The mnemonic "Citrate Is Krebs Starting Substrate For Making OAA" just BLEW MY MIND. Trying so hard to memorize it and this made it sooo much easier!! Thank you Lord for you and your team! Keep it up!!
@@lachyt5247 OP didn't say they weren't taught this in medical school, they said they didn't understand it. And yes it's troubling someone can get through medical school without understanding the very basics of cell metabolism.
25:18 - “Look at this freak...(points at enzyme)” cracked me up! As an artist crossing over into science I’ve learned so much from your methods and use of imagery. Thank you for making these lessons available.
He literally takes a chapter and condenses it into a 32 min video with more simplifications and better understanding than any professor I have had. Goodness gracious I only need him as a teacher for everything. He gets straight to the point without the fluff.
I learnt a mnemonic for the Krebs cycle and I thought I should share: Can- citrate I- isocitrate Keep- a Ketoglutarate Selling- succinyl CoA $3x- succinate For- fumarate Money- malate Officer- oxyloacetate
32:15 minutes and no mistaken terms, no mistakes at all! So fluent, quick enough and revising the necessary parts. I don't know how much work you put in this video (I think a lot in order to be so professional) but it's amazing👏
I don't think you realise just how fantastic of a teacher you are. You explain topics in great detail while simultaneously making it very easy for students to digest and remember everything. That's not easy nor common. You have a true gift! Thank you for sharing it with us.
I cannot thank you enough for your videos. I have watched probably 15-20 of them so far (some multiple times) which represents a significant amount of my study time because you explain these processes so clearly, you repeat the names of steps or enzymes and recap often, you draw pictures to help us remember, you give clinical applications to relate these concepts to real-world issues, and you are organized and methodical in your explanations making it easy to follow along. PLEASE keep up the good work and keep producing these incredible videos! Many, many thanks!
Your videos greatly helped me understanding biochemistry in med school! As a visual learner and as a person who loves taking down notes, I now know the bigger picture of these metabolic pathways and their clinical significance! Continue doing videos like these! :)
i have studied metabolism for one whole semester and understood nothing tomorrow is my exam and watching his 30 min video has made me understand every topic so clearly that im not afraid of metabolism now. thankyou sir!!!!!
Thank you. I'm just a layman, trying to educate myself about my diabetes.. So, the kidneys are very important to me. (I began my 'research' there). And so is getting at least a basic understanding about as much biology as I can cope with... I have to say young man.. your style of teaching is so very refreshing. You quite obviously have a thorough and total grasp of your subject.. and talk with such mastery and confidence. I'm impressed.. as are a great many medical students commenting here. I can hardly believe that I'm actually beginning to get a handle on the Kreb Cycle !! I first came across it (Kreb..) some months ago.. and quickly became a jibbering idiot trying to take it in.. and soon ran away with my tail between my legs !! I only wish I'd come across your channel earlier. I've subbed.. I've liked.. and I'll be seeing a whole lot more of your work in the future. Thanks again. .
One of the best videos and best teacher I have ever seen. He should be declared as the best teacher. Thank you so much sir for making biochem so easy like butter❤❤❤.
I got a whole medical degree and this man easily explained such tough concepts of my first year in 1 video with such attention to detail I didn't even blink before subscribing what an angel. thank you. thank you. you saved me.
You're the best ninja nerd...I love the way you explain every concept so simple and easy to understand. You're such a blessing, please keep it burning💯🔥
your explanation is so so amazing i've seen tons of videos on biochem here and yours are the best by far. love every single video in this series thank you so much for making these
Just finished watching this now with full focus! First time ever I’ve actually gained an understanding of the progressive process. Thank you Ninja Nerd!
my first exam is in 4 hours and I'm so glad I found you earlier rather than midway through the semester. Let me tell you that while I pulled an all nighter and watching the glycogenolysis video, I was thinking that's what my liver must be doing right now cause my brain was in desperate need of the glucose lol. You're a blessing in this world. Thank you for making these lectures so interesting. They really made me smile and giggle a little bit. my favorite part was when you said "look at this Humpty Dumpty enzyme" lol that cracked me up and I love your googlie eyed enzymes too
This is the best teacher ever. Thank you so much because I was really down, thinking that I am dense, but now I believe i am going to pass biochemistry 🎉. God bless you 🙏
You just helped me memorize this whole cycle, having spent a week circling in panic with only acetyl coa and oaa in my head. A stable genius you are, Zach.
