CELLULAR SENESCENCE & SENOLYTICS | How To Remove Senescent Cells [2020]
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- Опубликовано: 22 июл 2024
- ZOMBIE CELLS!!! What are they, and how the heck do I get rid of them? In this video, we’ll be taking a look a cellular senescence…and what to do about it.
We’ll be talking about the causes of cellular senescence, including telomere erosion, and the effects that senescent cells can have on their environment and their neighboring cells. Then we’ll turn out focus towards how to get rid of them. We’ll discuss how senolytics work and then examine several of the best senolytics.
Links:
www.fightaging.org/archives/2... 
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Thanks for another great video. This area of development is very important helping us incrementally improve health and avoid illness while waiting for the big breakthrough to reverse aging which is most likely decades away.
Hi Jason. I couldn't agree more.
very informative and summarized over a 10 hour book that I was reading about this
Excited to find this channel! Liked and subscribed. Looking forward to reviewing your past material.
Welcome aboard!
The best video on this topic on You Tube
Well done
Thanks!
Thanks for this - much appreciated!
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I have just started on Fisetin without changing anything else - we will see what happens - like your show
anything happened?
Brilliant and concise... thanks!
Glad you liked it!
Fisetin has roughly twice the senolytic potency as quercetin.[] A clinical trial in the U.S. is currently underway as of October 2018 to show effectiveness in humans.[
1.5g Fisetin with 500mg Quercetin Phytosome for two consecutive days a month (just ahead of my monthly 3-4 day prolonged fast). Been on this protocol for almost a year and grey hair in my beard and side of my temples has bizarrely disappeared. Unsure if this is to do with the senolytic treatment or not however as I take a full longevity stack daily too.
That's great to hear. I'm gathering research right not for a video I'm planning on doing of fisetin. There's a lot of different protocol for taking fisetin, and I haven't landed on one yet.
What is your daily supplement list
That's pretty interesting. Would like to know if you're in your 20s, 30s or 40s and if your greying is not premature. My stack include Tru Niagen NR, Astaxanthin, Omega 3, Zn + Cu, Shilajit, Vit. D3 5kIU + K2 90mcg, Super B-Complex. I've done some research on Fisetin. Due to too much stress and poor sleep with sleepless nights and insomnia, my hair started going white in my early to mid 30s. Will test Fisetin and see how it goes. I'm on a mostly vegan diet and partially vegetarian as I use milk, butter and cheese in my diet sometimes. Also, would like to know your longevity stack and type of diet. Thanks!
@david what is your longevity stack?
What does your longevity stack contain?
Hiya Lance. Do you know whether or not senolytics are effective while not fasting? I do extended fasts once a quarter, during which I load up on senolytics for maximum effect (hopefully,) but I'm trying to determine whether or not it's worth adding another round or two of senolytics during non fasting periods as well. Cheers.
It would be so much better if your videos could be shorter, I do respect all the work you put in this video.
thanks for another great video
Thanks for watching!
I didn't know about the lack of human testing vis a vis Fisetin. But according to Wikipedia, it's been shown to increase longevity in mice, that's why I ingest strawberries a lot.
Thanks for the great report!
Great point!
I also eat a lot of freeze dried strawberry powder when I don´t have fresh ones. I also take a lot of Aronia and wild Blueberry freed dried powders. I´m 38 and people think I´m 30. This study using strawberries is very interesting. pubmed.ncbi.nlm.nih.gov/28551262/
Good video 👍🏻 Thanks for sharing 🙏🏻
Thank you too
Great presentation
Thanks
Is there a way for us to test our senescent cells so we can see the results of our protocol?
Thanks for breaking it down ...
You're welcome.
Very thorough
Thanks
There are people I know who behave like senescent cells.
Ha! Don't we all?
Talk about the science and studies behind cannabis and the endo cannabinoid reception system in the ability it has to turn apoptosis back on in rogue cells.. hence the benefits in some cancers
I always wondered what Cypher was up to after the Matrix.
Thank You, Lance
My pleasure!
Hi, there! Pls someone tell me how to identify zombie cells. I’m 74 and suffer from chronic fatigue due to mito issues. My feet are a little swollen and blotchy and no medical cause found. Thanks to my open minded doctor who put me on Metformin, which is a senolytic...and the good news is it’s dirt cheap compared to MNM.
does stem cells have this heyflick limit?
