Gluconeogenesis Pathway Made Simple - BIOCHEMISTERY

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  • Опубликовано: 21 дек 2024

Комментарии • 306

  • @aizamd
    @aizamd 5 лет назад +802

    It is important to note that oxaloacetate cannot cross outside the mitochondrion. It has to be converted to Malate, which will be transported to the cytosol via Malate-Aspartate Shuttle. Malate (now in cytosol) is then converted back to oxaloacetate (because of high amount of NAD+ in the cytosol) allowing phosphoenolpyruvate kinase to catalyze it into phosphoenol pyruvate. 😊

    • @AnkitaSingh-wh2qq
      @AnkitaSingh-wh2qq 3 года назад +9

      Thnxx for the information ❤

    • @dylanmuneku9291
      @dylanmuneku9291 3 года назад +3

      Thank you very much

    • @Jelieto
      @Jelieto 3 года назад +15

      Ok I'm here to learn a bit about a low carb high fat diet and I have absolutely no idea what you're talking about 🤣

    • @nathanhaigler8139
      @nathanhaigler8139 2 года назад +4

      Very clear description. Thank you

    • @patiencechepkorir5596
      @patiencechepkorir5596 2 года назад +3

      True Aiza....thumbs up 😌 for being keen

  • @juststudies8341
    @juststudies8341 4 года назад +268

    4:38 The enzyme used to convert Phosphonenolpyruvate to Pyruvate is Pyruvate Kinase not PFK1. It's written in biochem textbooks and can also be found online when you search for step 10 of glycolysis

  • @ALMLSAN
    @ALMLSAN 4 года назад +34

    Hexokinase also converts glucose to glucose 6 phosphate. Glucokinase does the same job but specifically in the liver. Thanks for the video 👍

    • @Natasha_Mirza
      @Natasha_Mirza 2 года назад +5

      Glucokinase is 4th form of hexokinase. So you can also say it hexokinase.

    • @yadinoori7372
      @yadinoori7372 2 года назад +2

      @@Natasha_Mirza yeah i was about to reply with that

    • @queennoor6474
      @queennoor6474 Месяц назад

      Hexokinase is an enzyme that help glucose convert into fructose 6 phosphate

  • @sariasultan5370
    @sariasultan5370 7 лет назад +414

    wait the enzyme which converts PEP to pyruvate is pyruvate kinase not phophorfructokinase

    • @hasithaliyanaarachchi3648
      @hasithaliyanaarachchi3648 7 лет назад +11

      u ar correct..its not PFK

    • @alons222
      @alons222 7 лет назад +13

      yes you are right!!
      terrible error!

    • @MrPridizzle
      @MrPridizzle 7 лет назад +4

      Saria Sultan good eye, good eye

    • @mohanjr
      @mohanjr 7 лет назад +1

      I saw it even me right now

    • @DrSultanV
      @DrSultanV 7 лет назад +6

      I saw it and I rolled down to see an explanation and here you are lol

  • @aishwarya6362
    @aishwarya6362 6 лет назад +24

    Found it on the last day of preparation. Helps a lot :)

    • @HR_51_FBD
      @HR_51_FBD 4 года назад

      Can you make me understand....in more simplified way..

  • @DrSultanV
    @DrSultanV 7 лет назад +146

    very helpful and simplifying, but please avoid mistakes such as the pfk mistake in the step 10 of glycolysis. this could be misleading for students who are having an exam. at least put a correction in the comments or the discription.

    • @jadumonigogoi403
      @jadumonigogoi403 3 года назад +1

      no donations no corrections,correct ion can be done at glucokinase/hexokinase,phosphofructokinase/pyruvate kinase, malate/oxaloacetate shunt. huh.

  • @fajarqadeer5505
    @fajarqadeer5505 4 года назад +3

    Your channel makes my concepts always clear. This is really superb way to understand anyone.

