The Biology of Long Covid | Why the NAD+ Deficiency Theory Could Be The Answer
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- Опубликовано: 30 июл 2024
- The pathophysiology of Long Covid remains elusive. But might this theory of NAD+ deficiency come close to describing how the immune cascade creates the plethora of debilitating symptoms?
In this film, I speak to Nikita Alexandrov, the author of this piece, which has gained a large amount of traction in the scientific community.
/ the-team-of-front-line...
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The Long Covid Handbook (Oct 2022), by Gez Medinger and Professor Danny Altmann and published by Penguin Books is now available in paperback, ebook and audiobook. A singular resource that brings together everything patients, clinicians and academics have learnt about the condition since early 2020, as well as lessons from sufferers and researchers of ME/CFS and other chronic conditions. It offers world leading expert advice on understanding, managing and treating Long Covid. The Long Covid Handbook is available from the following links:
US: a.co/d/0gvkJCU
UK: amzn.eu/d/9KjurGb
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IMPORTANT: It is ESSENTIAL to talk to your doctor before taking any supplements that you have not taken before, or begin taking them at a larger dose. This regimen is NOT appropriate for children so they should speak to their doctor before taking any of these.
Nicotinic acid / Niacin also has several strong counter-indications, they can be seen here:
www.nice.org.uk/donotdo/do-no...
So, all that said - here is what I am currently taking.
Niacin: started at low dose 10-20mg once a day / be careful of flushing)
Selenium: 100mcg / day
Zinc: 15-30mg / day
Quercetin: 500mg 3x / day
Vitamin C: 500-1000mg 3x / day
Vitamin D: 3-5000iu / day
REFERENCES:
Viral persistence in olfactory epithelium:
www.biorxiv.org/content/10.11...
Viral persistence in gut linked to low antibody response:
www.nature.com/articles/s4142...
Coverscan results reported in BMJ:
www.bmj.com/content/371/bmj.m...
Miller, Wentzel and Richards - NAD+ deficiency and Covid 19:
www.ncbi.nlm.nih.gov/pmc/arti...
NAD+ role in energy production:
neurohacker.com/nad-introduct... 
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I was a long hauler since April. Followed your protocol profiled in prior vids and I had persistent symptoms until November. Followed your protocol for a month with dramatic improvements. I am close to 70 yrs and was worried, but your channel helped enormously. Thanks beyond thanks for your work.
So glad to hear it’s helped!
In a nutshell can you tell me the protocol, please.
Chantelle Knight It’s in the description but best to speak to your doctor first.
I am close to 70 yrs and was never worried;
Using this type of approach I almost miss what was like;
Long term is very important to strategy ~ flare here dates to about 11 April so there are other plausible factors such as community viral loading may affect individual responses by obvious epidemiological ideas ( exposure )
I’ve been sick since August, pls explain what you took . I started niacin and felt much better for 2 days then it came back. My stomach makes all kinds of noises. Did you completely change your diet too?
Oh Thankyou so much for mentioning ME/CFS, this long Covid is so similar its scary. I have ME and have been suffering cascades of a multitude of symptoms for 20 years, i know it has something to do with my immune system but its deeper than that. I am so hopeful that more research will be done on this now as we have been packed off into the wilderness too long.
Please look into low dose naltrexone for auto immune issues. For me, that made a massive unbelievable difference, but only in conjunction with total dietary changes. (No gluten or dairy and mostly low carb) I have also greatly benefited from NR, NMN and resveratrol. I agree with you about CFS being so similar to long covid. I have narcolepsy and an autoimmune disorder and it took years to fix my health. So I am fearful of getting long covid as I tend to get extremely ill with the normal flu. But if I get covid, I plan to take Ivermectin, among other supplements. I really hope you continue your efforts to get better. Do not give up. 🤍
Healthy life style all package and gut health will control auto immune diseases.deep detailed education,persistent,strict in making and even growing your own food.The environment is toxic ,air,water,soil,we are part of all ecosystem.
@Diane Carubia Have you heard of the Five Biological Laws pertaining to the action of the embryological layers of the brain? It's outlined in GNM. Search it on YT there's a 7 part series slide presentation by Carolin Markolin on JB channel that is a great introduction to it. I've been applying it with mind purification, somatics and vagus nerve reset exercises (pandiculation) and my M.E. /CFS symptoms are unravelling as I understand what is happening.
@@LifeDIY What is NR and NMN?
@@danya-louisehow are you now?
Thanks again for all your hard work and research! I feel there is a light at the end of the tunnel for all of us.
I deeply appreciate all you are discovering, uncovering, pursuing, and sharing. Thank you!
Great video again Gez. We're incredibly thankful you are doing these. Especially considering you're not well yourself.
Thank you! It’s worth it :)
Thanks again for your work and research! This is our hope to overcome the situation!
Great vid once again! I especially like how you give us hope without jumping on the newest fad (that gets pretty devastating) and always telling us about the limitations of science. I admire your honesty!
Thank you!
More people need to know about this channel. So glad you've found something that's helping!
Thank you Karston!
