Chronic Inflammation | Top 5 Causes of Inflammation in your Body- Thomas DeLauer
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- Опубликовано: 25 июн 2019
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Chronic Inflammation | Top 5 Causes of Inflammation in your Body- Thomas DeLauer
AGEs:
Many of the foods on the SAD diet contain high levels of advanced glycation end products (AGEs), or glycotoxins. AGEs are formed through a nonenzymatic reaction between reducing sugars and free amino groups of proteins, lipids, or nucleic acids - in other words, they’re harmful compounds created when sugar reacts with proteins or lipids (fats) in a process called glycation. The rise in processed food sector shows that more and more people are diverging towards modern processed foods. As modern diets are largely heat processed, they are more prone to contain high levels of AGEs. The pathologic effects of AGEs are related to their ability to promote oxidative stress and inflammation by binding with cell surface receptors or cross-linking with body proteins, altering their structure and function.
Obesity:
Fat-cell-secreted hormones bind to specific receptors on themselves (autocrine secretion), as well as to receptors on adjacent inflammatory cells, macrophages, (paracrine secretion) that normally infiltrate fatty (adipose) tissue. The more fat a fat cell contains, the more active it is in paracrine secretion - the higher the fat content of adipose tissue, the more macrophages (inflammatory cells) take up residence there. Once activated, the macrophages, in turn, secrete additional hormones, cytokines (TNF alpha, IL-6, etc.), which stimulate the immune system, triggering an inflammatory reaction that can adversely affect tissues throughout the body.
Gut Health (Bacterial Imbalance)
When beneficial bacteria populations decrease in the intestine, “gram-negative” bacteria gain ground. When these bacteria die, they release molecules called endotoxins (lipopolysaccharides), known for their pro-inflammatory action. Chylomicrons are fat transporters responsible for the absorption and transfer of dietary fat and cholesterol from the gut to the blood - LPS bind to chylomicrons and can be carried through the gut wall into the blood. Binding and transport of LPS by chylomicrons is a natural process that helps remove LPS and take it to the liver for detoxification.
Prolonged Stress:
Prolonged stress results in the prolonged release of cortisol, which works to suppress nonessential-in-an-emergency functions, like your immune response. The hormone also fuels the production of glucose, or blood sugar, boosting energy to the large muscles, while inhibiting insulin production and narrowing arteries, which forces the blood to pump harder to aid our stressor response. Adrenaline is also released, which tells the body to increase heart and respiratory rate, and to expand airways to push more oxygen into muscles - your body also makes glycogen, or stored glucose (sugar), available to power muscles. In addition, stress decreases lymphocytes, white blood cells that are part of the immune system. The problem with prolonged stress is that it alters the effectiveness of cortisol to regulate the inflammatory response because it decreases tissue sensitivity to the hormone - in other words, immune cells become insensitive to cortisol's regulatory effect. Since those that are stressed are more insensitive to it, their cells keep producing more and more cortisol, which results in increased transcription of factor nuclear factor kappa B (NF-kB), and pro-inflammatory cytokine production.
Lack of Sleep:
Poor sleep habits are known to cause inflammation - sleep loss induces a systemic, low-grade inflammation characterized by the release of several molecules, including cytokines and acute-phase proteins. Getting less than, or more than, 7-8 hours of sleep per night has been shown to result in increased levels of inflammatory markers in the blood, like C-reactive protein (CRP) and interleukin-6 (IL-6)
Brain Toxins:
Getting ideal amounts of sleep reduces inflammation and restores the brain by flushing out toxins - one of these toxins is a toxic protein called beta-amyloid.
Resources:
1) www.ncbi.nlm.nih.gov/pubmed/1...
2) www.ncbi.nlm.nih.gov/pmc/arti...
3) www.ncbi.nlm.nih.gov/pubmed/1...
4) www.ncbi.nlm.nih.gov/pubmed/1...
5) www.ncbi.nlm.nih.gov/pubmed/2...
6) www.ncbi.nlm.nih.gov/pubmed/2...
7) www.ncbi.nlm.nih.gov/pubmed/1...
8) juvenon.com/bloated-fat-cells...
9)www.sciencedaily.com/releases...
10) www.ncbi.nlm.nih.gov/pubmed/2...
11) www.ncbi.nlm.nih.gov/pubmed/1...
12) selfhacked.com/blog/lipopolys...
13) www.ncbi.nlm.nih.gov/pmc/arti...
14) www.ncbi.nlm.nih.gov/pubmed/2...
15) www.nih.gov/news-events/nih-r...
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I used to think I needed a new bed because I woke up sore and not rested.. I just needed a new diet. My bed feels great now.
