. I take some of these like fisetin episodically. Likewise, with apigenin as a senolytic and CD38 modulator. Very true, dose matter, as well as duration.
Very interesting. You may find yoga study touches on aging too. Hatha yoga, very ancient teaching, serious studies are mostly avoided in the west at least.. Inverted postures slow the aging process. As do slow breathing. Great benefits for hormonal system. How about fo-ti? Gives greater energy in 2 weeks. And shilajit from high altitude mountains. (15,000' ft+)
For me, AKG is a no-brainer. I have been taking it before my NAD+ booster in the am for 2 months now. The reason it is a no-brainer is that it is so easily tolerated. No side effects; just less inflammation. AKG has not once caused me stomach upset or sleep problem.
@@PandaA-cv3mm Hi Panda, I still take 300mg dissolved in water first thing in the am. Kirkman. Ingredients say Alpha Ketoglutaric acid 300 mg. 20 mg of that is calcium AKG and 10 mg of that is magnesium AKG. My PA also has me on a gram a day of apigenin before the NAD+ booster. That is newish. To me, does the same sorta thing: anti-inflammatory.
@@izzerstennisscorekeeper3971 I surely will. I live in the U.K. now but will try to get that brand as there aren’t many available that are well respected from what I can see. How quickly would you say you noticed a difference in inflammation? Best wishes 😊
Thanks for the vid. I know this is dated but j also know you update your info on these vids. Resveratrol dietary supplements IMO are a waste of money. The compound has 3 hydroxyl groups and is metabolized very quickly as a result, resulting in poor absorption. I believe most of the RCTs for resveratrol are either done in vitro, ex vivo, or done IV. Correct me if I'm wrong on that last part. Its methylated analog, pterostilbene, is FAR SUPERIOR, and I find it works best when paired with an NM supplement, even if research on dietary NM is also conflicting.
Man, check out Ford Brewer md he takes megadoses of regular naicin..just build up to it..To me nmn and nad are proven on a cellular level but not long term ingestion by humans..too expensive for me until it is proven.Niacin may even be more effectatious..
@@geraldfriend256 thnx. ✌i watcjed that dude. Never knew his name. He turned me on cinnamon. Also, Rhonda Patrick. All this stuff works together. I can vouch for it. Im 49 and i have abs and i dont work out at the moment. I see overweight men/coworkers my age with land nad cars and property but in such poor health, overweight with one foot in the grave. But people are so clueless and uniformed and dont want to listen because its just too much info and they are too far gone.
The three yamanaka factors are the best technology against aging we have today. Veritasium also agrees. Broccoli sprouts that were heated to a specific temperature for 10min then frozen are also the best thing against preventing cancer because it has tons of sulforophane which is good against cancer. Even if nmn gives cell more energy to live, it doesn't prevent cancer which 1/4 people get. But sulforophane does. Also, its important to note than nmn and reservatrol needs to be taken with oil, like olive oil, or else it won't be bio available.
hmmm... a trial of topical all-trans retinoic acid (tretinoin) had to be halted because the intervention arm experienced higher mortality. The authors stated that they did not think there was a causal relationship, but it is a bit troubling. jamanetwork.com/journals/jamadermatology/fullarticle/711869 The study population was comprised of military veterans, mostly male. Veterans often have higher rates of toxic exposure related to their military service - lead exposure from ammunition, in particular. There may be some interaction there - it is difficult to search on the topic since 'lead' is a homograph. I did manage to find one article that looks interesting but of course it is paywalled: pubmed.ncbi.nlm.nih.gov/24291063/ More on this topic here: rhyobrain.blogspot.com/2020/12/topical-all-trans-retinoic-acid-and.html
Since I cannot get metformin without a prescription, I searched for an alternative supplement… My research showed that Berberine has been found to assist in lowering glucose levels and to help regulate as well as assist in preventing Type 2 Diabetes. Is this a good substitute? Does this supplement have the potential to have the same effect upon our bodies as Metformin and its role in anti-aging??
What do you make of the GSK research from roughly 2012 and the most recent 2020 paper using CRISPR which both seem to show that resveratrol does not activate Sirtuin pathways?
Sheekey keep up yr informed analysis. With regard to healthspan do u have any views on proteolytic enzymes and/or proresolving mediators to reduce inflamtion and repair. Also AKG supplements are mostly not calcium but arginine based. Does this make a difference. (I'm an ageing engineer not biochemist).
