It's funny to think that by watching this video I learn how memory works, and by doing so, the exact mechanisms that are displayed in this video IS HAPPENING IN MY HIPPOCAMPUS RIGHT NOW AS WE SPEAK, I CAN FEEL THE GROWTH OF NEW SYNAPSES BY THE INFLUX OF CA2+ IN THE POSTSYNAPTIC CA1 CELL. THE ACTION POTENTIALS ARE AT A ALL TIME HIGH RIGHT NOW.
How is it that when one person (or three!) explain this it makes absolutely no sense and this makes it seem so super simple! I don't understand how people passed exams without google and youtube!! thank you so much!! xo
Being able to visualize this helps so much more than just reading and looking at pictures in the textbook. I don't think I'll ever forget this now, thanks !
Wow! I can't express how glad I am that I found this video. My book was not able to explain it as clear as this presentation, my understanding of this subject just expanded because of this video. Thanks!
The person or persons who created this video know exactly what they talk about - if anyone is doing psycho-biology this is a really helpful source since it explains simply - but in depth - what LTP is. For sure I am coming back for more, keep on doing these videos.
Brilliant! Dale Purves' "Neuroscience" offers some really in-depth stuff, but generally fails at mashing in small nails with big mallets, which we sometimes need when cramming. Succinct and precise, and gorgeously presented. Kudos!
I'd like to thank all the people involved in making this very informative video. LTP is a rather complex process and you have managed to make a video that explains the phenomenon in a precise way which makes the concept easier to comprehend. Thank you!
My professor should just show us this video instead of the 20 page incomprehensible power point slides. I was able to piece everything together so easily with this video. Great video!
Kudos to the speaker, who speaks VERY clearly and at a good pace! It can be frustrating to watch a video on complex material and not be able to understand the speaker, or hear a speaker to talks too fast to follow well.
Seriously this video was so awesome!!!! It was so helpful to see the representation of the long-term potentiation and hear the very clear explanation of what was happening. Definitely recommending this video to people in my class. Thank you!
THANK YOU! This was awesome! I've breen struggling to understand LTP for such a long time! I'm giving a presentation about memory and plasticity in a few days and now I think I finally understood this!
My primary interest and major is in Computer Science but I have very strong interest in Neuroscience, as well. I had difficulties understanding the working of synapse and neurotransmitters for memory. This video is very informative! My question has been successfully answered :)
Just had my neurosciece lecture about long term potentiation and depression this week. I wasn't able to focus in class. Glad I found your video it is super helpful! Love from Sheffield
Wow, this is an amazing video. I when to lecture, read the notes carefully and read the chapter in Neuroscience book and was still not fully understanding this. After the video I understand it fully. Thank you.
AWESOME VIDEO!! excellent explanation and one of the best voice over's I've ever heard! Great voice! And great explanation. Helped me understand it so much better!! Cannot thank you enough for this.
There is one more part of the early phase of the LTP that also strengthens the synapse. Part of the protein kinase cascade includes the movement of AMPA receptors from the base of the dendritic spines to the tips of the spines, allowing for a greater chance of contact with glutamate in the synapse. The video mentioned new AMPA receptors being installed from storage, but this facet of the LTP is just movement of previously installed receptors away from the cell body and toward the synapse.
Wow. Thank you for this video! My textbook really was not explain this in a digestible way (could be that there were no helpful diagrams and I’m very visual), but you guys made this very comprehendible! Seems as though many other people’s textbooks are also not very clear as well, which is interesting because after watching this it seems like a fairly straightforward concept. Could be that reading NMDA (especially when your brain registers it as MDMA because you watch to much Joe Rogan), AMPA and glutamate over and over gets a bit overwhelming and distracting from all of the actual concept of the function.
Fantastic video, thank you very much. This hopefully was part of the LTP in my studying and the forming of new AMPA receptors which hopefully will last a long time!
Thank you so much for making this great video! It finally makes sense (although I may need to watch it one more time to strengthen the connections, haha).