Definitely the cheaper way to go. LOL
Preach!
Before I lost 87lbs I was an inflammatory mess, stiffness set in if I sat down too long or upon waking, I needed help getting out of bed. My feet were always in pain. Now 98% gone!
How please?
Yes, more info please. ♥️
How did you do it
@@summertime6692 basically implement these steps he just mentioned
How are you now
You forgot to add my mother-in-law to your list!
Your mother-in-law is on my list! :)
Travis L lol & he actually liked it , my mother-in-low is my anti-inflammatory all time thing
Haha touché
Hahah
Hahahahahahaah
Thomas, don't worry about making your content " fun ". It's informational, and if your viewers truly want to know your opinion and get educated, they will exercise a bit of patience to receive that bit of knowledge.
Thanks for all you do. You're a life saver.
Exactly - we're not kids needing to be entertained. Trouble is, too much TV and our attention levels are up to shit.
Thank you for the support!
Jake Timm Agreed! Plus, as a nerd, his information is FUN!
100%!
Forget fun.
I go full geek mode when I watch his videos..... and rewatch them
This explains why I feel so much better when I get super lean and skinny . It’s frustrating bc people tell me I look too skinny when I really feel my best and when I put weight on past 125 lbs I start feeling the aches of inflammation and people tell me I look healthier 🤦🏼♀️
*SAVE TIME*
*Diet* (AGE's)
- Cook foods at lower temperatures
- Avoid combining sugars and proteins and sugars and fats
*Decrease size of fat cells* (lose weight)
*Gut health*
*Manage Stress*
*Sleep* (7-8 hours)
Can u give me an example of sugars and proteins as well as sugar and fats combinations?
@@itsasia_ Sugar is anything that contains sugar and sources of protein are chicken, meat, Dairy etc and fats include oils, avocado etc...
@@Bitachon Okay I know that was a stupid question, so basically your saying just eat clean.
Asia P
Don't combine sugar (carbohydrates) with protein and fat. Protein and fat combinations are ok.
so this means reduce sugar (carbohydrate)
Just eliminate sugar period, and you are good to go!
Hey Thomas, just completed just completed 72 hours water fasting. Thanks a lot 🙏. Love from India.
Rock on!
Congratulations
❤️
I did a total fast, no food or water for 5 days. I felt like I was floating off the ground. Funny thing I felt like I could keep doing it, but heard it was really bad for my health so I started back eating. Now I found there's a guy who fasted 382 days!
www.menshealth.com/health/a19533728/craziest-diet-ever/
This speaks volumes of truth. had I changed in my 30's and 40's. Even at 50. I wouldn't have this chronic inflamation in my body. I am healing tho. Through eating right, exercise and Thomas Delauer video's. Thanks Thomas.
What I dislike about Thomas is his level of certainty around the most complex system in the universe. He declares as fact things being debated because he has some strong logic about it.
I'm going to have to watch that a few times for all the info to sink in. Thanks for making a super 'nutritionally dense' episode! :)
Thomas for United States Surgeon General.
He or dr berg
Nah should be Dr Fung
@@beowolf4572 he's Canadian
Paperless One he’s way too informed , they don’t want people to eat healthy it will kill the diabetes drug market , those jobs all go big pharma shills
That’s dumb,,,ur dumb
Took your advice on breaking my fast. I went 74 hours had a cup of bone broth. Waited an hour and a half had a small piece of halibut and after 14 hours I'm having some tea with coconut oil til lunch at 2. I did drop an extra 2lbs from yesterday by doing that. Awesome advice thank you.
You're welcome!
Hi, Thomas! I’m a big fan of your videos, and I really appreciate how you the time to include your references in the comments. Thanks for keeping the science in health science!
I was 99years old.
After your advices 63!
This video was wonderful. This could not have been an easy thing to put together. I can't wait to share this with my patients.
Thomas you never cease to amaze me with your knowledge. I can't thank you enough for all you do! I always share your videos with family and friends because everyone deserves this information.
Thank you so much!
literally could have gone on for hours! this was a fun topic it literally explains EVERTHING for me right now!!!!!!!!!!!! OMG !!!!! THANK YOU! LOVE TO SEE MORE OF THIS
Finally a video I could follow from start to finish and understand at least 80%. My stress level just went down.
LOL
@@ThomasDeLauerOfficial oooohh thank you Thomas. I admire your work and dedication. Keep it up. Greetings from Aachen (Germany)
just be a fasting lad
That was a very amazing video on inflammation. No negativity at all just information. It definitely pushes me to look deeper into creating proactive ways to minimize inflammation.
