So have you seen the Princess Bride now then? ...seems askew to use a reference from a film you've still not seen (despite us badgering you to watch it)...or was that the point (whomever wrote the script?) ...I'm just curious as to whether you have seen it and if you enjoyed it, as it is a classic film that still holds up.
@@Karatop420 the herpetology community is definitely a unique one, huh? I've met several people who are prominent in the field and they are all very neat and cool people. There are some who are jerks/idiots, but for the most part most are down to earth and nice people. Jim Harrison of the Kentucky reptile zoo is a dear friend of mine. He worked with Bill Hasst in Florida way back in the day and helps supply a large portion of the snake venom used to make antivenom, pharmaceuticals, in many experiments that are going on these days and for scientific studies. I completely renovated the zoos Tropics building absolutely for free over the course of two weeks back in 2015. One of the best 2 weeks of my life.
@@Criwindustries no the cyanide just had delayed effect because his stomach lining was thicker that usual because he had just got done with an afternoon of boozing
not gonna lie, getting bit by a black mamba and living at all is a bit awesome, living without losing part of your body or having permanant damage is crazy, and comparing it to bee stings is honey badger level.
I told my GF that we don't need condoms because it's possible to become immune to pregnancy by taking small doses of semen. After our 8th child was born she started to have doubts about the process.
YES, if it is of animal origin it probably is possible. NO type of mineral poison can allow you to have immunity to it, BUT some can through thousands of years of natural selection.
My grandmother used to work in a greenhouse for poisonous plants in her teens and early 20s before she gave birth to my mother. My mother and I have also been immune to most plant based poisons, probably because much of our immune system is passed from mother to child in the womb. didn't really know i was immune until i went playing in the bushes while camping, and i gave poison ivy to all of my dad's family. never had so much as an itch.
What about poisonous plants like hemlock and yew and deadly nightshade? I thought Mithridates built up a lot of his tolerance eating toxic plants, but the video doesn't talk about them at all.
From what I recall of the story Mithridates built up an immunity to the local plants and animals of Georgia before sending out for more poisons from other countries. As with the primary point of the video, the effectiveness varies. For example some poisons neutralize each other when consumed so initially proper dosing could avoid initial reactions, and poison cocktails could have saved him later. On a more specific note, most ancient plant based poisons in the area were alkaloid based such as aconite. Alkaloids are natural muscle relaxants in small quantities and are used in heart medicines. There has been no modern studies on long term alkaloid poisoning, but early testing does indicate that a tolerance is built up in patients.
@@akatoshslayer7599 So again...why isn't he mentioned in the video? Seems like a good candidate. The guy had to bribe one of his guards to kill him with his sword because he was unable to poison himself to death while imprisoned - how does that not qualify?
This is one of the best explanations of how the body metabolises alcohol I've ever come across. I can say that the researcher on this video has done their job superbly. Well done simon on pronouncing those trickier words correctly!
I watched the Princess Bride for the first time just last year. I was 35. My official excuse is that I had previously lacked opportunities to watch it.
I don't know about poison, but watching five minutes of news every day should one day enable me to sit through a whole segment... it works on the same principle.
I also heard the explanation once that cyanide is deactivated by large doses of sugar, and since both the cake and wine consumed by Rasputin were highly sweetened, the high sugar content actually prevented the cyanide form doing its job.
That would make sense. Him needing to be clubbed and drowned despite being shot is also pretty mundane as well when you consider that bleeding to death from a gunshot wound can take hours
@@HouseLyrander that reminds me of what happened to the tsar's children after the Russian Revolution. They tried to execute them by firing squad but all five children survived. They then bayoneted the children but that didn't seem to work either, and eventually all five were shot in the head at close range.
Used to ba a treatment for malaria to gradually give you larger and larger doses daily of strychnine, to the point it killed the malaria parasites in the blood, but not quite killing you, Then taper the dose off again over a few weeks till you were no longer taking it. done when the British army had a lot of malaria cases in the tropics, and no quinine to treat it otherwise.
@@michaelmcurdy3459 you can factually eat a garter snake and not die so again that isn't poisonous my guy, that's venomous and just about everyone can name a venomous snake. A poisonous snake would be something like a tiger keeled back snake, which is both actually. Garter Snakes primarily feed on fish, slugs and earthworms which would not give them any of the necessary ingredients to poisonous. If you think that's being an ass you're too sensitive for the internet my friend that's called education through facts rather than sugar coating and hand holding. Misinformation leads to misrepresentation and fear, which is exactly what those of us who know, love and keep reptiles as a hobby or conservation effort are trying to avoid.
@@michaelmcurdy3459 that wasn't a proper sentence, I want you to be able to name a poisonous snake which a garter snake is not. A garter snake is venomous which is factually not the same as a poison.
I appreciate how you talk about not caring about anything but making money in your business blaze videos. It lets me know you don't care how good or bad your sponsors are, so I shouldn't trust you plugging them. Thanks!
