T cell functions. Immunology lecture 10 part 3
HTML-код
- Опубликовано: 2 окт 2024
- Please read and agree to the disclaimer before watching this video.
. Subscribe to the drbeen Channel HERE: bit.ly/2GBhiS0
For more content from drbeen, click HERE: bit.ly/2GB41bU
Watch drbeen videos HERE: bit.ly/2GB41bU
Like drbeen on Facebook HERE: bit.ly/2GSSTGS
Follow drbeen on Twitter HERE: bit.ly/2XeSVhV
Follow drbeen on Instagram HERE: bit.ly/2ST2Zih
Get new medical lectures across your devices. Stream anywhere, anytime. Try it for free! bit.ly/2QsIwQ5
This is the concluding lecture about the T cells. The function of T helper 1, and 2, cytotoxic T cells, NK cells, and T regulator cells (T17) are discussed. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
terrific lectures!
Sir, it means that MHC remains expressed on the surface even when it is not bound to any peptide??
Another query, while positive selection takes place in the thymus the which proteins are presented to the DP thymocyte-are they self antigens?
Also, I am curious to know, when positive selection occurs and either CD4 or CD8 gets selected, what happens to the other one-it gets internalized or gets abrogated.
As suggested by you I am leaving these comments on FB in your wall page.
Thank you so much Sir.
Regards
Chaitali
My understanding is that MHC molecule are delivered to surface after being loaded with antigens. So they will always have an antigen bound to them. Yes to self antigen question.
Cells that do not react with MHC or that reacts with self antigens are given apoptotic signal and they die.
I see your messages on the facebook page. I will respond there too.
M
Thanks. It was really very nice presentation.
But I have few queries:
1. Do T cell themselves express MHC I? If all nucleated cell express MHC 1, then T cell being a nucleated cell should also express MHC 1 themselves.
2. If T cell is expressing MHC 1, what role MHC 1 plays for them?
3. Do MHCs gets expressed on the surface of cells only in association with peptides?
If this is the case then why in virus-infected cell and cancer cells, the MHC are intentionally pulled inside to prevent the cell from recognition by MHC 1. In this case, NK cell checks the absence of MHC 1 expression on these infected cell as a marker of stress and kills those cells.
I am very confused, pls help me with the queries.
Thanks in advance
Chaitali
Yes T Cells express MHC I.
Same role as the other nucleated cells. That is, to express antigens that have entered the cells and internal proteins.
Yes
In virus infected cell and cancer cell MHC I reduce because the cell's machinary to produce peptides is high jacked.
Think it this way:
Healthy cell infected will display MHC I and get help.
If cell becomes so sick that it cannot make MHC I anymore then NK cells will jump in to help.
Hope this helps? You can continue this discussion on the FB too.
Drbeen Medical Lectures you are amazing
please clarify: Cytotoxic T cell can connect to a pathogenic antigen that is not presented on MHC?
Sir, I got it. It means NK cells will check for MHC with antigen on the surface of cell. Once, it fails to detect the presence of MHC, it signals the NK that something is wrong and cell is sick. In turn, particular cell is cleared by NK.
Sir, for second query I was asking about the situation when naive T cell gets positively selected and displays single marker-CD4 or CD8. Now this single positive T cell suppose survives negative selection and happy single naive T cell has been released into circulation. In this situation, what happened to its other receptor-has it got internalized in cytosol or its expression has got abolished?
You got it on NK cells.
Sorry I did not catch your previous question correctly. My understanding is that once the cell becomes single positive the gene for expressing the other MHC is locked out. The surface MHC will be internalized and digested. I maybe wrong but this is what I understand.
Thanks alot sir. This is a humble query... why do you take so long in publishing immunology lecs??? The first lec in ur series was 2 years back...... Kindly dont take me as thankless...... Am really grateful for ur efforts.....
Thanks to you I aced one of my questions on T cells in my final year exam. You're awesome.
So glad to hear that. Be the best always.
Finally I’m understanding immunology 😭💗
I can’t emphasize on HOW GREAT OF A DOCTOR U ARE THANK U FOR RELATING THE CONCEPTS TO USMLE QUESTIONS
Thank you very much for your kind note. Study well and be an amazing doctor.
Thank you so much, you helped me answer the questions for my final year exam, you sir are a legend!
You are welcome. Check drbeen.com for more lectures. We continue to upload new lectures all the time.
thanx doc ........ you are a gift. god bless
After 2 months of studying immunology now only I have been got a clear concept about TH1
Thanks doc
would any of your lecture explain the cause of t cell lymphoma cancer?
thanks
+Hamid S not the immunology lectures. Lymphoma is covered in the hematology lectures. These lectures are not uploaded on the youtube.
Sir, I had a question about the interaction of cytotoxic T cell with the antigen on pathogen. I was wondering that don't the T-cells require an antigen bound to MHC to interact with? I guess that's what you taught in previous lectures. If it is so then how is the cytotoxic T cell is interacting with the pathogen in this lecture? Please help.
Interaction is with the cells that contain the pathogen.
Thank you so much for the clarification!
thank you for these useful lectures>>but i have a Q ... how dose the cytotoxic T cells recognize the pathogen directly ??
T cell receptors have a similar structure (almost) like an immunoglobulin. These receptors allow the T cells to bind with antigens and wait for co-stimulation.
Mobeen Syed Sir,the ability of the TCR to bind directly to antigen is it restricted only to T killer cell??? Can Th do the same thing???
Yes. All T cells bind to the antigen using their receptors. Please pay attention to the lectures. I have clarified this.
Mobeen Syed Sir, thank for the reply.In the video , you have shown that the cytotoxic cells can bind directly to the pathogen without MHC. Hence, i got confused a bit and wanted to know whether TH cells are also capable to bind to the pathogens without any MHC protiens?
Thank you so much! You made this so clear
You are most welcome. Please find more lectures at drbeen.com.
finaly!