  • @allinone-ps3ou
    @allinone-ps3ou 7 лет назад +4

    Sir I am watching your channel from last 1year I really love the way you share the topics to us,becouse you have been teaching us sir I have started my channel on RUclips just getting inspiring from you i started my channel last weak only,I really thank you a lot for making me inspire sir.

  • @aniketdas7803
    @aniketdas7803 Год назад +1

    Very helpful. Explain the topic in a very crisp and profound manner.
    Thank you.

  • @NagulanMusical19
    @NagulanMusical19 5 лет назад +3

    I think glucokinase which converts Glucose to Glucose 6 phosphate, only can be found in the Liver. Usually, Glycolysis can occur in all cells, so Hexokinase is the one that would replace glucokinase.

  • @darkmaster1803
    @darkmaster1803 7 лет назад +11

    I like your videos. They are short and easy but please don't make mistakes in enzymes or steps.

  • @prashantbhandari7953
    @prashantbhandari7953 6 лет назад +44

    4: 38 it is Pyruvate kinase not phosphofructokinase. BTW good 👍video.

  • @punyaprasadini
    @punyaprasadini 9 месяцев назад +2

    Thank you very much sir. ❤ from Sri Lanka

  • @drmidhunjn
    @drmidhunjn 7 лет назад +7

    Best explanation in short time every found in internet. Thanks for explaining once more about Glycolysis

  • @rayaroy519
    @rayaroy519 4 года назад +16

    You should also mention that Glucose to G6P is converted by Glucokinse/Hexokinase as Glucokinase is only present in hepatocytes and B-cells of pancreas.

  • @aishuaish3763
    @aishuaish3763 4 года назад +3

    And also...the oxaloacetate inside the mitochondria is first converted to mate which is transferred to cytoplasm where it again become oxaloacetate

  • @victorvk2506
    @victorvk2506 7 лет назад +9

    thanku so much. this video helped me to understand gluconeogenesis.

  • @ayubabukarosman985
    @ayubabukarosman985 5 лет назад +1

    From somalia thnks , for u lecture, it is very nice

  • @hellohari85
    @hellohari85 5 лет назад +1

    Pyruvate-->Acetyl coA-->OAA-->Malate(crosses mitochondria) ---> PEP ( in the cytosol)

  • @sanjaykumarskr579
    @sanjaykumarskr579 3 года назад +2

    Verithanam 🔥🌟

  • @IshwariPetkar
    @IshwariPetkar 7 месяцев назад +2

    Thank you so much sir from Maharashtra

  • @diptiranjanbiswal6277
    @diptiranjanbiswal6277 5 лет назад +1

    Itz. Amazing Lecture __100% understanding thnks to MedSimplified

  • @saherali6662
    @saherali6662 7 лет назад +1

    best channel ever

  • @faridalam798
    @faridalam798 6 лет назад

    This is the best I have ever seen

  • @sangitasharma4692
    @sangitasharma4692 Год назад

    4:55 pyruvate is directly converted to oxaloacetate or is first converted to acytyl coA then oxaloacetate as in krebs cycle

  • @bethusilegamedze946
    @bethusilegamedze946 10 месяцев назад

    Glucose is converted to G6P by enzyme Kinase and it's called the phosphorylation step(1st step) and ADP is converted to ATP as it is energy investment phase with the cofactor Mg2+

  • @rimshasaif6026
    @rimshasaif6026 4 года назад +3

    Such a great videos...splendid..
    May u get success in every field.. Plz do it on anothers topics of biochemitry.

  • @drdineshraja5335
    @drdineshraja5335 7 лет назад +3

    Great outline of this pathway sir👏👏

  • @TheMGPforlife
    @TheMGPforlife 7 лет назад +2

    Thankyou ! Great revision for my metabolism exam 😄

  • @saptashreegavali7363
    @saptashreegavali7363 3 года назад +2

    Thankyou soo much !!!!! U really help in understanding biochemistry easily 💛

  • @nystagmus
    @nystagmus 5 лет назад +1

    You should redo this video with the corrections because it really is very good on how your layout things so simply. It is excellent so I suggest you re- do the video with corrections.