Short answer: No, you can't. Long answer: Yes there are some compounds when taken will boost specific enzymes in your liver that makes you need a higher dose to see effect but it doesnt make you 'immune'. Theoretically it could work for cyanide but there is lack of a needed substrate in yr body
There was a lady in my neighborhood who told my mom that mosquitoes never bit her, they would often sit on her skin but will never bite her, if they do so, they will die. That goes same for her daughter too, but not for her husband and her son. My dad told us about how at some places small children are given small amount of poison throughout their childhood and they turn out to have poisonous blood when they grow up.
I have a friend, he's a heavy smoker and swears it saved his life. He got sick, was having a hard time breathing, and ignored his symptoms until friends dragged him to the ER. His blood oxygen levels were so low average people would have died l, but because his body was used to low oxygen he pulled through. Still smokes almost 20 years later.
A Botanist at Cornell University collected wild mushrooms and would test them for cooking by consuming an increasing amount daily and would discard if he had symptoms. He had a dinner party for his graduate students where he cooked with the "safe" mushrooms. Everyone went to the emergency room except him. My supervisor, a Ph.D. in horticulture, was one of his victims. This happened in the early sixties. He told me the story in 1973. I never had a reason to disbelieve him.
Basically, in summary there are three main cases: 1. Complex poisons/toxins: Lasting, gradual immunization possible by humoral response; temporary immunization possible through anti-serum 2. Molecular/simple toxins with evolved counter-measures: Accommodation of physiological response (e.g. enzyme production) possible 3. Molecular/simple toxins without evolved counter-measures: No immunization/accommodation possible on somatic, individual level (4. Any toxin a species is exposed to enough to generate a significant fitness advantage if resistance is developed might lead to actual resistance by process of natural selection/random mutations, e.g. resistance by conformational changes to core proteins that disallow the action of a toxin or evolution of enzymatic processes to breakdown toxins)
wanted to know about poisons, ended up with a lecture about venoms.... still really cool, but what about plant based poisons. would that be something that could be built up against?
Varies widely. It's really specifically about each poison and if the body has the ability to metabolize it. Immune system doesn't help against poisons (unlike many venoms). There are also genetic variances - for example, the stuff that causes rashes to form from poison ivy/oak some people are basically immune to.
it should also be noted their are chemicals that are harmless but over time become poisonous. long term painters get turpentine poisoning over time and become "hypersensitive" to it as it builds up in their system after frequent exposure.
I was thinking of Bill Bill Haast when I first clicked! When he first started working with snakes, he reckoned he'd get bit sometime. So, over years, he'd inject small traces of venoms daily. He survived the bites of Black Cobra twice and his [personally him, not saying everyone could] immunity developed over years allowed him to flying cross-country so a sample of his his blood could be quickly processed into an emergency anti-venom! I am certain he had some personal genetics that aided his idea - but what a gift Haast was!
3 years ago I was diagnosed with seasonal allergies and mad allergic to birch tree. Last year I was brutalized with the sneezing, wheezing, etc. of seasonal allergy. This past spring I enjoyed a few birch leaves every day as they emerged (growing larger each day). I had zero allergy. I will repeat this spring to see if the results are the same.
Imagine your a snake, some dude comes poking around your den so you bite him to kill him with your highly deadly and always reliable poison. Then said dude goes “Hur hur antibodies go brrrrrrrr”
This video actually reminded me of the very interesting research being done on therapeutic uses of different poisons and toxins in the world. One use I’ve heard of is as a treatment for chronic pain. Could you maybe do a video on something like that?
I get that we just dismiss these sorts of people as crazy - but humanity owes a lot to those crazy enough to do stuff like this. (attempting to become immune to poisons/venoms)
Unfortunately some toxins have a toxicity level like Mercury where it collects in your cellular material until you reach a saturation level that kills you so that's a very important thing to check before you even consider doing something like this.
Arsenic ("Hittrach") was used as a stimulant in some alpine regions until the mid-20th century. According to reports some people ingested quite astonishing amounts. If those are accurate it seems that you can aquire a tolerance to arsenic.
Possibly. The book "Search and Research: The Story of the Chemical Elements", claimed that arsenic-eaters in Austria could build up a tolerance. But perhaps there was arsenic in their water sources, and so over time, had the same gene that the village in South America has.
With that optic nerve damage fact, is that where we get the "blindness from drinking moonshine" knowledge from. Asking for a friend, i was drinking vodka during this.
My grandfather was a beekeeper and over time he was practically immune to bee venom. This also seemed to leave him with no arthritic conditions, he died at 91.
That's because bee venom again falls under the category of "stuff your immune system deals with". IgG antibodies more specifically, you don't want your body creating IgE antibodies against bee venom because those more or less end up having the opposite effect, if you produce both at the same time you might be fine though, since IgE antibodies are such a small part of total antibody concentration.
part of tolerance is your body adjusting to the presence of a substance so it can still function as close to normal as possible this is why withdrawals are a thing because your body needs to readjust to it not being there
You can also become allergic to some toxins. I developed a bee allergy after getting stung when I was 28. Before that, I had no issues. Now each time I'm stung the reaction is a little worse. Poison ivy can also do this. As a landscaper, I've seen many people develop an allergy to it.
I inherited my mom's pineapple allergy. When I was in 2nd grade my school had a salad bar that had pineapple every day, which I partook from. I loved the stuff, and despite the feeling my mouth being full of small cuts, I pressed on and happily ate my treat. To this day I love me some some pineapple, and eat it raw, cooked, canned, fresh, any which way. I no longer suffer any noticable effects, and regard this as the best stupid decision my child self ever made...
