Dr John O’Neill on Circadian Timekeeping | Everything You Always Wanted to Know About Jet Lag

Dr John O’Neill’s research focuses on the key mechanisms of cellular circadian timekeeping and how the many daily rhythms in our biology come about. He spoke to MRC about his research in March 2021 as part of our seminar series.
A biological clock in every cell allows our bodies to prepare for the differing demands of day and night, by driving #circadianrhythms in our performance and physiology. Normally our body clocks are fine-tuned each day by the schedule we keep, particularly the timing of meals and light exposure.
When we see bright light or eat at the wrong time, as in #jetlag or shift work, it disrupts our internal rhythms and increases the risk of #chronicillness. Conversely, the effectiveness of many drugs and surgeries can vary with the biological time of treatment.
Delineating the molecular mechanisms that impart daily rhythms to our biology is therefore important for understanding human health and may provide new insights into the prevention and treatment of many diseases.
Dr John O’Neill’s current #research is focused on understanding the fundamental mechanisms of daily cellular timekeeping and how circadian regulation of biological function is achieved. To achieve these goals he employs a wide range of molecular biology, proteomic, metabolomic and biochemical techniques, supported by real-time fluorescent and bioluminescent reporters.
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