@@annebooyse1112 Hi Anne! It's ok, no worries)) Biosil, it's just ®Biosil, in drops or in pills. Astaxanthin, it's Bio Astin, American brand, as others are just repurchase from them. There's a scandinavic astaxanthin, but it's not so effective. Curcumin - Natural facteurs therra Curcumin. Sulphoraphane-here I get French brand prostaphane, it's very very effective. In USA and Canada they have SMART. Berberine.. Hard to say.. I'm getting here on the website Sunday.fr. Gaba + 5HTP, I'm also getting on Sunday website. Before I was ordering on e vitamins or Amazon the brand Natural factors.
What do you think of Pterostilbene vs Resveratrol? Elysium uses Pterostilbene in their NR supplement (Basis) instead of Resveratrol. They do a pretty good job of explaining why on their site.
I know this one is boring but simple Vitamin D should be on this list. It's also one of the few things NOT found in any natural food in any mentionable quantity.
@@tatifrench9365 Wrong, i t is absorbed (fat soluble) by the human body. There just is not enough in natural sources, supplements are the only solution! (Always controlled, and best taken with K2, Mg++ and Zn)
Great videos! Where can you purchase these? Such as reversatrol that will not be fake and have actual potency ? Is Berberine ok to take if you can’t get a prescription for metformin? Thank you :)
Awesome video! Surprise not to see Sulforaphane mentioned anywhere here. I guess there is much better than Sulforaphane Its nice to hear there are many other ways to battle aging. Cooking broccoli sprouts seems like a hassle and the supplements are not very absorable and expensive
Thank you for your work. Please is there any research regarding the foxOgene or telomere regulating gene? I believe the answer to health and longevity is there, but who am I to say this hehe
I do eat pine nuts ,garlic and cheese as well chuck in a small amount of as much vegetable matter the more variety the better variety is the spice of life! But one main meal per day!
80% of extra virgin olive olive is adulterated in the world. I find only organic extra Virgin olive oil from some companies correct. I add reversatrol to it.
@@APBCTechnique getting the right stuff eh !there was a Chinese herbalist that lived a long time! Supposed to have been documented to have survived for over 260years! And if believed the sumerian kings list some survived for over 50,000 years! David Sinclair eat your hat!
@@grahamfleming9179 China is very toxic now and most of their herbs. A old chinese herbalist told me they are grown with pesticides. Adam lived to just under 1000 years in the Bible. 😆 50,000 years 🤩
Please consider flexing your amazing intellect on an analysis of Sermoreline. Please include the various means of delivery into the body ie. injections, nasal, etc.... Thank you in advance for your due consideration to the aforementioned request. Respectful Regards, John Aging Stack-Bedtime: Glycine 1300mg (2 pills) NAC 1300mg (2 pills) Taurine 3000mg (3 pills) Sermoreline (nasel spray 2 pumps each nostril)
Cancer is the only condition it’s not good to take in. For the rest it’s a blessing. I take 750mg everyday and I can’t thank God enough. It’s a dream come true.
Id be really interested in this, I know there are mouse and worm studies on longevity along various studies looking at people who take it as a supplement. Its an interesting one as its a really cheap supplement.
@@jcrowviral price and safety are fairly important to me as I’m fairly young so if im going to take something, I’m going to be taking it a while. More trials on cheaper stuff and stuff that’s been around longer so we know more about the safety would be great.
@@TheSheekeyScienceShow Aha no, I know those are auto-generated; I was referring to pronunciation :P Great channel btw, you're about to get an extra view and I'll bet a thumbs-up on each video. The binge starts now ! 😁
The metformin trial still hasn't even STARTED? I remember that being announced YEARS ago! Medical science is way too slow! Been following a clinical trial involving rapamycin for treating autism for years, started in 2015 and is projected to end 2024 (!)
Metformin and rapamicin should be avoided if you want a peak phisique... They both inhibir regeneration and growth, which of course is good for longevity. NAD+ and alfa cetoglutarate, which improves mitocondrial health are the way. I'm not sure about revestarol... BAM15 should be in you list pretty soon! A safe decoupler that seems to remove unhealthy mitocondria and increase energy expenditure. Anyways, good video.
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](/img/1.gif)
I made this video more for a bit of fun, these are just my opinions, *not recommendations* and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it!
Do my top 5 match yours?