If i remember correctly he has mentioned watching it at least one on the podcast Brainfood Show with Daven... if you have not listened to the podcast yet you should give it a shot.
Arsenic does build up a tolerance by the reduction of bioavialability. It was used in Switzerland as a stimulant. Look up Arsenikesser in the German Wikipedia.
I remember watching some old guy on TV that was healthy looking an he said his secret was injecting himself daily with a mixture of several snake venoms.
That would have been the legendary Bill Haast. He did many interviews and documentaries over the years. In one of them he recounts how his blood was in fact used as antivenom on numerous occasions with him at least once flying to a hospital in another state to save child I believe was bitten by an unknown species of snake.... he was quite impressive...If i were him i would have die early from a stress induced heart attach from all those snakes he had.
I grew up near one of the largest lead smelters in the world (Trail, BC, Canada). At one point in time, they found that milk decreased the level of lead in the blood, so they actually had a dairy farm owned by the smelter and provided milk to workers to help decrease lead levels. Unfortunately, they later found out that the milk was helping the lead to migrate into bones, and the apparent decrease in lead levels wasn't actually as great as they thought. The company sold the dairy farm after that.
@@30-x-dshaayonchakravarty85 11:04 in the camera pans. You can see this is a fairly clean photo. What doesn't pan is the "brown dirt filter" that is smeared all over it. Makes the photos look like crap even if they are clear. I think they are going for an old timey look but they over use it cram it into everything.
I have a buddy in Mexico that regularly does dots of snake venom. burn a tiny hole on a pore and let it soak in. But he also regularly does other ordeal poisons.
@@crazymusicchick No, Blaze is the most informative. Otherwise, they’ll never realize the dangers of cocaine and ignore the lucrative career in elevator design.
The Dose Makes the poison for most things. As Simon said, it depends on the what the poison is, is it an organic or is it some sort of mineral and if it is a compound, what does it metabolize in to? Some things metabolise in to other more deadly stuff. In the case of alcohol, sudden cessation after regular consumption can be deadly. If you do build a tolerance to something, it can be, um, bad, to suddenly stop. Some compounds you can build a tolerance to without much adverse effects. Other stuff has cumulative damage. It really depends.
Snake bite immunization is one of the ancient medical practices that actually works. As someone who used to breed snakes, I have seriously considered doing this. I ultimately decided it wasn't worth the effort, as my snake breeding was never intended to be a livelihood, and I don't have much in the way of native venomous snakes. We have rattlers and water moccasins, and they are rare here.
How has there not been an episode of Rajneeshpuram? That is such an insane story that I don't see HOW it can't be an episode on one of Simon's 1000 channels.
Yeah it's resistance like alcohol tolerance, like the video sorta says. You're more resistant to the venom, so much so that a snake isn't going to be able to inject enough to truly harm you, but enough would still be very very bad
I had the misfortune of drinking contaminated home-brew and was very lucky to have been able to have been treated and have suffered very minor side effects of methanol poisoning
@@davidvanderbrook3988 The story given in this video is considered mostly accurate. There is a "heroic" version Yusupov used to tell but later in life recanted. That's the one with Rasputin coming back to life three times. The more reasonable story Yusupov told is that the three conspirators tried to poison him, failed, then Yusupov shot him in the chest and hid his body without checking first if he'd really died. Kosorotov, the doctor performing the autopsy, actually found this first bullet lodged in his chest cavity, but concluded it wasn't fatal. As Yusupov told it, it actually wasn't, and Rasputin managed to get up and try to attack him as he was showing the body to his co-conspirators who arrived later. It took two more shots, one to the head, to take him out. They then wrapped the body in some sort of cloth for trasnsport but unwrapped the cloth when they dumped it in the river.
I understood that as larger than inorganic molecules, but then my chemistry knowledge is basically nonexistent so no idea whether that's at all better.
Yes it true , people /natives/fishermen who eat alot of fish where reef fish are common, those people can be immune/resistant to when red tide algae blooms occur , while it will kill tourists if they eat the local fish during a red-tide. People who get bit by rattlesnakes several times will develop resistance to rattlesnake venom, I knew a zoologist whose field of study was primarily rattlesnakes and he had literally about 30 different rattlesnakes species and about 200 rattlesnakes in total and had been bitten many times . (I helped feed the snakes ) for a year or so. He did not worry about the occasional bite.
What about certain rockstar, for example Ozzy Osborne? The amount of hard drugs (aka poison) that they have taken, and come back, sometimes quickly, other times over time relatively well is legendary, and at times documented. Also while some like Elton John have gone ahead and helped sponsor people after going to rehab themselves, and some like again Ozzy is well known to have had negative effects, like his speech, the fact they have taken so much drugs over a long period of time, and are alive and still able to perform is incredible. Granted Keith Richards recently went to the hospital for heart problems, his age plus the amount of activity performed on stage, Richards' drug use probably isn't the only factor, and may not even be a major factor to his recent hospital stay. In all seriousness I think some of these people need to be studied. Maybe not by having them take drugs, but by studying their blood, and enzymes, and trying to find ways to test how their bodies interact with drugs without still giving it to them. As while they have shown they can handle it, doing so at the age that many people who always lived healthfully and sober have already died, may be tempting fate.