I first left a comment on here after first watching and for the first ever time gaining an understanding of this 3 months ago, I'm now 9 weeks into medical school and Glycolysis, TCA cycle and Electron Transport Chain crept up, honestly I did not understand the lecturer at all, I watched your Glycolysis video and made a literal transcript of it! And now just finished watching this video of yours on the TCA/Kreb/Citric Acid cycle and made a literal transcript of what you have said and honestly I genuinely understand this! THANK YOU FOR SAVING ME AT MEDICAL SCHOOL! Love from Dundee School of Medicine, Scotland, UK! Keep going!!
During my six years of university education (masters included), the concepts always seemed elusive to me. With just a week left until my MCAT, you managed to explain the Krebs cycle to me in just 30 minutes, and I'm incredibly grateful!
I don't even know how to thank you, I don't have words for the amazing content you make, a content which is so useful for med school students beacause it is detailed enough and made in a so engaging way thank you so much !! And the mnemotechnic is just INCREDIBLE thanks !!!
@@NinjaNerdOfficial sir what will happen to those substances (like for example alpha-ketogluterate) if their next step is being stopped (succinyl COA binds to alpha-KG D.H. to inhibit conversion of alpha-ketogluterate to succinyl COA)? will those substances just stay in place?
Someone watched this in 2020 of Covid 19, you are the nerd. Thank you so much for sharing. You are amazing. Keep going to produce good videos for medical learners. Wish you all the best.
the drawings are so beautiful and easy to understand. the teaching style is too and the slow pace and frequent repetition of the facts make the information easier to remember. glad i found this channel, thank you for the work you do Ninja Nerd Science !
Your online lectures are truly gamechangers! Pre-med student checking in, thank you so much for your content, you do a fantastic job! Your illustrations and explanations are extremely clear and helpful! I have been following since your glycolysis break down, and structure of DNA, and I am hooked! Thank you so much!
Love your videos, however I'd like to point out an error for other people who may be watching. Mutations in Isocitrate Dehydrogenase, NOT alpha-ketoglutarate DH (as you mentioned in the video) lead to accumulation of 2-hydroxyglutarate and ultimately cancer. If anybody is familiar with cancer literature, you'll often read about "IDH mutations" which are very common in certain cancers (gliomas and acute myeloid leukemia especially). "IDH" is just a fancy abbreviation for "isocitrate dehydrogenase." IDH normally converts isocitrate to alpha-ketoglutarate; however when it is mutated, it also converts alpha-ketoglurate to 2-hydroxyglutarate which causes the problems mentioned in the video. More specifically and for those people who may be interested, there are three human IDH isoforms: IDH1, IDH2, and IDH3. IDH3 is what was discussed in the video and functions in the mitochondria to convert isocitrate to alpha-ketoglutarate while reducing NAD to NADH. The other two isoforms, IDH1 and IDH2 are the isoforms that are mutated in cancers and reduce NADP to NADPH (rather than NAD to NADH). IDH1 functions in the cytosol whereas IDH2 functions in the mitochondria. IDH3 is not normally mutated in cancers. Otherwise great video Here are some links if you want to learn more: www.ncbi.nlm.nih.gov/pmc/articles/PMC4109985/ advances.sciencemag.org/content/advances/5/5/eaaw4543/F1.large.jpg
Omg this is actually the best learning video I have ever seen !! In my second year of uni and watched a lot of different teaching and this is another level I loved it
Someone give this man an award please. Best teacher I've ever seen.