Matches most of mine. I’ve been following spemidine and it’s found in concentration wheat germs. However would it be safe to take a small mg dose 2-3mg from this? Spermidine Free Base, 25 Grams smile.amazon.com/dp/B0771PZQ62/ref=cm_sw_r_cp_api_glt_fabc_NHJ2FbKHX9G2D
1-rapamycin dosed weekly
2- metformin
3- CaAKG
4- spermidine
5-GDF-11
Tried nr and nmn, neither showed effect on my bio markers
What are your views on Berberine as a substitute for prescription Metformin?
What do you think of red algae?
Could be because they only are 25% bioavailable. I take 600 mg of NR and 1g of nmn because of this. I know it’s expensive but it works.
These are the supplements I take;
-NAD
- Resveratrol
- Glutathione
- alpha lipoic acid
- D3-K2
- Turmeric-Ginger compound
- Multi-vitamin
- Vitamin C 1000 mg
- CoenzymeQ10 200 mg
I'm 68 years old and bench press 36kg+36kg dumbbells 3 sets 12 reps.
This formula is working quite well for me.
Turmeric is pretty much a liver poison, isn't it?
@@bluellamaslearnbeyondthele2456 I think the dosage is the key factor. Too much of every supplement is harmful for the body. I have my liver functions checked now and then. I personally didn't come across any problem.
Turmeric ginger compound nedir curcumin mi?
@@karga9014 ZADE VİTAL Curcumin Forte
Nmn?
My Top Five Anti-Ageing Supplements
1. Sirolimus (Rapamycin)
2. NR + Niacinamide (Not MNM)
3. Lithium Orotate
4. Melatonin
5. Resveratol
(Regular exercise is by far the most proven healthspan extender. Number 2 is time-restricted eating.)
The reason Metformin does not make the list is that while an excellent supplement for younger people it is very problematic for older people. I am 80 yrs. old and do not take it.
I think melatonin is an extremely underrated and underappreciated healthspan and life extension supplement. I have been using it for 40 yrs and long before I started taking the other supplements. I am in excellent health and epigenetic age tests claim my epigenetic age is 64.
I go to the gym 3 to 6 times a week. My BMI is 22.
Congrats dude :)
I’m 24 and looking to stay healthy for the rest of my life
I feel lucky to be on the bio-hacking train already :)
Reservatol doesn't do anything.
I’m 64.....My top 5....bio-identical HRT, marine collagen, biotin, NAD, vitamin D. What I don’t consume......sugar, omega 6 oils, artificial sweeteners flavours and colours, refined carbohydrates. Love from Australia 🇦🇺
@pr k You need to be consistent. It takes a month to feel better and a year to look younger
@pr k Some for years, marine collagen and NAD for 6 months so far. They need time so make them part of what you do EVERY day 😊
You are a GILF.
Ur hot for a 64 year old.
1. AKG
2. Metformin
3. Nad+ (nmn)
4. Resveratrol
5. Rapamycin
1. lack of compound, see calorie restriction/fasting 2. berberine 3. garlic, 4.sulforaphane 5.ubiquinol
Fasting for sure and eating right all year around (recommend getting a dietitian), lyft weights, sunscreen and max 10 minutes a day out in the sun.
Good to see that you added sulforaphane.
@@GuidetteExpert "Sunscreen and max 10 minutes a day out in the sun." Er, no. You are confusing sunshine and sunburn. Sunshine has cardiovascular benefits - and these quite apart from vitamin D3, and cardiovascular benefits that are not trivial. Remember the principle advised by natural medicine cardiologist Dr Jack Wolfson of "Sunshine good, sunburn bad" and you can't go far wrong. Also, sunscreens have chemicals that are not part of humans' natural environment, for which there is no physiological requirement or known deficiency disease, and which could be toxic; a few of these are. The foregoing stated without frivolity or vexatiousness.
Epitalon and Thymalin
@@JahreadyKnow Sad truth is that humanity evolved within the shelters they built. Their DNA got corrupted by false environment. If humans never stayed inside homes and always outside and let the environment decide their evolution, then they'd be genetically superior species today. Skin would've evolved protective layers to screen from harmful radiations as well.
So much quality, I'm in love. All the books I've read summised in one vid
I'd say she's already taken.
Epitalon and Thymalin
#1 Epitalon
#2 Thymalin
#3 Emoxypine
#4 SS-31
#5 Maritime Bark Extract
newer and probably better choices than hers
@@Holypikemanz I thought it was a good list. Just passing on info I've learned. Thanks for the reply
@@BryanHocking reliable source for epitalon? benefits of Emoxypine?