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So have you seen the Princess Bride now then? ...seems askew to use a reference from a film you've still not seen (despite us badgering you to watch it)...or was that the point (whomever wrote the script?) ...I'm just curious as to whether you have seen it and if you enjoyed it, as it is a classic film that still holds up.
I _could_ take tiny bits of a medication I'm allergy to & not have a reaction, sure. _BUT,_ my body still don't like it. Miss a dose & die?
@@Do_Odles Davan probably wrote or at least edited the script :) He may be learning from Sam.
Great try for Nord
I take small non lethal doses of alcohol.
Unfortunately, I'm building up an immunity.
When he introduced Tim Fried as a 'self taught immunologist' from Wisconsin I did not think it was going to go the way it did
Aye!!! I actually know Tim. He has visited my house to hang out a few times.
@@Karatop420 the herpetology community is definitely a unique one, huh? I've met several people who are prominent in the field and they are all very neat and cool people. There are some who are jerks/idiots, but for the most part most are down to earth and nice people. Jim Harrison of the Kentucky reptile zoo is a dear friend of mine. He worked with Bill Hasst in Florida way back in the day and helps supply a large portion of the snake venom used to make antivenom, pharmaceuticals, in many experiments that are going on these days and for scientific studies. I completely renovated the zoos Tropics building absolutely for free over the course of two weeks back in 2015. One of the best 2 weeks of my life.
And also the sweetness in the cakes served to Rasputin cancelled out the poisonous effects of the cyanide.
Chasing the dragon for science
@@Criwindustries no the cyanide just had delayed effect because his stomach lining was thicker that usual because he had just got done with an afternoon of boozing
"certain metals can be mistaken for calcium and used in its place forming bones"
OK, I've heard enough!.. will start consuming Adamantium
I have some. It's totally not lead and cesium.
@@BaronVonQuiply I believe you...send it over
Bye teeths!
@@ME262MKI not the teeth!
Strontium makes weak bones, but it’s really pretty in cow’s milk.
The rule about never getting involved in a land war in Asia still applies.
Exactly, you dig a canal into the center of Asia and bring your navy in. 😁
Try a communist revolution. That usually works.
Risk taught me that.
Hong Kong wouldn't be a land war.
Unless your British or have Britain as an ally.
not gonna lie, getting bit by a black mamba and living at all is a bit awesome, living without losing part of your body or having permanant damage is crazy, and comparing it to bee stings is honey badger level.
I told my GF that we don't need condoms because it's possible to become immune to pregnancy by taking small doses of semen. After our 8th child was born she started to have doubts about the process.
Semen
@@Lspace
*fixed. Thanks, my autocorrect is a prude.
@@acetate909 lol no probs, i never use autocorrect, it sucks!
That was a good joke tho, cracked me up 🤣
She will eventually become immune. You just need to wait long enough.
Worked after the 11th one mate, keep going
Short answer: yes, with and IF
Long answer: no, with a BUT
BUT what IF...?
We love the accurate answers.🤖 Simple answers are for simple people.
It highly depends on the poisen or toxin...
YES, if it is of animal origin it probably is possible.
NO type of mineral poison can allow you to have immunity to it, BUT some can through thousands of years of natural selection.
The crab answer: Mayhaps
My grandmother used to work in a greenhouse for poisonous plants in her teens and early 20s before she gave birth to my mother. My mother and I have also been immune to most plant based poisons, probably because much of our immune system is passed from mother to child in the womb.
didn't really know i was immune until i went playing in the bushes while camping, and i gave poison ivy to all of my dad's family. never had so much as an itch.
What about poisonous plants like hemlock and yew and deadly nightshade? I thought Mithridates built up a lot of his tolerance eating toxic plants, but the video doesn't talk about them at all.
From what I recall of the story Mithridates built up an immunity to the local plants and animals of Georgia before sending out for more poisons from other countries. As with the primary point of the video, the effectiveness varies. For example some poisons neutralize each other when consumed so initially proper dosing could avoid initial reactions, and poison cocktails could have saved him later.
On a more specific note, most ancient plant based poisons in the area were alkaloid based such as aconite. Alkaloids are natural muscle relaxants in small quantities and are used in heart medicines. There has been no modern studies on long term alkaloid poisoning, but early testing does indicate that a tolerance is built up in patients.
@@akatoshslayer7599 That's very informative, thank you.
With most organic poisons, you can build up a tolerance
@@akatoshslayer7599 Are you a professional poisoner? The hek is that offhand knowledge
@@akatoshslayer7599 So again...why isn't he mentioned in the video? Seems like a good candidate. The guy had to bribe one of his guards to kill him with his sword because he was unable to poison himself to death while imprisoned - how does that not qualify?
This is one of the best explanations of how the body metabolises alcohol I've ever come across. I can say that the researcher on this video has done their job superbly.
Well done simon on pronouncing those trickier words correctly!
I've been regularly biting small snakes for years. It's working so far.