Many thanks for your hard-won efforts in researching and compiling yet another excellent, informative and a very plausible NAD deficiency theory of Long Covid ( while still in recovery) , plus advice on easily accessible supplements to treat it. Very encouraging comments from Long Haulers who have taken your advice and are finally seeing improvements, as well as improvements in yourself ( you're looking brighter. ) At this rate , you'll be one of the first to collate what actually works for LC, and it could be a potential resource used by both patients and GPs, not only for LC but ME/CFS and MCAS ( EDS ) patients. Huge appreciation!
Is that a new window I see behind you?! Cx
Please continue to do what you do for people like us. Your videos are the only thing that give me hope. 🙏
Hi Eleanor, there’s lots of positive research going on at the moment out there to give us all hope!
Many thanks. Maureen and Graham if you are reading this, hope you had a safe journey!
This is explaining a lot of the last 40 years
Thank you so much for sharing this. NMN has helped me immensely with past chronic fatigue issues. I say past because I have not had much of that since starting on NMN and also some NR.
Hi what does NMN mean?
Thank you so much for this, RUN-DMC. I really appreciate all that you are doing for the long-COVID community. I get so frustrated with the side-tracking of so many other videos on side issues and you really take long COVID directly. I think you may have provided a key to one of my most challenging MCAS-related symptoms: Internal tremors. Histamine foods worsen the symptom and to limit histamines I have had to cut back on so many foods that provoke release, which has made my diet so painfully sparse. I was taking B vitamins plus extra supplementation of B1, B4 and B12. But adding B3 now. I am hopeful that this could help.
I was at my one-year anniversary of COVID-10 on December 10, 2020. I was gaslighted by people who claimed I could not possibly have had COVID in December 2019, but finally I was vindicated. I knew I would be eventually, but the fools I had to suffer. Not so bad among the novices, but it's a horrible abuse by medical professionals to deny that a person could have had COVID, especially in the absence of testing. New release of data about blood that was drawn in California in December 2019 shows that frozen samples had antibodies in December 2019 indicating it was spreading in California long before the first official case in January. I should get an apology from at least 1 or 2 medical professionals, but I doubt it will ever happen.
Thanks for your comment, and best of luck with your recovery.
It was actually reported to have been in the U.S. as early as August or September of 2019. Several mainstream media outlets had reported on it, but I think those facts were too inconvenient for their own narrative that they had been running with since 2020.
Again, thank you Gez, your videos are always so welcome and have helped me greatly. X
Thank you Gillian! Hope you’re starting to see some recovery.
I could cry with happiness at finding this as dramatic as that may sound; I had COVID twice last year (and also severely in April 2020), since having it in October I’ve been wrecked since with back to back severe secondary infections and a range of other horrible symptoms. I’ve been off sick from work since December and am desperate to get better and go back. I’ll be following that supplement regime and fingers crossed I’ll feel better soon and stop getting continuous awful infections. Thanks so much for making such informative content!!! 😊
It’s the least I can do! Wishing you the best in your recovery :)
Thank you!! You are my primary source now for my long-haul COVID - hopes for getting better.
Hope you are seeing some recovery Dede!
I saw a video which reviewed many studies on ivermectin. It appeared to have good results for long covid so do some research. Good luck
How are you doing now Dede? Thanks
Always brilliant work! Thank you!
Thank you Catherine!
Thank you for your work on this
Thanks so much for creating these highly informative videos! Thanks to your work, some of us are able to start regaining some sense of energy and normalcy after so many months of long covid this year
Hope you feel like you’re recovering Cynthia!
@@RUNDMC1 Thank you, yes--following some of the Dr.Bruce Hoffman protocol tips seem to be helping; also utilizing a Nevlers Himalayan Salt Inhaler. A thousand thanks to you for sharing so much wonderful information, and bringing clarity to the possible relationship between MCAS and long covid.
Ty for devoting your time and energy..I rely on your videos.
I rewatch the 10 minutes all week.
Appreciate your straightforward presentations. Ah, that Gut.... 👍💥
Thank you for your research, your work is steadily helping me recover from covid after effects as you share emerging theories
Best of luck with your recovery!
For the first time in my 9 month long-covid there is some sense in possible causes and some clues to battle it. Great work, Gez! With brain fog it must cost you a lot of energy, but know it gives us all a lot of energy back! 🙏
Thank you Frank!
Update frank?
@@TheBushRanger. Still going long covid, struggling but hopeful fast evolving diagnostics will at the end help us getting better.
macuna
Hoi Frank, ik hoop dat het wat beter gaat?
Amazing videos! Keep up the good work
Thanks David!
Very interesting as usual, thanks
Hi RUN-DMC Thank you - this makes sense in terms of what happened to both of us and what eventually helped us to improve after several weeks
Do you mind saying what helped you improve?
This is extremely helpful. Thank you so much!
Great work Gez, you're looking brighter 🤩
Thanks Zoe!
Great News! I think this kind of research will change the lives of millions of people who are suffering from post viral disease! Keep communicating Dude!
Thanks David!
Thanks Gez your work and dedication is invaluable.