Thanks!
Dosing, synergistic response (with other compounds, supplements, medication, diet, etc), medical pre-conditions, , age at which administered, etc, are among key issues if one chooses to go the compound route,
1: AKG
2. Metformin
3. NAD+ precursors
4. Resveratrol
5. Rapamycin
my top 5.
1. Nac.
2. niacin.
3. resveretrol
4. apigenin
5. D3 & C
Great needed that 💖💖💖💖💖💖
2. NmN ? A particular type of niacin kept in fridge cold. Should be white powder as if brown oxidated to nicamidide and isnt NMN??💖
Also need amounts in Grams pls 💖
@@jimtempleton4312
This is just my stack and not what you should be taking for example Nicain B3 with flush, I increased slowly.
1. Nac. --> 3000mg per day in 2 doses
2. niacin. --> 500mg per day and every few days 750mg in 500mg + 250mg
3. resveretrol --> 500mg trans resveratrol in yogurt with olive oil
4. apigenin --> from dried parley added to Yogurt. 2 table spoons in a cup of yogurt
5. D3 & C --> D3 is combined with K2-MK7 --> that I use once a week 5000UI of D3 and 200 mcg this is every few days loosely every 3'd day or so.
C I take 2 times a day 500mg each.
Great list. Im learning alot about Nac and niacin.
Awesome video as always!
yes, but she sounds 12 or 13 years old. she should not see any real aging till she is 45 years old. just saying
Thank you, epic content ! Keep it coming! "On" brocolli / avos / fish / berries for years now, never felt better, occasional NR / resveratrol... Let's see where this is going :D
Epitalon and Thymalin
1.) 3:10 Alpha-Ketoglutarate. (AKG) Particularly good if you are a black mouse.
2.) 6:16 Metformin.
3.) 8:54 NAD+ precursors (NMN, NR, Niacin)
4.) 11:30 Resveratrol. Not just for mice. Also good if you are a fruitfly.
5.) 12:50 Rapamycin
Excellent sensible commentary and details along the way.
Epitalon and Thymalin
Great Video. I'd definitely think about adding Urolithin A to the list due to it's ability to induce mitophagy. Plus maybe Nobiletin as it's a potential clock enhancing molecule and circadian dampening is highly associated with ageing and disease progression.
Epitalon and Thymalin
Wow, you really do your homework, really in-depth stuff.
Epitalon and Thymalin
I take nmn sublingual 750mg, trans resveratrol, TMG, parsley flakes, olive oil for anti-aging. And intermittent fasting as well
I follow all the main people involved in anti aging and after seeing Dr Nichola Conlon speak at the main anti aging conference (RAAD I think) two years ago , I was looking forward to the NAD+ product Time , which I now use. The data is on the website, but they appear to have boosted NAD levels 4x over the other NMN and NAD products. There are many great NAD , NMN products so I am not trying to sell lol, it just should be looked at by anyone looking for the best boost without IV infusions !
@pr k in short yes for sure; energy and focus heightened and skin nails are outward youthful improvements
is it working
where do you get the sublingual trans resveratrol? I have allergies to the pill form.
Lifespan is the key to a good retirement, never heard of akg interested
Hey Sheekey! wOw I love your content. I have been looking for this sort of thing for a while and thought it just might not exist. As someone who is trying to get into cellular therapies and the field of aging I really appreciate you following the science and not jumping to conclusion or making exaggerated claims!!! Please keep up the good work.
Wow, this was a great video. Thanks Sheeky!
Enjoyed you video and took notes. Thank you for doing the research for me.
Metformin is difficult to obtain without a prescription, even on the Internet. An alternative is berberine ("poor mans" metformin) which can be purchased.
I think that the TAME study will change all that. Nils Barzilai predicts that in a few years once you turn 60/65 metformin will automatically be given out by gps.
I bought a lot of metformin OTC in Colombia and Mexico
Lots of Indian pharmacies on the internet that will send you metformin. Had good luck with alldaychemists. The online order from will ask for a prescription, but as long as you make a valid payment, they will send your order anyway.
I’m in Thailand now stocking up on metformin 18 months supply
@@APBCTechnique Careful about recalls - www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-metformin
Great upload! Tip for the future though, always do Top 5s or 10s starting at the bottom and working your way up to the Number 1 ( best thing ) last. It keeps people hooked and builds excitement ; - )
Please make this video a habit? Maybe once or twice a year? or whenever you feel their are changes worth updating? TY for all your excellent videos :-)
Thanks for making this video. Appreciated!