Madlad
* when you confuse venom and poison * xD c:
I LOLed at Simon referencing the famous Princess Bride scene as though he was actually familiar with it. We all know he hasn't seen the movie yet!
lul the dude has seen like a dozen movies his entire life!
Can i make myself immune to sadness and depression by taking a small dose everyday?
I hope that works, seems to be my strategy about half the time.
Small dosis
no thats how you get depression
I hope so, otherwise boy, am I in trouble!
@@sanghelian pretty sure that would be more accurately described as already having mild depression.
Was this script made so that Daven could finally convince you to watch the Princess Bride?
Wait people need a reason
@@AirQuotes they shouldn't, but it has been years and Simon has yet to watch it. Rather than watching First Contact again, put on The Princess Bride!
I watched the Princess Bride for the first time just last year. I was 35.
My official excuse is that I had previously lacked opportunities to watch it.
@@AirQuotes it's like saying you need a reason to watch the holy grail
Lol I was going to say it but I decided to check to see if someone beat me to it! Simon for goodness sakes just watch it! 🤣
I don't know about poison, but watching five minutes of news every day should one day enable me to sit through a whole segment... it works on the same principle.
I also heard the explanation once that cyanide is deactivated by large doses of sugar, and since both the cake and wine consumed by Rasputin were highly sweetened, the high sugar content actually prevented the cyanide form doing its job.
That would make sense. Him needing to be clubbed and drowned despite being shot is also pretty mundane as well when you consider that bleeding to death from a gunshot wound can take hours
@@HouseLyrander Especially since handguns in those days have problem hitting the side of a barn from 20 or more feet away
@@HouseLyrander that reminds me of what happened to the tsar's children after the Russian Revolution. They tried to execute them by firing squad but all five children survived. They then bayoneted the children but that didn't seem to work either, and eventually all five were shot in the head at close range.
Isaac Bruner That was more because they had a bunch of gemstones and jewelry sewn into their clothing
Used to ba a treatment for malaria to gradually give you larger and larger doses daily of strychnine, to the point it killed the malaria parasites in the blood, but not quite killing you, Then taper the dose off again over a few weeks till you were no longer taking it. done when the British army had a lot of malaria cases in the tropics, and no quinine to treat it otherwise.
You sure you don't mean quinine instead of strychnine?
@@civilwildman Lack of quinine meant the doctors had to use alternative treatments, basically try to kill the parasite before killing the host.
Sounds like chemo
I love that he references a movie he's never watched
Same thing I was thinking, good script cuz if I didn't know any better ...
What movie?
@@bobfg3130 princess bride
"If your enemies are trying to poison you with snakes, you're probably awesome" well, i now have new life goals so Simon thinks I'm cool 😂
venom and poison aren't the same though, not many snakes are poisonous and i guarantee you nor the host could even name one.
@@justaguyonyoutube garter snake. There you go now you aren't the smartest person in the room. Maybe have fun instead a bit of an ass.
@@michaelmcurdy3459 you can factually eat a garter snake and not die so again that isn't poisonous my guy, that's venomous and just about everyone can name a venomous snake. A poisonous snake would be something like a tiger keeled back snake, which is both actually. Garter Snakes primarily feed on fish, slugs and earthworms which would not give them any of the necessary ingredients to poisonous. If you think that's being an ass you're too sensitive for the internet my friend that's called education through facts rather than sugar coating and hand holding. Misinformation leads to misrepresentation and fear, which is exactly what those of us who know, love and keep reptiles as a hobby or conservation effort are trying to avoid.
@@justaguyonyoutube so you want you know a deadly poisonous snake then?
@@michaelmcurdy3459 that wasn't a proper sentence, I want you to be able to name a poisonous snake which a garter snake is not. A garter snake is venomous which is factually not the same as a poison.
I appreciate how you talk about not caring about anything but making money in your business blaze videos. It lets me know you don't care how good or bad your sponsors are, so I shouldn't trust you plugging them. Thanks!
Amazing what humans will do in researching for an antidote. I take my hat off to those who sacrificed themselves, being a Guinea Pig.
Short answer: Yes, but it depends on the poison, how much you take in, and how much you damaged yourself during the immunity process.
Short answer: No, you can't.
Long answer: Yes there are some compounds when taken will boost specific enzymes in your liver that makes you need a higher dose to see effect but it doesnt make you 'immune'.
Theoretically it could work for cyanide but there is lack of a needed substrate in yr body
Princess Bride one of my favorite films ever:)
As for poison immunity would be glad to develop that
Keep doing what your doing, your taught us all a lot over these videos!
Next video should be TIFO how to use "you, your and you're"
Ummm these are for entertainment. They shouldn't have to be used to keep yourself safe.
@@davidvanderbrook3988 I never meant it like that, it was about his videos generally, not this specific video lol
Hats off to the madlads letting venomous snakes bite them in order to find a better treatment.
Nord VPN" You looking to protect yourself or deal some damage".
Some might call it junk. Me, I call it treasure!
"Just about everything on display here really"
There was a lady in my neighborhood who told my mom that mosquitoes never bit her, they would often sit on her skin but will never bite her, if they do so, they will die. That goes same for her daughter too, but not for her husband and her son. My dad told us about how at some places small children are given small amount of poison throughout their childhood and they turn out to have poisonous blood when they grow up.