Also has anyone been informed about these long covid clinics that were supposed to start at the end of last month, 40 of them in the uk but my GP hadn’t heard about them
Hi Claire - I’ve spoken to my GP about it and got a chest x Ray tomorrow but no sign of a clinic!
Thank you so much for your research on insight into long covid. I am sharing your RUclips videos with everyone I know who knows someone who has had covid. I think it's very important to let your listeners know that you are a long distance runner that can no longer run like you used to. many people that I speak to are so cavalier and say "well everybody's going to get it so that's just the way it is" and throw caution to the wind. People need to be educated so they understand that it's possible to be a long hauler and maybe they'll be more cautious?
Yes, we have to hope so. Thanks for you support. (I’ve still not run again yet)
💯💯💯💯 if more people knew how horrible long hauler covid is they would take wearing a mask and social distancing more seriously!
Good work!
Thank you for all your videos.
Now I know why my gut is so messed up!
Another excellent (yet a wee complex) video
Yes it is a little! Apologies for that :)
Omg thank you. This really is good work your doing I'm sharing as much as I can so more people see this.
I appreciate you so much; thank you🙏
Thankyou so much..so informative and makes complete sense.
Thank you for you research and sharing us. Could you please explain or share us information about covid and deep vein insufficiency/ venous insufficiency? I had/have covid for 11 months and developed venous insufficiency months ago...
THANKS for the great infom.
Thank you so much for your videos! I have ME/CFS and not sure if I have long covid or not (I know that might be confusing to some people, but I was just assuming my ME/CFS has been flaring up badly this year, until I started watching these videos and starting to wonder whether the mild unknown infection I had back in February, before covid was known to be in my location, might have actually been covid...) Anyway, even coming from the point of view of just ME/CFS this is incredible information and giving me lots to think about. If one positive thing can come out of covid and long covid its that so much attention and research is being done now into post-viral problems, like ME/CFS is suspected, and its been so long ignored and underfunded. I've been dealing with debilitating ME/CFS for 16 years now, and would love that to change!
Yes agreed - there could be big positives to come from all this for the ME/CFS community
@@RUNDMC1 I've had CFS for the last 5 years and now have Long Covid, coming up for my 1 year Covid Anniversary - caught it on 9 March 2020. I started the MCAS treatment (without prescription meds), 4 weeks ago, introducing 1 supplement a week. I was already on 1 antihistamine, vitamin D, selenium and zinc. I started with niacin, increased to 2 histamines a day and went on an antihistamine diet, which isn't that hard you're already gluten and dairy free. I have more energy and miraculously the muscle pain I've had for the last 5 years has gone! I still have Long Covid, but this treatment has changed the CFS ... I think you might be right when you say that these the MCAS treatments and NAD + treatments may pave the way for CFS treatments. Next week, I'm starting on Quercetin and the week after vitamin C. I take the cautious approach so I ascertain what has worked and also to monitor side effects. I am hugely optimistic about my physical health and my future. Thank you so much for your excellent videos and giving me so much hope and optimism during a tough year.
16 years?...I've been suffering 35 yrs. It seems to me that if you don't catch this early, your trapped in a spiraling cascade of downward poor health. The people that do the best ,are people that eat the least.
I can eat veggies and nothing else for 2 weeks and feel ,to some degree, better but I cannot live on veggies alone so I start eating foods which most any normal person can eat, ant the trouble starts.
@@roonbooks1418 try researching Dr konynenberg's glutathione protocol, there are videos on YT. Or Katarina Voss cistus incanus natural antiviral protocol. There's an English translation on her blog. Or Raelan Agle on YT - many people recover from ME/CFS it takes time.
Excellent - We have both arrived at taking the same set of supplements without having had any direct discussion.. genius :)
I'm adding long intermediate fasting sessions into my week also to try to encourage autophagy to help weed out any remaining viral loads.
Have the supplements made a difference for you?
@@xeztan yes they have made a difference but I'm still on the roller coaster, just maybe not quite as crazy as before.
That is really smart of you! I did 23 hrs one day and my head/heart pouding went away (till I had dinner and it all came back). I should really try and do the same (easier said than done)!
Thanks for the video, you never fail to bring light to this subject. Hope your recovering yourself ;)
Slowly!
Thank you Gez
Pleasure :)
Thanks again for the good work and great vid!
Question, can we just drop the anti histamine and the DAO supplement?
What do you think?
I would keep taking them to be honest
Again big thanks. What about taking tryptophan directly if that is what is low?
I got covid in August. I didn't go back to work til towards the end of September.
After i recovered , I realized I had long covid. Fast heart beat, sever brain fog, my hands and legs kept shaking, I get tired in 15mins of working etc....
Then I found out that NRF2 and NAD that I've been taking helps with long covid.
I double dose on them. Within 2 weeks, my appetite came back, my hands and legs aren't shaking anymore, no fast heart rate, brain fog gone etc.
Definitely would recommend my company's products!
I am bang in the middle of your research - Strong fatigue symptoms back in March ( but not classic cough/smell issues)- No postive Covid test as not available- I then had both types of antibody tests in May -both negative ! ....But I am still suffering from Long haul! Very interested by your supplements/anti histamine/Niacin and thoughts around gut and NAD+ deficiency-THANKS!