Excellent video packed with highly valuable and well supported statements
Really excellent video. Possibly the best I've seen on this subject so far (and I've watched loads!!). Thank you, you have a new subscriber!
Thank you!! 😊
1. “Mediterranean Keto” Diet. 4 liters EVOO, fiber, green veggies, fatty fish, eight cloves garlic, polyphenols, Italian spices, Natto,
2. Six hour time restricted eating window and quarterly 48 hr fasts
3. Berberine taken with milk thistle.
4. Theracummin or Longvida Curcumin
5. HITT and resistance training
If you aren't pre-diabetic or diabetic drop berberine/metformin. Recent studies have shown no benefit over excercise alone and in fact they reduce exercise performance.
For skin anti aging, I would say sunscreen and vitamin A. And for hair, I would say 5-alpha-reductases and minoxidil. Pterostilbene may be another honorable mention.
Minoxidil is life commitment
@@mostafa202023 so is everything else...
Brilliant, thanks for the info. My Top 5: NR, Fisetin, Quercetin, Tumeric, Gamma E and as a bonus: C, D3-K2 ;) p.s. Intermittent fasting and I HIGHLY recommend reading The Phoenix Protocol Dry Fasting for Rapid Healing and Radical Life Extension: Functional Immortality it's an eye opener. Would love to get your take on it.
Epitalon and Thymalin
Any insights on berberine vs metformin? The former seems to have the edge in the supplemental space, no? Kind regards
Great content thanks for the concise information.
I absolutely love this channel
Great list and info as always, Eleanor! Glucosinolates also come to mind. Are you familiar with DR Jed Fahey's work? I know Rhonda Patrick is a huge fan!
definitely nrf2 activators such as sulforaphane as well as other isothiocyanates should be mentioned. I love Rhonda.
I agree, the list can change so quickly now, the exponential growth in computing power is coupled with an ever increasing number of people researching year after year and it now seems like there's always something new being announced. A very exciting time to be alive...
Cheers for the video it really helps with research towards improving my health, you deserve a shit tonne more subs!
And I’ll get them for her. Super star 🌟
you are awesome, please keep on doing this :)
I've divided my anti-aging/bio-hacking into three levels. Level 1. Lifestyle such as IF, CR, sleep, HIT/HIIT ie. Level 2. Hormon level. Level 3. Pathways and cells. My number one go to is dr. Khavidson protocol on Epitalon. Then d3/K2, B12, C, Magnesium, GlyNAC, DHEA/7-keto DHEA, Omega-3, fermented broccoli sprouts - some...
Great information 👍
Thank you very much for the very interesting video.
If you take all these expensive and weird supplements yet continue to consume processed foods, refined carbohydrates, animal products, and seed oils, then you're canceling the benefits, I think. Why not just eat a whole-food plant-based diet with plenty of omega-3 fatty acids and green vegetable juices and so on. You'll stay young that way.
If you want to enjoy a disease free life just eat foods that don't have a label, drink unfluorodated water and get plenty of fresh air and sunshine. If there's a lack of sunshine then vit D but no need for loads of other supplements. Also avoid doctors, big pharma and above all the va##ines.
Animal products are good for you.
Plant based diets are whack.
We’re all entitled to our own opinions. These are some of mine.
And I won’t touch these covid vaccines regardless of how much they pressure me to do so. We most certainly agree on that one.
@@iancraft7391 very horrible take
So much great info!
I'm glad you mentioned ND38, this might become more and more important as a precursessor
just stumbled on your channel and instant subbed, keep it up :)
My top 5: Benfotiamine(fat-soluble B1), Niacin, PQQ, Astaxanthin, Phospholipids(Antarctic Krill)...
2nd category list
@@juliontrump7539 what's your first category list? Please kindly elaborate.
Thanks. I take some of these like fisetin episodically. Likewise, with apigenin as a senolytic and CD38 modulator. Very true, dose matter, as well as duration.
What is a CD 38?
@@BK-dy8jk a NAD+ depletor that is overexpresed on a proaging enviroment
Mine:
1. Ca-akg
2. Glycine
3. NAC
Very interesting. You may find yoga study touches on aging too. Hatha yoga, very ancient teaching, serious studies are mostly avoided in the west at least.. Inverted postures slow the aging process. As do slow breathing. Great benefits for hormonal system. How about fo-ti? Gives greater energy in 2 weeks. And shilajit from high altitude mountains. (15,000' ft+)
Love it!
