This years biggest breakthroughs in longevity (2023 edition) !!!
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- Опубликовано: 31 июл 2024
- Every year I compile what I think were some important contributions to longevity research. Here is my list for 2023.
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Intro - 00:00
What causes aging? - 00:32
Hallmarks Of Aging: An Expanding Universe
The DREAM Complex Functions As Conserved Master Regulator Of Somatic DNA-Repair Capacities
Biomarkers - 02:00
The Aging Biomarker Consortium Represents A New Era For Aging Research In China
Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock
A Foundation Model For Generalizable Disease Detection From Retinal Images
Cellular reprogramming - 04:30
Chemically induced reprogramming to reverse cellular aging
Loss of epigenetic information as a cause of mammalian aging
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
Lifespan extension - 07:30
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
Taurine deficiency as a driver of aging
Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice
Optogenetic Rejuvenation Of Mitochondrial Membrane Potential Extends C. Elegans Lifespan
Reversal Of Biological Age In Multiple Rat Organs By Young Porcine Plasma Fraction
Multi-Omic Rejuvenation And Life Span Extension On Exposure To Youthful Circulation
Biotechnology - 13:50
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
Why we age - 15:15
Ageing as a software design flaw
The Longevity Bottleneck Hypothesis: Could Dinosaurs Have Shaped Ageing In Present‐Day Mammals?
Reconsidering Life History Theory Amid Infectious Diseases
Blood Group A Enhances SARS-CoV-2 Infection
What's next? - 16:50
There are many items missing from this list - these are only the papers I found time to read. Please post below any I missed!
ICYMI
2022 longevity papers
2021 longevity papers
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
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Happy New Year!
same to you :)
Thanks Sheeky. New subscriber here 😊Watching the old ones
Happy New Year to you and the fam. Much Health and Wealth for 2024 and beyond.
Great overview of some of the advances - thank you! How about the work of Michael Levine’s lab / intercellular communication? Congratulations on the completion of your PhD. 😊
Happy new year 🎉
Congrats on defending!! Now you choose your own path! We need more people working on longevity, aging reversal, and age-related disease! Thank you!!
Congrats on your successful doctoral defense! 👏🏼
I recently came across João Passos (Mayo Clinic) talk at ARDD 2023 talk and thought that should be bigger news. To actually show that the SASP senescent cells occurs because of leakage of mtDNA and it was possible to remove aging effects by blocking the leakage (dramatically reducing SASP) without killing the senescent cells was quite interesting.
Link?
Links are removed immediately. You can, however, copy/paste the title of the report.... @@richfuller
Congrats! Really hope you keep posting. This topic needs people that take the science seriously!
Congratulations its great you are doing something you clearly love.😀
Congrats on your doctoral achievement! Understanding what a challenge this process can be, combined with my appreciation of the quality and subject matter of your videos, I was inspired to support. I hope you are able to sustain and balance both activities.
I'm always suspicious of Sinclair's studies in which they claim to "induce aging," and then "reverse" it. Is the repair of artificial damage that they themselves cause really the same as "age reversal?" I highly doubt it. But that's how Sinclair always pitches it. The dude strikes me as kind of a charlatan.
well i am not a fan of sinclair since there are a lot of people telling that working of resveratrol is not confirmed
Congratulations on your academic career - and thanks for continuing this amazing channel!
Congratulations and happy new year!!! ... thanks for sharing this amazing content
Excellent summary of the year's longevity breakthroughs. I am looking forward to seeing the breakthroughs of the next year. Happy New Years.
Congratulations and thank you so much for sharing this important topic. Much good wishes for you in the year ahead.
cngrats Dr. Sheekey! I love what you are doing.
Happy New Year! You are the best!
I wish you continued success on your channel
Your videos are awesome!
Keep it up!
Thank you, Sheekey, for an outstanding, concise assemblage, as usual. Regarding taurine, you might be interested that inhibition of the taurine transporter (TauT/SLC6A6) mediates muscle atrophy (Warskulat U, 2004; Baliou S, 2020). One cause of TauT inhibition is nitration of its tyrosine residues by peroxynitrate generated in conditions of nitrative stress (Webster, 2008; Khullar, 2004; Roos, 2004). Also, regarding possible selective advantage of aging, there is the theory that where food is limited for a species, individuals of reproductive age compete for food with those past reproductive age, thus hastening death after reproductive age increases biotic potential of a species. Happy New Year!