Pleasure Simon 👍
Thank you! I started taking everything in the list in the doses given three days ago. (I was already taking all of them in lower doses.) The Quercetin in high doses is contraindicated with thyroid disease. I decided to try something similar to Quercetin that is a natural antihistamine and is a better supplement for me. (My diet is already anti-inflammatory.) The first day, I saw huge improvement and had two normal days in a row. Today, I woke up feeling great and wish I could un-retire. Thank you more than I can say!
No worries - I’m glad it’s making a difference for you Elizabeth!
Please may i ask about the quercitine substitute - I have a thyroid prob as well. I have nadh - is that the same by the way???
@@freddienardari5679 Hi Freddie, I substituted liquid stinging nettle extract. I take a dropper full twice a day, at lunch and supper, in a glass tart cherry juice at lunch and hibiscus tea at supper. I don’t take at breakfast, because I don’t want to interfere with prescription meds. It doesn’t seem to interfere with anything doing what I am doing, and it also gives immediate, temporary relief from nasal allergies-a surprise bonus. I am concerned about the high dose of Niacin, and don’t want to continue it for very long. Fingers crossed that symptoms won’t come back when I cut back to normal amount in my multivitamin. One other thing: I keep a clean diet, following the Wahls protocol, because of multiple autoimmune diseases (since 2018). My doctors checked out everything, thinking I was having a flare, but my numbers were all good. One doctor thought I was depressed-I am not. The other thought I had not cleared the virus. This is day four following what Gez discovered, and I continue to feel well. Good luck!
Do you know if consuming nutritional yeast would work to get the niacin?
If you don't mind I'd also love to hear how are you doing with this vitamin protocol and if you found some prescription that helped. I know that we are all different but it's interesting to see what works or not for other people! Thanks for this videos.
I’ve definitely had more energy and more cognitively functional hours in the day the last couple of weeks.
@@RUNDMC1 that's great!!! 💪💪
@@RUNDMC1 is it because nad+ ?
Hi @RUN-DMC / Gez Medinger thank you for your video, really helpful. Pre-covid my partner and I had 4 years of Lyme disease, with many of the same symptoms of long covid. We got covid withouth so much ill-effects, but unfortunately post-vaccines we have found after each dose we were progressively more debilitated, and again, very similar to Lyme immune dysfunction symptoms. As things are now I have tried the Niacin stack with some positive effects but also some negative in that it seems to really de-regulate my blood sugar. This too could also just be a post-vaccine symptom. Would be interested to hear your thoughts on potential impact of vaccine as the MS and ME society surveys show c. 10% of sufferers experience long-term issues (3+months) for the vaccines too-no matter which type/brand administered which suggests there is something unique about these patients immune responses to it. I've also read quite a lot of anecdotes about vaccine-induced diabetes being discovered in some of the population, which is also concerning. Is it something you have encountered already?
Hi there - I’ve not come across the diabetes yet, but negative responses to the vaccine aren’t unusual at all - I posted a film up about it recently - worth a watch!
What dose of niacin should we work up to for best outcome? I see it says start at 20 mg, but what is the recommended final dose? Thank you!
100mg generally, although some people take it as high as 500mg. That is very much based on your personal tolerance
Thank you from, yet, another Long Hauler.
Merry Christmas!!! ...from NY.
Thanks Gerald!
I believe covid is still living in my digestive tract. I've been taking high-dose reishi 10 x500mg /day + 2x22mg Zinc picolinate + 2x 500mg NAC to keep it under control and had a good improvement in symptoms - though I haven't been able to overcome the extreme fatigue yet. Maybe I need to try the niacin to address this.
The reshi alone created a massive change in my mood. For months I felt like I was clinically depressed and after starting to take reishi on an empty stomach to try to suppress the virus in my digestive system, my mood became better and better. Now I feel pretty happy most of the time!
what brand u use for nac and reishi
Are you also still eating a low-histamine diet? If so, do you think that is helping and are you minimizing lectin and oxalate foods?
I was wondering if a lack of niacin is the problem: is a deficiency easily traceable by a simple vitamin b3 bloodtest?
I am about to start adding niacin to my supplementstack but maybe it's worth to first get my blood tested on niacin levels. Did anyone else did this perhaps?
Thanks for your wonderful work.
Do you know of any study with probiotics? This persistence in the gut could be dependent of microbiota? In your inquiries have you ever look on the food people take, are vegetarian and vegan also affected. Can the use of NAC in the acute fase prevent long haul development? Sorry for so much questions...
There’s not much out there, but there is this!
www.cuh.nhs.uk/news/friendly-gut-bacteria-speeds-long-covid-recovery/
Sorry am just curious are you also implementing these supplement protocols as well and the anti histamine diet? Cheers for the hard work again 💛
Hi Nay, yes I’m also doing the low histamine diet and the supplements 👍
@@RUNDMC1 thanks mate i think you will crack this and make a brilliant contribution to what's going just don't burn yourself out 😅cheers again
Could you please give me a amount I should take for the first protocol you mentioned?
