Hello! Your videos helped me so much you can't even imagine. English is not even my native language (and I'm not even bilingual) but you explain so greatly that I don't have any problem understanding you.
hi great video again! One small thing you said that glucose generated from gluconeogenesis will be used to make glycogen for storage. Generally because of the effect of hormones, gluconeogenesis will be proceeding when the body is in a low energy (glucose) state and in contrast glycogenesis when there is a high energy state. When glycolysis is stopped by the high energy state at the level of PFK-1, there is will backup and increased amount of the glucose 6-phosphate the first step of glycosis and that glu 6-p will enter straight into glycogenesis.
@nikola 1809 Let me guess, you attend some prestigious university where they teach this in first year and everybody understands it easy peasy lemon squeezey.
@somebody someone freshman year: 2 semesters gen chem, Sophomore year: 2 semesters organic chem, Junior year: 400 level biochem Makes perfect sense. You take prerequisites first. You can understand biochem more deeply after learning about reaction mechanisms in o chem. If you learned all this when you were 18 that is wonderful for you. Things are seriously wrong with you if you're going to make fun of someone for being where they're at.
@somebody someone i go to the University of Toronto(18th in the world and where insulin was discovered) and I'm learning this in my 3rd year. But I'm also taking genetics, microbio, and cell bio classes alongside this class. the fact that you need to put others down shows you are insecure. USA and Canada learn in a different order from wherever you are from, and have the top 100 research universities in the world for a reason.
I have been watching your video for 2,3 years .your video is very easy to understand. I always watching your video when I can't understand some biochemical regulation. it helps me a lot on my exam thank you .i always send your video to my classmate, but some of their English level not good enough to understand =( thank you, sir.
thank you! i was confused why gluconeogenesis occurs in a fasting state, but then is activated by atp, but this helped! there is atp but that atp is not from glucose from glycolysis , the atp is from another source, and there needs to be more glycogen made
hey sir, thank for the detail explanation in regulation of gluconeogenesis and glycolysis. My question is do they regulate by insulin and glucagon? and if it does regulate by the two hormones for example if insulin activate glycogen synthase will it also activate glycolysis because the glucose level in blood is high?
As always the best! One question though, why can't the process of gluconeogenesis be that it transforms for ex Glycerol into DHAP , but instead of it going through the rest of the gluconeogenesis pathway, it would just continue in the glycolysis pathway instead?
Hey AK LECTURES just a quick question regarding gluconeogenesis, would ATP not regulate Pyruvate to PEP since it indicates that there is a high energy charge, or is activation ONLY through Acetyl CoA?
great lecture as always, but i have a doubt, gluconeogenesis is activated when the body is in a starvation state, why was it said in the video that gluconeogenesis is activated when the body has high energy charge, isn't the amount of atp low during starvation? hope i'd get an answer thank you so much sir
glucose is liberated from the liver by gluconeogenesi in order to get to muscle tissues for them to produce ATP by glycolisis, if what was said in the video was true ( gluconeogenesis is activated when we have high atp) what would gluconeogenesis serve for !? thank you again
Right, but remember that during starvation Beta oxidation of fatty acids is activated, which provides the huge amounts of ATP that are needed for gluconeogenesis (which in turn is needed by specific tissues and organs that rely on glucose exclusively for energy (i.e. The brain "in which fatty acids cannot cross the blood-brain-barrier", red blood cells "which lack mitochondria, that couples glycolysis with energy production via Krebs Cycle & the Oxidative Phosphorylation in the Electron Transport Chain").
When we have food, there's a flood of glucose in the blood, and Glycolysis converts that glucose into energy (ATP) but as we eventually get to the starvation state, a lot of glucose has been converted into ATP. Hence, there's an excess of ATP and a lack of glucose. At this point, gluconeogenesis comes into play, and uses that ATP to form glucose.
Wouldn't we use 4 ATP molecules in GNG if we are using 2 pyruvate? Pyruvate Carboxylase uses 2 ATP to convert 2 pyruvate to 2 Oxaloacetate. But step 7 in glycolysis where 1,3BPG is converted to 3PG produces 2 ATP so in GNG, we would instead be using 2 ATP. So 2+ 2 is 4 ATPs used in GNG in total?
great lecture from great teacher, thank u sir for hard working …… but you have a simple mistake in 13:42 instead of saying inhibited you said activated
Gluconeogenesis is triggered by low glucose and ATP levels so you wouldn't have a lot of ATP at the beginning, but the process will lead to the production of glucose that can be broken down in glycolysis to produce ATP.
Thank you so much! You broke down in 16 minute what I spent over an hour trying to understand.
Wow, straight to the point, making everything clear! your style of teaching is 10/10! keep it up!
Hello! Your videos helped me so much you can't even imagine. English is not even my native language (and I'm not even bilingual) but you explain so greatly that I don't have any problem understanding you.
hi great video again! One small thing you said that glucose generated from gluconeogenesis will be used to make glycogen for storage. Generally because of the effect of hormones, gluconeogenesis will be proceeding when the body is in a low energy (glucose) state and in contrast glycogenesis when there is a high energy state. When glycolysis is stopped by the high energy state at the level of PFK-1, there is will backup and increased amount of the glucose 6-phosphate the first step of glycosis and that glu 6-p will enter straight into glycogenesis.