Why wait? Award him💃💯
He desreves more than that ♥️
he deserves an award for real#nobel prize teacher -of those 37 ppl (30 of them were his classmates and he topped there score, and 7 just cant learn)
💯💯💯
Its me who I'm gonna make it!!!!! Leh me finish did high school first$!!!!
The mnemonic "Citrate Is Krebs Starting Substrate For Making OAA" just BLEW MY MIND. Trying so hard to memorize it and this made it sooo much easier!! Thank you Lord for you and your team! Keep it up!!
One I found online was “Can I keep selling s*x for money, Officer?”🤣
In 5 years of medical school, i never understood this and you just lad this out so easily in merely 30 minutes. You're a blessing!
Which Med School?
HAHAHAHAHA! EXACTLY!
this is why I don't visit doctors...
@@KidVll You don't visit doctors because they studied medicine instead of biochemistry?
@@lachyt5247 OP didn't say they weren't taught this in medical school, they said they didn't understand it. And yes it's troubling someone can get through medical school without understanding the very basics of cell metabolism.
Like seriously I can't imagine am just watching this video released since 7 years ago and it really helping my academic career as a medical student.
25:18 - “Look at this freak...(points at enzyme)” cracked me up! As an artist crossing over into science I’ve learned so much from your methods and use of imagery. Thank you for making these lessons available.
You’re so welcome! Glad to help!
You're Bob Ross!
That freak looks like Picasso's genius work.
@@NinjaNerdOfficial Literally Sir, thanks for your lectures make my work far easier. Looking for more interesting topics ahead.
That part cracked me up, too! 😂
He literally takes a chapter and condenses it into a 32 min video with more simplifications and better understanding than any professor I have had. Goodness gracious I only need him as a teacher for everything. He gets straight to the point without the fluff.
I learnt a mnemonic for the Krebs cycle and I thought I should share:
Can- citrate
I- isocitrate
Keep- a Ketoglutarate
Selling- succinyl CoA
$3x- succinate
For- fumarate
Money- malate
Officer- oxyloacetate
Good job
Yeah you took that from The Berkeley Review.
this just saved my winter credit. love you fam.
yes you can 😂
That is very good😅
7 years from this video and you still help people, thanks for your great teaching!!
You're right! I'm a 2nd year medical student and tomorrow we're having a quiz about TCA Cycle
I’m a first medical student and my life has been easier when I found your channel.. thank you ❤️
same here
Me tooo❤
Me too here
Same here😝😝
Same
32:15 minutes and no mistaken terms, no mistakes at all! So fluent, quick enough and revising the necessary parts. I don't know how much work you put in this video (I think a lot in order to be so professional) but it's amazing👏
I just cant stress enough how much I love you man. Thanks for existing. May Allah bless you.
Ameen
ameen
Ameeen
@CALLIE-CO 2 this didnt age well
aamiiin
I don't think you realise just how fantastic of a teacher you are. You explain topics in great detail while simultaneously making it very easy for students to digest and remember everything. That's not easy nor common. You have a true gift! Thank you for sharing it with us.
University lectures are an hour and a half, yours are thirty minutes! Insane.
I know!! Mine are two hours, this guy is amazing!
Ours is 3 hours straight 😅
Maaaaaan... Doc, thank you
Professor Zach Murphy is the truly gifted teacher!
Arguably the best Medical Teaching I've ever seen ,he deserves an honuor
Beat thing ever to happen on planet Earth are this man’s videos😭 Best teacher ever!!!!!!
He’s making my life a hundred times more easier
This guy is the absolute GOAT!!!! He makes it so easy to understand such a “complex” process🤙🏾
I cannot thank you enough for your videos. I have watched probably 15-20 of them so far (some multiple times) which represents a significant amount of my study time because you explain these processes so clearly, you repeat the names of steps or enzymes and recap often, you draw pictures to help us remember, you give clinical applications to relate these concepts to real-world issues, and you are organized and methodical in your explanations making it easy to follow along. PLEASE keep up the good work and keep producing these incredible videos! Many, many thanks!