Is NAD+ deficiency also responsible for post covid Dysautonomia? It would be really awesome if you could ask this question to next time. Thank you Gez! You have been a beacon of hope in this horrible nightmare.
The theory is that yes the cascade that starts with NAD+ deficiency ends with POTS/dysautonomia. I talk to Dr Wentzel about this in my next film
how can we reach you for consultation?
This is one of the best videos I have seen, not only on this subject but in exploring the broader picture.
I am a journalist/researcher with an interest in medicine and the hopes of aiding medical research with my resources.
I have written several articles about "weird viruses" or "really tough" viruses that sicken many for months, sometimes years, and some people are permanently damaged. Our local doctors have used the terms weird and really tough. Nobody has given a damn, if the patient doesn't recover in 14 days, the doctor thinks there is something intrinsically wrong with the patient. If the patient is significantly ill after 14 days, s/he is sent to a psychiatrist or other mental health source. Out of sight, out of mind! Patients with ME or chronic fatigue become mental patients and nobody cares about them!
In 2017, '18 and '19, outbreaks of "really tough" viruses happened in early spring, around March/April. These monster infections begin with what seems like symptoms of the 'common cold" but quickly attack the digestive system.
My friends and I have discussed the 'old days' when we got colds, flu or 'stomach flu', had specific symptoms and recovered in a normal amount of time. Now, most illnesses we pick up have massive effects on the nervous system and digestive system and take months for a semblance of recovery.
In Dec. 2019-Jan. 2020 my household of nine people at that time, became infected with what seemed to be a mild respiratory infection. Amazingly, most of these people had a profound loss of smell and taste during the illness! Our source of infection was a boy who had visited relatives in a northeast corner of Oregon state which is in the Umatilla School District. That school district had closed down for fumigation in late November as they had had 61% absenteeism due to a weird viral infection. (Reliable sources now admit COVID was in Washington state by December 2019 and that state borders Oregon.)
Long story shorter, I did not lose smell and taste but the chronic, severe, genetic migraine I have became daily and much worse. When I was in the ER with migraine a couple weeks ago, the doctors there said we had had COVID, based upon our symptoms. It is too late for the tests to be accurate.
Most of us recovered fairly easily. My best friend, a middle aged female like me, had pneumonia three times afterward but was successfully treated at home with antibiotics. Other adults in the home may have had lingering depression or emotional lability.
As I said, the migraine became extremely disabling and for the FIRST time in my life I had the feeling of clinical depression. I worked very hard to dig out of that since I am not a depressed person. I ended up taking Co-Q10 which is recommended by Health Canada as a migraine preventative. This helped with the depression, I believe. After a few weeks of this, my damaged digestive system rebelled. I don't want to describe those symptoms. At this time I am having to be very vigilant about the depression. If I have too much stress in my life, I feel it creeping back so I fight back. So far, so good.
I have a lot of questions for researchers. I wonder if the past, severe, "weird", presumed viral infections protected us from COVID? I have followed the epidemiology of COVID in my area. Though it is hard to know all the factors that fuel outbreaks, it seems that northeast corner of Oregon has had less COVID. The problem with statistics is, categories like percapita infections per underpopulated county can look high though there may be less than 500 diagnosed cases. Politically, the worse the statistics look, the more aid a state might get. (In at least one of these sparsely populated counties, there were, it appears, deliberate gatherings intended to create herd immunity. This surely skewed the overall numbers of community spread, IMO.)
From a perspective of boots on the ground, 500 diagnosed cases in almost a year, in a county of under 30,000, does not seem that bad.
In 2017 I had many of the symptoms of fairly severe COVID. My husband and I were hospitalized but not for extreme care. We eventually became too ill to care for ourselves. I had severe digestive and neurological symptoms for 7 months.
I do not claim any of these past infections were corona viruses. Nobody knows what they were. I wonder if various corona viruses or similar have been sickening populations for a long time? I have suggested in my writing, and in online conversations with researchers, that when one of these weird outbreaks occurs, biological samples should be taken from patients and stored for future research. Doctors in the field amid the horrors on WWI did as much, affixing biological samples to glass slides sealed with wax. I suggest various biological samples be stored in a vat of liquid nitrogen or something. I have been told my idea is great but it will never happen. NOW is the time to make it happen! If we knew what had been severely damaging people in these other outbreaks, we might better understand SARS-CoV-2, IMO!
Until now doctors ignored and dismissed lingering disability after "really tough" viral illnesses. One good thing about COVID is they are being forced to consider what weird viruses can do.
Thank you for following this subject. Thank you for this video.
(I make terrible links, but one of my articles on our experiences, presumably with COVID, is on Twitter, my pinned Tweet. I have had too many migraines to do much more research.)
Hi Anna, thanks for watching and taking the time to comment as brilliantly as that!
@@RUNDMC1 Thank you so much! And thank you for all your work!
Thanks Gez, your videos are always do helpful and informative!! I thought I world try niacin but I see there may be an interaction with ssri's. I Do you know if it is safe to take the two?
Ask your doctor if you’re already on medication. There is a list of contra-indications in the description too
I was placed on cytolopram for anxiety since covid, is this maybe why niacin isn’t helping me
My Selenium level was highlighted as being borderline after my blood tests back in August but my GP didn't think action was required.