Jonnyiswhatweaimfor Ideally, not many, you should check out other videos on the same topic too, read chapters from a textbook, maybe have someone create a test on the material for you to take.
Thank you for this awesome explanation of LTP. Now I can finish my paper (as soon as I figure out how to give credit in a citation of a youtube video). (:
Adding a TRANSCRIPT to the 'show more/show less' under the video would help too, as would true script-based closed captions. What I presume are computer-generated closed-captions are in this presentation pretty good, but not, I think, totally accurate. Where the cc says 'internal cortex' ~ 1.01 (sending signals to HC), I think he actually said 'entorhinal cortex', maybe?
Tell the creator they are doing an amazing job! With Shadow155's addition, this could be the most educational seven minutes and 59 seconds of my entire life.
Nice video! Some points that need ti be mentioned though: 1. Coincidence detector refers also to the binding of glycin or d-serin next to glutamate and the depolarisation through ampa. 2. It is misleading that there are more calcium and sodium intracellular after the depolarisation as in the video. Even a small amount is sufficient to cause an electrical depolarisation.
how does this interract with drug tolerance? With the sodium, calcium transmitters and magnesium preventing tolerance build up? Does one need more of a drug to pass enough ca++ to create a polarization?
It's funny to think that by watching this video I learn how memory works, and by doing so, the exact mechanisms that are displayed in this video IS HAPPENING IN MY HIPPOCAMPUS RIGHT NOW AS WE SPEAK, I CAN FEEL THE GROWTH OF NEW SYNAPSES BY THE INFLUX OF CA2+ IN THE POSTSYNAPTIC CA1 CELL. THE ACTION POTENTIALS ARE AT A ALL TIME HIGH RIGHT NOW.
I thought the same thing and actually laughed out loud at this lmao
Hi Paolo, you might love Havening Techniques :)
you're high
haha love it
It’s not a mechanism tho
How is it that when one person (or three!) explain this it makes absolutely no sense and this makes it seem so super simple! I don't understand how people passed exams without google and youtube!! thank you so much!! xo
Thanks for the feedback, Annie. Glad it was useful!
Lol, they read good textbooks.
3:26 Well thanks for reminding me while I'm studying for my exam today.
I've watched a lot of videos about neuroscience. A lot are good, some are great, this was magnificent!
Being able to visualize this helps so much more than just reading and looking at pictures in the textbook. I don't think I'll ever forget this now, thanks !
Wow! I can't express how glad I am that I found this video. My book was not able to explain it as clear as this presentation, my understanding of this subject just expanded because of this video. Thanks!
The person or persons who created this video know exactly what they talk about - if anyone is doing psycho-biology this is a really helpful source since it explains simply - but in depth - what LTP is. For sure I am coming back for more, keep on doing these videos.
Brilliant! Dale Purves' "Neuroscience" offers some really in-depth stuff, but generally fails at mashing in small nails with big mallets, which we sometimes need when cramming. Succinct and precise, and gorgeously presented. Kudos!
our teacher recommended this video. It is impossible to make it clearer than here. thank you
I'd like to thank all the people involved in making this very informative video. LTP is a rather complex process and you have managed to make a video that explains the phenomenon in a precise way which makes the concept easier to comprehend. Thank you!
My professor should just show us this video instead of the 20 page incomprehensible power point slides. I was able to piece everything together so easily with this video. Great video!
this video gave a clear and concise explanation of memory making it possible to remember!!!
Kudos to the speaker, who speaks VERY clearly and at a good pace! It can be frustrating to watch a video on complex material and not be able to understand the speaker, or hear a speaker to talks too fast to follow well.
Seriously this video was so awesome!!!! It was so helpful to see the representation of the long-term potentiation and hear the very clear explanation of what was happening. Definitely recommending this video to people in my class. Thank you!
This is what my teacher took an hour to explained, but explained very good in 8min, thanks!!
THANK YOU! This was awesome! I've breen struggling to understand LTP for such a long time! I'm giving a presentation about memory and plasticity in a few days and now I think I finally understood this!
doing the same in 2024 haha
My primary interest and major is in Computer Science but I have very strong interest in Neuroscience, as well.