It will be sad to lose you, but I know life changes and decisions have to be made but I enjoyed your channel and dependent on it for information so hope you stay with us for as long as you’re able
Thanks for 2023- Happy 2024!
Always thank you for the great contents!
Happy new year❤
From 🇰🇷
Congrats! Dr. Sheekey!
Congratulations Dr. Sheekey!
Happy new year Dr. Sheeky!
Great video and congrats Dr!!
Congratulations on your doctorate degree!
Great summary of some of the year's biggest biogerontological research-related findings. This is especially useful for laypeople like me (who can't access all of the relevant peer-reviewed papers/reports)!
Congratulations!!
Great stuff. Very informative.
Congrats! Doc.
Congratulations!
Happy New Year Doctor!
HNY, thanks for making these videos
I believe I will hang about and perhaps have a spot of tea while I enjoy your video.
Congrats 🍾🎈🎊🎉
Hooray for the successful defense! Also, looking forward to that video which is currently in your editing queue :)
You're doing good work for those of us who are 20 years ahead of you and wonder if any of this stuff is going to be ready for us. The clock's ticking for everyone.
Congrats!
Hopefully by the 30s we’ll have discovered immortality
As usual, Im late to the party. But Congratulations on your Doctorate Degree!! What an accomplishment!!
What supplements or other interventions do you take Sheeky?
Loved your singing. Making it more fun
Congratulations on your successful thesis defense! Lots of opportunities for you anywhere, but hoping you decide to try the USA for a while.
Congratulations Dr. S!
On astaxanthin, disappointing the ITP used doses orders of magnitude higher than in diet or supplements. Researchers should provide human equivalent doses in their papers to make this clear, and also test realistic doses along side higher doses. Similar for Fisetin in that it appears ITP dose (600 ppm) may have been low compared to what James Kirkland used (20 mg/kg of body weight) or method of delivery (not bolus) not ideal. Again, with fisetin, human equivalent doses should have been given. Simple plasma dilution (Conboy lab 2020 and 2022 papers), a practical intervention, is not getting enough traction as it appears to have many of the benefits as heterochronic parabiosis, not practical as an intervention.
I go for a walk when the mood takes me. Seems to work quite well.
Thanks for putting this together Ms... ahem, I mean Dr Sheekey. I enjoyed the occasional goofy touches (mean that in the most positive sense.. I'm a Pippy Longstocking fan forever lol). If you like constructive critisism, it would be that I'd have loved a conclusion for lay people per section, in some quantitative way that communicates amount of benefit. This satisfies both the deeply technical types and lay people alike, plus .. reaching more audiences is a good way to improve the channel.
Dr. Sheekey I presume? Congratulations on obtaining your doctorate.
Not completely official, but due to be!
Which tablet are you using for handwriting in your videos?
thx for timestamp
Just what I need, to live longer so I can listen to earth’s death moans.
Good luck.
Big life changes... Good luck with those.
You should review Michael Greger’s new book How Not To Age
What supplements do you take? Are there any special foods that you eat to get naturally formed molecules in lieu of those found in supplements that are extracted or synthesized? Right now I'm taking around a hundred different supplements a day. The one that scares me the most that I haven't taken yet is fisetin. According to Rimon of wellness messiah the recommended dosage is 20 mg per KG of body weight one time once every one to three months. Low levels continuously have now effect which is why the experimental results he cited showed no effect. I never heard of anyone dying of eating too many strawberries. Maybe a stomach ache but not serious illness or death. 😊Would you try it yourself? Have you tried it?
What the now effect?
❤❤
15:40 Ruddy dinosaurs! 🦕🦖😉
What about a summary of Spermidine and Ca-AKG?
one more you have to know and i found is that senesencce occur because of stem cell deficiency and signals of it propagate to other cells to come to sene and do not apoptosis because there is no there to differentiate raldh1 deficiency as it is the stem cell marker that they express to turn retinal to retinoic to differentiate , beause of this if we use retinoic acid forcefully it will have side effects in long run
Congratulations on your PhD achievement😊あけましておめでとう
Thanks for a great show! Now why do we age? Because over population threatens the species and eco system. We need to break with reductionist ideas of individual darwinian selection. Happy New Year!
Congrats on the PhD defense!
Good content . But Rambling communication.
Hi. Your videos are great. But can you please talk slower and more clear? As a non British speaker, many times I find your accent vague. Thanks
CDC ? LOL, Negative !
Rambling talk.
Perhaps would be easier if you focus better on the subject. Thanks
You are talking waaaaaay too much before the important stuff, it is annoying to listen sorry