Your channel is next level man! Very informative and inspiring. Thank you.
Change my life around all because of your videos. I just did my first 48 hour water fast with electrolytes. Thank you 🙏🏽
Thanks, Thomas. Always instructive, appreciated a great deal.
it was exactly what I needed! And apparently so did a lot of others. Thank You !
A friend shared your videos with me. You have no idea how much you have helped me. I've been in a bad 28 year marriage and years or working nightshift has caused a destructive arthritis mutilan psoriasis arthritis. I'm going to get healthy and I thank you from the bottom of my heart.
How are you now hun
Your videos are very helpful. I have been following your channel since earlier this year. And I have been trying so very hard to stay on a ketogenic diet. But stress really throws everything off. And this past month it has really come to a point that I started hurting and it wouldn't go away. Went to the Dr, and all they did was draw blood because they had no clue as to what was going on. All my labs look great so far except my rhuematoid factor was 56.4 and the normal high is 14. So I have a major inflammatory issue going on. So this is giving me an even bigger push to get myself on track and take control of my stress and my diet. Thank you for the content that you make. I am surly hoping that it will help me out. Because to be honest being 34yrs old and feeling the way I do, sucks right now.
These videos are the best!! .. the back to the basics .. thanks Thomas!
This is great information. I am a 58 yr old man who was involved in a motorcycle/car accident when I was 19. Shattered both fibula and tibia in both legs, a couple ribs, left humerus bone, C3 in my neck, totalled out my right shoulder, and a few other things. Over the years I have been fighting the inflammation pain train by trial and error mostly, I don't like taking the meds for it. I found the drastic ways diet makes me feel years ago, eat the wrong stuff and the next day I feel it. Videos like this help me dial in what works best for me.
What works best for you?
I really appreciate you posting the references. And you summarizing the information. Thanks.
Thank you for sharing information about this subject!
I love your videos man! I went on Keto for 3 months and I'm transitioning off of it still but your content helped me a lot.
Thanks to Thomas for breaking down inflammation and not dumbing it down. I’ve been trying to understand what causes inflammation from the science perspective, and now I feel I get it baes on this video!
Loving this ❤️ Tom you're awesome! Thank you!!!
Not boring at all Thomas, very Informative. Keep up posting all of these amazing videos. You're changing lives each and every day.
Thanks for the support!
A lot of us like this type of information... we like to know "why?" Keep it coming, Thomas!
Will do!
EXCELLENT info, thanks Thomas!!
Excellent video!! Thank you for the info!!!
Fantastic information as always!! Thank you!
Thank you... You are miles ahead of the game 🙏
Very informative, thanks for sharing! Just found your channel x
Congratulations Thomas for transformation. Well explained
I just discovered your channel. Obsessed! You jam pack each video with great info, I’ve learned so much already!
As usual very informative you are always so descriptive I love it.. I feel like I am back in science class 😝👊
Hopefully it's more fun!
Heard your interview on Primal Health podcast. Thank you for channeling your perfectionism to make such informative vids!
One tries
Oh Thomas, this was so NOT boring - in fact that last bit, on inflammation and Aalzheimer's, was both scary *and* life-changing!
Im happy you are talking about inflammation its a crippling condition this should be discussed more often to bring more awareness.
Thanks for providing the information behind why this is necessary. Getting ready to get back to keto.
Didn't understand or care about all the inflammation talk until I got gastritis- thankful for your content on this.
Very much appreciate your insights. Thank you.
Thanks for that.. very informative and very good.
Thank you so much! God Bless
INHO this is your best video. I'm in the medical field and I agree inflammation is a core issue with every disease.
Great content, thank you for your's and your team's time. Best learning channel on the internet that directly helps you in your own life! Thanks again!
You're welcome!
seriously i dont come here for fun (though many of your vids ARE fun!), i come here to learn and you always deliver interesting info. thank you!
Very good advise and information! Thank you for sharing!
Just beginning all this. You’re a big help. Just subscribed! 👍
Invaluable information, thanks!
Inflammation is very common and so important to know how to manage it, thank you Thomas I totally love your knowledge.
Thank you for making these videos keep them coming 😊
Will do!
Right on Thomas!!
Thanks. It's truly helpful information.
WOW, you are amazing! Thank you God Bless. So educational!
Probably the best explanation on the subject! I have RA doctor that you might want to teach. You know more than him on all levels. Great video
I don't think this was boring or negative at all! Super, super interesting. Have to say that you blew my mind with the info in CSF!!!
Thank you!! Good stuff👍🏻👍🏻
You're welcome!
So interesting, thank you!