On the basis of your video i ordered some Selenium supplements that aslo include vitamins A, C, E from Amazon.... the latter probably not required but as the dosages are low and i'm yet to hear back from my GP i decided to take them anyway.
I'm now on day three of taking the Selenium supplememts and already i notice a big difference in my energy level... the most remarkable thing is that the nausea and fatigue that have plagued me since February appear to have gone completely... i still feel very tired but that may just be my body re-adjusting?
Time will tell if the Selenium supplements actually have helped, it shouldn't take long before yet another crash happens if they haven't...
Fyi, i'm hesitant to mess around with Niacin until i speak to my GP.
No matter if anything helps i thank you anyway.
A quick follow up that i've been meaning to do for a few days now... i orderered Niacin (flush type), Zinc, along the other supplements you suggested.
Sadly these did not work for me and i have abandoned the supplement route, at least for now.
Selenium on it's own appeared to have helped, i don't know because i was very slowly improving anyway... all i know is that when i started taking the other supplements i regressed very quickly and was struck down for four days with brian fog, GI pain and insomnia.
Prior to taking supplements it was becoming very rare for me to suffer from more than two symptoms for prolonged periods at any one time, so when i was struck again by three that persisted the only common denomonator i could think of were the supplememnts so i stopped taking them.
I appear now to be back in the situation i was in before taking the supplements so no harm has been done.
Overall, i'm glad to have tried the supplements, but on this occasion they weren't for me.
Hi. Thanks so much for this. Why Niacin and not nicotinamide? I’ve used the riboside in the past but is that no good here?
Nicotinamide is the breakdown product of NAD+, not a building block (like nicotinic acid) which is what you need
❤❤❤ this video. Thank you. 💯/💯 🙏
Thank you for all your efforts 👍🏿
Great! Is there a list of all the supplements somewhere? Thank you.
In the description!
@@RUNDMC1 ah ok phone doesn’t show it - thanks
Gael McLaughlin. Did you find a good source of niacin. I have already been taking a number of the other supplements. Thank you
Has your brain fog improved significantly? Or steadily? After following the protocol
Would something like 'healing earth'/Heilerde help reg persistent virals in the gut? Here in Germany they sell it in drug stores also for histamin intolerance, the product name is Luvos Imutox as granulate or capsules. Some people take those instead of DAOsin, since initial price 7,99 Euro for 64 capsules is way cheaper than those DAO enzyme capsules (30-45 Euro for 60 capsules).
I don’t know enough about it to comment - sorry Christian!
Thank you for your reply. Do you know of a online support group I can view, to specifically find help regarding vascular issues? I've had something similar to 'raynauds' in both my hands and feet since the initial infection, that has continued to get worse as the months pass.
If you’re on Facebook there’s lots of support groups - just search and you’ll find them. Otherwise there’s the Body Politic group on Slack too.
@@RUNDMC1 HI, and thanks! Would the niacin help Colin's raynauds also?
Erin O'Reilly honestly I don’t know Erin!
Hi, thanks for going to all this effort. I have a question though about the form of vitamin B3 to take. You say it's necessary to replace Nicotinic acid, so take Niacin - but as far as I can find out, Niacin is a synonym of Nicotinic Acid. The alternative form, which you say to avoid, is Nicotinamide or Niacinamide - again these appear to be synonyms. Virtually all supplements appear to be the Amide form. Can you clarify which form is best, and what it's trying to do?
Nicotinamide is the breakdown product of NAD+ and what we’re trying to add is the building block to enable change in the metabolic pathways used by the body - and that’s nicotinic acid. Hence you want this form of niacin.
@@RUNDMC1 Great, many thanks. (I had taken 'replace' to mean 'substitute with something else' instead of 'put back what's missing').
I’m 23 & been dealing with long Covid symptoms since November 16, 2020. Have seen multiple doctors none say anything helpful except try and convince me to get vaccinated! 😒 I need a solution first I need to be able to breath properly and not get weird panic attacks that I’ve never had before. Thanks to your videos and research you’re really giving me some hope, I just want to feel normal again I want my health back 😔. Bless your heart!
Best of luck with your recovery Cassandra - sorry you’ve not found a helpful doctor yet!
So how is ur symptoms?
Thank you for all your research and for your informative videos. As a long covid sufferer for nearly 9 months now your research is very helpful. I'm interested to know your thoughts on the vaccine, do you think it will promote enough of a immune response to eliminate any residual virus in our cells? I really hope so!
We just don’t know unfortunately, but there is certainly reason to think it might.
I’ve just seen a tweet by Dr Tina Peers where she suggests that treating early covid symptoms with the same principles of treatment as she is now using in long covid. The same occurred to me as I tried to help a relative who has started out with covid -I’m not medical in the least but NAD /niacin stack seems to be really helping with long covid symptoms and I was pondering whether it might not be flipped - as these actions in the body start at the get -go? And I think that in the article or video somewhere the doctor who developed NAD / niacin stack therapy also mentions it as a preventative approach not just for long covid sufferers. So even a protective pre-symptom approach as well as a treatment. I think this very interesting and I would hazard a guess that there would be little too lose (as long as individuals cleared to do do medically) and an awful lot of potential gain. Thoughts welcome :-)
I completely agree with Tina!
