Also a PhD student in Neurobiology but I needed this quick review .... this is such a great summary for the NMDA & AMPA receptors! You def did a better job than my Neurobiology Professor.
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Is the nmda receptor, involved with the Gad65/67 antibodies, with the transglutaminase pathway in people whith autoimmune dusease such Diabetes, Celiac disease, Sjogren syndrome, Hashimoto thyroiditis ? Thanks
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are the AMPA and NMDA receptors only in synapses with glutamate activity or do they play a role in potentiation of other post synaptic receptors like dopamine? Also, are the NMDA receptors responsible for potentiation in all regions (mesolimbic, cortical, nigrostriatal, etc.)?
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@@jokingbat5not sure about Ca, but for Na the ionic state is only 1+ vs. Mg2+, so maybe because of the difference in repulsion force. Na1+ is repulsed, but by a much lower force, and the other forces pushing/pulling the Na through the receptor dominate
@@taggah2000 That's a plausible reason, but it should apply for Ca2+ ions too. Else, you have to provide an ad hoc hypothesis as to why Ca2+ ions are a special case. Perhaps the sizes of the ions play a role?
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NMDA receptors, or N-Methyl-D-Aspartate receptors, consist of subunits designated NR1 (GluN1), NR2 (GluN2A, GluN2B, GluN2C, GluN2D), and NR3 (GluN3A, GluN3B). NMDA receptor nomenclature typically includes these components to specify receptor composition. For example, NR1/NR2B denotes a receptor with NR1 and NR2B subunits. These receptors are essential in synaptic plasticity and learning processes within the brain.
Also, I would just like to add that NMDA isnt just another name for glutamate receptors. There are also many other glutamate receptors that are not NMDA.
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Hi Alina, thanks for your question. -50mV is relatively more positive than -70 lets say. The Resting membrane Potential of a typical neuron is about −65 mV, with the interior of the cell negative in charge to the outside. So when it becomes -40 lets say then its slightly positive inside ( not much ) and you get small currents at this state.
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Also a PhD student in Neurobiology but I needed this quick review .... this is such a great summary for the NMDA & AMPA receptors! You def did a better job than my Neurobiology Professor.
Glad it was helpful! Please share with friends
you answered all of my question in a very simple way! THANK YOU
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Great video! Just recently came across your channel and it is exactly what I was looking for! Keep up the good work!
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Very clearly explained..👍
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Is the nmda receptor, involved with the Gad65/67 antibodies, with the transglutaminase pathway in people whith autoimmune dusease such Diabetes, Celiac disease, Sjogren syndrome, Hashimoto thyroiditis ? Thanks
Thank you for this very succinct and informative video!
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İngilizce bilmediğim halde anladım. Teşekkür ederim ❤
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
are the AMPA and NMDA receptors only in synapses with glutamate activity or do they play a role in potentiation of other post synaptic receptors like dopamine? Also, are the NMDA receptors responsible for potentiation in all regions (mesolimbic, cortical, nigrostriatal, etc.)?
excellent... very well explained......
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@@animatedbiologywitharpan definitely... They deserve to be seen by many... I will share for sure .. keep doing the good work...
Why does the positive potential repel the Mg ion block but not the Ca and Na ions even though they all are cations?
yeah I dont understand either.
Did you find the answer?
@@vd8614 Nope. Not yet. I haven't really looked for it. When I do and if I find it, I will update it here.
@@jokingbat5not sure about Ca, but for Na the ionic state is only 1+ vs. Mg2+, so maybe because of the difference in repulsion force. Na1+ is repulsed, but by a much lower force, and the other forces pushing/pulling the Na through the receptor dominate
@@taggah2000 That's a plausible reason, but it should apply for Ca2+ ions too. Else, you have to provide an ad hoc hypothesis as to why Ca2+ ions are a special case. Perhaps the sizes of the ions play a role?
Good explanations, thanks!
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Good explanation
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Wonderful video
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General doubt :
What carbon atoms of glucose end up as a carboxyl group in pyruvate?
Please give fate of glucose carbon in pyruvate
Ok this is a topic for new video
Yo WHAT?!
Super
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thank u
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Feel spread goodness
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NMDA receptor is just another name for glutamate receptor and glutamate that binds to it, NMDA isn’t an actual receptor
NMDA receptors, or N-Methyl-D-Aspartate receptors, consist of subunits designated NR1 (GluN1), NR2 (GluN2A, GluN2B, GluN2C, GluN2D), and NR3 (GluN3A, GluN3B). NMDA receptor nomenclature typically includes these components to specify receptor composition. For example, NR1/NR2B denotes a receptor with NR1 and NR2B subunits. These receptors are essential in synaptic plasticity and learning processes within the brain.
Also, I would just like to add that NMDA isnt just another name for glutamate receptors. There are also many other glutamate receptors that are not NMDA.
🧬💯
Suggested videos : AMPA receptor, LTP, LTD, synaptic plasticity
❤
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Why is there a small inward current between -50 and 0?
Hi Alina, thanks for your question. -50mV is relatively more positive than -70 lets say. The Resting membrane Potential of a typical neuron is about −65 mV, with the interior of the cell negative in charge to the outside. So when it becomes -40 lets say then its slightly positive inside ( not much ) and you get small currents at this state.
Watch the video on AMPA receptor to know more about it ruclips.net/video/u7Ev9gwSMrw/видео.html.
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
I'm on facebook & Instagram as @animatedbiologywitharpan. Install the app to download notes and flash cards. instagram.com/invites/contact/?i=1p41h314q3fv8&
You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me