Man, this is the ART! state of art!
Your videos greatly helped me understanding biochemistry in med school! As a visual learner and as a person who loves taking down notes, I now know the bigger picture of these metabolic pathways and their clinical significance! Continue doing videos like these! :)
i have studied metabolism for one whole semester and understood nothing tomorrow is my exam and watching his 30 min video has made me understand every topic so clearly that im not afraid of metabolism now. thankyou sir!!!!!
Thank you.
I'm just a layman, trying to educate myself about my diabetes..
So, the kidneys are very important to me. (I began my 'research' there).
And so is getting at least a basic understanding about as much biology as I can cope with...
I have to say young man.. your style of teaching is so very refreshing.
You quite obviously have a thorough and total grasp of your subject.. and talk with such mastery and confidence.
I'm impressed.. as are a great many medical students commenting here.
I can hardly believe that I'm actually beginning to get a handle on the Kreb Cycle !!
I first came across it (Kreb..) some months ago.. and quickly became a jibbering idiot trying to take it in.. and soon ran away with my tail between my legs !!
I only wish I'd come across your channel earlier.
I've subbed.. I've liked.. and I'll be seeing a whole lot more of your work in the future.
Thanks again.
.
One of the best videos and best teacher I have ever seen.
He should be declared as the best teacher.
Thank you so much sir for making biochem so easy like butter❤❤❤.
You should teach University. A lot less students would fail.
if he does teach biochemistry, other professors will lose their jobs now ~~~~!
@@froglegs4910😂😂😂😅
Exactly @ninjanerdscience
Elias Klein ageed
Literally ... MASHALLAH he is an amazing teacher 👍✨👍
your passion for the subject and wanting your students to understand is amazing.
Biochemistry made simple and oh so interesting! Thank you so much for making these amazing videos :D
You’re very welcome Amenah!
:-)
I got a whole medical degree and this man easily explained such tough concepts of my first year in 1 video with such attention to detail I didn't even blink before subscribing what an angel. thank you. thank you. you saved me.
You're the best ninja nerd...I love the way you explain every concept so simple and easy to understand. You're such a blessing, please keep it burning💯🔥
It's nothing but a blessing....it has Been the happiest 30 mins enjoying Krebs.
The mnemonic bro.....it won my heart❤️
one in a million people has inborn gift of conveying their knowledge in a simplified, beautiful manner. you are that "ONE".
My goodness! ninja how do you have all this information in your head? You really made this lesson interesting.. Keep it up
I'm in my third year of medical school and you just don't know how easy you make my life..Thank you Ninja
Dude I’ve never seen someone teach kerbs cycle like this 😳👌 pretty simple
I was blank after lecture,,, but when I got this am full.Best teacher ever I will over nothing bigger than thanks giving.
Nobody needs this more than I do 😊. Thanks sir. You’re the enzyme used to catalyze my passion for this course (Biochemistry)
I love how you added the inhibition in this video as it made it much more informative, and the visual enzymes make the process easy to remember :)
your explanation is so so amazing i've seen tons of videos on biochem here and yours are the best by far. love every single video in this series thank you so much for making these
Anytime i watch ur videos i begin to cry........you are just too good. U have no idea how u are touching peoples lives
Omigosh I love you. When I get my Microbiology and Chemistry degrees I'm going to shout out Ninja Nerd Science
Just finished watching this now with full focus! First time ever I’ve actually gained an understanding of the progressive process. Thank you Ninja Nerd!
my first exam is in 4 hours and I'm so glad I found you earlier rather than midway through the semester. Let me tell you that while I pulled an all nighter and watching the glycogenolysis video, I was thinking that's what my liver must be doing right now cause my brain was in desperate need of the glucose lol.