Your channle is completely underrated. My issue is trusting the supplement makers. So hard to know what you are really getting.
Thanks for the video!
amazing content as allways) ty!!
Yes, I would like to ask you what are your thoughts on Epitalon?
For me, AKG is a no-brainer. I have been taking it before my NAD+ booster in the am for 2 months now. The reason it is a no-brainer is that it is so easily tolerated. No side effects; just less inflammation. AKG has not once caused me stomach upset or sleep problem.
That’s great! May I ask what form and brand you take? ( Ca-AKG or Arginine AKG). Appreciate you sharing your positive results.
@@PandaA-cv3mm Hi Panda, I still take 300mg dissolved in water first thing in the am. Kirkman. Ingredients say Alpha Ketoglutaric acid 300 mg. 20 mg of that is calcium AKG and 10 mg of that is magnesium AKG. My PA also has me on a gram a day of apigenin before the NAD+ booster. That is newish. To me, does the same sorta thing: anti-inflammatory.
@@izzerstennisscorekeeper3971 That’s good to know. Thanks so much for sharing ;)
@@PandaA-cv3mm Let me know if you like the effects.
@@izzerstennisscorekeeper3971 I surely will. I live in the U.K. now but will try to get that brand as there aren’t many available that are well respected from what I can see. How quickly would you say you noticed a difference in inflammation? Best wishes 😊
I subscribed just because you are so close to 100,000
Great video thank you! 😎
Thanks for the vid. I know this is dated but j also know you update your info on these vids.
Resveratrol dietary supplements IMO are a waste of money. The compound has 3 hydroxyl groups and is metabolized very quickly as a result, resulting in poor absorption. I believe most of the RCTs for resveratrol are either done in vitro, ex vivo, or done IV. Correct me if I'm wrong on that last part.
Its methylated analog, pterostilbene, is FAR SUPERIOR, and I find it works best when paired with an NM supplement, even if research on dietary NM is also conflicting.
Full flush/regular Niacin is a LOT cheaper as a precursor to NAD than NMN supplements. Is it as effective as NMN? Can you take both?
Unfortunately NMN is blocked by CD38. Niacin isnt.
@@ew2886 is that a good thing?
Man, check out Ford Brewer md he takes megadoses of regular naicin..just build up to it..To me nmn and nad are proven on a cellular level but not long term ingestion by humans..too expensive for me until it is proven.Niacin may even be more effectatious..
@@geraldfriend256 thnx. ✌i watcjed that dude. Never knew his name. He turned me on cinnamon. Also, Rhonda Patrick. All this stuff works together. I can vouch for it. Im 49 and i have abs and i dont work out at the moment. I see overweight men/coworkers my age with land nad cars and property but in such poor health, overweight with one foot in the grave. But people are so clueless and uniformed and dont want to listen because its just too much info and they are too far gone.
Sorry for my slow reply. I can't say it is a good thing. You can watch Brad Stanfield, Rhonda Patrick etc.
Very complete...good job
Great info. Anything on car t and cancer? Cure?
The three yamanaka factors are the best technology against aging we have today. Veritasium also agrees. Broccoli sprouts that were heated to a specific temperature for 10min then frozen are also the best thing against preventing cancer because it has tons of sulforophane which is good against cancer.
Even if nmn gives cell more energy to live, it doesn't prevent cancer which 1/4 people get. But sulforophane does.
Also, its important to note than nmn and reservatrol needs to be taken with oil, like olive oil, or else it won't be bio available.
EXCELLENT !
I think retinol should be included, increases skin cell turnover rate and prevents skin cancer
hmmm... a trial of topical all-trans retinoic acid (tretinoin) had to be halted because the intervention arm experienced higher mortality. The authors stated that they did not think there was a causal relationship, but it is a bit troubling.
jamanetwork.com/journals/jamadermatology/fullarticle/711869
The study population was comprised of military veterans, mostly male. Veterans often have higher rates of toxic exposure related to their military service - lead exposure from ammunition, in particular. There may be some interaction there - it is difficult to search on the topic since 'lead' is a homograph. I did manage to find one article that looks interesting but of course it is paywalled:
pubmed.ncbi.nlm.nih.gov/24291063/
More on this topic here:
rhyobrain.blogspot.com/2020/12/topical-all-trans-retinoic-acid-and.html
great work, in an interesting field. for human trials i think the socioeconomic confounding should be but into consideration for longevity studies
Thanks so much!