Love that you made this video! This needs to be talked about more. Especially in the keto world where many are saying inflammation doesn't matter and it's all just about being in ketosis and weight loss. If you feel like crap, and you aren't healthy, who cares if you're skinny or in ketosis! Inflammation is everthing!!
Keto police are here to serve and protect lol
"Please step aside and put down the artificial sweeteners... I'm sorry, your gut lining called us miss".
I don't know how You can get always the content I need.
Mr. DeLauer, YOU ROCK MY WORLD! Thank you so much to you and your team for all your hard work to bring us AMAZING content. Been following you for quite some time, however I recently got serious about strict keto and am down 20+ pounds. It might not sound like a lot of weight loss, but as a 5’3”, 52-year-old female, it’s a HUGE difference. As a Flight Attendant, I’ve had to purchase much smaller sized uniforms 💋✈️💋 ✈️ I’m down to 125# and have you to thank for guiding the way!
Keto on!
Priceless information. Thank you!
You're welcome!
Brilliant info!
Awesome don't stop put these videos up love all comments below nice one Thomas
Thank you so much for this brilliant explanation of inflammation causes .
Omg I was just studying about that is all true as always I agree with Thomas! Thanks again!
Hi Thomas. Thanks for teaching about stress being hidden. Also, I like this style of video vs what you were trying out with the busy sound effects etc. much easier to listen and learn in today’s video. Just my opinion. 👍
Thanks for watching!
Lots of common sense . You are so down to earth . Thanks
Seven hours of sleep, the rest of the information was right on too. Best video vote. Thank you.
You're welcome!
Thank you!
Excellent information Thomas, as always!!!
Thank you!
So right man , im in my last week of exams and i feel shity , i need to sleep properly and relax
Greetings from Spain
Good luck!
Thanks Thomas you the man!!!
Great piece of information 👌🏿.
👏👏👏 Great video Thomas!
This is the best explanation of inflammation yet!
Thx alot f information!!!!!
Good vid TD, I will just add that some inflammation is necessary in life (such as exercise). It becomes an "issue" whenever you're dealing with chronic stressors that you don't properly recover from. And as a man who works the night shift and also tries to stay active dealing with all the stress that comes with is a "delicate balance" for me. Thanks for the vid. Just another reason to make sure I get adequate sleep and fast whenever I can't hit the gym. DEUCES!!!!
Great info in this video! Thank you SIR!
You're welcome!
I'm literally sick and and tired of being sick and tired plus constantly injured in someway between gout, trigger finger, tendonopathies, shoulder, strains, stress ulcers, upper respiratory infections.
I eat a pescatarian diet and limit diary plus take joint supplements, but it's still not enough for my active lifestyle and career in nursing.
Thank you for the detailed scientific based videos. Your fasting vid was extremely helpful in my injury recoveries. Looking to seriously implement more science based nutrition so I can recover even faster.
Excellent informative video
Great Video Thank You 🍒
Good job Thomas 👍
I did not find anything of what you said was boring. Awesome vid! I got a lot to chew on (mentally that is).
This channel changed my antire point of view on diet and training
I just love this channel!
Just extremely exceptional cool videos every time . We keep learning daily here
Thomas, I have learned a lot from you and Berg, but I am going to be honest. Sometimes I feel that trying to follow all of your rules and restrictions is going to cause me to be so stressed and overwhelmed that my body is going to be completely drenched in cortisol. For example, you say not to combine carbs with fats or protein...I’m like WTF! Eating goes from being enjoyable to totally frustrating because there’s no way I can consistently follow all of the guidelines. I guess I must find what is best for me personally, like everything else in life. Thanks for your help man, though my brain can only process maybe half of what you say... LoL
I'm thinking he's meaning simple sugars/carbs. Like a baked potato with butter and cream, etc.
Now like a baked potato, asparagus(veggies), and steak. I wouldn't think that insulin spike wouldn't automatically make you store the fat from steak.
Just eat balanced and don't over think. Just don't add all the "junk" and processed stuff to the plate.
Just my 2 cents.
Thanks so much for the information I had no clue that inflammation was that detrimental to the body. I really got to get myself together and restart my biological clock.
Never thought I’d love science so much. Thanks so much. Even over 60 I am still learning. Oh yes and losing weight
Thanks !
One of your best videos yet!
The impact of inflammation is so far reaching from aging the skin to depression, joint issues, cancer and autoimmune disease.
Maybe you could do a video on 'anti inflammation on a plate' (a what to eat in a day on an anti inflammatory diet) and a video on the hidden offenders for inflammation diet wise
One of your best videos to date!
Thank you!