Whats the problem with NMN (Nicotinamide) supplements?
Another brilliant video ! I had a terrible reaction to first Oxford Jab and never felt better after second jab - don’t wish to declare victory as I have had false dawns before- but something now feels different . Could there be a link between vaccine and viral debris?
The vaccines are essentially presenting viral ‘debris’ to the immune system so yes!
How long after second jab did you start to feel better?
If NAD+ leads to NADH then NADH leads to ATP, would supplementing with creatine not help ATP levels here????
Would niacinamide work for those who do not like the niacin "flush"....I know each has beneficial properties. We take both...I have Lyme disease (persistent viral infection) and niacinamide keeps Lyme arthritis at bay.
Inositol hexanicotinate is a slow-release variety of niacin that is flush-free. Nikita recommends against it because it has to be processed by the liver, but I doubt the "liver burden" is substantial enough to cause much harm in the short term.
Hi. Thanks very much for a very informative video. I have seen a massive improvement by introducing niacin. Could I ask, at what point do we know that we have taken the niacin for long enough to have done its job, and is there a risk that, if we take it for too long, we might upset the balance of the body? Is no longer flushing an indication that it has done its job? Thanks.
Take the niacin until your symptoms have largely subsided then start backing off the dose and see how you get on
@@RUNDMC1 Thanks -will do. Appreciate you answering.
hi how is ur progress now
Would Mr Alexandrow or you Gez recommend supplementing L-Tryptophan or 5HTP to increase Serotonin levels?
Good question, im going to add in l-tryptophan and GABA. My nervous system is taxed right now.
@@ChristianSkoda What were your symptoms bro?
I use them from time to time, when feeling a bit down, but not daily, at least not for long periods. Other tryptamines though, are a different story: melatonin and DMT I'd recommend taking every day, especially if you have covid!
@@thebiggestpicture3230 DMT?? 🤔😉
Thank you for the question it made me think of the solution to one of my own questions. Not sure what these dudes recommend, but here is my logic to NOT do that, based on the diagram presented:
If the issue is Tryptophan depletion (due to its depletion in turn by NAD+ synthesis), with neurotoxicity due to it's by-product glutamate, then adding tryptophan (to make more NAD+ via Niacin-neogenesis from Tryptophan) would STILL lead to increased glutamate/neurotoxicity (maybe even more so). Thus the Niacin instead I believe. Look at the diagram at 4:05, it is super helpful. See where the glutamate is made, with the arrow to neurotoxicity? More Tryptophan means more glutamate most likely.
Thanks for the videos. They give me hope. Just wanted to clarify: when you say “we need to replace nicotinic acid so stock up on niacin” you aren’t saying replace your nicotinic acid supplement with some other niacin supplement. You are actually saying we need to replace our body’s depleted nicotinic acid with a nicotinic acid supplement. Does that sound right?
Yes that’s right! Just take a Niacin supplement.
Any suggestions for severe post Covid gerd. My esophagus and stomach is severely inflamed, never had acid reflux and these chest pains in my life. Tried various diets, nothing seems to help.
You might benefit from some H2 blockers. Talk to your GP
Hey there, thanks so much for your videos. In regards to niacin, you mentioned it's important to avoid nicotinamide. What about niacinamide? I believe this is the non-flush variety you refer to?
It’s slightly less effective than actual Niacin
From my understanding:
Nicotinamide = niacinamide (no-flush)
Niacin = nicotinic acid (flush)
They are all a precursor to NAD+ so I also dont understand what makes Niacin more effective?
Also: it induces autophagy.
Also2: Niacin (nicotinic acid) first has to be converted to Niacinamide before the body can use it, where as nicotinamide is the active form. They sure made this single B3 vitamin hella complicated.
@@lauwebeats thanks for clarifying post; have you tried intermittent fasting to increase autophagy?
marg.hi.can somebody help me .i feel good for two days and then go back to feeling tired again.
Just out of curiosity, looking at the NAD+ side, if supplementing Niacin could be of use, how about tryptophan?
Yes many people add that too
I take my daily gram of NMN (nad+ precursor) and Resveratrol (signal compound to check cell reproduction).
So a signal to check the cell and the fuell to correct any problem(stop virus reproduction)
Hey!
You never mentioned how long you have been taking this stack and if you feel it’s having any effect, could I get a response on that?
And thanks for the fantastic work as usual
Couple of weeks and yes I’m definitely feeling better!
@@RUNDMC1 Can I ask if you are still feeling better after adding niacin? And about how long did it take to start feeling improvement once starting the Niacin? What dose do you take? - Thanks RUN, you are awesome!
Randy Levine yes I’ve definitely had more energy - started to feel it within a few days. I’m on 250mg a day now, but worked up to it smowlt
@@RUNDMC1 what symptoms exactly did this help with?
@@RUNDMC1 what about now? Have you stopped taking the supplements and how does that affect your symptoms?
my niacin says inositol hexanizotifiate.. is this ok? Is this the non flush niancin your talking about? or is this the wrong one
You’d have to ask a pharmacist that question, sorry!