    • @MEDSimplified
      @MEDSimplified  5 лет назад

      I took your advise to the heart brother. New videos on carbohydrate metabolism coming in a few weeks ok. 😉😉😉😉😉😉

    • @nystagmus
      @nystagmus 5 лет назад

      MEDSimplified thank you for teaching

  • @EasyMedEasyway
    @EasyMedEasyway 4 года назад

    Great work broda.👏👏😍

  • @abdulraimi766
    @abdulraimi766 6 лет назад +6

    HELPED ME A LOT THANKS MAN!

  • @drumartinez1918
    @drumartinez1918 6 лет назад

    man this stuff is like better than khan academy, very nice work

  • @shehlamahr9621
    @shehlamahr9621 6 лет назад +5

    Thanks a lot sir...Its really very helpful.. 💖 JazakAllah JazakAllah 🙏

  • @whatapainx5420
    @whatapainx5420 4 года назад

    The best explanation 👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻

  • @ahmadayyash3032
    @ahmadayyash3032 6 лет назад +1

    Thaaank you very much
    I like your videos so much
    Best wishes

  • @jessicap713
    @jessicap713 3 года назад +3

    thank you for this!! saving me in my macro metabolism class!

  • @vinniedolly716
    @vinniedolly716 6 лет назад +4

    Dear Sir, your videos are excellent. Please make a video on glycogenolysis also.

  • @gouriiiiii
    @gouriiiiii Год назад

    I have a doubt. When glycerol is used as a substrate, gycerol-3-phosphate is formed and it gets converted to dihydroxy acetone phosphate for reverse reaction. Can't the glycerol-3-phosphate directly participate in the reverse reaction?

  • @nasreenkhan694
    @nasreenkhan694 5 лет назад +1

    Thanks it's very sufficient and helpful

  • @jhanavijhanavi3958
    @jhanavijhanavi3958 3 года назад

    Wah!!! What explanation it easy to understand and write by own thanks alot sir ur explanation is superb 🙏

  • @gulzareen3182
    @gulzareen3182 6 лет назад

    Best teaching method 👍

  • @carakapawana
    @carakapawana 4 года назад +1

    After from mitochondria where the oxalo go?

  • @chandakumari9299
    @chandakumari9299 6 лет назад

    Made it clear , voice was good too ☺

  • @sayalisarode8686
    @sayalisarode8686 2 года назад

    Your lec are best ... 👍👍

  • @justbirjethings
    @justbirjethings 7 лет назад +13

    Can you upload glycogenesis, glycolysis, etc and hmp shunt?

    • @MEDSimplified
      @MEDSimplified  7 лет назад +3

      +Aishwarya Birje U can find the video on glycolysis but j our channel. Glycogenesis and hmp shunt will also be uploaded soon mam

    • @justbirjethings
      @justbirjethings 7 лет назад +2

      MEDSimplified Glycogenolysis* 👅 my bad!

    • @justbirjethings
      @justbirjethings 7 лет назад

      MEDSimplified and thanks!

    • @ashishpandor1970
      @ashishpandor1970 6 лет назад

      MEDSimplified hmp shunt pathway ?

  • @jagan2058
    @jagan2058 7 лет назад

    very easy to understand the concepts and steps...pls add more topics

  • @Supra_green_505
    @Supra_green_505 3 года назад

    This video help me in my project 😊

  • @rasikawade9852
    @rasikawade9852 5 лет назад

    You explain in the simplest way possible..just one request please try to cover the portion in details

  • @human2951
    @human2951 3 года назад

    Why did you not discuss Regulation of gluconeogenesis?

