Hi! It is important to highlight that it is not the lactate (lactic acid is never formed in physiological conditions) that causes acidosis. even if lactate production coincides with cellular acidosis there is not a cause effect correlation, as it is well explained by Robergs in the article " Biochemistry of exercise-educes metabolic acidosis". in addition to this, the production of lactate consumes 2 H+ and this retards acidosis! anyway, your lessons are very good, thanks a lot :)
Very clear explanations. Really usefull for me to complement with the book! You transmit concepts so clear that i understands some things better with you that with my class teacher that do it in my native language jajajajaj Keep it up man! Greetings from Argentina!
LOVE your videos! Video idea: Overview of FED vs. FAST STATES (interplay of glucolysis, fatty acid synth/beta oxidation, ketosis, insulin/glucagon, etc.)
Love your passion in this video!! well in all your videos but this one is exceptional. Thank you so much...makes me (somewhat) excited to learn more about this lol..
@@peybak 1:1 is expected in solution. Since both G6P and F6P are intermediate metabolites connecting to other pathways, the ratio should be a variable in vivo, regulated by other intermediates. It should be tissue dependent. Thank you very much for your reply.
@@jimmyren6381 Cool. I was just making a comment off the top of my head but it's a bit more complex. G6P is an important intermediate for PPP, gluconeogenesis and so on. Also, there is a substrate cycling that happens in muscles that converts F6P to FBP and back under normal conditions. But once the muscle amps up during exertion, it stops the cycles and straight goes into glycolysis, using up the intermediates. If you're still curious or studying, you can look up substrate cycle in muscle glycolysis. It's a control mechanism for glycolysis. Cheers!
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i will name my first born son AKLECTURES in tribute to you. Thank you for this incredibly insightful lecture.
Lol
My friend, you are the reason why I passed my Exercise Physiology exam....thank you
how in the earth would I learned without your lectures
Now , U r the reason why I understand and respect glucose circle , thank u sir
I really owe you because of of your perfect lectures!
Hi! It is important to highlight that it is not the lactate (lactic acid is never formed in physiological conditions) that causes acidosis. even if lactate production coincides with cellular acidosis there is not a cause effect correlation, as it is well explained by Robergs in the article " Biochemistry of exercise-educes metabolic acidosis". in addition to this, the production of lactate consumes 2 H+ and this retards acidosis!
anyway, your lessons are very good, thanks a lot :)
@STEPHANIE LIU, it is the pyruvate that causes acidosis.
Good call. You can simply look at the individual reactions and see that it's the pyruvate, even though all of literature calls it "lactic acidosis."
Very clear explanations. Really usefull for me to complement with the book!
You transmit concepts so clear that i understands some things better with you that with my class teacher that do it in my native language jajajajaj
Keep it up man!
Greetings from Argentina!
Thank you teacher for clearing my concept on glycolysis regulation in muscle cells..
LOVE your videos! Video idea: Overview of FED vs. FAST STATES (interplay of glucolysis, fatty acid synth/beta oxidation, ketosis, insulin/glucagon, etc.)
This is unbelievably good *_* thanks a ton
Love your passion in this video!! well in all your videos but this one is exceptional. Thank you so much...makes me (somewhat) excited to learn more about this lol..
Nice. What is the ratio of G6P to F6P in skeletal muscles?
It should be close to 1. But I imagine if muscle is making glycogen, G6P will be syphoned off.
@@peybak 1:1 is expected in solution. Since both G6P and F6P are intermediate metabolites connecting to other pathways, the ratio should be a variable in vivo, regulated by other intermediates. It should be tissue dependent. Thank you very much for your reply.
@@jimmyren6381 Cool. I was just making a comment off the top of my head but it's a bit more complex. G6P is an important intermediate for PPP, gluconeogenesis and so on. Also, there is a substrate cycling that happens in muscles that converts F6P to FBP and back under normal conditions. But once the muscle amps up during exertion, it stops the cycles and straight goes into glycolysis, using up the intermediates. If you're still curious or studying, you can look up substrate cycle in muscle glycolysis. It's a control mechanism for glycolysis. Cheers!
Is it the slowdown of glycolysis due to low pH a reason for muscle fatigue then? Or is there more to it?
love your videos!
Thank you so much❤
thank you!
dope vid
Thanx alot but plz try to not move much!!
Thank u agian 💓
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