I am taking Niacin along with Nattokinase Serrapeptase and NAC, along with other mentioned vitamins and supplements, is this combination alright, Niacin helped me but Natto-serra is much more helpful, can i go with this combination
Lots of people are taking those - but if you’re concerned please do consult your doctor
Hi are there any recommendations as to the brand of niacin? Trying to find the right kind. Thanks in advance!
Brand not so important! Get small doses so it’s easy to build up
@@RUNDMC1 this question is asked because they want to avoid getting the American brand that is marketed as niacin but isn't. Could you please recommend the one you are using ... Or even better give us a list of where you are getting the supplements... this would be a great help. Thank you
Colin Saxton As long as it’s nicotinic acid you’ll be fine - search on Amazon and you’ll find lots of options
What type "brand" vitamins would the experts recommend? Are ones you can buy at a regular store like target as an example be sufficient?
I wouldn’t worry about the brand 👍
@@RUNDMC1 another question. I could only find a B-Complex. It has 100 mg of " Niacin (as Niacinamide) is that the wrong one?
@@bradenhunt16 There is niacin on amazon.
www.amazon.co.uk/Nicotinic-Magnesium-Stearate-Additives-Capsules/dp/B00BM6QEQA?pd_rd_w=L3E6K&pf_rd_p=647842ca-6a51-4ad0-998c-1f034dda84d8&pf_rd_r=3821K0E3KKXGC873XPG8&pd_rd_r=17ab8c5d-f49b-4aee-9817-524998adb772&pd_rd_wg=ZIuOz&pd_rd_i=B00BM6QEQA&psc=1&ref_=pd_bap_d_rp_1_i
Where do I find the description for the doses of the vitamins? Thank you
In the description of the video, depends if you’re watching on mobile or computer but there’s usually a little drop down box
All very interesting .....I believe I had Covid and I am a chronic asthmatic but I only developed 4 of the symptoms and just isolated and rested but since then my asthma has improved incredibly I do not suffer much from it now. So I wonder if it did something to the mast cells so that they are not so reactive to the stressors that precipitated my allergic asthma ???????????????????
Did you have short of breath after covid? 6 months later I’m still struggling with this. I had asthma as a kid.
Can any one tell me where to purchase niacin. I want a low dose to start off with. I bought a vit B complex today ( Solgar), and apparently it contains nicotinamide 50 mgs not niacin . I am in UK. Thanks.
Vitamin B3 Niacin/Nicotinic Acid (Flush Effect) 50mg, Magnesium Stearate Free & No Nasty Additives, Made in Wales … (90 Capsules) www.amazon.co.uk/dp/B00BM6QEQA/ref=cm_sw_r_cp_api_i_gXO2Fb9TA71CX
Is this why fluvoxamine has been really helpful for long haulers according Dr Been?
The article says 100 mg niacin. Your description says up to 500 mg. Did I miss something or is that a mistake?
btw. Thank you for this. You are doing amazing work that no one else is doing
Start low and work your way up if your body tolerates it
Where does it say to take up to 500mg of niacin? Today (January 2023) it says take between 10 to 20mg daily 🤔
Been taking everything but niacin since two weeks, added niacin today. Had lovely flush, but worth it, if this will guide me back to health! Will keep you updated.
Nice work Charlotte!
Please report back if the added Niacin was effective for you. I just did the same thing and after 2 days (and a horrible 'flush' episode) I swear my symptoms have already begun to subside noticeably. Specifically the ringing in my ears which had been present for 9 months is lessening! - Hoping for further recovery... Please stay in touch. I think the niacin might be the pivotal supplement to the equation of the others we've been taking... BTW, I also added magnesium citrate and within 1 hour my mood shot straight up! And it hasn't changed for 2 weeks. I think it interacted with the D3. I feel so good every day now (emotionally) and my sleep has improved by 200%! - Something's going on with magnesium citrate.
@@rlwings I will! I did some reading myself after watching this excellent video and there are some positive results published already about the specific effect of niacin on long covid. There was one instance where someone was already taking zinc, vitamine C, D and selenium, but it was niacine that made the difference within a week. The flush variant that is. See also: nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d and www.thailandmedical.news/news/covid-19-supplements-studies-show-that-nad-nicotinamide-adenine-dinucleotide-could-play-a-key-role-in-treating-covid-19-and-long-covid
@@charlotteholst298 Thank you for these links! - Really excited to continue with Niacin (and all the other suggested supplements) I'm on day 3 now. Will report back. :)
I’ve been supplementing with Niacin and selenium. It has really helped me. I wake up refreshed and can do more activities without fatigue relapses. Highly recommend it.
Amazing work as always Gez- hats off! I was wondering if anyone can recommend a niacin supplement? I was confused as the bio hacker article referenced mentions that nicotinic acid should be taken, which seems to go against what Gez has said in the video!
Nicotinic acid is just another name for Niacin 👍
@@RUNDMC1 thanks ever so much!
Has anyone tried glutamine?? Or know if they have high free glutamate