  • @dr.baleeghwsaby8829
    @dr.baleeghwsaby8829 6 лет назад +1

    انت مبدع شكرا جزيلا لك from yemen thanks

  • @mak8721
    @mak8721 3 года назад

    I like your videos sir. These are helpful

  • @laibahafeez592
    @laibahafeez592 11 месяцев назад +1

    Please make a video on pentose phosphate pathway

  • @jordanc9100
    @jordanc9100 6 лет назад +2

    I was under the impression that gluconeogenesis could be classified as the creation of new glucose from non-carbohydrate sources - i.e., shuttling fructose into gluconeogenesis at the liver so it can be released to the rest of the peripheral organs as glucose.

  • @caleb6709
    @caleb6709 7 лет назад +1

    How often and in what amounts does this process actually happen during fasting? I've hear of gluconeogenesis happening with amino acids, but I think fatty acids actually convert to ketone bodies, not glucose, during fasting that lasts more than 24-48 hours. I'm willing to be that this reversal of pyruvate back to glucose happens on a very small scale, or maybe a temporary emergency situation when glyocogen stores are extremely low. I'm also willing to bet that muscle tissue used for energy is low as well during a fast. It only makes sense that during fasting, the body is smart enough to utilize the stored fuel in adipose tissue as it's primary source.

    • @caleb6709
      @caleb6709 7 лет назад

      Also, when it comes to fatty acid metabolism; two glycerol backbones of triglycerides can form one glucose molecule. Perhaps this is what you mean't by fatty acids being converted into glucose. This form of gluconeogenesis happens on a small scale as well, but it does portent that dietary carbohydrate intake may be completely unnecessary.

  • @divyabalani7382
    @divyabalani7382 7 лет назад +4

    very useful video at last I got it thank u so much medsimplified...

  • @sayalisarode8686
    @sayalisarode8686 2 года назад

    When phosphoenol pyruvate will convert to pyruvate enzyme should pyruvate kinase......you are saying phosphofructokinase
    So can you plzz guide what it should be sir...

  • @michaelsrowland
    @michaelsrowland 8 месяцев назад

    Does the body perform gluconeogenesis before fat metabolism??

  • @kaldanHamil
    @kaldanHamil 4 года назад

    Oxaloacetate is impermeable to mitochondrial membrane it is converted to malate and then transported to cytosol and oxaloacetate is regenerated by malate dehydrogenase enzyme

  • @aardishasah2949
    @aardishasah2949 Год назад

    Thank you❤ so much 😊

  • @victorwang3629
    @victorwang3629 2 года назад

    7 minutes video worth more than my lecturer slides lmaooo

  • @aditiboro4123
    @aditiboro4123 3 года назад

    very nice. also glycerol part of fat and not fat is converted to glucose

  • @rashim.jbajaj
    @rashim.jbajaj 3 месяца назад

    Great explanation

  • @shaktisingh2742
    @shaktisingh2742 6 лет назад

    Thnx dude got the notes for gluconeogenisis😉

  • @noorulainmalik6235
    @noorulainmalik6235 6 лет назад

    which app are you using to make videos ?

  • @masalakshmidevi2810
    @masalakshmidevi2810 3 года назад

    Thank u very much.
    It is a nice video .
    Try to make hmp shunt also.

  • @gouthamreddy3419
    @gouthamreddy3419 Год назад

    TQ short and relavent for mbbs

  • @srikantpanda7993
    @srikantpanda7993 2 года назад

    NIce Explanation Thanks

  • @thamisanqadeputy7695
    @thamisanqadeputy7695 5 лет назад +1

    i was confused but after 7 minutes I now understand this process

  • @juststudies8341
    @juststudies8341 4 года назад

    Don't we use hexokinase to convert glucose to glucose 6 phosphate?

  • @mohdomar92
    @mohdomar92 6 лет назад

    Isn't the enzyme converting phosphoenolpyruvate to pyruvate called pyruvate kinase?