You're a blessing in this world. Thank you for making these lectures so interesting. They really made me smile and giggle a little bit.
my favorite part was when you said "look at this Humpty Dumpty enzyme" lol that cracked me up and I love your googlie eyed enzymes too
How did ur exam go? I hope ur brain eventually got the glucose that it needed
This is the best teacher ever. Thank you so much because I was really down, thinking that I am dense, but now I believe i am going to pass biochemistry 🎉. God bless you 🙏
This video is so amazing and it helps us so much! Thank you!
You just helped me memorize this whole cycle, having spent a week circling in panic with only acetyl coa and oaa in my head. A stable genius you are, Zach.
Wow! Amazing teacher- I will remember this chart when I take a test- and also just learning the information- it now makes sense! Thank you so much!!!
I first left a comment on here after first watching and for the first ever time gaining an understanding of this 3 months ago, I'm now 9 weeks into medical school and Glycolysis, TCA cycle and Electron Transport Chain crept up, honestly I did not understand the lecturer at all, I watched your Glycolysis video and made a literal transcript of it! And now just finished watching this video of yours on the TCA/Kreb/Citric Acid cycle and made a literal transcript of what you have said and honestly I genuinely understand this! THANK YOU FOR SAVING ME AT MEDICAL SCHOOL! Love from Dundee School of Medicine, Scotland, UK! Keep going!!
Best mnemonic for Kreb cycle is ( Can I Keep Selling Sweet For Money Officer)
Underrated af 😂
💯💯💯💯💯💯💯
sounded so funny😭😭😭
During my six years of university education (masters included), the concepts always seemed elusive to me. With just a week left until my MCAT, you managed to explain the Krebs cycle to me in just 30 minutes, and I'm incredibly grateful!
Can't thank you guys enough for your hard work! This is beyond amazing🔥👑
The level of clarity u give to the pathways and regulations deserves a credit.
Thank you for blessing my life 😭
Why can’t all teachers be this good?!?! THANK YOU Mr. Ninja Nerd!!!!
Youre a blessing to all medical students! Thank you!
I don't even know how to thank you, I don't have words for the amazing content you make, a content which is so useful for med school students beacause it is detailed enough and made in a so engaging way thank you so much !! And the mnemotechnic is just INCREDIBLE thanks !!!
You are so freaking amazing. God bless you. You helped me so much!
+Casey McConnell We are so happy we could help Casey! Good luck to you!
@@NinjaNerdOfficial sir what will happen to those substances (like for example alpha-ketogluterate) if their next step is being stopped (succinyl COA binds to alpha-KG D.H. to inhibit conversion of alpha-ketogluterate to succinyl COA)? will those substances just stay in place?
simply the best medical lecturer on youtube
The mnemonic was very helpful.
It is ridiculous how well you teach this. The personification of enzymes... genius.
RIP Betty White, replenishing the levels of isocitrate in heaven.
this guy is saving my uni life i swear. i can't thank you enough
"We have another enzyme. Look at this, look at this freak!"
After watching your video, this cycle finally makes sense to me. Thank you tremendously for creating this video! Phenomenal work!
It's amazing! It has been 4 years trying to learn this, I never understood. Now it's done so easily :)
I know you get comments like this all the time but brother you're still helping uni students to this day. Really appreciate you!!
"I'm going to pick pocket this guy so hard" DYING xD. Had to pause the video and take a minute xD.
Same! GTP didn't even stand a chance
It's To MuCh Easy Way
Thanks And keep it up
This is by far the best krebs explanation I have seen on youtube. Thank you.
when he said 2+2 is 4, i thought he was going to say: -1 thats 3 quick maths
most understood able teacher ive ever seen in my life
"I'm going to pick pocket this guy so hard" LMAOOOOOOO
What is the meaning of that
All my classmates watches his videoes .... This channel has been the best thing ever
id fail without you
The video is awesome! "Citrate Is Krebs Starting Substrate For Making OAA" Best mnemonics ever!
Great video mate
Thanks so much Jerin!