Video starts at 3:10
Another cool science show! :)
Great . please keep the good work .
Examples of foods including these elements would be interesting
Since I cannot get metformin without a prescription, I searched for an alternative supplement…
My research showed that Berberine has been found to assist in lowering glucose levels and to help regulate as well as assist in preventing Type 2 Diabetes.
Is this a good substitute?
Does this supplement have the potential to have the same effect upon our bodies as Metformin and its role in anti-aging??
Yeah, I think it interrupts MPC1 pathway in mitochondria also and activates AMPK so it is a calorie restriction mimetic
What do you make of the GSK research from roughly 2012 and the most recent 2020 paper using CRISPR which both seem to show that resveratrol does not activate Sirtuin pathways?
Sheekey keep up yr informed analysis. With regard to healthspan do u have any views on proteolytic enzymes and/or proresolving mediators to reduce inflamtion and repair. Also AKG supplements are mostly not calcium but arginine based. Does this make a difference. (I'm an ageing engineer not biochemist).
Great job!
I take these at the moment: Hydrolyzed collagen peptides, Hyaluronic acid, NR, AKG, Apigenin, Quercetin, DHEA, Ubiquinol
Wow .. I had to listen more than once just for the accent !
Pretty fair, but quite pricy.. To start with its good to go with Biosil + Astaxanthin 12mg + Curcumin + Sulphorafane + Berberine + 5HTP/Gaba.
Phoebe Samui, which brand please?☺
Apologies, Phoebe Samaqui.☺
@@annebooyse1112 Hi Anne! It's ok, no worries)) Biosil, it's just ®Biosil, in drops or in pills. Astaxanthin, it's Bio Astin, American brand, as others are just repurchase from them. There's a scandinavic astaxanthin, but it's not so effective. Curcumin - Natural facteurs therra Curcumin. Sulphoraphane-here I get French brand prostaphane, it's very very effective. In USA and Canada they have SMART. Berberine.. Hard to say.. I'm getting here on the website Sunday.fr. Gaba + 5HTP, I'm also getting on Sunday website. Before I was ordering on e vitamins or Amazon the brand Natural factors.
What do you think of Pterostilbene vs Resveratrol? Elysium uses Pterostilbene in their NR supplement (Basis) instead of Resveratrol. They do a pretty good job of explaining why on their site.
I know this one is boring but simple Vitamin D should be on this list. It's also one of the few things NOT found in any natural food in any mentionable quantity.
It’s not absorbed by humans. Sun light is the only natural source.
@@tatifrench9365 Wrong, i t is absorbed (fat soluble) by the human body. There just is not enough in natural sources, supplements are the only solution! (Always controlled, and best taken with K2, Mg++ and Zn)
Consider Pterostilbene as an analog of Resveratrol that is more bio available and less expensive.
Great videos! Where can you purchase these? Such as reversatrol that will not be fake and have actual potency ? Is Berberine ok to take if you can’t get a prescription for metformin? Thank you :)
Just started NMN 6 days ago and have noticed a huge increase in energy and motivation.
70 years old and am lifting heavier weights also at the gym.
How much do u take ?
@@zibtihaj3213 Initially 500 mg, now 1 gram.
@@george6252 thx
TMG as well George?
I think TMG should be used to counter the negative effect of sulforaphane+niacinamide reaction . What do you think ?
What is the best NAD+ precursor - NR or NMN?
Anti-Aging Stack: Gly-Nac, Taurine, AKG, Fisetin, Sermoreline (nasal mist), and TRT.........I'm 60 6' 230 lbs Monday, Wednesday, and Friday morning whole body workouts.......then in the afternoon 8 sets of 25 pushups........
So how do you prevent all the benefits for healthy cells working for cancer cells as well?
Awesome video! Surprise not to see Sulforaphane mentioned anywhere here. I guess there is much better than Sulforaphane
Its nice to hear there are many other ways to battle aging. Cooking broccoli sprouts seems like a hassle and the supplements are not very absorable and expensive
Do you think that using streptomyces hygroscopicus the bacteria that produces rapamycin as a yogurt probiotic would have similar or better results?