  • @musikaaffection8570
    @musikaaffection8570 2 года назад

    Thank you soo much sir 🥰✌️

  • @tms2295
    @tms2295 3 года назад

    Isn't is supposed to be pyruvate kinase enzyme that converts Phosphoenol pyruvate to Pyruvate? :))

  • @The.Lilomay
    @The.Lilomay Год назад

    Do we only do Gluconeogenesis from Amino Acids when we fast?
    I’m currently trying to figure out how we react with excess amino acids taken into body
    And some people said it will convert to fat and some said don’t
    Any idea?

  • @spiceup4100
    @spiceup4100 3 года назад

    Very Good 🙂

  • @sarahjohny162
    @sarahjohny162 3 года назад

    Very helpful😊

  • @dhoom2080
    @dhoom2080 7 лет назад +2

    this channel helped me ALOT , much thx for u

  • @chaitalichakraborty7023
    @chaitalichakraborty7023 4 года назад

    It really helped me

  • @sohaibshah197
    @sohaibshah197 Год назад

    4:15 hexose kinase change glucose to glucose 6 phosphate ❤

  • @shifanashifana35783
    @shifanashifana35783 3 года назад

    Thank u so much sir....all ur videos are really awesome and i can understand well....can u please make a video on HMP shunt pathway ??

  • @vishnukp7942
    @vishnukp7942 4 года назад

    Sir how many amino acid can be used to make glucose...?25%?33%?50%?

  • @tejashreedurgi2935
    @tejashreedurgi2935 5 лет назад

    Superb sir thanks very much

  • @sandipchauhan6593
    @sandipchauhan6593 10 месяцев назад

    Thank you sir 🙏

  • @07akshayar46
    @07akshayar46 4 года назад

    Your videos are super 👌nice.
    Put videos for Amino acid metabolism and lipid metabolism. Fast As soon as possible.

  • @Om_Parmar
    @Om_Parmar 3 года назад

    Please make the video on HMP shunt pathway!

  • @Sanbonita1
    @Sanbonita1 5 лет назад

    4:37 The enzyme should be pyruvate kinase. Please heed this.

  • @athiraraj8854
    @athiraraj8854 2 года назад

    Please make a video on HMP shunt, your videos are just easy and good

  • @seandiorsimapuka3714
    @seandiorsimapuka3714 5 лет назад

    Phosphoenopyruvate is conveted to pyruvate by the enzyme Enolase not phosphofructokinase

  • @rohinirao7466
    @rohinirao7466 6 лет назад +1

    Please upload protein metabolism..nucleic acid metabolism video...

  • @sakshidhepale9342
    @sakshidhepale9342 2 года назад

    Thanks a lot sir....🙏

  • @avinashavi3465
    @avinashavi3465 6 лет назад +3

    thank you

  • @syedwaqar-1944
    @syedwaqar-1944 6 лет назад

    Nyc sir
    N ur voice is osmmm 👌👌👌👌

  • @moka100original2
    @moka100original2 3 года назад

    Thank you.

  • @divyamakhija8169
    @divyamakhija8169 6 лет назад

    How many ATPs are consumed in gluconeogenesis?

  • @iliyasuharuna5906
    @iliyasuharuna5906 3 года назад

    qn excellent work

  • @mahimkhan7351
    @mahimkhan7351 7 лет назад +2

    can u upload mechanism step involved in glycolysis wth some tricks so that we remember structure involve in reaction steps

  • @mohammedalmutasim4630
    @mohammedalmutasim4630 7 лет назад

    it,s very simplicity thank you

  • @ezrakorir3249
    @ezrakorir3249 3 года назад

    Magnificent share I like your videos

  • @diptiranjanbiswal6277
    @diptiranjanbiswal6277 5 лет назад

    Hey: Phosphoenol Pyruvate to Pyruvate by Pyruvate kinase Enzyme. Not phoshofructokinase as u mentioned ___"plz update soonly