Need an update and availability?? tnx Lance.
This channel is a good find and I will progressively work through it. I am compelled to take 100mg of dasatinib each day and there are few side effects. I have added quercetin (with bromelain to increase bioavailability). What sort of observation would I make about my health condition?
Wow! You take dasatinib every day? I've always heard that it should only be taken as a course of treatment 2-4 times a year.
@@LanceHitchings Yes, dasatinib is a "miracle" drug for leukaemia and holds me in a non-leukaemic state. I have to take it daily. It costs the National Health Service £33,000 a year for me. I am hoping that I get some added benefits from taking it.
@@sterlingtimes all the best to you...........i did not know my mother because of leukemia, she passed when i was three, a very very long time ago..........
You got it right
Thanks!
What about oxytocin?
Straight-forward information! I just started with my 1st 3 capsules of a brand name supplement cocktail with 325 mg Bio-Fisetin, Theaflavin 275 mg, Bio Quercetin 74 mg, Apigenin 50 mg. Is 3 capsule/week really safe for use?
I have no idea. I would assume that the brand provides accurate dosing info. There's a lot of conflicting dosing regimens regarding senolytics.
Mr. Lance what do you advice me to do? I'm 38 years old and I'm thinking of buying NMN and Senolytic together. I've read some comments in your other videos that if we start with the NMN after awhile we should stop and what shall we do after that? Can you please help? Thank you. I'm noticing the white hair is spreading really fast now within few months. I go to gym and i take all the vitamin supplements. I'm thinking to try Rogain for my hair loss and white /grey hair that is spreading fast. I really need your advice
Before you start taking NMN, I'd try to clear out senescent cells with a senolytic like fiseten or dasatinib & quercetin. Then I'd try supplementing with apigenin to block the effects of CD-38, which uses a lot of Nad+. I only take NMN after I tried all the other intervention. I did a video about this last week: ruclips.net/video/HiKTaCQaP78/видео.html
Thank you so much for giving me the information. I'm 49 and I hate getting old. I want to be 25 again. I'm looking into Foxo 4 DRI and it's available for purchase online. Will that rewind my old age by killing the senescent cells?
You need to do a lot more research. You cannot rewind your age but you CAN get A LOT of good results with energy and cell efficiency using lifestyle and supplement changes.
Killing senescent cells with supplements is a good step but aging is SO.. SO MUCH more than senescent cells..
Things you can't just fix include:
-stemcell exhaustion.
-telomere shortening.
You CAN improve:
-epigenome alteration (cut back on alcohol helps here)
-loss of proteostesis
-deregulated neutrient sensing
-mitochondrial dysfunction
-cellular senescence
-altered intracellular communication
-genomic instability
My advice:
Take only a few types of supplements to midigate danger and save your wallet.
If you want to go all out, take 500mg of NMN to boost NAD+ a day.
And take senescent cell killer supplements 2 consecutive days per month.
Sadly bioavailability (absorption rate) is hard with most of these senescent cell-killing drugs.. I'm still looking for which one gets absorbed at all into the body..
If you just BUY and hope you might end up with expensive poop.
Supplements are not the answer though.
You NEED to change your lifestyle.. supplements do just that.. supplement a lifestyle!
Stop eating any unhealthy snacks and start drinking only water and eat plenty of fruits/vegis.
Sleep 8+ hours a night and do exercise 3 times a week.
Also, fasting has MANY benifits. Fasting is something I didn't wanna do or believe in and I am about to start with it because damn.. the personal experiences I read about are insane.
@@randomshittutorials Oh I see. Then how can I rewind my age?
@@dmana3172 You cannot, they only did that in mice eyes as far as I know with very precise and high tech processes. Not possible for us consumers.
Body is too complex.
Reverting with high tech even can easily cause cancer.
You can revert some hallmarks of aging simply by changing your diet and lifestyle and taking SOME supplements if youre past half your lifespan. Even without supps tho.
Go watch sinclair podcast on what to eat and when, all is in there. Search it up.
One huge doubt that I have from telomere theory. If it causes senescence when the cells divide close to 50 times. Shouldn´t the body´s cells reach this limit all at a similar time?