I had difficulties understanding the working of synapse and neurotransmitters for memory.
This video is very informative! My question has been successfully answered :)
A great deal of long-term depression happened while I was watching this
😂😂😂
i have exam tomorrow and this is more clear than some of my lectures. THANK YOU
+luciferin22 same!
+luciferin22 Same!!
Same here
By far the best video I've seen! thanks
Just had my neurosciece lecture about long term potentiation and depression this week. I wasn't able to focus in class. Glad I found your video it is super helpful!
Love from Sheffield
Thank you for your explanation! Made an hour long lecture much more understandable and bearable!!
I'm studying this the night before of my exam. I understand I'm screwed.
I'm studying this a few hours before my exams lol
me too 😅
I'm studying this 26 hours before my exam
This was great!!
I wasnt logged into my account, but i did after watching this video just so that i could "LIKE" and Comment on your video :)
TheSick83 Thank you! We appreciate it! :)
This was even better than reading Purves. LTP memorized in 8 minuts. Great!
Wow, this is an amazing video. I when to lecture, read the notes carefully and read the chapter in Neuroscience book and was still not fully understanding this. After the video I understand it fully. Thank you.
It's 7 years later, but still. It's a great explanation of the LTP. Thank you!
Best explanation I've come across so far. Gr8 animation!
AWESOME VIDEO!! excellent explanation and one of the best voice over's I've ever heard! Great voice! And great explanation. Helped me understand it so much better!! Cannot thank you enough for this.
absolutely brilliant video - thank you so much! My lecturer couldn't explain this properly and through one video i've got it!
the best lecture with extraordinary explanation of the physiology of memory tq so much for your help and support..............
this was brilliant, and saved me from having to wrack my brain over written notes. thank you!
THANKS SOOOOOO SOOOO MUCH, this helps a heck of a alot!!!! i can not thank you enough for making this clip!!!
This video changed my life
There is one more part of the early phase of the LTP that also strengthens the synapse. Part of the protein kinase cascade includes the movement of AMPA receptors from the base of the dendritic spines to the tips of the spines, allowing for a greater chance of contact with glutamate in the synapse. The video mentioned new AMPA receptors being installed from storage, but this facet of the LTP is just movement of previously installed receptors away from the cell body and toward the synapse.
Gr8 video! Besides the misspelling of the AMPA- receptor (thumbs up!)
This si what i already needed, You' re the best
This was so much more clear than my professor was!
Wow. Thank you for this video! My textbook really was not explain this in a digestible way (could be that there were no helpful diagrams and I’m very visual), but you guys made this very comprehendible! Seems as though many other people’s textbooks are also not very clear as well, which is interesting because after watching this it seems like a fairly straightforward concept. Could be that reading NMDA (especially when your brain registers it as MDMA because you watch to much Joe Rogan), AMPA and glutamate over and over gets a bit overwhelming and distracting from all of the actual concept of the function.
Really good video. Excellent animations and commentary. Beautifull!
Fantastic video, thank you very much. This hopefully was part of the LTP in my studying and the forming of new AMPA receptors which hopefully will last a long time!
The memory of this memory is saved in my brains memory !
excellent! very clear explanation for a very confusing topic! thanks a lot
I feel so much better about taking this biopsych final now! Thank you!
Thank you so much for making this great video! It finally makes sense (although I may need to watch it one more time to strengthen the connections, haha).
Thank you for the video! Is very clear and understandable, it has been a great help for me!
3:30 so how many times should I watch this video?
Jonnyiswhatweaimfor Ideally, not many, you should check out other videos on the same topic too, read chapters from a textbook, maybe have someone create a test on the material for you to take.
Thank you! This video was so helpful, like the person under me, I felt the need to create an account just to say thank you!
I LOVE THIS VIDEO IT SAVED MY ESSAY AND THUS MY LIFE
+abcaimeex YAS
Really enjoyed and benefited from this. Please keep them coming!
Thanks!! Really good video, perfect for understanding the mechanism.