I read about this in The Count Of Monticristo.
I first ran into the troupe watching Ninja Scrolls a kid.
Mmmm i love a good Monte Cristo
Me favorite Alexandre Dumbass book
@@tempestgod8043 Nice reference to The Shashank Redemption!
About NORD vpn? 😮😮😮😮😮
I have a friend, he's a heavy smoker and swears it saved his life. He got sick, was having a hard time breathing, and ignored his symptoms until friends dragged him to the ER.
His blood oxygen levels were so low average people would have died l, but because his body was used to low oxygen he pulled through.
Still smokes almost 20 years later.
"Forced to commit suicide"
Is.. is that how it works though?
It can be.
Ep-stein...
Ever been in 7th grade World Cultures? Or have heard of a group of Japanese people called samurai?
This works with asbestos too. Miners who breathed in small amounts over the years were able to work the mines for many decades with no ill effects.
This is one of the most interesting videos I have watched in a very long time. Cheers.
My worst enemy keeps trying to poison me with alcohol.
Super impressed with your pronunciation through this whole episode :-)
This has nothing to do with the contents of the video, but as a Swedish person I'm very impressed with your pronunciation of Lund and Uppsala!
Self taught Wisconsin immunologist = man who watched one too many episodes of Toriko
Hey, Swedish person here..just wanted to drop in and say that you pronounced "Lund" and "Uppsala" university flawlessly. Good job!!
It’s just basically building up a tolerance .
*IF* your body can handle it AND not to every substance. 🧑🏫💉🐍🩸🥃☠
A Botanist at Cornell University collected wild mushrooms and would test them for cooking by consuming an increasing amount daily and would discard if he had symptoms. He had a dinner party for his graduate students where he cooked with the "safe" mushrooms. Everyone went to the emergency room except him. My supervisor, a Ph.D. in horticulture, was one of his victims. This happened in the early sixties. He told me the story in 1973. I never had a reason to disbelieve him.
Happy new year Simon mate!
Basically, in summary there are three main cases:
1. Complex poisons/toxins: Lasting, gradual immunization possible by humoral response; temporary immunization possible through anti-serum
2. Molecular/simple toxins with evolved counter-measures: Accommodation of physiological response (e.g. enzyme production) possible
3. Molecular/simple toxins without evolved counter-measures: No immunization/accommodation possible on somatic, individual level
(4. Any toxin a species is exposed to enough to generate a significant fitness advantage if resistance is developed might lead to actual resistance by process of natural selection/random mutations, e.g. resistance by conformational changes to core proteins that disallow the action of a toxin or evolution of enzymatic processes to breakdown toxins)
wanted to know about poisons, ended up with a lecture about venoms....
still really cool, but what about plant based poisons. would that be something that could be built up against?
Varies widely. It's really specifically about each poison and if the body has the ability to metabolize it. Immune system doesn't help against poisons (unlike many venoms). There are also genetic variances - for example, the stuff that causes rashes to form from poison ivy/oak some people are basically immune to.
it should also be noted their are chemicals that are harmless but over time become poisonous. long term painters get turpentine poisoning over time and become "hypersensitive" to it as it builds up in their system after frequent exposure.
I keep saying it, but you are way better than Stuff You Should Know. I followed them for a decade and dumped Josh and Chuck for you my friend.
I was thinking of Bill Bill Haast when I first clicked! When he first started working with snakes, he reckoned he'd get bit sometime. So, over years, he'd inject small traces of venoms daily. He survived the bites of Black Cobra twice and his [personally him, not saying everyone could] immunity developed over years allowed him to flying cross-country so a sample of his his blood could be quickly processed into an emergency anti-venom! I am certain he had some personal genetics that aided his idea - but what a gift Haast was!
"68% off for your a two year package"
We were on the verge of greatness, we were this close
3 years ago I was diagnosed with seasonal allergies and mad allergic to birch tree. Last year I was brutalized with the sneezing, wheezing, etc. of seasonal allergy. This past spring I enjoyed a few birch leaves every day as they emerged (growing larger each day). I had zero allergy. I will repeat this spring to see if the results are the same.
"Trending news" on Twitter
Oh Rip, getting the news from Twitter is like....whatever.
LMAO...
What is Twitter?
@@cuttwice3905
Twitter is pain
@@cuttwice3905 Twitter is where stupid congregates.
@@cuttwice3905 Cesspools
Imagine your a snake, some dude comes poking around your den so you bite him to kill him with your highly deadly and always reliable poison. Then said dude goes
“Hur hur antibodies go brrrrrrrr”
*venom
You knew what I meant
Good topic for New Years Eve. 🍻 🥂 😎
This video actually reminded me of the very interesting research being done on therapeutic uses of different poisons and toxins in the world. One use I’ve heard of is as a treatment for chronic pain. Could you maybe do a video on something like that?
What venom I want it NOW. I do get pot though lol.
For decades, I have been conducting a thorough investigation into ethanol tolerance levels. I am the only test subject.