This guy right here what a legend we need professors like this in the world
I can't believe you killed Betty White with Flouroacetate 😂 the audacity.
Someone watched this in 2020 of Covid 19, you are the nerd. Thank you so much for sharing. You are amazing. Keep going to produce good videos for medical learners. Wish you all the best.
❤️ Viděla jsem video paní učitelko
Beastmaster64
3§
the drawings are so beautiful and easy to understand. the teaching style is too and the slow pace and frequent repetition of the facts make the information easier to remember. glad i found this channel, thank you for the work you do Ninja Nerd Science !
U rock mate ❤️
+Mazen Essam thank you so much for those kind words. I hope it helped.
Great job now I got my ideas clear
Thank you! The time I used to take to decipher out concepts has diminished because of your incredible teaching.
Different to the mnemonic I was taught today... "Can I keep selling sex for money, Officer?" hahaha
Not the mnemonic for class but definitely using this
Okay .... This one is lit 🔥🔥
There is no way in hell I am gonna forget this one 😅
Save this man at all cost!!!! 6 years later your vids are getting me through med school!!!!
"look at this freak" smh bigotry is everywhere
Your online lectures are truly gamechangers! Pre-med student checking in, thank you so much for your content, you do a fantastic job! Your illustrations and explanations are extremely clear and helpful! I have been following since your glycolysis break down, and structure of DNA, and I am hooked! Thank you so much!
Best ever biochemistry teacher i have ever seen !! M literally crying :') !!
First time understood Krebs cycle in such a simple way , you're literally legend Sir ❤❤❤❤❤❤.
Everywhere ever time when I talk about Biochemistry,I never forget you
best lecture ever....i was frustrated abt biochemistry but this guy made it easier for me as well as for those like me....
NINJA NERD must be written in history one day as the GREATEST teacher of all time
This man has caused so many students get over their fear of the Glycolysis - Krebs Cycle - ETC. A blessing in disguise
Wow! To be honest this great man deserves a reward, concept driven home in the best way possible.
No, wait, that Mnemonic is just out of this world... Really, I appreciate you sir for everything you've been doing for us med students.
I don’t know what id do without you…. Life savior
Love your videos, however I'd like to point out an error for other people who may be watching. Mutations in Isocitrate Dehydrogenase, NOT alpha-ketoglutarate DH (as you mentioned in the video) lead to accumulation of 2-hydroxyglutarate and ultimately cancer. If anybody is familiar with cancer literature, you'll often read about "IDH mutations" which are very common in certain cancers (gliomas and acute myeloid leukemia especially). "IDH" is just a fancy abbreviation for "isocitrate dehydrogenase." IDH normally converts isocitrate to alpha-ketoglutarate; however when it is mutated, it also converts alpha-ketoglurate to 2-hydroxyglutarate which causes the problems mentioned in the video.
More specifically and for those people who may be interested, there are three human IDH isoforms: IDH1, IDH2, and IDH3. IDH3 is what was discussed in the video and functions in the mitochondria to convert isocitrate to alpha-ketoglutarate while reducing NAD to NADH. The other two isoforms, IDH1 and IDH2 are the isoforms that are mutated in cancers and reduce NADP to NADPH (rather than NAD to NADH). IDH1 functions in the cytosol whereas IDH2 functions in the mitochondria. IDH3 is not normally mutated in cancers.
Otherwise great video
Here are some links if you want to learn more:
www.ncbi.nlm.nih.gov/pmc/articles/PMC4109985/
advances.sciencemag.org/content/advances/5/5/eaaw4543/F1.large.jpg
Its the smoothest teaching strategy i've ever seen
DUDE YOU ARE UNBELIEVABLE, THE KREBS CYCLE WOULD NEVER EVER BE EASIER THANKS!!❤️❤️
This guy deserves a medal just for drawing the bilayer membrane around the board
Omg this is actually the best learning video I have ever seen !! In my second year of uni and watched a lot of different teaching and this is another level I loved it