Cheers from Chile
concise yet detailed description. thanks. now to study LTD
Great video on the topic! Better if links to videos of related topics are provided to form a playlist of the subject. Keep it up!
Thanks for the video! This was clear and informative. I would recommend this video to students of neuroscience!
Thank you for this awesome explanation of LTP. Now I can finish my paper (as soon as I figure out how to give credit in a citation of a youtube video). (:
great video! explained it better than my book thank you!
Thanks to the writers and animators and whoever made this video possible.
It's perfect. Thanks from Brazil.
Very good video. Made the topic very easy to understand
so, practice doesn't make perfect, but makes magnesium get out of the way?
Dehydration causes sodium to be elevated. So If someone was dehydrated often would that cause LTP Vs LTD? Thank you for any response.
Thanks everyone - so glad this video has been helpful! :)
Thanks! It really helped :)
Concise yet well explained!
Will an intake in Sodium, Protein, or Calcium give increased cognitive performance in any way?
Slowest action potential I ever saw XD
I don;t know why this made me laugh.
it was just superb
u sir are a legend and im not indian
i would like to have handy some of the missing references, concerning the LTP leading to production of growth factors for example. Really good video.
Brilliantly explained, thank you! :)
This video is great and very didactic! It helped me a lot, thank you!
Great video. I would suggest adding some text during the video to reiterate a few points, though.
Shadow155 Thanks for the feedback! We are passing on suggestions and feedback to the video's creators.
I agree- text would be good for those who cannot spell very good. (I make notes while watching these videos)
I'm taking notes too, using the subtites. Great explanations, thank you so much!
Adding a TRANSCRIPT to the 'show more/show less' under the video would help too, as would true script-based closed captions. What I presume are computer-generated closed-captions are in this presentation pretty good, but not, I think, totally accurate. Where the cc says 'internal cortex' ~ 1.01 (sending signals to HC), I think he actually said 'entorhinal cortex', maybe?
Tell the creator they are doing an amazing job! With Shadow155's addition, this could be the most educational seven minutes and 59 seconds of my entire life.
Very informative and efficient. Thank you!
Very useful information provided by this video !
Thank you! This is fantastic!
Great video! thanks for making and posting.
Thanks for the video! It is a helpful supplement for studying for a test I have to take.
This video summarises the process really well and is super helpful in revising for my test
jeez, much more concise than my lecture of 2h duration
Great video! really helping me understand the concept.
his is a good video! hi from neuroscience enthusiast here!
Thank you so much. It's much clearer now
This VDO is very helpful. Thank you so muchh
awesome, clear and concise
Very clear explanation, thank you.
When the Mg+ leave , there is so many Na +. Why the Ca+ can go in?
the video is very good and easy for understanding
Una maravilla este video! Increíble!
Nice video! Some points that need ti be mentioned though:
1. Coincidence detector refers also to the binding of glycin or d-serin next to glutamate and the depolarisation through ampa.
2. It is misleading that there are more calcium and sodium intracellular after the depolarisation as in the video. Even a small amount is sufficient to cause an electrical depolarisation.
Amazing informative video of LTP
Excellent! Great video, it helps me a lot!
This was super helpful, thank you!
Very beautiful and helpful Animation
V helpful for my exam tomorrow, thanks!
What about desensitization of the AMPA-receptor due to the increased concentration of glutamate?
thank you so much!!! Great and clear explanations! I feel the synaptic changes in my brain right now , my synapses will be stronger haha :)
Brilliant video. Thank you!
I wonder why only AMPA and not NMDA receptors are increased in number? Thanks so much for the fantastic video
great... helped me in understanding the concept... Thank u.....
how does this interract with drug tolerance? With the sodium, calcium transmitters and magnesium preventing tolerance build up? Does one need more of a drug to pass enough ca++ to create a polarization?
Why do the Sodium ions repel the Magnesium but not the Calcium? Is this overcome by active transport of Calcium ions through the NMDA receptor pore?
Great Video! Thank you very much
Excellent video and graphics! Should it also be mentioned that the CREB has to be phosphorylated in order to activate and enhance gene transcription?