I get that we just dismiss these sorts of people as crazy - but humanity owes a lot to those crazy enough to do stuff like this. (attempting to become immune to poisons/venoms)
Giving it a watch! Thanks sir. When I sign up for Nord VPN I'll be using your code ;)
Unfortunately some toxins have a toxicity level like Mercury where it collects in your cellular material until you reach a saturation level that kills you so that's a very important thing to check before you even consider doing something like this.
You should make a video about how people used to mail children through the post
Arsenic ("Hittrach") was used as a stimulant in some alpine regions until the mid-20th century. According to reports some people ingested quite astonishing amounts. If those are accurate it seems that you can aquire a tolerance to arsenic.
Possibly. The book "Search and Research: The Story of the Chemical Elements", claimed that arsenic-eaters in Austria could build up a tolerance. But perhaps there was arsenic in their water sources, and so over time, had the same gene that the village in South America has.
Good video 👍
With that optic nerve damage fact, is that where we get the "blindness from drinking moonshine" knowledge from. Asking for a friend, i was drinking vodka during this.
Well there goes my New Year’s resolution
My ADD kicked in during the Nord VPN ad. I'm gonna assume the answer is yes. Yes, 100% of the time.
Awesome!
Another great video question, gonna grab a coffee and fully enjoy it :D
My grandfather was a beekeeper and over time he was practically immune to bee venom. This also seemed to leave him with no arthritic conditions, he died at 91.
That's because bee venom again falls under the category of "stuff your immune system deals with". IgG antibodies more specifically, you don't want your body creating IgE antibodies against bee venom because those more or less end up having the opposite effect, if you produce both at the same time you might be fine though, since IgE antibodies are such a small part of total antibody concentration.
3:38 thought i heard him say assh*le-taldehyde😂
I read your comment exactly as I noticed that at 4:21
part of tolerance is your body adjusting to the presence of a substance so it can still function as close to normal as possible this is why withdrawals are a thing because your body needs to readjust to it not being there
*"You killed my father"*
*"You killed my father"*
*"👁 👄 👁"*
You can also become allergic to some toxins. I developed a bee allergy after getting stung when I was 28. Before that, I had no issues. Now each time I'm stung the reaction is a little worse.
Poison ivy can also do this. As a landscaper, I've seen many people develop an allergy to it.
I inherited my mom's pineapple allergy. When I was in 2nd grade my school had a salad bar that had pineapple every day, which I partook from. I loved the stuff, and despite the feeling my mouth being full of small cuts, I pressed on and happily ate my treat. To this day I love me some some pineapple, and eat it raw, cooked, canned, fresh, any which way. I no longer suffer any noticable effects, and regard this as the best stupid decision my child self ever made...
The pronunciation on Upsala was almost flawless
Have you even seen the Princess Bride Simon? The way you talk on Business Blaze I doubt it.
Of course he hasn’t. Simon hates fantasy.
@@cherraberra7346 Simon just hatea
Simon, it’s really a sci-fi - you’d love it!
If i remember correctly he has mentioned watching it at least one on the podcast Brainfood Show with Daven... if you have not listened to the podcast yet you should give it a shot.
Simon is a god for rolling through those pronunciations after the 3 min mark.
Your narration makes me immune to boredom
I love your voice, and I love the way this video was displayed. You've earned a subscriber good sir
Oh good. Riddick was still scientifically accurate. Thanks Dr. Diesel.
I've been talking about this for weeks and this finally popped up. Too bad Express and Nord didn't stop the algorithm from this.
Simon just whistles through all those long vocabulary words so easily, doesn't he?
Simon just speaks English, doesn't he?
@@qtulhoo lmao
Arsenic does build up a tolerance by the reduction of bioavialability. It was used in Switzerland as a stimulant. Look up Arsenikesser in the German Wikipedia.
I remember watching some old guy on TV that was healthy looking an he said his secret was injecting himself daily with a mixture of several snake venoms.
Snake venom is the type of poison you can develop an immunity to.
That would have been the legendary Bill Haast. He did many interviews and documentaries over the years. In one of them he recounts how his blood was in fact used as antivenom on numerous occasions with him at least once flying to a hospital in another state to save child I believe was bitten by an unknown species of snake.... he was quite impressive...If i were him i would have die early from a stress induced heart attach from all those snakes he had.
@@alexlail7481 instead he lived to be 100! Maybe that snake venom did him some good.
"And yes, everyone's favourite furry badass, the hunnybadger" lololololololol!!!
If you eat small amounts of Taco Bell you can build up immunity to the sh*ts.
Edited for: allegedly
I grew up near one of the largest lead smelters in the world (Trail, BC, Canada). At one point in time, they found that milk decreased the level of lead in the blood, so they actually had a dairy farm owned by the smelter and provided milk to workers to help decrease lead levels. Unfortunately, they later found out that the milk was helping the lead to migrate into bones, and the apparent decrease in lead levels wasn't actually as great as they thought. The company sold the dairy farm after that.
Why do you guys out the "dirt filter" on old pictures. Why are you making the photos worse?
What?
@@30-x-dshaayonchakravarty85 11:04 in the camera pans. You can see this is a fairly clean photo. What doesn't pan is the "brown dirt filter" that is smeared all over it. Makes the photos look like crap even if they are clear. I think they are going for an old timey look but they over use it cram it into everything.