Thank you for your work. Please is there any research regarding the foxOgene or telomere regulating gene? I believe the answer to health and longevity is there, but who am I to say this hehe
Carnosine. Astaxanthin. Curcumin. Grape seed extract. Nac. Zinc. Quercetin. D3. Cilantro/parsley.
Extra virgin oil is far more effective than reservatol and parsley and basil could be added the list is endless well done though.
This, looks like nothing like a good pesto with olive oil :D but no pasta!!!
I do eat pine nuts ,garlic and cheese as well chuck in a small amount of as much vegetable matter the more variety the better variety is the spice of life! But one main meal per day!
80% of extra virgin olive olive is adulterated in the world. I find only organic extra Virgin olive oil from some companies correct. I add reversatrol to it.
@@APBCTechnique getting the right stuff eh !there was a Chinese herbalist that lived a long time! Supposed to have been documented to have survived for over 260years! And if believed the sumerian kings list some survived for over 50,000 years!
David Sinclair eat your hat!
@@grahamfleming9179 China is very toxic now and most of their herbs. A old chinese herbalist told me they are grown with pesticides. Adam lived to just under 1000 years in the Bible. 😆 50,000 years 🤩
how about telomerase activators such as cycloastragenol come to mind
Love your channel. You do fantastic work. Thank you.
i made a recent video on telomeres, thanks
AKG might be good for macular degeneration; would like to see a trial.
Please consider flexing your amazing intellect on an analysis of Sermoreline. Please include the various means of delivery into the body ie. injections, nasal, etc....
Thank you in advance for your due consideration to the aforementioned request.
Respectful Regards,
John
Aging Stack-Bedtime:
Glycine 1300mg (2 pills)
NAC 1300mg (2 pills)
Taurine 3000mg (3 pills)
Sermoreline (nasel spray 2 pumps each nostril)
good stuff. you could have tossed in a few CD 38 inhibitors :)
What do you think the risk of stimulating cancer with NR or NMN is?
I’ve heard it’s not good in case of Cancer.
@@diptimnm I heard that it is not good if you have cancer as well.
Cancer is the only condition it’s not good to take in. For the rest it’s a blessing. I take 750mg everyday and I can’t thank God enough. It’s a dream come true.
I've heard these things are probably not good for someone who has existing cancer, but I am no expert.
Excellent.
Thoughts on Glucosamine, which may reduce all cause mortality - maybe by improving mitochondrial function?
Id be really interested in this, I know there are mouse and worm studies on longevity along various studies looking at people who take it as a supplement. Its an interesting one as its a really cheap supplement.
you beat me to it; there are a few possible mechanisms for glucosamine - rhyobrain.blogspot.com/2020/12/another-epidemiological-study-finds.html
Lithium cheap af too
@@IEatUnicornFishCake the best stuff is cheap it seems. Niacin, oleic acid, vit c, akg. All affordable.
@@jcrowviral price and safety are fairly important to me as I’m fairly young so if im going to take something, I’m going to be taking it a while. More trials on cheaper stuff and stuff that’s been around longer so we know more about the safety would be great.
You sound like a biochemist. What is your training in this subject? Thank you for sharing and the disclaimers for this information. Good work.
Haha, yes am a biochemist. BA & Msci Biochemistry. Now Phd student 😊
@@TheSheekeyScienceShow Just pointing out that it's "DNA Methylation" and not "DNA meflation" but overall pristine stuff! New subscriber right here :)
@@___Zack___ i don't right the subtitles if that's what you are referring to and thanks!
*write, haha
@@TheSheekeyScienceShow Aha no, I know those are auto-generated; I was referring to pronunciation :P
Great channel btw, you're about to get an extra view and I'll bet a thumbs-up on each video. The binge starts now ! 😁
The metformin trial still hasn't even STARTED? I remember that being announced YEARS ago! Medical science is way too slow!
Been following a clinical trial involving rapamycin for treating autism for years, started in 2015 and is projected to end 2024 (!)
Metformin and rapamicin should be avoided if you want a peak phisique... They both inhibir regeneration and growth, which of course is good for longevity. NAD+ and alfa cetoglutarate, which improves mitocondrial health are the way. I'm not sure about revestarol... BAM15 should be in you list pretty soon! A safe decoupler that seems to remove unhealthy mitocondria and increase energy expenditure. Anyways, good video.
L arginine, L citrulline as ON gas as heart and veins protect.
Mg treonate as brain protect.
Also less lectins to help Akkermansia in gut.