Thank you so much for this. Khan Academy has helped me in my first and second year at uni, but you've been helping me with third and onwards.
@nikola 1809 Let me guess, you attend some prestigious university where they teach this in first year and everybody understands it easy peasy lemon squeezey.
@somebody someone freshman year: 2 semesters gen chem,
Sophomore year: 2 semesters organic chem,
Junior year: 400 level biochem
Makes perfect sense. You take prerequisites first. You can understand biochem more deeply after learning about reaction mechanisms in o chem. If you learned all this when you were 18 that is wonderful for you. Things are seriously wrong with you if you're going to make fun of someone for being where they're at.
@somebody someone I am, LOL
@somebody someone First 2 years in U.S. colleges is typically fulfilling pre-reqs.
@somebody someone i go to the University of Toronto(18th in the world and where insulin was discovered) and I'm learning this in my 3rd year. But I'm also taking genetics, microbio, and cell bio classes alongside this class. the fact that you need to put others down shows you are insecure. USA and Canada learn in a different order from wherever you are from, and have the top 100 research universities in the world for a reason.
it's really a great job!! thank you very much for being super helpful
믿고 듣습니다 선생님
I have been watching your video for 2,3 years .your video is very easy to understand. I always watching your video when I can't understand some biochemical regulation. it helps me a lot on my exam thank you .i always send your video to my classmate, but some of their English level not good enough to understand =( thank you, sir.
yes. your videos are really clear and understandable. i really like it
i love your channel, thank you so much !!
So clear; great teaching series.
YOOO that was good. Thanks a bunch!
so many things to keep track of. ugggghhh. my brain turned into mash potatoes
My brain was already mash potatoes to being with. Now I'm just potato liquid
Haha same 😂
this is an excellent university level lecture summarised. v good job man +sub
You Sir are an angel❤️💚
great lecture!
Thank you it was really helpful
i love this man
you saved my day :)
thank you! i was confused why gluconeogenesis occurs in a fasting state, but then is activated by atp, but this helped! there is atp but that atp is not from glucose from glycolysis , the atp is from another source, and there needs to be more glycogen made
Thank you so much❤️❤️
hey sir, thank for the detail explanation in regulation of gluconeogenesis and glycolysis. My question is do they regulate by insulin and glucagon? and if it does regulate by the two hormones for example if insulin activate glycogen synthase will it also activate glycolysis because the glucose level in blood is high?
Thanks
Very good 👍
As always the best! One question though, why can't the process of gluconeogenesis be that it transforms for ex Glycerol into DHAP , but instead of it going through the rest of the gluconeogenesis pathway, it would just continue in the glycolysis pathway instead?
why citrate only inhibit pfk in liver cells and not in muscle cells?(it is said at 12:16)
Hey AK LECTURES just a quick question regarding gluconeogenesis, would ATP not regulate Pyruvate to PEP since it indicates that there is a high energy charge, or is activation ONLY through Acetyl CoA?
great lecture as always, but i have a doubt, gluconeogenesis is activated when the body is in a starvation state, why was it said in the video that gluconeogenesis is activated when the body has high energy charge, isn't the amount of atp low during starvation? hope i'd get an answer thank you so much sir
glucose is liberated from the liver by gluconeogenesi in order to get to muscle tissues for them to produce ATP by glycolisis, if what was said in the video was true ( gluconeogenesis is activated when we have high atp) what would gluconeogenesis serve for !? thank you again
Right, but remember that during starvation Beta oxidation of fatty acids is activated, which provides the huge amounts of ATP that are needed for gluconeogenesis (which in turn is needed by specific tissues and organs that rely on glucose exclusively for energy (i.e. The brain "in which fatty acids cannot cross the blood-brain-barrier", red blood cells "which lack mitochondria, that couples glycolysis with energy production via Krebs Cycle & the Oxidative Phosphorylation in the Electron Transport Chain").
When we have food, there's a flood of glucose in the blood, and Glycolysis converts that glucose into energy (ATP) but as we eventually get to the starvation state, a lot of glucose has been converted into ATP. Hence, there's an excess of ATP and a lack of glucose. At this point, gluconeogenesis comes into play, and uses that ATP to form glucose.
Thank you for saving me from messing up this 🥹
Why is there an asterisk next to Citrate if you said PFK is also inhibited in liver cells by citrate?
please can you do photosynthesis ? or lipid metabolism?
thanks
Thaaaaanks ❤️
Wouldn't we use 4 ATP molecules in GNG if we are using 2 pyruvate? Pyruvate Carboxylase uses 2 ATP to convert 2 pyruvate to 2 Oxaloacetate. But step 7 in glycolysis where 1,3BPG is converted to 3PG produces 2 ATP so in GNG, we would instead be using 2 ATP. So 2+ 2 is 4 ATPs used in GNG in total?
great lecture from great teacher, thank u sir for hard working …… but you have a simple mistake in 13:42 instead of saying inhibited you said activated
said in-activated
If gluconeogenesis occurs when you’re in the starved state, why would you have a lot of ATP?
Gluconeogenesis is triggered by low glucose and ATP levels so you wouldn't have a lot of ATP at the beginning, but the process will lead to the production of glucose that can be broken down in glycolysis to produce ATP.
You need to a better job explaining what your saying you are just regurgitating knowledge. Your goal should be application