Nope. Different types of tissue have different cellular lifespans. Some cells die after only a few months, some never die. But on average, most of the cells in the body renew themselves very 7 years or so. They're replaced from our store of stem cells.
@@LanceHitchings Suppose a person lives 70 years. So several of his cells have renewed 10 times. The 10th cell has the same internal characteristics as the first one? Or the only problem in the renewal process is really senescence?
Isn't it true that intermittent fasting promotes autophagy? And wouldn't this be a better option for clearing out senescent cells?
An extended fast over 24 hours promotes autophagy, although 72 hours is better. Not so sure about intermittent fast, if you're talking about an eating window of 18 hours. Usually, you have to fast for at least 24 hrs. to ignite autophagy...as I understand it.
I don’t have a thyroid; can I still take fisetin? I’ve read that it could interfere with thyroid hormone and function.
That's a great question, and I don't have an answer, I think that's a question for your physician.
I don't think the average MD or DO has a clue.
Was he talking about piper longum? I'm not sure but perhaps he was pronouncing it wrong. Or is there a piper longumen? I'm so confused.
My bad...I was referring to piper longum.
@@LanceHitchings it turns out you were right actually. The active chemical in piper longum is called piper longumine. Although I'd say it sounded like you were mixing the two words. No worries. Thanks for responding and also for the informative content.
Pippi Longstocking?
Due to chronic disease I had multiple CT scan we all know the damage on DNA from those invasive test in couple of years lots of troubles could show up including leukemia my question what will the best supplément for me to take to try to avoid side effects from those radiation I prefer to take care of it now then wait for the problems to come thanks to everyone and health to all of you
I've had the same problems, and I don't really have an answer. I stopped getting the CT scans. I thing that best thing that you can do is to exercise regularly and occasionally do extended fasts. Good luck.
@@LanceHitchings what kind of fast you are doing? I am looking up for Reishi mushroom and beta glucan very good for radiation protection if you heard about it .
@@sami-pe1no kelp or iodine help with radiation
Fistein found in strawberries apples persimmons onions and cucumbers?
But not in a therapeutic dose.
@@LanceHitchings could you not juice the strawberries how many kilos daily would you need to reach a therapeutic dose.
Do when do you think we will have a pill for all this ? (aging weakening population is not good ).
I don't. The notion that a pill will replace good nutrition and exercise is truly science fiction...for now. Who knows what the future holds?
@@LanceHitchings not replacing .... adding , (like TRT therapy )
Are telomeres introns?
I don't believe they are. While both are non-coding sections of DNA, introns are regions of DNA that are located within genes that encode for a protein but are removed prior to encoding. Telomeres are non-coding sections of DNA that repeat at the ends of chromosomes. But I'm not the expert here.
Wouldn't it be odd, if senescence were an evolutionary experiment that tries to achieve immortality?
I see autophagy as the better option.
That would be odd, since as I understand it, senescence is one of the big drivers of aging.
This is basically like the green knight saying it's just a flesh wound
How do you kill senescent cells naturally?
Great question. I'm sure that good nutrition and exercise can help, but I'm not sure that there is a reliable way to get rid of senescent cells. The best way that I've been able to find is to take a senolytic. Since fisetin is a natural plant flavonoid, it might be considered a "natural" strategy. And it's turning out to be a pretty effective senolytic. I'll be doing a video on fisetin on Dec. 29, or at least that's the plan.
@@LanceHitchings does resveratrol (trans) helps?
@@LanceHitchings Post the video in the New Year when you can Lance, and thanks for the excellent content.
@@LanceHitchings Post the video in the New Year when you can Lance, and thanks for the excellent content.
@@LanceHitchings how do u get rid of cancer cells
Piperlongumine
His Hair follicle cells went into Senescence.....
I won't to no more
Don't eat for a few days starve your cells will get rid of zombie cells 🙋♂️
I do both, fasting and taking senolytics.
Sorry to many error statements for me.
LIke...for example?
Senescent cells become Democrats?
I believe that in the section of the video that you may be referring to, I say that senescent cells become a detriment, not Democrats. LOL
@@LanceHitchings Potato ... po tah to ... haha
You live longer if you stay out of politics
@@Harmony7771 There are some politicians that seem to live a long time.
🤣