Tyrosine Kinase Associated Receptor || JAK STAT pathway

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Video Summary:
Tyrosine kinase-associated receptor itself is a simple receptor molecule without enzymatic activity. But they associate with the Janus or Src family of tyrosine kinases. Under the resting state, the receptors exist as monomers. The binding of a ligand causes dimerization, recruitment of JAK, phosphorylation of each other and phosphorylation of receptor, recruitment of STAT, its phosphorylation, dissociation and formation of dimer, entry into the nucleus and regulation of gene expiration.
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@user-qb8zq6bk4s]

loved it so much, very well explained thank you

[@saielawate6128]

This is a great video thank you so much! Just one thing, I think during examples you display GH but said growth factor… small correction.

[@altafalinaushad6368]

Short and sweet! I understand how much you have to read to make such a complex topic so easy! Let alone the superb animations!!
Thankyou so much🙏🏼

[@NonstopNeuron]

Yup. It takes lots of effort. Thank you. And please share. We need support.

[@anushkasable585]

U make it so easy just amazing

[@johnlind6892]

thank you, this is so good

[@adem3088]

Perfect!

[@YusufNusretKurkcuoglu]

Your thumbnails with the enzymes as guns are really tempting. Couldnt help but to watch.

[@veenatelikicherla6782]

Amazing👍

[@user-zc7et8pe3j]

awsome

[@axdx2320]

In the video we see transphosphorylstion of jaks and receptor domains, but in the summary the transphosphorylstion isnt shown,which one is correct?

[@abheeverma6732]

Bhaut bhaut bhaut accha tha sir, apke sahare kat raha hai mbbs

[@NonstopNeuron]

Sahi hai... Beda par laga denge...😄

[@josetrujillo738]

Could you translate this into English: I’m curious to what this means. Lol

[@davidoluic2525]

HI, can you tell me here does we need 1 ligand or 2 ligands for activating this receptor? And is this receptor dimer or became dimer after ligand binding?

[@NonstopNeuron]

I didn't find it mentioned explicitly but figures in the book I referred shows 1 ligand. And receptors dimerize on ligand binding.

[@davidoluic2525]

@@NonstopNeuron thanks a lot for the answer.

[@yogitakumari8375]

Best 👍

[@NonstopNeuron]

Thank you so much 😀