@@ccovemaker oh ok
Smash that dislike button.
I have a buddy in Mexico that regularly does dots of snake venom. burn a tiny hole on a pore and let it soak in. But he also regularly does other ordeal poisons.
I think I’ll pull my kids out of school and just let them watch all the Simon Whistler channels.
Maybe not buiness blaze though
@@crazymusicchick lol, aye but space heater information is hard to find.
I’ve probably learned more from RUclips than I do in high school
@@crazymusicchick No, Blaze is the most informative. Otherwise, they’ll never realize the dangers of cocaine and ignore the lucrative career in elevator design.
The Dose Makes the poison for most things. As Simon said, it depends on the what the poison is, is it an organic or is it some sort of mineral and if it is a compound, what does it metabolize in to? Some things metabolise in to other more deadly stuff.
In the case of alcohol, sudden cessation after regular consumption can be deadly. If you do build a tolerance to something, it can be, um, bad, to suddenly stop.
Some compounds you can build a tolerance to without much adverse effects. Other stuff has cumulative damage. It really depends.
Another top video guys!
(Heavy) metal chelation would make a great topic to spin off from this one!
Snake bite immunization is one of the ancient medical practices that actually works. As someone who used to breed snakes, I have seriously considered doing this. I ultimately decided it wasn't worth the effort, as my snake breeding was never intended to be a livelihood, and I don't have much in the way of native venomous snakes. We have rattlers and water moccasins, and they are rare here.
"Ground squirrel" always sounds like a pizza topping to me.
It is, if you are brave enough.
How has there not been an episode of Rajneeshpuram? That is such an insane story that I don't see HOW it can't be an episode on one of Simon's 1000 channels.
Have a friend who's "immune" to rattlesnake venom from doing this to himself, I'd say he's more resistant than immune, but still.
If that’s true, tell him to let researches draw some of his blood and study it.
Yeah it's resistance like alcohol tolerance, like the video sorta says. You're more resistant to the venom, so much so that a snake isn't going to be able to inject enough to truly harm you, but enough would still be very very bad
Get new friends lol
@@Skyrendofficialyt yeah everyone should go get boring friends that don't do cool shit
I had the misfortune of drinking contaminated home-brew and was very lucky to have been able to have been treated and have suffered very minor side effects of methanol poisoning
Common misconception. Rasputin wasn't wrapped in a carpet.
I think most of the story was made up. I think gun shots were the cause of death.
@@davidvanderbrook3988 The story given in this video is considered mostly accurate. There is a "heroic" version Yusupov used to tell but later in life recanted. That's the one with Rasputin coming back to life three times. The more reasonable story Yusupov told is that the three conspirators tried to poison him, failed, then Yusupov shot him in the chest and hid his body without checking first if he'd really died. Kosorotov, the doctor performing the autopsy, actually found this first bullet lodged in his chest cavity, but concluded it wasn't fatal. As Yusupov told it, it actually wasn't, and Rasputin managed to get up and try to attack him as he was showing the body to his co-conspirators who arrived later. It took two more shots, one to the head, to take him out. They then wrapped the body in some sort of cloth for trasnsport but unwrapped the cloth when they dumped it in the river.
Vladamir Ras Putin.
I fully expect to see videos on land wars in Asia and Sicilian death wagers.
"Larger organic molecules"... "like [ethanol]", one of the smallest organic molecules possible...
I understood that as larger than inorganic molecules, but then my chemistry knowledge is basically nonexistent so no idea whether that's at all better.
To be fair, most poisons are large organic molecules or even proteins, so ethanol really is the smallest example next to methanol
Yes it true , people /natives/fishermen who eat alot of fish where reef fish are common, those people can be immune/resistant to when red tide algae blooms occur , while it will kill tourists if they eat the local fish during a red-tide.
People who get bit by rattlesnakes several times will develop resistance to rattlesnake venom, I knew a zoologist whose field of study was primarily rattlesnakes and he had literally about 30 different rattlesnakes species and about 200 rattlesnakes in total and had been bitten many times . (I helped feed the snakes ) for a year or so. He did not worry about the occasional bite.
I poisoned my wifes pita dip
The police charged me with hummus-cide
Yuk yuk.
I like tis
What about certain rockstar, for example Ozzy Osborne? The amount of hard drugs (aka poison) that they have taken, and come back, sometimes quickly, other times over time relatively well is legendary, and at times documented. Also while some like Elton John have gone ahead and helped sponsor people after going to rehab themselves, and some like again Ozzy is well known to have had negative effects, like his speech, the fact they have taken so much drugs over a long period of time, and are alive and still able to perform is incredible. Granted Keith Richards recently went to the hospital for heart problems, his age plus the amount of activity performed on stage, Richards' drug use probably isn't the only factor, and may not even be a major factor to his recent hospital stay. In all seriousness I think some of these people need to be studied. Maybe not by having them take drugs, but by studying their blood, and enzymes, and trying to find ways to test how their bodies interact with drugs without still giving it to them. As while they have shown they can handle it, doing so at the age that many people who always lived healthfully and sober have already died, may be tempting fate.
Simon's wife is a whistleblower 😂😂😂
Guess I’ve been building tolerance to poison for awhile, Dyamn beer.